Wei Bian, Xi Hu, Ruixue Xiao, Rui Yao, Bo Zhang, Mingjian Zhu, Tianqi Liu, Yamin Liu, Jing Li, Peihua Lin, An Xie, Fangyuan Li, Daishun Ling
To overcome current limitations in photoimmunotherapy, such as insufficient tumor antigen generation and a subdued immune response, a novel photo-/metallo dual-mode immunotherapeutic agent (PMIA) is introduced for potent near-infrared (NIR) light-triggered cancer therapy. PMIA features a dumbbell-like AuPt heterostructure decorated with starry Pt nanoclusters, meticulously engineered for enhancing plasmonic catalysis through multi-dimensional regulation of Pt growth on Au nanorods. Under NIR laser exposure, end-tipped Pt nanoclusters induce efficient electron-hole spatial separation along the longitudinal axis, resulting in radial and axial electron distribution polarization, conferring unique anisotropic properties to PMIA...
May 30, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)