keyword
https://read.qxmd.com/read/38201655/expression-of-interleukin-13-receptor-alpha-2-in-brainstem-gliomas
#21
JOURNAL ARTICLE
Xiaoou Li, Xiong Xiao, Yi Wang, Guocan Gu, Tian Li, Yi Wang, Chunzhao Li, Peng Zhang, Nan Ji, Yang Zhang, Liwei Zhang
The objective of this study was to investigate IL13Ra2 expression in brainstem glioma (BSG) and its correlation with key markers, functions, and prognostic implications, evaluating its therapeutic potential. A total of 80 tumor samples from BSG patients were analyzed. Multiplex immunofluorescence was used to examine six markers-IL13Ra2, H3.3K27M, CD133, Ki67, HLA-1, and CD4-establishing relationships between IL13Ra2 and these markers. Survival analysis, employing Kaplan-Meier and Cox proportional hazard regression models, encompassed 66 patients with complete follow-up...
January 3, 2024: Cancers
https://read.qxmd.com/read/38183008/efficacy-and-indications-of-gamma-knife-radiosurgery-for-recurrent-low-and-high-grade-glioma
#22
JOURNAL ARTICLE
Ying Sun, Peiru Liu, Zixi Wang, Haibo Zhang, Ying Xu, Shenghui Hu, Ying Yan
PURPOSE: To investigate the indications and efficacy of gamma knife radiosurgery (GKRS) as a salvage treatment for recurrent low-and high-grade glioma. METHODS: This retrospective study of 107 patients with recurrent glioma treated with GKRS between 2009 and 2022, including 68 high-grade glioma (HGG) and 39 low-grade glioma (LGG) cases. The Kaplan-Meier method was used to calculate the overall survival (OS) and progression-free survival (PFS). The log-rank test was used to analyze the multivariate prognosis of the Cox proportional hazards model...
January 5, 2024: BMC Cancer
https://read.qxmd.com/read/38176222/the-etiology-and-outcome-of-area-postrema-syndrome-in-childhood-two-cases-and-a-literature-review
#23
REVIEW
Yuriko Tomari, Yuhei Igata, Pin Fee Chong, Kenta Kajiwara, Eriko Hatai, Yuri Sonoda, Utako Oba, Noriyuki Kaku, Yuhki Koga, Yasunari Sakai, Shouichi Ohga
BACKGROUND: Area postrema syndrome (APS), a rare childhood condition, manifests as intractable nausea and hiccups. APS has high diagnostic significance in neuromyelitis optica syndrome spectrum disorders (NMOSD) and can be the initial presentation of other critical diseases, including brainstem glioma. METHODS: We described two representative cases of unrelated Japanese patients with APS. An etiologic evaluation, including a detailed intracranial neuroradiological examination and autoantibodies assessment, was performed...
March 2024: Pediatric Neurology
https://read.qxmd.com/read/38172189/prmt5-inhibition-shows-in-vitro-efficacy-against-h3k27m-altered-diffuse-midline-glioma-but-does-not-extend-survival-in-vivo
#24
JOURNAL ARTICLE
Elizabeth J Brown, Leire Balaguer-Lluna, Adam P Cribbs, Martin Philpott, Leticia Campo, Molly Browne, Jong Fu Wong, Udo Oppermann, Ángel M Carcaboso, Alex N Bullock, Gillian Farnie
H3K27-altered Diffuse Midline Glioma (DMG) is a universally fatal paediatric brainstem tumour. The prevalent driver mutation H3K27M creates a unique epigenetic landscape that may also establish therapeutic vulnerabilities to epigenetic inhibitors. However, while HDAC, EZH2 and BET inhibitors have proven somewhat effective in pre-clinical models, none have translated into clinical benefit due to either poor blood-brain barrier penetration, lack of efficacy or toxicity. Thus, there remains an urgent need for new DMG treatments...
January 3, 2024: Scientific Reports
https://read.qxmd.com/read/38141508/an-uncommon-presentation-of-early-brainstem-high-grade-glioma-in-a-33-year-old-male-a-case-study-and-review-of-literature
#25
Sadegh Ghaderi, Sana Mohammadi, Masoud Hoseini Pourasl, Farzad Fatehi
INTRODUCTION AND IMPORTANCE: Unlike children, high-grade brainstem glioma (HG-BSG) in adults is a rare and diverse group of tumors. They can be classified based on their location and physical characteristics, which distinguishes them from pediatric brainstem gliomas. They are rare in adults, constituting only 1 % to 2 % of intracranial gliomas. They are often aggressive and have a poor prognosis, with a median survival time of 24 months. The diagnosis of brainstem gliomas typically involves a combination of clinical evaluation and imaging studies, mainly magnetic resonance imaging (MRI), which provides detailed images and can help identify the characteristics of the tumor...
January 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38106809/concurrent-wounded-glioma-syndrome-and-distant-wounded-glioma-syndrome-following-a-gross-total-resection-of-glioblastoma-a-case-report
#26
John Michael V Calubayan, Paul Vincent A Opinaldo
Surgery is the initial form of treatment for glioblastoma, and a maximum resection without impairing neurological function improves survival. Wounded glioma syndrome (WGS) is a clinical picture observed after the resection of high-grade tumors. This syndrome, developing within hours to a few days after glioma surgery, is characterized by hemorrhage into the postoperative cavity and cerebral edema and at times occurs in areas distant from the site of the resection, i.e., distant wounded glioma syndrome (DWGS)...
November 2023: Curēus
https://read.qxmd.com/read/38102910/a-decade-of-treating-brain-stem-gliomas-single-institutional-experience
#27
JOURNAL ARTICLE
Pankaj Vats, Prince Arvind, Arti Sarin, Sankalp Singh, Manish Sandhu
INTRODUCTION: Brainstem is a rare yet challenging site for primary brain tumors. We present the patient characteristics, treatment-related details, and survival outcomes of patients with brain stem gliomas treated over a decade, from August 2010 to July 2022, at a tertiary care center in northern India. MATERIALS AND METHODS: Twenty-seven patients of brainstem gliomas were treated in our hospital from August 2010 to July 2022. All of these patients were treated with radiation therapy based on a radiological diagnosis only...
December 15, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38094386/retracted-prediction-of-cancer-specific-survival-of-brainstem-glioma-in-children-based-on-risk-stratification-model
#28
Computational And Mathematical Methods In Medicine
[This retracts the article DOI: 10.1155/2022/3436631.].
2023: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/38039022/clinical-characteristics-and-prognostic-factors-of-surgical-treatment-in-children-with-brainstem-tumor
#29
JOURNAL ARTICLE
Y-Z He, Q Zhou, W-Y Deng, L-Y Huang, Y-Y Lu, Y-Y Ruan, H Du
OBJECTIVE: Brainstem tumors present a significant challenge in surgical treatment, and the prognostic factors in children are lacking. This study aimed to investigate clinical characteristics and prognostic factors of surgical treatment in children with brainstem tumors. PATIENTS AND METHODS: 50 children with brainstem tumors who underwent surgical treatment, including frameless- or frame-based stereotactic biopsy and resection, were included and followed up for clinical and biological analysis...
November 2023: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38037182/h3k27-altered-diffuse-midline-gliomas-with-mapk-pathway-alterations-prognostic-and-therapeutic-implications
#30
JOURNAL ARTICLE
Catherine Gestrich, Kristina Grieco, Hart G Lidov, Lissa C Baird, Katie P Fehnel, Kee Kiat Yeo, David M Meredith, Sanda Alexandrescu
Large-scale sequencing led to the identification of driver molecular alterations such as FGFR1 and BRAF in occasional diffuse midline gliomas (DMGs) H3K27-mutant but their significance has not been completely explored. We evaluated these associations in our institutional cohorts. We searched our archives for H3K2M7-mutant gliomas and analyzed the co-occurring genetic alterations. The demographics, clinical information, and pathology were reviewed. Oncoplots and Kaplan-Meier survival curves were generated with the maftools R package...
December 22, 2023: Journal of Neuropathology and Experimental Neurology
https://read.qxmd.com/read/38028289/h3-k27-altered-diffuse-midline-glioma-in-adults-arising-from-atypical-regions-two-case-reports-and-literature-review
#31
Narushi Sugii, Yuki Ninomiya, Yu Akimoto, Takao Tsurubuchi, Eiichi Ishikawa
Diffuse midline glioma (DMG), H3 K27-altered, is a newly defined "pediatric-type," diffuse, high-grade glioma under current WHO classifications (updated in 2021). An essential diagnostic criteria of DMG is its occurrence in the midline structures; most intracranial DMG occurs in the brainstem or thalamus but can also occur in other midline structures. We experienced 2 adult cases of intracranial DMGs in areas other than the brainstem and thalamus that were initially difficult to diagnose. Case 1 was a 49-year-old man with extensive T2 high-signal lesions in the bilateral frontal lobes and corpus callosum on brain MRI...
January 2024: Radiology Case Reports
https://read.qxmd.com/read/37999129/surgical-management-of-adult-brainstem-gliomas-a-systematic-review-and-meta-analysis
#32
REVIEW
Tamara Ius, Giuseppe Lombardi, Cinzia Baiano, Jacopo Berardinelli, Andrea Romano, Nicola Montemurro, Luigi Maria Cavallo, Francesco Pasqualetti, Alberto Feletti
The present review aims to investigate the survival and functional outcomes in adult high-grade brainstem gliomas (BGSs) by comparing data from resective surgery and biopsy. MEDLINE, EMBASE and Cochrane Library were screened to conduct a systematic review of the literature, according to the PRISMA statement. Analysis was limited to articles including patients older than 18 years of age and those published from 1990 to September 2022. Case reports, review articles, meta-analyses, abstracts, reports of aggregated data, and reports on multimodal therapy where surgery was not the primary treatment were excluded...
November 7, 2023: Current Oncology
https://read.qxmd.com/read/37976149/surgical-characteristics-of-intracranial-biopsy-using-a-frameless-stereotactic-robotic-platform-a-single-center-experience
#33
JOURNAL ARTICLE
Daniel C Kreatsoulas, Joshua Vignolles-Jeong, Yamenah Ambreen, Mark Damante, Asad Akhter, Russell R Lonser, J Bradley Elder
BACKGROUND AND OBJECTIVES: Cranial robotics are a burgeoning field of neurosurgery. To date, all cranial robotic systems described have been computerized, arm-based instruments that take up significant space in the operating room. The Medtronic Stealth Autoguide robot has a smaller operating room footprint and offers multiaxial, frame-based surgical targeting. The authors set out to define the surgical characteristics of a novel robotic platform for brain biopsy in a large patient cohort...
November 17, 2023: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/37946847/two-pediatric-patients-with-acute-acquired-comitant-esotropia-as-the-first-symptom-of-brainstem-tumor-a-case-report
#34
Ayaka Yagasaki, Taishi Miyase, Shota Sakai, Kiyofumi Mochizuki, Hirokazu Sakaguchi, Teiji Yagasaki, Naoyuki Ohe, Shiho Yasue, Saori Endo, Michio Ozeki
INTRODUCTION: Acute acquired comitant esotropia (AACE) is an acquired strabismus with uncrossed sudden-onset diplopia due to esodeviation, comitant esotropia without accommodation factor, or paretic eye movement. The diagnosis of AACE entails differentiation from incomitant esotropia caused by abnormalities in the central nervous system. We present 2 pediatric patients with AACE as the first symptom of brainstem tumor. CASE PRESENTATION: The 2 patients were aware of their diplopia and had no other neurological abnormalities...
2023: Case Reports in Ophthalmology
https://read.qxmd.com/read/37936887/brainstem-tumors-in-children-a-monocentric-series-in-the-light-of-genetic-and-bio-molecular-progress-in-pediatric-neuro-oncology
#35
JOURNAL ARTICLE
Rel Gerald Boukaka, Pierre-Aurélien Beuriat, Federico Di Rocco, Alexandre Vasiljevic, Alexandru Szathmari, Carmine Mottolese
INTRODUCTION: Brainstem tumors represent a challenge. Their management and prognosis vary according to anatomopathological findings and genetic and bio-molecular fingerprints. We present our experience with pediatric brainstem tumors. MATERIAL AND METHODS: All patients admitted for a brainstem tumor at the Pediatric Neurosurgical Unit at Hôpital Femme Mère Enfant hospital between January 1997 and December 2019 were considered. Patients data were obtained through a retrospective review of the medical records; follow-up was from the last outpatient consultation...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37926739/diffusion-mri-is-valuable-in-brainstem-glioma-genotyping-with-quantitative-measurements-of-white-matter-tracts
#36
JOURNAL ARTICLE
Xiong Xiao, Ne Yang, Guocan Gu, Xianyu Wang, Zhuang Jiang, Tian Li, Xinran Zhang, Longfei Ma, Peng Zhang, Hongen Liao, Liwei Zhang
OBJECTIVES: To investigate the value of diffusion MRI (dMRI) in H3K27M genotyping of brainstem glioma (BSG). METHODS: A primary cohort of BSG patients with dMRI data (b = 0, 1000 and 2000 s/mm2 ) and H3K27M mutation information were included. A total of 13 diffusion tensor and kurtosis imaging (DTI; DKI) metrics were calculated, then 17 whole-tumor histogram features and 29 along-tract white matter (WM) microstructural measurements were extracted from each metric and assessed within genotypes...
November 6, 2023: European Radiology
https://read.qxmd.com/read/37907311/x-linked-cerebral-adrenoleukodystrophy
#37
JOURNAL ARTICLE
Cara Louise Weldrick, Peter Boers, Patrick Kiely, Liam O'Halloran
A man in his 30s presented with a 6-month history of progressive left face, arm and leg weakness. Medical history included epilepsy and vitamin B12 deficiency. Three maternal second degree relatives died before the age of 7 from various neurological disorders. Examination revealed a mild left facial droop and weakness of the left shoulder, hip and ankle. Reflexes were symmetrical and tone was normal. Differential diagnosis included glioma, subacute infarction, lymphoma and demyelination. MRI brain showed an extensive right sided subcortical white matter lesion, with extension into the brainstem...
October 31, 2023: BMJ Case Reports
https://read.qxmd.com/read/37905976/editorial-for-prediction-of-h3k27m-alteration-status-in-brainstem-glioma-using-multi-shell-diffusion-mri-metrics
#38
EDITORIAL
Kyu Sung Choi
No abstract text is available yet for this article.
October 31, 2023: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/37897190/bench-to-bedside-investigations-of-h3-k27-altered-diffuse-midline-glioma-drug-targets-and-potential-pharmacotherapies
#39
REVIEW
Julian S Rechberger, Samantha M Bouchal, Erica A Power, Leo F Nonnenbroich, Cody L Nesvick, David J Daniels
INTRODUCTION: H3 K27-altered diffuse midline glioma (DMG) is the most common malignant brainstem tumor in the pediatric population. Despite enormous preclinical and clinical efforts, the prognosis remains dismal, with fewer than 10% of patients surviving for two years after diagnosis. Fractionated radiation remains the only standard treatment options for DMG. Developing novel treatments and therapeutic delivery methods is critical to improving outcomes in this devastating disease. AREAS COVERED: This review addresses recent advances in molecularly targeted pharmacotherapy and immunotherapy in DMG...
2023: Expert Opinion on Therapeutic Targets
https://read.qxmd.com/read/37889147/prediction-of-h3k27m-alteration-status-in-brainstem-glioma-using-multi-shell-diffusion-mri-metrics
#40
JOURNAL ARTICLE
Xiaolu Xu, Peng Zhang, Zhizheng Zhuo, Yunyun Duan, Liying Qu, Dan Cheng, Ting Sun, Jinli Ding, Cong Xie, Xing Liu, Sven Haller, Frederik Barkhof, Chuyang Ye, Liwei Zhang, Yaou Liu
BACKGROUND: Multi-shell diffusion characteristics may help characterize brainstem gliomas (BSGs) and predict H3K27M status. PURPOSE: To identify the diffusion characteristics of BSG patients and investigate the predictive values of various diffusion metrics for H3K27M status in BSG. STUDY TYPE: Prospective. POPULATION: Eighty-four BSG patients (median age 10.5 years [IQR 6.8-30.0 years]) were included, of whom 56 were pediatric and 28 were adult patients...
October 27, 2023: Journal of Magnetic Resonance Imaging: JMRI
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