Sandra Rodríguez-Rodero, Agustín F Fernández, Juan Luís Fernández-Morera, Patricia Castro-Santos, Gustavo F Bayon, Cecilia Ferrero, Rocio G Urdinguio, Rocío Gonzalez-Marquez, Carlos Suarez, Iván Fernández-Vega, Manuel Florentino Fresno Forcelledo, Pablo Martínez-Camblor, Veronika Mancikova, Esmeralda Castelblanco, Marco Perez, Pablo Isidro Marrón, Marta Mendiola, David Hardisson, Pilar Santisteban, Garcilaso Riesco-Eizaguirre, Xavier Matías-Guiu, Amancio Carnero, Mercedes Robledo, Elías Delgado-Álvarez, Edelmiro Menéndez-Torre, Mario F Fraga
OBJECTIVE: The purpose of this study was to determine the global patterns of aberrant DNA methylation in thyroid cancer. RESEARCH DESIGN AND METHODS: We have used DNA methylation arrays to determine, for the first time, the genome-wide promoter methylation status of papillary, follicular, medullary, and anaplastic thyroid tumors. RESULTS: We identified 262 and 352 hypermethylated and 13 and 21 hypomethylated genes in differentiated papillary and follicular tumors, respectively...
July 2013: Journal of Clinical Endocrinology and Metabolism