Ellie Mainou, Stella J Berendam, Veronica Obregon-Perko, Emilie A Uffman, Caroline T Phan, George M Shaw, Katherine J Bar, Mithra R Kumar, Emily J Fray, Janet M Siliciano, Robert F Siliciano, Guido Silvestri, Sallie R Permar, Genevieve G Fouda, Janice McCarthy, Ann Chahroudi, Jessica M Conway, Cliburn Chan
While the benefits of early antiretroviral therapy (ART) initiation in perinatally infected infants are well documented, early ART initiation is not always possible in postnatal pediatric HIV infections, which account for the majority of pediatric HIV cases worldwide. The timing of onset of ART initiation is likely to affect the size of the latent viral reservoir established, as well as the development of adaptive immune responses, such as the generation of neutralizing antibody responses against the virus...
July 22, 2023: bioRxiv