keyword
https://read.qxmd.com/read/38185068/salvianolic-acid-a-provides-neuroprotective-effects-on-cerebral-ischemia-reperfusion-injury-in-rats-via-pka-creb-c-fos-signaling-pathway
#21
JOURNAL ARTICLE
Ran Yang, Nan Hu, Ting-Yu Liu, Yue Qu, Jie Liu, Jin-Hui Wang, Bao-Feng Yang, Chun-Li Li
BACKGROUND: Cerebral ischemia-reperfusion injury (CIRI) is a phenomenon that pathological injury of ischemic brain tissue is further aggravated after the restoration of blood supply. The complex pathological mechanism of CIRI has led to the failure of multiple neuroprotective agents in clinical studies. Salvianolic acid A (SAA) is a neuroprotective extract from Salvia miltiorrhiza Bge., with significant pharmacological activities in the treatment of brain injury. However, the neuroprotective mechanisms of SAA remain unclear...
December 28, 2023: Phytomedicine
https://read.qxmd.com/read/38183677/transforming-growth-factor-%C3%AE-1-protects-against-white-matter-injury-and-reactive-astrogliosis-via-the-p38-mapk-pathway-in-rodent-demyelinating-model
#22
JOURNAL ARTICLE
Yi Xie, Xuejiao Chen, Xinyue Wang, Shuai Liu, Simiao Chen, Zhiyuan Yu, Wei Wang
In central nervous system (CNS), demyelination is a pathological process featured with a loss of myelin sheaths around axons, which is responsible for the diseases of multiple sclerosis, neuromyelitis optica, and so on. Transforming growth factor-beta1 (TGF-β1) is a multifunctional cytokine participating in abundant physiological and pathological processes in CNS. However, the effects of TGF-β1 on CNS demyelinating disease and its underlying mechanisms are controversial and not well understood. Herein, we evaluated the protective potential of TGF-β1 in a rodent demyelinating model established by lysophosphatidylcholine (LPC) injection...
January 6, 2024: Journal of Neurochemistry
https://read.qxmd.com/read/38176284/benefits-of-ahsct-over-alemtuzumab-in-patients-with-multiple-sclerosis-besides-disability-and-relapses-sustained-improvement-in-cognition-and-quality-of-life
#23
JOURNAL ARTICLE
Bente Braun, Felix Fischbach, Johanna Richter, Lena Kristina Pfeffer, Heike Fay, Stefanie Reinhardt, Manuel A Friese, Jan-P Stellmann, Nicolaus M Kröger, Christoph Heesen, Vivien Häußler
BACKGROUND: Autologous hematopoietic stem cell transplantation (aHSCT) exhibits promising results for multiple sclerosis (MS) in the short term. We investigated the long-term outcome differences in disease progression and cognitive impairment after aHSCT and alemtuzumab treatment. METHODS: 20 patients receiving aHSCT and 21 patients treated with alemtuzumab between 2007 and 2020 were included in this monocentric observational cohort study. The primary objective was to compare the outcome of both groups with regards to achieving No Evidence of Disease Activity (NEDA-3), defined by the absence of relapses, EDSS progression, and MRI activity...
December 27, 2023: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38151081/the-polysaccharides-from-the-fruits-of-lycium-barbarum-ameliorate-high-fat-and-high-fructose-diet-induced-cognitive-impairment-via-regulating-blood-glucose-and-mediating-gut-microbiota
#24
JOURNAL ARTICLE
Xinyi Tian, Wei Dong, Wangting Zhou, Yamei Yan, Lu Lu, Jia Mi, Youlong Cao, Yi Sun, Xiaoxiong Zeng
High-fat and high-fructose diet (HFFD) consumption can induce cognitive dysfunction and gut microbiota disorder. In the present study, the effects of the polysaccharides from the fruits of Lycium barbarum L. (LBPs) on HFFD-induced cognitive deficits and gut microbiota dysbiosis were investigated. The results showed that intervention of LBPs (200 mg/kg/day) for 14 weeks could significantly prevent learning and memory deficits in HFFD-fed mice, evidenced by a reduction of latency and increment of crossing parameters of platform quadrant in Morris water maze test...
December 25, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38151008/impact-of-sleep-deprivation-on-the-brain-s-inflammatory-response-triggered-by-lipopolysaccharide-and-its-consequences-on-spatial-learning-and-memory-and-long-term-potentiation-in-male-rats
#25
JOURNAL ARTICLE
Maryam Salari, Khadijeh Esmaeilpour, Lily Mohammadipoor-Ghasemabad, Farahnaz Taheri, Mahmoud Hosseini, Vahid Sheibani
INTRODUCTION: Both sleep deprivation (SD) and inflammation can negatively affect cognitive function. This study aimed to investigate how SD impacts the brain's inflammatory response to lipopolysaccharide (LPS) and its subsequent effects on cognitive functions. METHODS: To this end, male rats were tested through a Morris water maze (MWM) to assess their spatial learning and memory. Also, in vivo field potential recordings (to evaluate synaptic plasticity) were done in Saline, SD, LPS1 (1mg/kg/7 days), and LPS1+SD groups...
December 27, 2023: Neuroimmunomodulation
https://read.qxmd.com/read/38148785/the-influence-of-social-support-on-sleep-and-fatigue-level-among-patients-receiving-hemodialysis-in-saudi-arabia-a-cross-sectional-correlational-design
#26
JOURNAL ARTICLE
Bushra Alshammari, Sameer A Alkubati, Eddieson Pasay-An, Awatif Alrasheeday, Norah Madkhali, J Silvia Edison, Venkat Bakthavatchaalam, Marim Saud Alshammari, Amnah Ayed AlRashidi, Farhan Alshammari
BACKGROUND: Patients on hemodialysis (HD) are more likely to experience sleep problems and fatigue that may affect their health outcomes. Management of these patients with social support may improve their sleep quality and fatigue as well as their health. AIM: This study aimed to assess the influence of social support on sleep quality and fatigue levels among HD patients. METHODS: A cross-correlational study was conducted among 260 conveniently sampled HD patients from four dialysis centers in Hail and Al-Qassim cities of Saudi Arabia from Jun 2022 to January 2023...
2023: Frontiers in Psychology
https://read.qxmd.com/read/38115976/chinese-version-of-exercise-dependence-scale-revised-psychometric-analysis-and-exploration-of-risk-factors
#27
JOURNAL ARTICLE
Yingbo Shao, Haoyu Zhang, Xiaonan Zhang, Qian Liang, Hui Zhang, Feifei Zhang
INTRODUCTION: Exercise addiction (EA) is a dysfunctional behavior characterized by exaggerated training which has adverse effects on physiology and psychology. To examine the reliability and validity of the Chinese version of the Exercise Dependence Scale-Revised (EDS-R) and the social and psychological aspects related to EA, a large sample behavioral study was conducted. METHODS: College students were selected as the target group. All of them were asked to finish the scales about exercise, including the Chinese version of EDS-R and the Motives for Physical Activity Measure-Revised scales...
2023: Frontiers in Psychology
https://read.qxmd.com/read/38110713/a-scoping-review-of-interventions-and-outcome-measures-in-trials-of-dental-behavior-support
#28
JOURNAL ARTICLE
Caoimhin Mac Giolla Phadraig, Aisyah Binti Ahmad Fisal, James Bird, Pedro Vitali Kammer, Isabel Fleischmann, Andrew Geddis-Regan
BACKGROUND: Dental behavior support (DBS) describes all techniques used by dental professionals to ensure that dental care is safe, effective, and acceptable. There is a need to standardize outcome measures across DBS techniques to reduce heterogeneity, limit selective reporting, promote consistency, and optimize outcomes across DBS research. A comprehensive review of existing measures is a prerequisite to understanding potential outcomes related to the area of interest. AIM: This review had three aims: first, to identify the outcome measures (OMs) reported in trials of dental behavior support; second, to categorize the component DBS techniques reported within interventions according to emerging agreed terminology; and, third, to map outcome measures to intervention type...
December 18, 2023: Special Care in Dentistry
https://read.qxmd.com/read/38107399/cognitive-function-improvement-effects-of-gintonin-enriched-fraction-in-subjective-memory-impairment-an-assessor-and-participant-blinded-placebo-controlled-study
#29
JOURNAL ARTICLE
Rami Lee, Han Sang Lee, Won-Woo Kim, Manho Kim, Seung-Yeol Nah
BACKGROUND: Gintonin is a new material of ginseng that acts through the ginseng-derived lysophosphatidic acid (LPA) receptor ligand. The gintonin-enriched fraction (GEF) inhibits amyloid plaque accumulation in the cortex and hippocampus, improves cognitive dysfunction by increasing acetylcholine levels, and promoted hippocampal neurogenesis in an animal model of Alzheimer's disease. We evaluated the effect of the GEF on the cognitive performance of subjects with subjective memory impairment (SMI)...
November 2023: Journal of Ginseng Research
https://read.qxmd.com/read/38095150/cognitive-reserve-physical-reserve-and-cognitive-efficiency-of-older-people-living-in-the-sardinian-blue-zone-an-exploratory-study
#30
JOURNAL ARTICLE
Maria Chiara Fastame, Benedetta Brandas, Massimiliano Pau
This study mainly intended to disentangle the role played by physical reserve as a mediator of the relationship between cognitive reserve and global cognitive functioning in older people aging well. A sample of 120 67-101-year-old community-dwellers was recruited in the Sardinian Blue Zone, an area characterized by the extreme longevity of its inhabitants. Each respondent completed a battery of tests examining cognitive functioning, perceived physical health, cognitive reserve, and physical reserve (objectively assessed through accelerometric-derived measures)...
December 14, 2023: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://read.qxmd.com/read/38090736/novel-ibuprofen-prodrug-a-possible-promising-agent-for-the-management-of-complications-of-alzheimer-s-disease
#31
JOURNAL ARTICLE
Anjali Nayak, Rashu Raju, Paramita Das, Kuntal Das, A Suvitha, Biswa Ranjan Meher, Saad Alobid, Ali Ibrahim Almoteer, Moneer E Almadani, Ahmed Alshehri, Adel Alghamdi, Fuzail Ahmad, Syed Imam Rabbani, Syed Mohammed Basheeruddin Asdaq, Naira Nayeem
BACKGROUND: Alzheimer's disease (AD) is a severe, varied, and complex brain condition that gradually impairs memory and cognitive function. Epidemiological studies have shown that patients who have a history of long-term NSAID use have a decreased risk of developing AD. The objective of this study is to conduct the structural analysis of a novel ibuprofen prodrug and test its anti-Alzheimer's properties. METHODS: Computational and docking studies were conducted using AMBER 18 package...
January 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38082507/poke-and-delayed-drink-intertemporal-choice-task-poke-addict-an-open-source-behavioral-apparatus-for-intertemporal-choice-testing-in-rodents
#32
JOURNAL ARTICLE
Andrea Stefano Moro, Daniele Saccenti, Alessia Seccia, Mattia Ferro, Antonio Malgaroli, Jacopo Lamanna
Advancements in neuroscience research present opportunities and challenges, requiring substantial resources and funding. To address this, we describe here "Poke And Delayed Drink Intertemporal Choice Task (POKE-ADDICT)", an open-source, versatile, and cost-effective apparatus for intertemporal choice testing in rodents. This allows quantification of delay discounting (DD), a cross-species phenomenon observed in decision making which provides valuable insights into higher-order cognitive functioning. In DD, the subjective value of a delayed reward is reduced as a function of the delay for its receipt...
December 11, 2023: Animal Models and Experimental Medicine
https://read.qxmd.com/read/38056710/hippocampal-estrogens-rescued-the-decline-of-synaptic-plasticity-after-surgery-and-anesthesia-by-inhibiting-microglia-overactivation
#33
JOURNAL ARTICLE
Xiao-Xiang Tan, Hong-Yu Dai, Juan Yao, Jia-Jia Wang, Yu-Chen Dai, Tian-Hao Zhang, Li-Li Qiu, Jie Sun
BACKGROUND: Elderly patients experience postoperative cognitive impairment frequently; therefore, effective interventions are urgently needed. Central nervous inflammation characterized by microglia may promote the progression of POCD by reducing synaptic plasticity. Notably, clinical studies revealed that the incidence of female patients was significantly lower than that of male patients. Besides, the brain estrogens have an anti-inflammatory effect and regulate the microglia at the same times...
December 4, 2023: Behavioural Brain Research
https://read.qxmd.com/read/38035091/antibody-induced-seizure-susceptibility-and-impaired-cognitive-performance-in-a-passive-transfer-rat-model-of-autoimmune-encephalitis
#34
JOURNAL ARTICLE
Şura Akat Pişkin, Hande Yüceer Korkmaz, Canan Aysel Ulusoy, Elif Şanlı, Cem Ismail Küçükali, Filiz Onat, Erdem Tüzün, Nihan Çarçak
OBJECTIVE: Autoimmune encephalitis (AE) is a distinct neuro-immunological disorder associated with the production of autoantibodies against neuronal proteins responsible for pharmacoresistant seizures, cognitive decline and behavioral problems. To establish the causal link between leucine-rich glioma inactivated 1 (LGI1) antibody and seizures, we developed an in-vivo antibody-mediated AE rat model in which serum antibodies (IgG) obtained from blood samples of leucine-rich glioma inactivated 1 (LGI1) protein antibody (IgG) positive encephalitis patients were passively transferred into non-epileptic Wistar rats...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38034300/validation-study-for-the-academic-maladjustment-questionnaire-on-a-romanian-sample
#35
JOURNAL ARTICLE
Ana-Maria Cazan, Maria Magdalena Stan, Aurel Ion Clinciu, Camelia Truţa, Catalin Ioan Maican
INTRODUCTION: The problem of academic dropout in the first year of studies represents an important issue for higher education, in that it accounts for an important indicator of quality but also for the negative consequences it produces on individual, institutional and social level. The main aim of the study is to validate and evaluate a robust measure of overall academic maladjustment. METHOD: The participants were 809 first-year students from various Romanian universities...
2023: Frontiers in Psychology
https://read.qxmd.com/read/38022987/relationship-between-learning-flow-and-academic-performance-among-students-a-systematic-evaluation-and-meta-analysis
#36
Zhang Jinmin, Fang Qi
INTRODUCTION: The concept of "flow experience," characterized by a state of immersive enjoyment and profound engagement, pertains to individuals' deep involvement in intriguing and pleasant tasks. In the field of study, individuals are in a state of flow when encountering challenging tasks, which matters considerably in completing the tasks. Therefore, learning flow is considered a hotspot in education that may be related to improving academic performance. Nonetheless, there remains contention regarding the extent of learning flow's impact on academic performance...
2023: Frontiers in Psychology
https://read.qxmd.com/read/37989445/curcumin-alleviates-alzheimer-s-disease-by-inhibiting-inflammatory-response-oxidative-stress-and-activating-the-ampk-pathway
#37
JOURNAL ARTICLE
Sen Shao, Xiaojun Ye, Wenwen Su, Yanbo Wang
BACKGROUND: Alzheimer's disease (AD) is a common degenerative brain disorder with limited therapeutic options. Curcumin (Cur) exhibits neuroprotective function in many diseases. We aimed to explore the role and mechanism of Cur in AD. MATERIALS AND METHODS: Firstly, we established AD mice by injecting amyloid-β1-42 (Aβ1-42) solution into the hippocampus. Then, the AD mice received 150 mg/kg/d Cur for 10 consecutive days. The Morris water maze test was conducted to evaluate the cognitive function of the mice by hidden platform training and probe trials...
December 2023: Journal of Chemical Neuroanatomy
https://read.qxmd.com/read/37980665/effect-of-virgin-coconut-oil-supplementation-on-cognition-of-individuals-with-mild-to-moderate-alzheimer-s-disease-in-sri-lanka-vco-ad-study-a-randomized-placebo-controlled-trial
#38
JOURNAL ARTICLE
Malika G Fernando, Renuka Silva, W M A D Binosha Fernando, H Asita de Silva, A Rajitha Wickremasinghe, Asoka S Dissanayake, Hamid R Sohrabi, Ralph N Martins, Shehan S Williams
BACKGROUND: Virgin coconut oil (VCO) is a potential therapeutic approach to improve cognition in Alzheimer's disease (AD) due to its properties as a ketogenic agent and antioxidative characteristics. OBJECTIVE: This study aimed to investigate the effect of VCO on cognition in people with AD and to determine the impact of apolipoprotein E (APOE) ɛ4 genotype on cognitive outcomes. METHODS: Participants of this double-blind placebo-controlled trial (SLCTR/2015/018, 15...
2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/37969944/seizure-onset-zone-identification-using-phase-amplitude-coupling-and-multiple-machine-learning-approaches-for-interictal-electrocorticogram
#39
JOURNAL ARTICLE
Yao Miao, Yasushi Iimura, Hidenori Sugano, Kosuke Fukumori, Toshihisa Tanaka
Automatic seizure onset zone (SOZ) localization using interictal electrocorticogram (ECoG) improves the diagnosis and treatment of patients with medically refractory epilepsy. This study aimed to investigate the characteristics of phase-amplitude coupling (PAC) extracted from interictal ECoG and the feasibility of PAC serving as a promising biomarker for SOZ identification. We employed the mean vector length modulation index approach on the 20-s ECoG window to calculate PAC features between low-frequency rhythms (0...
December 2023: Cognitive Neurodynamics
https://read.qxmd.com/read/37954184/the-influence-of-learning-styles-on-academic-procrastination-among-students-in-mathematics
#40
JOURNAL ARTICLE
Wan Anis Syamimi Wan Hussin, Mohd Effendi Ewan Mohd Matore
INTRODUCTION: Procrastination is a complex psychological and behavioral construct that is strongly influenced by certain personality traits. In mathematics learning, students find it difficult to master the concepts because of less exposure to learning styles. Poor knowledge of mathematical concepts leads to academic procrastination in the subject of Mathematics among students. Therefore, this study aims to identify students' learning styles in Mathematics, identify the stages of students' academic procrastination in Mathematics, and determine whether there is a significant influence of learning styles (visual, auditory, and kinesthetic) on academic procrastination among secondary school students in Mathematics...
2023: Frontiers in Psychology
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