Xingxia Wang, Wei Hu, Liqun Qu, Jian Wang, Anguo Wu, Hang Hong Lo, Jerome P L Ng, Yong Tang, Xiaoyun Yun, Jianhui Wu, Vincent Kam Wai Wong, Sookja Kim Chung, Linna Wang, Weidan Luo, Xiang Ji, Betty Yuen Kwan Law
Tricin, a natural nontoxic flavonoid distributed in grasses and euphorbia plants, has been reported to scavenge free radicals, possess anti-inflammatory and antioxidative effects. However, its autophagic effect on Parkinson's disease (PD) has not been elucidated. By adopting cellular and C. elegans models of PD, the autophagic effect of tricin was identified based on the level of autophagy markers (LC3-II and p62). Besides, the pharmacological effects on neurotransmitters (tyrosine hydroxylase and dopamine), inflammatory cytokines (IFN γ, TNFα, MCP-1, IL-10, IL-6 and IL-17A), histology (hematoxylin & eosin and Nissl staining) and behavioural pathology (open-field test, hindlimb clasping, Y-maze, Morris water-maze and nest building test) were also confirmed in the A53T-α-transgenic PD mouse model...
August 14, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society