Lilla Horváth, Imre Boncz, Zsuzsanna Kívés, Noémi Németh, Katalin Biró, Krisztina Fendrik, Katalin Koltai, Gábor Késmárky, Dóra Endrei
Összefoglaló. Bevezetés: A perifériás verőérbetegség napjaink egyik világméretű népegészségügyi problémája, több mint 200 millió embert érint világszerte. A Peripheral Artery Disease Quality of Life (PADQOL) kérdőívet azzal a céllal fejlesztették ki, hogy a betegség fizikai tünetein kívül annak szubjektív betegségterhét, pszichoszociális és emocionális hatásait is vizsgálja. Célkitűzés: Az eredeti, angol nyelvű PADQOL betegségspecifikus, önkitöltős kérdőív magyar nyelvű, érvényes változatának kifejlesztése, annak fordítása, kultúrközi adaptációja és magyar nyelvi validálása...
December 20, 2020: Orvosi Hetilap
Jie Zhao, Qihui Shi, Hongda Tian, Youzhi Li, Yan Liu, Zhen Xu, Anne Robert, Qiong Liu, Bernard Meunier
Besides targeting amyloid or tau metabolisms, regulation of redox metal ions is a recognized therapeutic target for Alzheimer's disease (AD). Based on the bioinorganic chemistry of copper, we designed specific chelators of copper(II) (TDMQs) insight to regulate copper homeostasis in the brain and to inhibit the deleterious oxidative stress catalyzed by copper-amyloid complexes. An oral treatment by TDMQ20 was able to fully reverse the cognitive and behavioral impairment in three different murine models, two nontransgenic models mimicking the early stage of AD and a transgenic model representing a more advanced stage of AD...
December 15, 2020: ACS Chemical Neuroscience
Elena Nicora, Gaurvi Goyal, Nicoletta Noceti, Alessia Vignolo, Alessandra Sciutti, Francesca Odone
MoCA is a bi-modal dataset in which we collect Motion Capture data and video sequences acquired from multiple views, including an ego-like viewpoint, of upper body actions in a cooking scenario. It has been collected with the specific purpose of investigating view-invariant action properties in both biological and artificial systems. Besides that, it represents an ideal test bed for research in a number of fields - including cognitive science and artificial vision - and application domains - as motor control and robotics...
December 15, 2020: Scientific Data
Chunsheng Xu, Chu Wang, Xiaocao Tian, Yili Wu, Dongfeng Zhang, Zengchang Pang, Shuxia Li, Qihua Tan
OBJECTIVE: Leisure activity has been shown to be beneficial to mental health and cognitive aging. The biological basis of the correlation is, however, poorly understood. This study aimed at exploring the genetic and environmental impacts on correlation between leisure activities and cognitive function in the Chinese middle- and old-aged twins. METHODS: Cognition measured using a screening test (Montreal Cognitive Assessment, MoCA) and leisure activities including intellectual and social activity were investigated on 379 complete twin pairs of middle- and old-aged twins...
December 9, 2020: Aging & Mental Health
Ling Zhang, Qian Zhou, Chun-Li Zhou
OBJECTIVE: To explore the effect of RTA-408 on the propofol-induced cognitive impairment of neonatal mice via regulating Nrf2 and NF-κB p65 nuclear translocation. METHODS: C57BL/6 neonatal mice were randomized into intralipid, propofol, vehicle + propofol, and RTA-408 + propofol groups. The learning and memory ability was inspected by Morries water maze (MWM) test. TUNEL staining was performed to examine the apoptosis of neurons in hippocampus. The gene and protein expressions in hippocampus were detected by immunohistochemistry, qRT-PCR, or Western blotting...
December 9, 2020: Brain and Behavior
Alberto Zani, Alice Mado Proverbio
Several studies showed that shifting of visuospatial attention modulates sensory processing at multiple levels of the visual pathways and beyond, including the occipital striate cortices level. However, inconsistent findings have been reported thus leaving these issues still disputed. 21 participants took part to the present study (the EEG signals of 4 of them were discarded due to artifacts). We used ERPs and their neural sources to investigate whether shifting spatial attention in space across the horizontal meridian of the visual field affected striate cortices activation at the earliest latency...
November 2020: Heliyon
Ali Tehrani-Saleh, Christoph Adami
How cognitive neural systems process information is largely unknown, in part because of how difficult it is to accurately follow the flow of information from sensors via neurons to actuators. Measuring the flow of information is different from measuring correlations between firing neurons, for which several measures are available, foremost among them the Shannon information, which is an undirected measure. Several information-theoretic notions of "directed information" have been used to successfully detect the flow of information in some systems, in particular in the neuroscience community...
March 28, 2020: Entropy
Juan Fierros-Campuzano, Paola Ballesteros-Zebadúa, Joaquín Manjarrez-Marmolejo, Penélope Aguilera, Mónica Méndez-Diaz, Oscar Prospero-García, Javier Franco-Pérez
Some reports have described that a high fructose diet is associated with a deficit of hippocampus-dependent cognitive functions. In this study, we have evaluated the effects of fructose on spatial memory and molecular markers in the hippocampus and prefrontal cortex and analyzed whether those alterations are reversible. Male Wistar rats ( n  = 60) began their treatment during adolescence. A group was forced to drink a solution of 10% fructose for twelve weeks. Another group was subjected to the same fructose intake schedule, but later fructose was removed, and tap water was provided for four weeks...
December 3, 2020: Nutritional Neuroscience
Laura Toro-Giraldo, Norma Morales Flores, Omar Santana-Cruz, Arturo Ramirez-Miranda, Alejandro Navas, Andrew Olivo-Payne, Alejandro Lichtinger, Aida Jimenez-Corona, Enrique O Graue-Hernández
PURPOSE: To explore corneal cooling as a method of pain management in corneal-accelerated collagen cross-linking. METHODS: This was a prospective and interventional randomized clinical trial registered in the National Institutes of Health Clinical Trials through the identifier NCT030760770. The research was conducted at the Institute of Ophthalmology "Conde de Valenciana." A total of 98 patients were randomly assigned to one of the following 2 groups: cold riboflavin (4°C) group or control group (riboflavin at room temperature)...
January 2021: Cornea
Samu Kainulainen, Brett Duce, Henri Korkalainen, Akseli Leino, Riku Huttunen, Laura Kalevo, Erna S Arnardottir, Antti Kulkas, Sami Myllymaa, Juha Töyräs, Timo Leppänen
Objectives: Besides hypoxaemia severity, heart rate variability has been linked to cognitive decline in obstructive sleep apnoea (OSA) patients. Thus, our aim was to examine whether the frequency domain features of a nocturnal photoplethysmogram (PPG) can be linked to poor performance in the psychomotor vigilance task (PVT). Methods: PPG signals from 567 suspected OSA patients, extracted from Type 1 diagnostic polysomnography, and corresponding results of PVT were retrospectively examined...
October 2020: ERJ Open Research
Shaohui Ma, Ming Zhang, Yang Liu, Dun Ding, Peng Li, Xueying Ma, Hongjuan Liu, Junya Mu
BACKGROUND: End-stage renal disease (ESRD) patients are at a substantially higher risk for developing cognitive impairment compared with the healthy population. Dialysis is an essential way to maintain the life of ESRD patients. Based on previous research, there isn't an uncontested result whether cognition was improved or worsened during dialysis. METHODS: To explore the impact of dialysis treatment on cognitive performance, we recruited healthy controls (HCs), predialysis ESRD patients (predialysis group), and maintenance hemodialysis ESRD patients (HD group)...
November 26, 2020: BMC Nephrology
Marta Hernández-García, Marta Gómez-García, Eva Sotelo, Inés Fernández-Linsenbarth, Pilar Andrés-Olivera, Rubén de Alarcon-Gómez, María Fe Muñoz-Moreno, Vicente Molina
Anomalous self-experiences (ASEs) are prevalent in schizophrenia, but its underpinnings are not completely understood. Given the likely complex substrate of the experience of the self, neurocognitive functions requiring coordinate cerebral activity may relate to ASEs. Moreover, cognitive deficits functioning may be involved in the link between self-experience disturbances and some aspects of social dysfunction in schizophrenia. We have assessed ASEs in 41 schizophrenia patients (11 first episodes) using the Inventory of Psychotic-Like Anomalous Self-Experiences (IPASE), and the general cognition using the Brief Assessment of Cognition in Schizophrenia (BACS)...
November 22, 2020: European Archives of Psychiatry and Clinical Neuroscience
Ningwei Zhu, Xiao Liang, Ming Zhang, Xiaolan Yin, Hui Yang, Yajun Zhi, Guizhen Ying, Jialing Zou, Lei Chen, Xiaokun Yao, Hongwei Li
OBJECTIVE: The purpose of this study was to evaluate the effect of astaxanthin (AST) on cognition function, inflammatory response and oxidative stress in vascular dementia (VD) mice. METHOD: VD mice model was established by left unilateral common carotid arteries occlusion (LUCCAO). Following LUCCAO, AST was intragastrically administered for 30 days. Object recognition test and morris water maze test were used to evaluate cognitive function. Hematoxylin and eosin staining was performed to observe the hippocampal neuron structure...
November 18, 2020: Behavioral and Brain Functions: BBF
Wei Hua, Jianhua Hou, Taiyi Jiang, Bin Su, Jiangning Fu, Runsong Sun, Biru Chang, Wei Xia, Hao Wu, Tong Zhang, Caiping Guo, Wen Wang
Objective: China has the largest population living with dementia, causing a tremendous burden on the aging society. Cardiovascular disease (CVD) may trigger a cascade of pathologies associated with cognitive aging. We aim to investigate the association between cardiovascular risk (CVR) factors and cognitive function in the nationally representative cohort in China. Methods: Participants were recruited from 150 counties in 28 provinces via a four-stage sampling method. The outcomes included several cognitive tasks...
2020: Frontiers in Cardiovascular Medicine
Ambra Gentile, Stefano Boca, Yolanda Demetriou, David Sturm, Simona Pajaujiene, Ilona Judita Zuoziene, Fatma Nese Sahin, Özkan Güler, Manuel Gómez-López, Carla Chicau Borrego, Doris Matosic, Antonino Bianco, Marianna Alesi
Purpose: Besides the evident positive effect on body development, physical activity has proven to boost executive functions, especially if the exercises are enriched with cognitive stimuli. Previous studies have shown that introducing challenging exercises in the physical activity routine can also enhance motivation. Therefore, enriching a physical education program with cognitively challenging exercises may also foster children's motivation during physical education classes, where the motivation is high at the beginning of the school year and low at the end of it...
2020: Frontiers in Psychology
Gabriela Delevati Colpo, Natalia Pessoa Rocha, Erin Furr Stimming, Antonio Lucio Teixeira
Huntington's disease (HD) is an inherited neurodegenerative disease. Besides the well-characterized motor symptoms, HD is marked by cognitive impairment and behavioral changes. In this study, we analyzed the blood of HD gene carries using RNA-sequencing techniques. We evaluated samples from HD gene carriers with ( n = 8) and without clinically meaningful depressive symptoms ( n = 8) compared with healthy controls ( n = 8). Groups were age- and sex-matched. Preprocessing of data and between-group comparisons were calculated using DESeq2...
November 11, 2020: International Journal of Molecular Sciences
Eric L R Moura, Hellin Dos Santos, Ana Paula M Celes, Taysa B Bassani, Leonardo C Souza, Maria A B F Vital
Background: It has been studied that nutrition can influence Alzheimer's disease (AD) onset and progression. Some studies on rodents using intraventricular streptozotocin (STZ) injection showed that this toxin changes cerebral glucose metabolism and insulin signaling pathways. Objective: The aim of the present study was to evaluate whether a nutritional formulation could reduce cognitive impairment in STZ-induced animals. Methods: The rats were randomly divided into two groups: sham and STZ...
September 3, 2020: JAD Reports
Halil Onder, Ozge Ozyurek
AIMS: To investigate the impact of distinct cognitive dual-task abilities in patients with Parkinson's disease (PD) and compare the impact of these dual-tasks in association with the severity of PD and its clinical features. MATERIALS AND METHODS: Modified Hoehn and Yahr Scale, UPDRS, and Standardized Mini-Mental State Examination (SMMSE) were evaluated in all PD patients. The subtype of PD and the presence of freezing of gait (FOG) were also evaluated. The Timed Up and Go (TUG) test was applied under single- and dual-task conditions including the digit span-forwards, digit span-backwards, delayed recall memory, counting down the days, counting backwards from 20, and animal fluency tests...
November 4, 2020: Neurological Sciences
Mengdai Xu, Hao Huang, Xiaoxing Mo, Yalun Zhu, Xi Chen, Xiaoqin Li, Xiaobo Peng, Zihui Xu, Liangkai Chen, Shuang Rong, Wei Yang, Shuang Liu, Liegang Liu
SCOPE: Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) related imbalance, tau-hyperphosphorylation, and neuroinflammation, in which Aβ and neuroinflammation could induce brain insulin resistance (IR). Gut microbiome disorder is correlated with inflammation in AD. As of yet, there are no effective treatments clinically. Thus, we focus on the potential benefit of quercetin-3-O-glucuronide (Q3G), a pharmacologically active flavonol glucuronide, on AD treatment by regulating brain IR and the gut microbiome...
November 3, 2020: Molecular Nutrition & Food Research
Wellington de Almeida, Heloísa Deola Confortim, Bruna Ferrary Deniz, Patrícia Maidana Miguel, Milene Cardoso Vieira, Loise Bronauth, Adriana Souza Dos Santos, Karine Bertoldi, Ionara Rodrigues Siqueira, Lenir Orlandi Pereira
Neonatal hypoxia-ischemia (HI) can lead to cognitive impairments and motor dysfunction. Acrobatic exercises (AE) were proposing as therapeutic option to manage HI motor deficits, however, the cognitive effects after this treatment is still poorly understood. Therefore, we evaluated the effects of AE protocol on memory impairments and brain plasticity markers after Rice-Vannucci hypoxia-ischemia rodent model. Wistar rats on the 7th  postnatal day (PND) were submitted to HI model and after weaning (PND22) were trained for 5 weeks with AE protocol, then subsequently submitted to cognitive tests...
November 1, 2020: International Journal of Developmental Neuroscience
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