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JOURNAL ARTICLE
Yan Liu, Nuo-Xuan Liu
OBJECTIVE: To evaluate the variations in serum levels of microRNA-21 (miR-21) and S-100B protein in neonates with hypoxic-ischemic encephalopathy (HIE) after receiving hypothermia therapy and explore the correlation of these biomarkers with the neurodevelopmental prognosis of the infants. METHODS: This retrospective analysis included 90 neonatal HIE patients diagnosed and treated between January 2019 and December 2022. Real-time quantitative PCR and enzyme-linked immunosorbent assay (ELISA) methods were used to measure miR-21 and S-100B protein levels...
March 21, 2024: International Journal of Neuroscience
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JOURNAL ARTICLE
Ingrid Kvestad, Manjeswori Ulak, Suman Ranjitkar, Merina Shrestha, Ram K Chandyo, Antoine Guedeney, Hanne C Braarud, Mari Hysing, Tor A Strand
BACKGROUND: Social withdrawal in infants may be a signal of distress and a precursor for non-optimal development. OBJECTIVE: To examine the relationship between infant social withdrawal and neurodevelopment up to 4 years in Nepalese children. METHODS: A total of 597 Nepalese infants 6-11 months old were assessed with the modified Alarm Distress Baby Scale (m-ADBB), and of these, 527 with the Bayley Scales of Infant and Toddler Development 3rd edition (Bayley-III) during early childhood, and the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) and NEPSY-II subtests at 4 years...
March 18, 2024: BMC Pediatrics
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JOURNAL ARTICLE
Basic Environmental Supports for Positive Brain and Cognitive Development in the First Year of Life.
Joan L Luby, Max P Herzberg, Caroline Hoyniak, Rebecca Tillman, Rachel E Lean, Rebecca Brady, Regina Triplett, Dimitrios Alexopoulos, David Loseille, Tara Smyser, Cynthia E Rogers, Barbara Warner, Christopher D Smyser, Deanna M Barch
IMPORTANCE: Defining basic psychosocial resources to facilitate thriving in the first year of life could tangibly inform policy and enhance child development worldwide. OBJECTIVE: To determine if key environmental supports measured as a thrive factor (T-factor) in the first year of life positively impact brain, cognitive, and socioemotional outcomes through age 3. DESIGN, SETTING, AND PARTICIPANTS: This prospective longitudinal cohort study took place at a Midwestern academic medical center from 2017 through 2022...
March 18, 2024: JAMA Pediatrics
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COMMENT
Tarah T Colaizy, Brenda B Poindexter, Scott A McDonald, Edward F Bell, Waldemar A Carlo, Susan J Carlson, Sara B DeMauro, Kathleen A Kennedy, Leif D Nelin, Pablo J Sánchez, Betty R Vohr, Karen J Johnson, Dianne E Herron, Abhik Das, Margaret M Crawford, Michele C Walsh, Rosemary D Higgins, Barbara J Stoll, Namisavayam Ambalavanan, Myra H Wyckoff, Carl T D'Angio, George W Bugg, Robin K Ohls, Anne Marie Reynolds, Gregory M Sokol, Abbot R Laptook, Steven L Olsen, Jessica R White, Sudarshan R Jadcherla, Monika Bajaj, Prabhu S Parimi, Barbara Schmidt, Matthew M Laughon, John Barks, Kimberley A Fisher, Anna Maria Hibbs, Myriam Peralta-Carcelen, Noah Cook, Roy J Heyne, Brenna Cavanaugh, Ira Adams-Chapman, Janell Fuller, Michelle E Hartley-McAndrew, Heidi M Harmon, Andrea F Duncan, Abbey C Hines, Howard W Kilbride, Laurie A Richards, Nathalie L Maitre, Girija Natarajan, Andrea N Trembath, Martha D Carlson, William F Malcolm, Deanne E Wilson-Costello
IMPORTANCE: Maternal milk feeding of extremely preterm infants during the birth hospitalization has been associated with better neurodevelopmental outcomes compared with preterm formula. For infants receiving no or minimal maternal milk, it is unknown whether donor human milk conveys similar neurodevelopmental advantages vs preterm formula. OBJECTIVE: To determine if nutrient-fortified, pasteurized donor human milk improves neurodevelopmental outcomes at 22 to 26 months' corrected age compared with preterm infant formula among extremely preterm infants who received minimal maternal milk...
February 20, 2024: JAMA
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REVIEW
Khoa L Nguyen, Dominic A Fitzgerald, Annabel Webb, Barbara Bajuk, Himanshu Popat
OBJECTIVE: To investigate the neurodevelopmental outcomes for preterm infants born < 29 weeks gestation with/without bronchopulmonary dysplasia (BPD). STUDY DESIGN: Preterm infants < 29 weeks' gestation born 2007-2018 in New South Wales and the Australian Capital Territory, Australia, were included. Infants who died < 36 weeks' postmenstrual age and those with major congenital anomalies were excluded. Subjects were assessed at 18-42 months corrected age using the Bayley Scales of Infant Development, 3rd edition...
March 1, 2024: Paediatric Respiratory Reviews
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JOURNAL ARTICLE
Catherine Forward, Zana Bayley, Liz Walker, Justine Krygier, Caroline White, Kasonde Mwaba, Helene Elliott-Button, Paul Taylor, Miriam J Johnson
BACKGROUND: Social homecare workers provide essential care to those living at home at the end of life. In the context of a service experiencing difficulties in attracting and retaining staff, we have limited knowledge about the training, support needs and experiences of this group. AIM: To gain a timely understanding from the international literature of the experience, training and support needs of homecare workers providing end-of-life care. METHODS: We conducted a rapid review and narrative synthesis using the recommendations of the Cochrane Rapid Reviews Methods Group...
March 15, 2024: BMJ Supportive & Palliative Care
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JOURNAL ARTICLE
Adam Mutsaers, Ahmed Abugharib, Ian Poon, Joshua Loblaw, Andrew Bayley, Liying Zhang, Lee Chin, Madette Galapin, Darby Erler, Arjun Sahgal, Kevin Higgins, Danny Enepekides, Antoine Eskander, Irene Karam
PURPOSE: To report clinical outcomes for patients with metastatic disease to the head and neck (HN) treated with stereotactic body radiation therapy (SBRT). METHODS: A retrospective review of patients treated with SBRT to HN sites from 2012 to 2020 was conducted. Treatment indications included the following: oligometastases, oligoprogression, and control a dominant area of progression (DAP). Kaplan-Meier method was used to estimate local control (LC), regional control (RC), overall survival (OS), and progression-free survival (PFS)...
March 15, 2024: Supportive Care in Cancer
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JOURNAL ARTICLE
Thiviya Selvanathan, Steven Ufkes, Ting Guo, Vann Chau, Helen M Branson, George M Ibrahim, Linh G Ly, Edmond N Kelly, Ruth E Grunau, Steven P Miller
IMPORTANCE: Early-life exposure to painful procedures has been associated with altered brain maturation and neurodevelopmental outcomes in preterm infants, although sex-specific differences are largely unknown. OBJECTIVE: To examine sex-specific associations among early-life pain exposure, alterations in neonatal structural connectivity, and 18-month neurodevelopment in preterm infants. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study recruited 193 very preterm infants from April 1, 2015, to April 1, 2019, across 2 tertiary neonatal intensive care units in Toronto, Canada...
March 4, 2024: JAMA Network Open
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JOURNAL ARTICLE
Cainá Corrêa do Amaral, Fernanda Nedel, Camila Perelló Ferrúa, Tiago Fernandez Garcia, Geovanna Peter Corrêa, Roberta Giorgi, Aline Longoni Dos Santos, Adriano Martimbianco de Assis, Luciana de Avila Quevedo, Gabriele Cordenonzi Ghisleni, Mariana Bonati de Matos, Karen Amaral Tavares Pinheiro, Jéssica Puchalski Trettim, Ricardo Tavares Pinheiro
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth...
2024: Frontiers in Human Neuroscience
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JOURNAL ARTICLE
Adriana Milena Bonilla Bonilla, Tatiana C Gavilánez Buñay, Matías Bayley, Germán A Colareda, Soledad I Matera, María Luján Flores, Osvaldo León Córdoba, Julián J Prieto, María Esperanza Ruiz, Alicia E Consolini, María Inés Ragone
BACKGROUND: Gomphrena perennis L. is a native plant of South America whose pharmacological properties have not been studied yet. AIM: To evaluate the cardiovascular and intestinal pharmacological effects of Gomphrena perennis L. leaves tincture (GphT) and the mechanisms involved. EXPERIMENTAL PROCEDURE: The chromatographic profile of GphT was done. Its ex vivo effects were evaluated by contractile concentration-response curves (CRCs) obtained from the agonist carbachol or calcium found in isolated rat small intestine, as well as in the relaxant CRCs...
March 2024: Journal of Traditional and Complementary Medicine
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JOURNAL ARTICLE
Behnaz Shahabi, Carmen Hernández-Martínez, Núria Voltas, Josefa Canals, Victoria Arija
Omega-3 Long-Chain Polyunsaturated Fatty Acids ( n -3 LCPUFAs) play a key role in early neurodevelopment, but evidence from observational and clinical studies remains inconsistent. This study investigates the association between maternal n -3 LCPUFA, Docosahexaenoic Acid (DHA), and eicosapentaenoic acid (EPA) concentrations during pregnancy and infant development functioning at 40 days. This study includes 348 mother-infant pairs. Maternal serum concentrations were assessed in the first and third trimesters alongside sociodemographic, clinical, nutritional, psychological, and obstetrical data...
February 28, 2024: Nutrients
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JOURNAL ARTICLE
Yu Gao, Yan Zhang, Jiajun Luo, Dandan Mao, Xiaoning Lei, Chong Liu, Shanyu Zhang, Qian Yao, Jiong Li, Jun Zhang, Xiaodan Yu, Ying Tian
BACKGROUND: Pregnant women in the Shanghai Birth Cohort (SBC) of China faced dual threats of per- and polyfluoroalkyl substances (PFAS) exposure and vitamin D (VD) insufficiency, potentially impacting offspring neurodevelopment. However, little is known about whether maternal VD status modifies PFAS-related neurodevelopment effect. OBJECTIVES: To explore the modifying role of maternal VD status in the effect of prenatal PFAS exposure on childhood neurodevelopment...
March 5, 2024: Environment International
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JOURNAL ARTICLE
Vilmaris Quinones Cardona, Susan S Cohen, Noah Cook, Mehmet Cizmeci, Amit Chandel, Robert DiGeronimo, Semsa Gogcu, Eni Jano, Kojima Katsuaki, Kyong-Soon Lee, Ryan M McAdams, Ogechukwu Roland Menktiti, Ulrike Mietzsch, Eric Peeples, Elizabeth Sewell, Jeffrey Shenberger, An Massaro, Girija Natarajan, Rakesh Rao, Maria L V Dizon
OBJECTIVE: To determine neonatal neurodevelopmental follow-up (NDFU) practices across academic centers. STUDY DESIGN: Cross-sectional survey that addressed center specific neonatal NDFU practices within the Children's Hospitals Neonatal Consortium. RESULT: Survey response rate was 76% and 97% of respondents had a formal NDFU program. Programs were commonly staffed by neonatologists (80%), physical therapists (77%), and nurse practitioners (74%)...
March 8, 2024: American Journal of Perinatology
#54
JOURNAL ARTICLE
Time to death and its determinants of under-five children in rural Ethiopia by using shared frailty.
Getahun Dejene Yemane, Abiyu Abadi Tareke, Hamdi Fekredin Zakaria, Bayley Adane Takele, Sebwedin Surur Jemal
Under-five (U5M) is one of the most significant and sensitive measures of the community's health. Children who live in rural areas are more likely than those who live in urban areas to die before the age of five. Therefore, the study aimed to assess the Survival status of under-five mortality and its determinants in rural Ethiopia. The 2019 Ethiopia Mini Demographic and Health Survey was used in this study as a secondary source (EMDHS). A total of 4426 weighted under-five children were included in the study...
March 7, 2024: Scientific Reports
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JOURNAL ARTICLE
Lan Mai Tran, Phuong H Nguyen, Melissa F Young, Reynaldo Martorell, Usha Ramakrishnan
Limited evidence exists on the long-term effects of early feeding practices on child growth and development. We examined the relationships between infant feeding practices and child height and development at ages 2 and 6-7 years. We studied 885 mother-child dyads from a randomized controlled trial of preconception supplementation in Vietnam. Early initiation of breastfeeding (EIBF), exclusive breastfeeding (EBF), breastfeeding (BF) duration and minimum dietary diversity (MDD) were assessed using World Health Organization (WHO) guidelines...
March 7, 2024: Maternal & Child Nutrition
#56
JOURNAL ARTICLE
Robert Teasell, Cecilia Flores-Sandoval, Shannon Janzen, Heather M MacKenzie, Sarvenaz Mehrabi, Keith Sequeira, Mark Bayley, E Ali Bateman
Outcomes from traumatic brain injury (TBI) including mortality differ significantly between high-, middle-, and low-income countries. However, little is known about differences in TBI research across the globe. The objective of this paper was to examine randomized controlled trials (RCTs) of moderate-to-severe TBI in high-income countries (HICs) compared to low- and middle-income countries (LMICs), as defined by the World Bank income per capita cut-off of $13,205 USD. A systematic review was conducted for articles published in the English language to December 2022 inclusive using MEDLINE, PubMed, Scopus, CINAHL, EMBASE, and PsycINFO in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
March 7, 2024: Journal of Neurotrauma
#57
JOURNAL ARTICLE
Yuan Zhu, Xiaoyu Li, Junyu Chen, Wenjie Gong
BACKGROUND: The objective of the current study was to investigate the correlation between trajectories of maternal perinatal depression (PND) spanning from early pregnancy to one year postpartum and developmental delays observed in one-year-old children. METHODS: The dataset under examination encompassed 880 women who took part in a mother-child birth study conducted in China. Latent class growth analysis (LCGA) was employed to identify patterns in Edinburgh Postnatal Depression Scale (EPDS) scores of women, spanning from early pregnancy to one year postpartum...
March 6, 2024: BMC Pregnancy and Childbirth
#58
JOURNAL ARTICLE
Maria Kekic, Adam Rose, Cameron Baker, Daniel Bayley
WHAT IS KNOWN ON THE SUBJECT?: Inpatient mental health settings pose unique challenges for patient safety, in part because psychiatric disorders are well-known risk factors for self-harm and suicide. Ward staff follow protocols to try and keep patients safe including carrying out in-person safety checks, usually every 15 min, but patients unfortunately still find opportunities to harm themselves. A vision-based patient monitoring system (VBPMS) is a contact-free technology that can help mental health nurses to monitor patients in hospital more effectively...
March 5, 2024: Journal of Psychiatric and Mental Health Nursing
#59
REVIEW
Melissa Biscardi, Zane Grossinger, Angela Colantonio, Mark Bayley, Tatyana Mollayeva
BACKGROUND: Mild traumatic brain injury (mTBI) can cause persistent symptoms suggestive of oculomotor deficits. This research synthesized evidence on restitutive interventions for reducing oculomotor deficits in adults with mTBI to understand if these interventions have clinical utility for improving recovery. METHODS: Medline, EMBASE, CINHAL, PsychInfo, and Scopus, databases were searched for experimental studies published in English. We rated risk of bias (RoB) using recommended tools, and the certainty of the evidence according to GRADE guidelines...
March 3, 2024: Brain Injury
#60
JOURNAL ARTICLE
Ursula Kiechl-Kohlendorfer, Burkhard Simma, Angelika Berger, Berndt Urlesberger, Martin Wald, Nadja Haiden, Renate Fuiko, Jean-Pierre Ndayisaba
AIM: The current study determined the neurodevelopmental outcome of extremely preterm infants at 2 years of age. METHODS: All live-born infants 23-27 weeks of gestation born between 2011 and 2020 in Austria were included in a prospective registry. Neurodevelopmental outcome at 2 years of corrected age was assessed using Bayley Scales of Infant Development for both motor and cognitive scores, along with a neurological examination and an assessment of neurosensory function...
March 3, 2024: Acta Paediatrica
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