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JOURNAL ARTICLE
Franziska Jannasch, Daniela V Nickel, Manuela M Bergmann, Matthias B Schulze
Previously, the attempt to compile German dietary guidelines into a diet score was predominantly not successful with regards to preventing chronic diseases in the EPIC-Potsdam study. Current guidelines were supplemented by the latest evidence from systematic reviews and expert papers published between 2010 and 2020 on the prevention potential of food groups on chronic diseases such as type 2 diabetes, cardiovascular diseases and cancer. A diet score was developed by scoring the food groups according to a recommended low, moderate or high intake...
June 6, 2022: Nutrients
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JOURNAL ARTICLE
Noga Fuchs Weizman, Brandon A Wyse, Janice Montbriand, Sahar Jahangiri, Clifford L Librach
Cannabis is increasingly consumed by women of childbearing age, and the reproductive and epigenetic effects are unknown. The purpose of this study was to evaluate the potential epigenetic implications of cannabis use on the female ovarian follicle. Whole genome methylation was assessed in granulosa cells from 14 matched case-control patients. Exposure status was determined by liquid-chromatography-mass-spectrometry (LC-MS/MS) measurements of five cannabis-derived phytocannabinoids in follicular fluid. DNA methylation was measured using the Illumina TruSeq Methyl Capture EPIC kit...
June 8, 2022: Molecular Human Reproduction
#43
JOURNAL ARTICLE
Sarah Redmond, Jon Tilburt, Andrea Cheville
INTRODUCTION: Opioids may be necessary for guideline-concordant acute perioperative pain management, but their use carries risks for unintended prolonged use and addiction. Guidelines recommend use of validated non-pharmacological pain care (NPPC) approaches in conjunction with prescribed opioids and other analgesics. Our protocol outlines a population-level, pragmatic trial that will test a bundled intervention comprised of an electronic health record (EHR) portal-based conversation guide, EHR clinical decision support (CDS), and a suite of self-management educational and support materials to encourage and advance NPPC use...
June 3, 2022: Pain and Therapy
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JOURNAL ARTICLE
Ahmed Abdelhafez, Khaled Hosny, Ahmed R El-Nahas, Matthew Liew
Objective: To examine the health-related quality of life (HRQoL) of patients with prostate cancer managed with active surveillance (AS) compared with those who receive definitive treatment using the Expanded Prostate Cancer Index Composite (EPIC) Survey. Methods: We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and searched PubMed and ScienceDirect for articles published between April 2010 and April 2020. Eligible studies reported original data on the HRQoL of men undergoing AS for prostate cancer, including studies comparing AS to curative methods particularly radical prostatectomy, radiotherapy, and brachytherapy...
2022: Arab Journal of Urology
#45
JOURNAL ARTICLE
Nicole Huang, Lu Chen, Jing He, Quan D Nguyen
Objective A breast exam is a low-risk, low-cost method for early detection, which is crucial for improved mortality. However, clinical breast exams (CBE) and breast self-exams (BSEs) remain controversial with unclear guidelines. This study analyzes the efficacy of these two exam types in evaluating palpable breast masses. Methods This retrospective cross-sectional study included 2019 medical records from Epic of women with breast lumps. Patient demographics, provider types, and breast exam types were recorded...
February 2022: Curēus
#46
Ahmed Mohfouz, Manar Hamed, Anshul Patel, Shams Tasnim, Princy Shah
Pseudomyxoma peritonei (PMP) is any mucin-producing tumor in the abdomen. If left untreated, it can compress vital abdominal organs. We describe a misleading presentation of disseminated peritoneal adenomucinosis (DPAM) of appendiceal origin. Treatment strategies for PMP vary from watchful waiting to cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) or early postoperative intraperitoneal chemotherapy (EPIC). The rarity of PMP has precluded any randomized studies, and few institutions see sufficient cases to report a series...
February 2022: Curēus
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JOURNAL ARTICLE
Daniel W Spaite, Chengcheng Hu, Bentley J Bobrow, Bruce Barnhart, Vatsal Chikani, Joshua B Gaither, Kurt R Denninghoff, Gail H Bradley, Amber D Rice, Jeffrey T Howard, Samuel M Keim
STUDY OBJECTIVE: Little is known about the out-of-hospital blood pressure ranges associated with optimal outcomes in traumatic brain injuries (TBI). Our objective was to evaluate the associations between out-of-hospital systolic blood pressure (SBP) and multiple hospital outcomes without assuming any predefined thresholds for hypotension, normotension, or hypertension. METHODS: This was a preplanned secondary analysis from the Excellence in Prehospital Injury Care (EPIC) TBI study...
July 2022: Annals of Emergency Medicine
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JOURNAL ARTICLE
Kristin K Zorn, Melinda E Simonson, Jennifer L Faulkner, Cyndee L Carr, Joshua Acuna, Tiffany L Hall, John F Jenkins, Karen L Drummond, Geoffrey M Curran
PURPOSE: Up to 10% of cancers may be associated with an inherited mutation that increases cancer risk. National guidelines emphasize referral for genetic counseling and testing for patients whose personal and/or family history increases their risk of having a hereditary cancer syndrome. METHODS: To increase appropriate referrals for cancer genetic counseling and testing, we piloted an automated alert known as a Best Practice Advisory (BPA) in the electronic health record, Epic, to notify oncology providers when a patient had a personal and/or family history that merited referral to cancer genetics...
July 2022: JCO oncology practice
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JOURNAL ARTICLE
Mehrvash Haghighi, Dayanandan Adhimoolam, Ricky Kwan, Melissa Gitman, Maria McGuire, Damodara R Mendu, Adolfo Firpo-Betancourt, Russell B McBride, Carlos Cordon-Cardo, Catherine K Craven
BACKGROUND: Pandemics are unpredictable and can rapidly spread. Proper planning and preparation for managing the impact of outbreaks is only achievable through continuous and systematic collection and analysis of health-related data. We describe our experience on how to comply with required reporting and develop a robust platform for surveillance data during an outbreak. MATERIALS AND METHODS: At Mount Sinai Health System, New York City, we applied Visiun, a laboratory analytics dashboard, to support main response activities...
2022: Journal of Pathology Informatics
#50
JOURNAL ARTICLE
Morteza Noshad, Christian C Rose, Jonathan H Chen
OBJECTIVE: Mapping real-world practice patterns vs. deviations from intended guidelines and protocols is necessary to identify and improve the quality of care for emergent medical conditions like acute ischemic stroke. Most status-quo process identification relies on expert opinion or direct observation, which can be biased or limited in scalability. We propose a mixed graphical and quantitative process mining approach to Electronic Health Record (EHR) event log data as a unique opportunity not only to more easily identify practice patterns, but also to compare real-world care processes and measure their conformance or variability...
January 24, 2022: Journal of Biomedical Informatics
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JOURNAL ARTICLE
Marinka Steur, Laura Johnson, Stephen J Sharp, Fumiaki Imamura, Ivonne Sluijs, Timothy J Key, Angela Wood, Rajiv Chowdhury, Marcela Guevara, Marianne U Jakobsen, Ingegerd Johansson, Albert Koulman, Kim Overvad, Maria-José Sánchez, Yvonne T van der Schouw, Antonia Trichopoulou, Elisabete Weiderpass, Maria Wennberg, Ju-Sheng Zheng, Heiner Boeing, Jolanda M A Boer, Marie-Christine Boutron-Ruault, Ulrika Ericson, Alicia K Heath, Inge Huybrechts, Liher Imaz, Rudolf Kaaks, Vittorio Krogh, Tilman Kühn, Cecilie Kyrø, Giovanna Masala, Olle Melander, Conchi Moreno-Iribas, Salvatore Panico, José R Quirós, Miguel Rodríguez-Barranco, Carlotta Sacerdote, Carmen Santiuste, Guri Skeie, Anne Tjønneland, Rosario Tumino, W M Monique Verschuren, Raul Zamora-Ros, Christina C Dahm, Aurora Perez-Cornago, Matthias B Schulze, Tammy Y N Tong, Elio Riboli, Nicholas J Wareham, John Danesh, Adam S Butterworth, Nita G Forouhi
Background There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. Methods and Results We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study...
November 19, 2021: Journal of the American Heart Association
#52
JOURNAL ARTICLE
Emmanuelle Ter Beek, Milan Kos, Mirte Streppel, Linda Dusseljee-Peute, Martijn van Oijen
Due to the COVID-19 pandemic, multidisciplinary team (MDT) meetings have to switch from physical to digital meetings. However, the technology they currently use to facilitate these meetings can sometimes be lacking, therefore many software companies have developed new software to ease our new digital workspace. In this study, we propose a new method, a comparative participatory cognitive walkthrough, which can show mismatches in cognitive models. To test our method, we tested the compatibility of EPIC EMR (EPIC Care) and the NAVIFY Tumor Board for preparing MDT meetings...
November 8, 2021: Studies in Health Technology and Informatics
#53
JOURNAL ARTICLE
D Nganga, A Hoover
PURPOSE/OBJECTIVE(S): Relative to 3D conformal radiation therapy (RT), intensity modulated radiation therapy (IMRT) is associated with decreased acute bowel toxicity during adjuvant RT for gynecologic cancers. Delineating the peritoneal space as a 'bowel bag' is a common method to assess RT dose and volume parameters during treatment planning. However, there is a relative lack of evidence-based bowel bag dose/volume constraints that can be used to guide clinicians. Previously, we described a method to normalize dose/volume measures based on the proportion of adipose tissue within the bowel bag contour and demonstrated this technique more closely correlates with acute toxicity than standard measures...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics
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JOURNAL ARTICLE
C Haskins, O M Siddiqui, J Y Lin, S M Bentzen, M V Mishra, Z Vujaskovic
PURPOSE/OBJECTIVE(S): Previous research identified Lactobacillus-based probiotic administration significantly reduced median and percent rectal volumes in prostate cancer (PC) patients undergoing daily radiation therapy (RT). However, Lactobacillus is sensitive to the acidic environment in the stomach. Pediococcus-based probiotics are resistant to pH as low as 1.5. We designed a prospective randomized trial to determine if administration of a Pediococcus-based probiotic therapy is feasible in patients undergoing prostate RT...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics
#55
JOURNAL ARTICLE
C M Bryant, R H Henderson, W M Mendenhall, R C Nichols, X Liang, Z Su, M Bandyk, K C Balaji, J Costa, N P Mendenhall
PURPOSE/OBJECTIVE(S): To report 10-year outcomes for patients treated with proton therapy for localized prostate cancer. MATERIALS/METHODS: The 10-year outcomes from a prospective outcome tracking protocol were assessed and reported for 1272 men with localized prostate cancer. Risk groups were classified per NCCN guidelines. Median proton therapy dose was 78 GyRBE (72 to 82 GyRBE) delivered at 1.8 to 2 GyRBE per fraction. Androgen deprivation therapy (ADT) was received by 193 men for a median 6 months (range 1 to 36 months)...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics
#56
JOURNAL ARTICLE
R Boyajian, W J Gordon, A M Kowtoniuk, K R Boyajian, M Mackin, N E Martin, P F Orio, G P Walsh, P L Nguyen
PURPOSE/OBJECTIVE(S): To describe the development, clinical impact, financial impact, and patient satisfaction with a Virtual Prostate Cancer Clinic (VPCC) for follow up of patients treated for prostate cancer. MATERIALS/METHODS: In 2015, we developed an algorithm-based, nurse-practitioner led, VPCC with a digital health platform (DHP) infrastructure to take the place of routine in-person follow-ups for men who had completed definitive treatment with prostate cancer...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics
#57
REVIEW
Esther Ubago-Guisado, Miguel Rodríguez-Barranco, Ana Ching-López, Dafina Petrova, Esther Molina-Montes, Pilar Amiano, Aurelio Barricarte-Gurrea, María-Dolores Chirlaque, Antonio Agudo, María-José Sánchez
The European Prospective Investigation into Cancer and Nutrition (EPIC) is a multicentre prospective study conducted in 23 centres in 10 European countries. Here we review the findings from EPIC on the relationship between diet-related exposures and incidence or mortality from the four most frequent cancers in the European population: colorectal, breast, lung, and prostate cancer. We conducted a systematic review following PRISMA guidelines and identified 110 high-quality studies based on the EPIC cohort. Fruit and vegetable consumption had a protective effect against colorectal, breast, and lung cancer, whereas only fruit had a protective effect against prostate cancer...
October 13, 2021: Nutrients
#58
JOURNAL ARTICLE
Giles T Hanley-Cook, Inge Huybrechts, Carine Biessy, Roseline Remans, Gina Kennedy, Mélanie Deschasaux-Tanguy, Kris A Murray, Mathilde Touvier, Guri Skeie, Emmanuelle Kesse-Guyot, Alemayehu Argaw, Corinne Casagrande, Geneviève Nicolas, Paolo Vineis, Christopher J Millett, Elisabete Weiderpass, Pietro Ferrari, Christina C Dahm, H Bas Bueno-de-Mesquita, Torkjel M Sandanger, Daniel B Ibsen, Heinz Freisling, Stina Ramne, Franziska Jannasch, Yvonne T van der Schouw, Matthias B Schulze, Konstantinos K Tsilidis, Anne Tjønneland, Eva Ardanaz, Stina Bodén, Lluís Cirera, Giuliana Gargano, Jytte Halkjær, Paula Jakszyn, Ingegerd Johansson, Verena Katzke, Giovanna Masala, Salvatore Panico, Miguel Rodriguez-Barranco, Carlotta Sacerdote, Bernard Srour, Rosario Tumino, Elio Riboli, Marc J Gunter, Andrew D Jones, Carl Lachat
BACKGROUND: Food biodiversity, encompassing the variety of plants, animals, and other organisms consumed as food and drink, has intrinsic potential to underpin diverse, nutritious diets and improve Earth system resilience. Dietary species richness (DSR), which is recommended as a crosscutting measure of food biodiversity, has been positively associated with the micronutrient adequacy of diets in women and young children in low- and middle-income countries (LMICs). However, the relationships between DSR and major health outcomes have yet to be assessed in any population...
October 2021: PLoS Medicine
#59
JOURNAL ARTICLE
Lauren A Vanderlinden, Randi K Johnson, Patrick M Carry, Fran Dong, Dawn L DeMeo, Ivana V Yang, Jill M Norris, Katerina Kechris
OBJECTIVE: Illumina BeadChip arrays are commonly used to generate DNA methylation data for large epidemiological studies. Updates in technology over time create challenges for data harmonization within and between studies, many of which obtained data from the older 450K and newer EPIC platforms. The pre-processing pipeline for DNA methylation is not trivial, and influences the downstream analyses. Incorporating different platforms adds a new level of technical variability that has not yet been taken into account by recommended pipelines...
September 8, 2021: BMC Research Notes
#60
JOURNAL ARTICLE
Andrew E Grulich, Fengyi Jin, Benjamin R Bavinton, Barbara Yeung, Mohamed A Hammoud, Janaki Amin, Gesalit Cabrera, Shawn Clackett, Erin Ogilvie, Stefanie Vaccher, Tobias Vickers, Anna McNulty, David J Smith, Nila J Dharan, Christine Selvey, Cherie Power, Karen Price, Iryna Zablotska, David A Baker, Mark Bloch, Katherine Brown, Christopher J Carmody, Andrew Carr, Daniel Chanisheff, Nicholas Doong, Robert Finlayson, David A Lewis, Josephine Lusk, Sarah Martin, Catriona Ooi, Phillip Read, Nathan Ryder, Don Smith, Clara Tuck Meng Soo, David J Templeton, Emmanuel Vlahakis, Rebecca Guy
BACKGROUND: Daily pre-exposure prophylaxis (PrEP) is effective in preventing HIV, but few long-term data are available on effectiveness and adherence in real-world settings. Here, we report trends in HIV incidence over 3 years in individuals at high risk who were prescribed PrEP in New South Wales (NSW), as well as adherence before the transition to subsidised PrEP. METHODS: Expanded PrEP Implementation in Communities-New South Wales (EPIC-NSW) was a pragmatic, prospective, single-arm, implementation study of daily, oral PrEP in 31 sites (sexual health clinics, general practices, and a hospital) in NSW, Australia...
August 2021: Lancet HIV
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