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REVIEW
Miguel Muniz, Charles L Loprinzi, Jacob J Orme, Regina M Koch, Ahmed M Mahmoud, Adam M Kase, Irbaz B Riaz, Jack R Andrews, Matthew P Thorpe, Geoffrey B Johnson, Ayse T Kendi, Eugene D Kwon, Jones T Nauseef, Alicia K Morgans, Oliver Sartor, Daniel S Childs
Clinical trials of prostate-specific membrane antigen (PSMA) targeted radiopharmaceuticals have shown encouraging results. Some agents, like lutetium-177 [177Lu]Lu-PSMA-617 ([177 Lu]Lu-PSMA-617), are already approved for late line treatment of metastatic castration-resistant prostate cancer (mCRPC). Projections are for continued growth of this treatment modality; [177 Lu]Lu-PSMA-617 is being studied both in earlier stages of disease and in combination with other anti-cancer therapies. Further, the drug development pipeline is deep with variations of PSMA-targeting radionuclides, including higher energy alpha particles conjugated to PSMA-honing vectors...
April 30, 2024: Cancer Treatment Reviews
#2
JOURNAL ARTICLE
Zoë E Havlena, Louise D Hose, Harvey R DuChene, Gretchen M Baker, J Douglas Powell, Amanda L Labrado, Benjamin Brunner, Daniel S Jones
Lehman Caves is an extensively decorated high desert cave that represents one of the main tourist attractions in Great Basin National Park, Nevada. Although traditionally considered a water table cave, recent studies identified abundant speleogenetic features consistent with a hypogenic and, potentially, sulfuric acid origin. Here, we characterized white mineral deposits in the Gypsum Annex (GA) passage to determine whether these secondary deposits represent biogenic minerals formed during sulfuric acid corrosion and explored microbial communities associated with these and other mineral deposits throughout the cave...
2024: Geobiology
#3
JOURNAL ARTICLE
Rasmus O Jensen, Frederik Schulz, Simon Roux, Dawn M Klingeman, Wayne P Mitchell, Daniel Udwary, Sarah Moraïs, Vinicio Reynoso, James Winkler, Shilpa Nagaraju, Sashini De Tissera, Nicole Shapiro, Natalia Ivanova, T B K Reddy, Itzhak Mizrahi, Sagar M Utturkar, Edward A Bayer, Tanja Woyke, Nigel J Mouncey, Michael C Jewett, Séan D Simpson, Michael Köpke, David T Jones, Steven D Brown
The genus Clostridium is a large and diverse group within the Bacillota (formerly Firmicutes), whose members can encode useful complex traits such as solvent production, gas-fermentation, and lignocellulose breakdown. We describe 270 genome sequences of solventogenic clostridia from a comprehensive industrial strain collection assembled by Professor David Jones that includes 194 C. beijerinckii, 57 C. saccharobutylicum, 4 C. saccharoperbutylacetonicum, 5 C. butyricum, 7 C...
May 1, 2024: Scientific Data
#4
JOURNAL ARTICLE
Mohsen Alayche, Justen Choueiry, Adnan Mekdachi, Donna E Maziak, Andrew J E Seely, Sudhir R Sundaresan, Patrick J Villeneuve, Daniel Jones, William Klement, Sebastien Gilbert
OBJECTIVE: There is limited clinical evidence to support any specific parenchymal air leak resolution criteria when using digital pleural drainage devices following lung resection. The aim of this study is to determine an optimal air leak resolution criteria, where duration of chest tube drainage is minimized while avoiding complications from premature chest tube removal. METHODS: Airflow data averaged at 10-minute intervals was collected prospectively using a digital pleural drainage device (Thopaz; Medela) in 400 patients from 2015 to 2019...
April 2024: JTCVS open
#5
REVIEW
Lee M Jeys, Joachim Thorkildsen, Vineet Kurisunkal, Ajay Puri, Pietro Ruggieri, Matthew T Houdek, Richard A Boyle, Walid Ebeid, Eduardo Botello, Guy V Morris, Minna K Laitinen, Adesegun Abudu, Keisuke Ae, Manish Agarwal, Vivek Ajit Singh, Toru Akiyama, Jose I Albergo, John Alexander, Bugra Alpan, Ahmed Aoude, Apichat Asavamongkolkul, William Aston, Thomas Baad-Hansen, Tessa Balach, Joseph Benevenia, Peter Bergh, Nicholas Bernthal, Odion Binitie, Michele Boffano, Jos Bramer, Harriet Branford White, Bernadette Brennan, Jorge Cabrolier, Jose A Calvo Haro, Domenico A Campanacci, Rodrigo Cardoso, Richard Carey Smith, Nicolas Casales Fresnga, Jose M Casanova, Oscar Ceballos, Chung M Chan, Yang-Guk Chung, Miguel A Clara-Altamirano, Gillian Cribb, Solomon Dadia, Dietmar Dammerer, Marieke de Vaal, Javier Delgado Obando, Shaneel Deo, Claudia Di Bella, Davide M Donati, Makoto Endo, Levent Eralp, Bulent Erol, Scott Evans, Will Eward, Fabrice Fiorenza, Joao Freitas, Philipp T Funovics, Marcos Galli Serra, Michelle Ghert, Kanishka Ghosh, Luis C Gomez Mier, Jesus Gomez Vallejo, Anthony Griffin, Ashish Gulia, Maurice Guzman, Jendrik Hardes, John Healey, Adriana Hernandez, Asle Hesla, Chindanai Hongsaprabhas, Francis Hornicek, Keith Hosking, Shintaro Iwata, Jake Jagiello, Luke Johnson, Andy Johnston, Min Joo, Paul Jutte, Bilal Kapanci, Zeeshan Khan, Hiroshi Kobayashi, Yehuda Kollender, Sebastian Koob, Daniel Kotrych, Louis-Romee Le Nail, Pawel Legosz, Burkhard Lehner, Andreas Leithner, Valerae Lewis, Peng Lin, Francisco Linares, Santiago Lozano Calderon, Ashish Mahendra, Ferdiansyah Mahyudin, Eric Mascard, Jean-Camille Mattei, Louise McCullough, Manuel R Medellin Rincon, Rhidian Morgan-Jones, Diego J Moriel Garcesco, Sophie Mottard, Robert Nakayama, Prashant Narhari, Gary O'Toole, Oliveira Vania, André Olivier, Mohamed Omar, Eduardo Ortiz-Cruz, Harzem Ozger, Korhan Ozkan, Emanuela Palmerini, Panayiotis Papagelopoulos, Michael Parry, Sam Patton, Michael M Petersen, Gerard Powell, Mark Puhaindran, Anand Raja, Raja B Rajasekaran, Lauris Repsa, Mickael Ropars, Andrea Sambri, Thomas Schubert, Ahmad Shehadeh, Geoffrey Siegel, Scott Sommerville, Andre Spiguel, Jonathan Stevenson, Gwen Sys, Thomas Temple, Frank Traub, Hiroyuki Tsuchiya, Juan Valencia, Michel Van de Sande, Gualter Vaz, Roberto Velez Villa, Oleg Vyrva, Hazem Wafa, Wan I Wan Faisham Numan, Edward Wang, David Warnock, Joel Werier, Kwok-Chuen Wong, Yamamoto Norio, Ye Zhaoming, Suraya Zainul Abidin, Tomas Zamora, Juan P Zumarraga, Ghaith Abou-Nouar, Carsten Gebert, R L Randall
Chondrosarcoma is the second most common surgically treated primary bone sarcoma. Despite a large number of scientific papers in the literature, there is still significant controversy about diagnostics, treatment of the primary tumour, subtypes, and complications. Therefore, consensus on its day-to-day treatment decisions is needed. In January 2024, the Birmingham Orthopaedic Oncology Meeting (BOOM) attempted to gain global consensus from 300 delegates from over 50 countries. The meeting focused on these critical areas and aimed to generate consensus statements based on evidence amalgamation and expert opinion from diverse geographical regions...
May 1, 2024: Bone & Joint Journal
#6
MULTICENTER STUDY
Donald O Mutti, Loraine T Sinnott, Susan A Cotter, Lisa A Jones-Jordan, Robert N Kleinstein, Ruth E Manny, J Daniel Twelker, Karla Zadnik
SIGNIFICANCE: Clinicians and researchers would benefit from being able to predict the onset of myopia for an individual child. This report provides a model for calculating the probability of myopia onset, year-by-year and cumulatively, based on results from the largest, most ethnically diverse study of myopia onset in the United States. PURPOSE: This study aimed to model the probability of the onset of myopia in previously nonmyopic school-aged children. METHODS: Children aged 6 years to less than 14 years of age at baseline participating in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study who were nonmyopic and less hyperopic than +3...
April 1, 2024: Optometry and Vision Science: Official Publication of the American Academy of Optometry
#7
JOURNAL ARTICLE
Yaniv Steinfeld, Bheeshma Ravi, Daniel Pincus
The supine 'off-table' anterior-based muscle-sparing (ABMS) approach is an established approach for primary total hip arthroplasty. The approach is performed with the patient positioned supine on a regular operating room table. It combines utilizing the Watson-Jones interval (without disrupting the abductor muscles) with principles of capsular management borrowed from the direct anterior approach. The approach may also be utilized for complex primary and revision hip arthroplasties. One clinical scenario the ABMS approach may be particularly well-suited to is conversion hip arthroplasty when retained hardware requires removal...
June 2024: Arthroplasty Today
#8
JOURNAL ARTICLE
Andrea Giustina, John P Bilezikian, Robert A Adler, Giuseppe Banfi, Daniel D Bikle, Neil C Binkley, Jens Bollerslev, Roger Bouillon, Maria Luisa Brandi, Felipe F Casanueva, Luigi di Filippo, Lorenzo M Donini, Peter R Ebeling, Ghada El-Hajj Fuleihan, Angelo Fassio, Stefano Frara, Glenville Jones, Claudio Marcocci, Adrian R Martineau, Salvatore Minisola, Nicola Napoli, Massimo Procopio, René Rizzoli, Anne L Schafer, Christopher T Sempos, Fabio Massimo Ulivieri, Jyrki K Virtanen
The 6th International Conference, "Controversies in Vitamin D," was convened to discuss controversial topics, such as vitamin D metabolism, assessment, actions, and supplementation. Novel insights into vitamin D mechanisms of action suggest links with conditions that do not depend only on reduced solar exposure or diet intake and that can be detected with distinctive noncanonical vitamin D metabolites. Optimal 25-hydroxyvitamin D (25(OH)D) levels remain debated. Varying recommendations from different societies arise from evaluating different clinical or public health approaches...
April 27, 2024: Endocrine Reviews
#9
JOURNAL ARTICLE
Matthew J Lee, Ellen Lee, Mike Bradburn, Daniel Hind, Emily B Strong, Farhat Din, Arkadiusz P Wysocki, Jon Lund, Christine Moffatt, Jonathan Morton, Asha Senapati, Helen Jones, Steven R Brown
AIM: Pilonidal sinus disease is a common condition treated by colorectal surgeons. There is a lack of literature in the field to guide optimal management of this condition. As part of the PITSTOP study, we aimed to identify policy and research priorities to provide direction to the field. METHOD: Patients and surgeons were invited to participate. A 'So what, now what' exercise was conducted, informed by data from PITSTOP. This generated statements for research and practice priorities...
April 26, 2024: Colorectal Disease
#10
JOURNAL ARTICLE
Astros Th Skuladottir, Lilja Stefansdottir, Gisli H Halldorsson, Olafur A Stefansson, Anna Bjornsdottir, Palmi Jonsson, Vala Palmadottir, Thorgeir E Thorgeirsson, G Bragi Walters, Rosa S Gisladottir, Gyda Bjornsdottir, Gudrun A Jonsdottir, Patrick Sulem, Daniel F Gudbjartsson, Kirk U Knowlton, David A Jones, Aigar Ottas, Ole B Pedersen, Maria Didriksen, Søren Brunak, Karina Banasik, Thomas Folkmann Hansen, Christian Erikstrup, Jan Haavik, Ole A Andreassen, David Rye, Jannicke Igland, Sisse Rye Ostrowski, Lili A Milani, Lincoln D Nadauld, Hreinn Stefansson, Kari Stefansson
Essential tremor (ET) is a prevalent neurological disorder with a largely unknown underlying biology. In this genome-wide association study meta-analysis, comprising 16,480 ET cases and 1,936,173 controls from seven datasets, we identify 12 sequence variants at 11 loci. Evaluating mRNA expression, splicing, plasma protein levels, and coding effects, we highlight seven putative causal genes at these loci, including CA3 and CPLX1. CA3 encodes Carbonic Anhydrase III and carbonic anhydrase inhibitors have been shown to decrease tremors...
April 26, 2024: Communications Biology
#11
JOURNAL ARTICLE
Rebecca L Jones, Andrew W Tomlinson, Duncan M Barnes, Rebecca S Hood, Jamie P McClement, Daniel M Ogden, Mark A Owen, Jeremy R Onyett, Myles B Walton
OBJECTIVE: To report the use of a Lateral Epicondylar Anatomical Plate for the management of humeral condylar fractures (HCF) in dogs. STUDY DESIGN: Medical records of dogs with HCF stabilized using the Lateral Epicondylar Anatomical Plate at six UK veterinary referral centres between April 2018 and February 2021 were reviewed. Long-term follow-up (>6 months) was obtained via owner questionnaire, which incorporated the Liverpool Osteoarthritis in Dogs clinical metrology instrument...
April 26, 2024: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
#12
JOURNAL ARTICLE
Madeleine A Z Ball, Daniel E Sack, Sophia A Druffner, Ian Jones, Jesse O Wrenn, Mitchell M Sexton, Marybeth Shinn, Jennifer J Hess
IMPORTANCE: Unstable housing and homelessness can exacerbate adverse health outcomes leading to increased risk of chronic disease, injury, and disability. However, emergency departments (EDs) have no universal method to identify those at risk of or currently experiencing homelessness. OBJECTIVE: To describe the extent of housing insecurity among patients who seek care in an urban ED, including chief concerns, demographics, and patterns of health care utilization...
April 1, 2024: JAMA Network Open
#13
JOURNAL ARTICLE
Emma Titmuss, Irene S Yu, Erin D Pleasance, Laura M Williamson, Karen Mungall, Andrew J Mungall, Daniel J Renouf, Richard Moore, Steven J M Jones, Marco A Marra, Janessa J Laskin, Kerry J Savage
Immune checkpoint inhibitors (ICIs) are increasingly used in the treatment of many tumor types, and durable responses can be observed in select populations. However, patients may exhibit significant immune-related adverse events (irAEs) that may lead to morbidity. There is limited information on whether the presence of specific germline mutations may highlight those at elevated risk of irAEs. We evaluated 117 patients with metastatic solid tumors or hematologic malignancies who underwent genomic analysis through the ongoing Personalized OncoGenomics (POG) program at BC Cancer and received an ICI during their treatment history...
March 30, 2024: Current Oncology
#14
JOURNAL ARTICLE
Brandon C Witte, Tyler C Schouten, Jessica A Westphal, Adam W VanZile, Daniel D Jones, Tricia L Widenhoefer, Ward C Dobbs, Andrew R Jagim, Joel A Luedke, Thomas G Almonroeder
Witte, BC, Schouten, TC, Westphal, JA, VanZile, AW, Jones, DD, Widenhoefer, TL, Dobbs, WC, Jagim, AR, Luedke, JA, and Almonroeder, TG. The modified reactive strength index is a valid measure of lower-body explosiveness in male and female high school athletes. J Strength Cond Res XX(X): 000-000, 2024-The modified reactive strength index (mRSI) is a commonly used metric to quantify lower-body explosiveness during countermovement jump (CMJ) performance. However, few studies have attempted to examine its validity as a measure of explosiveness, particularly among high school athletes...
April 25, 2024: Journal of Strength and Conditioning Research
#15
JOURNAL ARTICLE
Bradley S Jones, Daniel D Hu, Kathleen R Nicholson, Rachel M Cronin, Simon D Weaver, Matthew M Champion, Patricia A Champion
The mycobacterial cell envelope is a major virulence determinant in pathogenic mycobacteria. Specific outer lipids play roles in pathogenesis, modulating the immune system and promoting the secretion of virulence factors. ESX-1 (ESAT-6 system-1) is a conserved protein secretion system required for mycobacterial pathogenesis. Previous studies revealed that mycobacterial strains lacking the outer lipid PDIM have impaired ESX-1 function during laboratory growth and infection. The mechanisms underlying changes in ESX-1 function are unknown...
April 25, 2024: MSphere
#16
Abigail L Gilbert, Jungwha Lee, Linda Ehrlich-Jones, Pamela A Semanik, Jing Song, Christine A Pellegrini, Daniel Pinto, Dorothy D Dunlop, Rowland W Chang
No abstract text is available yet for this article.
April 23, 2024: Seminars in Arthritis and Rheumatism
#17
JOURNAL ARTICLE
Rachel E Kerwin, Jaynee E Hart, Paul D Fiesel, Yann-Ru Lou, Pengxiang Fan, A Daniel Jones, Robert L Last
Tremendous plant metabolic diversity arises from phylogenetically restricted specialized metabolic pathways. Specialized metabolites are synthesized in dedicated cells or tissues, with pathway genes sometimes colocalizing in biosynthetic gene clusters (BGCs). However, the mechanisms by which spatial expression patterns arise and the role of BGCs in pathway evolution remain underappreciated. In this study, we investigated the mechanisms driving acylsugar evolution in the Solanaceae. Previously thought to be restricted to glandular trichomes, acylsugars were recently found in cultivated tomato roots...
April 26, 2024: Science Advances
#18
JOURNAL ARTICLE
Oluwaseun A Sobowale, Isabel C Hostettler, Teddy Y Wu, Calvin Heal, Duncan Wilson, Darshan G Shah, Daniel Strbian, Jukka Putaala, Turgut Tatlisumak, Andy Vail, Gagan Sharma, Stephen M Davis, David J Werring, Atte Meretoja, Stuart M Allan, Adrian R Parry-Jones
BACKGROUND: The relationship between baseline perihematomal edema (PHE) and inflammation, and their impact on survival after intracerebral hemorrhage (ICH) are not well understood. OBJECTIVE: Assess the association between baseline PHE, baseline C-reactive protein (CRP), and early death after ICH. METHODS: Analysis of pooled data from multicenter ICH registries. We included patients presenting within 24 h of symptom onset, using multifactorial linear regression model to assess the association between CRP and edema extension distance (EED), and a multifactorial Cox regression model to assess the association between CRP, PHE volume and 30-day mortality...
2024: Frontiers in Neurology
#19
JOURNAL ARTICLE
Matthew J Lee, Ellen Lee, Mike Bradburn, Daniel Hind, Emily B Strong, Farhat Din, Arkadiusz P Wysocki, Jon Lund, Christine Moffatt, Jonathan Morton, Asha Senapati, Helen Jones, Steven R Brown
AIM: Research in pilonidal disease faces several challenges, one of which is consistent and useful disease classification. The International Pilonidal Society (IPS) proposed a four-part classification in 2017. The aim of this work was to assess the validity and reliability of this tool using data from the PITSTOP cohort study. METHOD: Face validity was assessed by mapping the items/domains in the IPS tool against tools identified through a systematic review. Key concepts were defined as those appearing in more than two-thirds of published tools...
April 21, 2024: Colorectal Disease
#20
JOURNAL ARTICLE
Daniel Edmonston, Hillary Mulder, Elizabeth Lydon, Karen Chiswell, Zachary Lampron, Christina Shay, Keith Marsolo, W Schuyler Jones, Javed Butler, Raj C Shah, Alanna M Chamberlain, Daniel E Ford, Howard S Gordon, Wenke Hwang, Alexander Chang, Ajaykumar Rao, Hayden B Bosworth, Neha Pagidipati
Placebo-controlled trials of sodium-glucose cotransporter-2 inhibitors (SGLT2i) demonstrate kidney and cardiovascular benefits for people with type 2 diabetes (T2D) and chronic kidney disease (CKD). We used real-world data to compare the kidney and cardiovascular effectiveness of empagliflozin to dipeptidyl peptidase-4 inhibitors (DPP4i), a commonly prescribed antiglycemic medication, in a diverse population with and without CKD. Using electronic health record data from 20 large US health systems, we leveraged propensity overlap weighting to compare outcomes for empagliflozin and DPP4i initiators with T2D between 2016 and 2020...
April 17, 2024: American Journal of Cardiology
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