Yi-Shu Huang, Wen-Yi Tseng, Felix I L Clanchy, Louise M Topping, Joy Ogbechi, Kay McNamee, Dany Perocheau, Nien-Yi Chiang, Peter Ericsson, Anette Sundstedt, Zhong-Tian Xue, Leif G Salford, Hans-Olov Sjögren, Trevor W Stone, Hsi-Hsien Lin, Shue-Fen Luo, Richard O Williams
Chronic inflammatory diseases like rheumatoid arthritis are characterized by a deficit in fully functional regulatory T cells. DNA-methylation inhibitors have previously been shown to promote regulatory T cell responses and, in the present study, we evaluated their potential to ameliorate chronic and acute animal models of rheumatoid arthritis. Of the drugs tested, decitabine was the most effective, producing a sustained therapeutic effect that was dependent on indoleamine 2,3-dioxygenase (IDO) and was associated with expansion of induced regulatory T cells, particularly at the site of disease activity...
May 11, 2021: Proceedings of the National Academy of Sciences of the United States of America