Elham Mashayekh, Zahra Nouri Khajeh Ghiasi, Iman Bhia, Zohreh Arefi Khorrami, Omid Malekahmadi, Mohammed Bhia, Samira Malekmohammadi, Yavuz Nuri Ertas
Metal-organic frameworks (MOFs) are utilized as nanocarriers to enhance the efficiency of chemotherapy drugs, including cisplatin, which exhibit limitations such as side effects and resistance mechanisms. To evaluate the role of MOFs, we employed a molecular dynamics simulation, which, unlike other experiments, is cost-effective, less dangerous, and provides accurate results. Furthermore, we conducted molecular docking simulations to understand the interaction between cisplatin and MOF, as well as their internal interactions and how they bind to each other...
April 30, 2024: ACS Omega