Dmitry V Chistyakov, Viktoriia E Baksheeva, Veronika V Tiulina, Sergei V Goriainov, Nadezhda V Azbukina, Olga S Gancharova, Eugene A Arifulin, Sergey V Komarov, Viktor V Chistyakov, Natalia K Tikhomirova, Andrey A Zamyatnin, Pavel P Philippov, Ivan I Senin, Marina G Sergeeva, Evgeni Yu Zernii
Ocular inflammation contributes to the pathogenesis of blind-causing retinal degenerative diseases, such as age-related macular degeneration (AMD) or photic maculopathy. Here, we report on inflammatory mechanisms that are associated with retinal degeneration induced by bright visible light, which were revealed while using a rabbit model. Histologically and electrophysiologically noticeable degeneration of the retina is preceded and accompanied by oxidative stress and inflammation, as evidenced by granulocyte infiltration and edema in this tissue, as well as the upregulation of total protein, pro-inflammatory cytokines, and oxidative stress markers in aqueous humor (AH)...
January 21, 2020: International Journal of Molecular Sciences