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JOURNAL ARTICLE
Pei Li, Yajie Liu, Julia N Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Jianrong Li, Richard J Gumina, Shan-Lu Liu
UNLABELLED: The rapid evolution of SARS-CoV-2 variants presents a constant challenge to the global vaccination effort. In this study, we conducted a comprehensive investigation into two newly emerged variants, BA.2.87.1 and JN.1, focusing on their neutralization resistance, infectivity, antigenicity, cell-cell fusion, and spike processing. Neutralizing antibody (nAb) titers were assessed in diverse cohorts, including individuals who received a bivalent mRNA vaccine booster, patients infected during the BA...
April 9, 2024: MBio
#42
REVIEW
Marianne Leruez-Ville, Christos Chatzakis, Daniele Lilleri, Daniel Blazquez-Gamero, Ana Alarcon, Nicolas Bourgon, Ina Foulon, Jacques Fourgeaud, Anna Gonce, Christine E Jones, Paul Klapper, André Krom, Tiziana Lazzarotto, Hermione Lyall, Paulo Paixao, Vassiliki Papaevangelou, Elisabeth Puchhammer, George Sourvinos, Pamela Vallely, Yves Ville, Ann Vossen
Congenital cytomegalovirus (cCMV) infection carries a significant burden with a 0.64% global prevalence and a 17-20% chance of serious long-term effects in children. Since the last guidelines, our understanding, particularly regarding primary maternal infections, has improved. A cCMV guidelines group was convened under the patronage of the European Society of Clinical Virology in April 2023 to refine these insights. The quality and validity of selected studies were assessed for potential biases and the GRADE framework was employed to evaluate quality of evidence across key domains...
May 2024: The Lancet regional health. Europe
#43
JOURNAL ARTICLE
Felicity Liew, Claudia Efstathiou, Sara Fontanella, Matthew Richardson, Ruth Saunders, Dawid Swieboda, Jasmin K Sidhu, Stephanie Ascough, Shona C Moore, Noura Mohamed, Jose Nunag, Clara King, Olivia C Leavy, Omer Elneima, Hamish J C McAuley, Aarti Shikotra, Amisha Singapuri, Marco Sereno, Victoria C Harris, Linzy Houchen-Wolloff, Neil J Greening, Nazir I Lone, Matthew Thorpe, A A Roger Thompson, Sarah L Rowland-Jones, Annemarie B Docherty, James D Chalmers, Ling-Pei Ho, Alexander Horsley, Betty Raman, Krisnah Poinasamy, Michael Marks, Onn Min Kon, Luke S Howard, Daniel G Wootton, Jennifer K Quint, Thushan I de Silva, Antonia Ho, Christopher Chiu, Ewen M Harrison, William Greenhalf, J Kenneth Baillie, Malcolm G Semple, Lance Turtle, Rachael A Evans, Louise V Wain, Christopher Brightling, Ryan S Thwaites, Peter J M Openshaw
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1 . Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment...
April 2024: Nature Immunology
#44
JOURNAL ARTICLE
J Guillermo Sanchez, Scott Rankin, Emily Paul, Heather A McCauley, Daniel O Kechele, Jacob R Enriquez, Nana-Hawa Jones, Siri A W Greeley, Lisa Letourneau-Friedberg, Aaron M Zorn, Mansa Krishnamurthy, James M Wells
The gastrointestinal tract is complex and consists of multiple organs with unique functions. Rare gene mutations can cause congenital malformations of the human GI tract, although the molecular basis of these has been poorly studied. We identified a patient with compound-heterozygous mutations in RFX6 presenting with duodenal mal-rotation and atresia, implicating RFX6 in development of the proximal intestine. To identify how mutations in RFX6 impact intestinal patterning and function, we derived iPSCs from this patient to generate human intestinal organoids (HIOs)...
April 8, 2024: Development
#45
JOURNAL ARTICLE
Shannon C White, John M Ruiz, Matthew Allison, Bert N Uchino, Timothy W Smith, Daniel J Taylor, Dusti R Jones, Michael A Russell, Emily B Ansell, Joshua M Smyth
This study examined the cardiovascular disease (CVD) risk profiles of male law enforcement officers (LEOs) and civilians. CVD risk profiles were based on data collected using traditional objective (e.g., resting BP, cholesterol), novel objective (e.g., ambulatory BP) and self-report measures (e.g., EMA social vigilance). A subset of male LEOs ( n = 30, M age = 41.47, SD = 8.03) and male civilians ( n = 120, M age = 40.73, SD = 13.52) from a larger study were included in analyses. Results indicated LEOs had significantly higher body mass index [BMI], 31...
2024: Health Psychology Open
#46
JOURNAL ARTICLE
Daniel Upmann, Dirk Bockfeld, Peter G Jones, Eliza Târcoveanu
The structures of ten phosphane chalcogenide complexes of gold(III) halides, with general formula R 1 3- n R 2 n P E Au X 3 ( R 1 = t -butyl; R 2 = i -propyl; n = 0 to 3; E = S or Se; X = Cl or Br) are presented. The eight possible chlorido derivatives are: 9a , n = 3, E = S; 10a , n = 2, E = S; 11a , n = 1, E = S; 12a , n = 0, E = S; 13a , n = 3, E = Se; 14a , n = 2, E = Se; 15a , n = 1, E = Se; and 16a , n = 0, E = Se, and the corresponding bromido derivatives are 9b - 16b in the same order. Structures were obtained for 9a , 10a (and a second polymorph 10aa ), 11a (and its deutero-chloro-form monosolvate 11aa ), 12a (as its di-chloro-methane monosolvate), 14a , 15a (as its deutero-chloro-form monosolvate 15aa , in which the solvent mol-ecule is disordered over two positions), 9b , 11b , 13b and 15b ...
March 1, 2024: Acta Crystallographica. Section E, Crystallographic Communications
#47
JOURNAL ARTICLE
Elie Massaad, William J Smith, Joseph Bradley, Eric Esposito, Mihir Gupta, Evan Burns, Ryan Burns, José K Velarde, Inka K Berglar, Rajiv Gupta, Maria Martinez-Lage, Jorg Dietrich, Jochen K Lennerz, Gavin P Dunn, Pamela S Jones, Bryan D Choi, Albert E Kim, Matthew Frosch, Fred G Barker, William T Curry, Bob S Carter, Brian V Nahed, Daniel P Cahill, Ganesh M Shankar
BACKGROUND: Survival is variable in patients with glioblastoma IDH wild-type (GBM), even after comparable surgical resection of radiographically-detectable disease, highlighting the limitations of radiographic assessment of infiltrative tumor anatomy. The majority of post-surgical progressive events are failures within 2cm of the resection margin, motivating supramaximal resection strategies to improve local control. However, which patients benefit from such radical resections remains unknown...
April 6, 2024: Neuro-oncology
#48
John Sharp, Daniel Jones, Julia Rotow, Panos Fidias, Erin Bertino, Dwight Owen
No abstract text is available yet for this article.
April 5, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#49
JOURNAL ARTICLE
Christopher M Callahan, Amy Carter, Hannah S Carty, Daniel O Clark, Tedd Grain, Seth L Grant, Kimberly McElroy-Jones, Deanna Reinoso, Lisa E Harris
A recent National Academies report recommended that health systems invest in new infrastructure to integrate social and medical care. Although many health systems routinely screen patients for social concerns, few health systems achieve the recommended model of integration. In this critical case study in an urban safety net health system, we describe the human capital, operational redesign, and financial investment needed to implement the National Academy recommendations. Using data from this case study, we estimate that other health systems seeking to build and maintain this infrastructure would need to invest $1 million to $3 million per year...
April 4, 2024: American Journal of Public Health
#50
JOURNAL ARTICLE
Katie Tunks Leach, Daniel Demant, Paul Simpson, Joanne Lewis, Tracy Levett-Jones
Ambulance staff wellbeing programs aim to support the bio-psycho-social and sometimes spiritual needs of paramedics. While evidence demonstrates strong connections between spirituality and/or religion to wellbeing outcomes, little is known about spiritual care in ambulance services or its impact. The aim of this study was to investigate paramedics' perspectives on the role and value of Australian ambulance chaplains. A cross-sectional online study of registered paramedics in Australia was conducted between November and December 2022...
April 4, 2024: Journal of Health Care Chaplaincy
#51
JOURNAL ARTICLE
Laura Vang Rasmussen, Ingo Grass, Zia Mehrabi, Olivia M Smith, Rachel Bezner-Kerr, Jennifer Blesh, Lucas Alejandro Garibaldi, Marney E Isaac, Christina M Kennedy, Hannah Wittman, Péter Batáry, Damayanti Buchori, Rolando Cerda, Julián Chará, David W Crowder, Kevin Darras, Kathryn DeMaster, Karina Garcia, Manuel Gómez, David Gonthier, Purnama Hidayat, Juliana Hipólito, Mark Hirons, Lesli Hoey, Dana James, Innocensia John, Andrew D Jones, Daniel S Karp, Yodit Kebede, Carmen Bezner Kerr, Susanna Klassen, Martyna Kotowska, Holger Kreft, Ramiro Llanque, Christian Levers, Diego J Lizcano, Adrian Lu, Sidney Madsen, Rosebelly Nunes Marques, Pedro Buss Martins, America Melo, Hanson Nyantakyi-Frimpong, Elissa M Olimpi, Jeb P Owen, Heiber Pantevez, Matin Qaim, Sarah Redlich, Christoph Scherber, Amber R Sciligo, Sieglinde Snapp, William E Snyder, Ingolf Steffan-Dewenter, Anne Elise Stratton, Joseph M Taylor, Teja Tscharntke, Vivian Valencia, Cassandra Vogel, Claire Kremen
Agricultural simplification continues to expand at the expense of more diverse forms of agriculture. This simplification, for example, in the form of intensively managed monocultures, poses a risk to keeping the world within safe and just Earth system boundaries. Here, we estimated how agricultural diversification simultaneously affects social and environmental outcomes. Drawing from 24 studies in 11 countries across 2655 farms, we show how five diversification strategies focusing on livestock, crops, soils, noncrop plantings, and water conservation benefit social (e...
April 5, 2024: Science
#52
Joseph L Witztum, Daniel Gaudet, Marcello Arca, Alan Jones, Handrean Soran, Ioanna Gouni-Berthold, Erik S G Stroes, Veronica J Alexander, Richard Jones, Lynnetta Watts, Shuting Xia, Sotirios Tsimikas
No abstract text is available yet for this article.
October 13, 2023: Journal of Clinical Lipidology
#53
JOURNAL ARTICLE
Jason R Thomas, Claude Shelton, Jason Murphy, Scott Brittain, Mark-Anthony Bray, Peter Aspesi, John Concannon, Frederick J King, Robert J Ihry, Daniel J Ho, Martin Henault, Andrea Hadjikyriacou, Marilisa Neri, Frederic D Sigoillot, Helen T Pham, Matthew Shum, Louise Barys, Michael D Jones, Eric J Martin, Anke Blechschmidt, Sébastien Rieffel, Thomas J Troxler, Felipa A Mapa, Jeremy L Jenkins, Rishi K Jain, Peter S Kutchukian, Markus Schirle, Steffen Renner
Phenotypic assays have become an established approach to drug discovery. Greater disease relevance is often achieved through cellular models with increased complexity and more detailed readouts, such as gene expression or advanced imaging. However, the intricate nature and cost of these assays impose limitations on their screening capacity, often restricting screens to well-characterized small compound sets such as chemogenomics libraries. Here, we outline a cheminformatics approach to identify a small set of compounds with likely novel mechanisms of action (MoAs), expanding the MoA search space for throughput limited phenotypic assays...
April 2, 2024: ACS Chemical Biology
#54
JOURNAL ARTICLE
Sebastian H Röttger, Lukas J Patalag, Felix Hasenmaile, Lukas Milbrandt, Burkhard Butschke, Peter G Jones, Daniel B Werz
A convergent route toward nitrogen-bridged BODIPY oligomers has been developed. The synthetic key step is a Buchwald-Hartwig cross-coupling reaction of an α-amino-BODIPY and the respective halide. Not only does the selective synthesis provide control of the oligomer size, but the facile preparative procedure also enables easy access to these types of dyes. Furthermore, functionalized examples were accessible via brominated derivatives.
April 2, 2024: Organic Letters
#55
JOURNAL ARTICLE
Dong-Jin Lim, Brenton T Bicknell, Nicholas Rivers, Martin P Jones, Adithya J Menon, Olivia J Kelly, Daniel Skinner, Shaoyan Zhang, Bradford A Woodworth, Do-Yeon Cho
OBJECTIVES: Previously, we developed a novel double-coated sinus stent containing ciprofloxacin (inner layer) and azithromycin (outer layer) (CASS), but released drug concentrations were found to be insufficient for clinical usage. Our objectives are to improve drug release of CASS and assess safety and pharmacokinetics in rabbits. METHODS: Dip coating was used to create the CASS with 2 mg ciprofloxacin and 5 mg azithromycin. A uniformed double coating was assessed with scanning electron microscopy (SEM), and the release patterns of both drugs and lactate dehydrogenase (LDH) assay were evaluated over 14 days in vitro...
April 2, 2024: Laryngoscope
#56
Pei Li, Yajie Liu, Julia Faraone, Cheng Chih Hsu, Michelle Chamblee, Yi-Min Zheng, Claire Carlin, Joseph S Bednash, Jeffrey C Horowitz, Rama K Mallampalli, Linda J Saif, Eugene M Oltz, Daniel Jones, Jianrong Li, Richard J Gumina, Shan-Lu Liu
The rapid evolution of SARS-CoV-2 variants presents a constant challenge to the global vaccination effort. In this study, we conducted a comprehensive investigation into two newly emerged variants, BA.2.87.1 and JN.1, focusing on their neutralization resistance, infectivity, antigenicity, cell-cell fusion, and spike processing. Neutralizing antibody (nAb) titers were assessed in diverse cohorts, including individuals who received a bivalent mRNA vaccine booster, patients infected during the BA.2.86/JN.1-wave, and hamsters vaccinated with XBB...
March 11, 2024: bioRxiv
#57
JOURNAL ARTICLE
Adam M Staffaroni, Annie L Clark, Jack C Taylor, Hilary W Heuer, Mark Sanderson-Cimino, Amy B Wise, Sreya Dhanam, Yann Cobigo, Amy Wolf, Masood Manoochehri, Leah Forsberg, Carly Mester, Katherine P Rankin, Brian S Appleby, Ece Bayram, Andrea Bozoki, David Clark, R Ryan Darby, Kimiko Domoto-Reilly, Julie A Fields, Douglas Galasko, Daniel Geschwind, Nupur Ghoshal, Neill Graff-Radford, Murray Grossman, Ging-Yuek Hsiung, Edward D Huey, David T Jones, Maria I Lapid, Irene Litvan, Joseph C Masdeu, Lauren Massimo, Mario F Mendez, Toji Miyagawa, Belen Pascual, Peter Pressman, Vijay K Ramanan, Eliana Marisa Ramos, Katya Rascovsky, Erik D Roberson, M Carmela Tartaglia, Bonnie Wong, Bruce L Miller, John Kornak, Walter Kremers, Jason Hassenstab, Joel H Kramer, Bradley F Boeve, Howard J Rosen, Adam L Boxer
IMPORTANCE: Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and motor symptoms increase travel burden, and standard neuropsychological tests are not sensitive to early-stage disease. Remote smartphone-based cognitive assessments could mitigate these barriers to trial recruitment and success, but no such tools are validated for FTLD. OBJECTIVE: To evaluate the reliability and validity of smartphone-based cognitive measures for remote FTLD evaluations...
April 1, 2024: JAMA Network Open
#58
JOURNAL ARTICLE
Connie C Shao, Meghna H Katta, Burke P Smith, Bayley A Jones, Lauren T Gleason, Alizeh Abbas, Nikita Wadhwani, Eric L Wallace, Michael J Mugavero, Daniel I Chu
BACKGROUND: No-show visits have serious consequences for patients, providers, and healthcare systems as they lead to delays in care, increased costs, and reduced access to services. Telemedicine has emerged as a promising alternative to in-person visits by reducing travel barriers, but risks exacerbating the digital divide. The aim of this study was to assess the impact of telemedicine (video and phone) at a tertiary care academic center on no-show visits compared to in-person visits...
April 1, 2024: Journal of Telemedicine and Telecare
#59
JOURNAL ARTICLE
Austin D Reed, Sara Pensa, Adi Steif, Jack Stenning, Daniel J Kunz, Linsey J Porter, Kui Hua, Peng He, Alecia-Jane Twigger, Abigail J Q Siu, Katarzyna Kania, Rachel Barrow-McGee, Iain Goulding, Jennifer J Gomm, Valerie Speirs, J Louise Jones, John C Marioni, Walid T Khaled
Here we use single-cell RNA sequencing to compile a human breast cell atlas assembled from 55 donors that had undergone reduction mammoplasties or risk reduction mastectomies. From more than 800,000 cells we identified 41 cell subclusters across the epithelial, immune and stromal compartments. The contribution of these different clusters varied according to the natural history of the tissue. Age, parity and germline mutations, known to modulate the risk of developing breast cancer, affected the homeostatic cellular state of the breast in different ways...
March 28, 2024: Nature Genetics
#60
JOURNAL ARTICLE
Timothy Rosencrans, Ryan Jones, Daniel Griffin, India Loyd, Anna Grady, Mary Moon, Frederick Miller
Intro Medical students face challenging but important topics they must learn in short periods of time such as autonomic pharmacology. Autonomic pharmacology is difficult in that it requires students to synthesize detailed anatomy, physiology, clinical skills, and pharmacology. The subject poses a challenge to learn as it is often introduced early in the medical school curriculum. Methods To ease the difficulty of learning autonomic pharmacology, we created a free web application, PharmaMemory (www.pharmamemory...
March 28, 2024: Advances in Physiology Education
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