Yanjun Guo, Quanhong Liu, Zhilin Zheng, Mengxia Qing, Tianci Yao, Bin Wang, Min Zhou, Dongming Wang, Qinmei Ke, Jixuan Ma, Zhilei Shan, Weihong Chen
Association of circulating glycoprotein acetyls (GlycA), a systemic inflammation biomarker, with lung function and respiratory diseases remain to be investigated. We examined the genetic correlation, shared genetics, and potential causality of GlycA (N = 115,078) with lung function and respiratory diseases (N = 497,000). GlycA showed significant genetic correlation with FEV1 (rg = -0.14), FVC (rg = -0.18), asthma (rg = 0.21) and COPD (rg = 0...
May 4, 2024: Nature Communications