keyword
https://read.qxmd.com/read/38455524/factors-affecting-seizure-recurrence-in-the-emergency-department
#21
JOURNAL ARTICLE
Umit Can Dolek, Mustafa Gokce, Mehmet Muzaffer Islam, Serdar Ozdemir, Gokhan Aksel, Abdullah Algin
BACKGROUND: Information on Emergency Department (ED) follow-up of patients presenting with epileptic seizures is limited. OBJECTIVES: It was planned to investigate the factors affecting the recurrence of epileptic seizures in the follow-up of patients presenting to the ED with the complaint of epileptic seizures. MATERIALS AND METHODS: This prospective, observational, single-center study was carried out in an adult population presenting to the ED...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38455403/-tumor-treating-fields-delivered-via-electromagnetic-induction-have-varied-effects-across-glioma-cell-lines-and-electric-field-amplitudes
#22
JOURNAL ARTICLE
Rea Ravin, Teddy X Cai, Aiguo Li, Nicole Briceno, Randall H Pursley, Marcial Garmendia-Cedillos, Tom Pohida, Herui Wang, Zhengping Zhuang, Jing Cui, Nicole Y Morgan, Nathan H Williamson, Mark R Gilbert, Peter J Basser
Previous studies reported that alternating electric fields (EFs) in the intermediate frequency (100-300 kHz) and low intensity (1-3 V/cm) regime - termed "Tumor Treating Fields" (TTFields) - have a specific, anti-proliferative effect on glioblastoma multiforme (GBM) cells. However, the mechanism(s) of action remain(s) incompletely understood, hindering the clinical adoption of treatments based on TTFields. To advance the study of such treatment in vitro , we developed an inductive device to deliver EFs to cell cultures which improves thermal and osmolar regulation compared to prior devices...
2024: American Journal of Cancer Research
https://read.qxmd.com/read/38451916/does-radioactive-iodine-treatment-damage-the-lacrimal-system
#23
JOURNAL ARTICLE
Ceren Gürez, Nurhan Ergül
PURPOSE: In this prospective study, we aimed to make a quantitative assessment of the lacrimal glands before and after radioactive iodine (RAI) treatment in patients with hyperthyroidism and thyroid cancer. METHODS: The study included 80 eyes of 40 patients. There were 25 patients in group 1 (hyperthyroid group) and 15 patients in group 2 (thyroid cancer group). Group 1 has received low dose (131I) and group 2 high dose (131I). Before, and at the first and sixth month after RAI treatment, all patients underwent ophthalmological examinations, Schirmer tests, TBUT tests, tear osmolarity (TO), and ocular surface examinations...
March 7, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38449362/are-thermotolerant-and-osmotolerant-characteristics-of-acanthamoeba-species-an-indicator-of-pathogenicity
#24
JOURNAL ARTICLE
Merve Kahraman, Zübeyda Akın Polat
OBJECTIVE: The aim of this study was to evaluate the pathogenicity of Acanthamoeba strains with T4, T5, T11, and T12 genotypes by comparing the osmotolerance and thermotolerance characteristics of Acanthamoeba strains isolated from genotype groups, within species with the same genotype, and from environmental and keratitis cases. METHODS: In this study, after axenic cultures of 22 Acanthamoeba strains with T4 (Neff, A, B, D, E), T5, T11, and T12 genotypes isolated from clinical and environmental samples, thermotolerance (37 °C, 39 °C and 41 °C) and osmotolerance (0...
March 5, 2024: Türkiye Parazitolojii Dergisi
https://read.qxmd.com/read/38446023/iso-osmolar-vs-low-osmolar-contrast-agents-for-coronary-optical-coherence-tomography-a-blinded-prospective-randomized-controlled-study
#25
JOURNAL ARTICLE
Spyridon Kostantinis, Olga Mastrodemos, Larissa Stanberry, Yader Sandoval, Salman S Allana, Deniz Mutlu, Bahadir Simsek, Athanasios Rempakos, Judit Karacsonyi, Michaella Alexandrou, Brynn K Okeson, M Nicholas Burke, Bavana V Rangan, Emmanouil S Brilakis
BACKGROUND: The impact of contrast type on coronary optical coherence tomography (OCT) imaging has received limited research. METHODS: We conducted a blinded, prospective, single-center, randomized, controlled crossover study comparing iso-osmolar contrast media (IOCM) with low-osmolar contrast media (LOCM) in patients undergoing clinically indicated coronary OCT imaging. Patients were randomly assigned to undergo OCT imaging with either IOCM or LOCM as the initial contrast medium...
February 29, 2024: Journal of Invasive Cardiology
https://read.qxmd.com/read/38443813/rpos-role-in-antibiotic-resistance-tolerance-and-persistence-in-e-coli-natural-isolates
#26
JOURNAL ARTICLE
Estela Ynés Valencia, Felipe de Moraes Gomes, Katia Ospino, Beny Spira
BACKGROUND: The intrinsic concentration of RpoS, the second most abundant sigma factor, varies widely across the E. coli species. Bacterial isolates that express high levels of RpoS display high resistance to environmental stresses, such as temperature, pH and osmolarity shifts, but are less nutritional competent, making them less capable of utilising alternative nutrient sources. The role of RpoS in antibiotic resistance and persistence in standard laboratory domesticated strains has been examined in several studies, most demonstrating a positive role for RpoS...
March 5, 2024: BMC Microbiology
https://read.qxmd.com/read/38438487/an-array-of-signal-specific-moypd1-isoforms-determines-full-virulence-in-the-pathogenic-fungus-magnaporthe-oryzae
#27
JOURNAL ARTICLE
Sri Bühring, Antonia Brunner, Klemens Heeb, Marius-Peter Mergard, Greta Schmauck, Stefan Jacob
Magnaporthe oryzae is placed first on a list of the world's top ten plant pathogens with the highest scientific and economic importance. The locus MGG_07173 occurs only once in the genome of M. oryzae and encodes the phosphotransfer protein MoYpd1p, which plays an important role in the high osmolarity glycerol (HOG) signaling pathway for osmoregulation. Originating from this locus, at least three MoYPD1 isoforms are produced in a signal-specific manner. The transcript levels of these MoYPD1-isoforms were individually affected by external stress...
March 4, 2024: Communications Biology
https://read.qxmd.com/read/38436552/characterization-of-c-di-amp-signaling-in-the-periodontal-pathobiont-treponema-denticola
#28
JOURNAL ARTICLE
Aidan D Moylan, Dhara T Patel, Claire O'Brien, Edward J A Schuler, Annie N Hinson, Richard T Marconi, Daniel P Miller
Pathobionts associated with periodontitis, such as Treponema denticola, must possess numerous sensory transduction systems to adapt to the highly dynamic subgingival environment. To date, the signaling pathways utilized by T. denticola to rapidly sense and respond to environmental stimuli are mainly unknown. Bis-(3'-5') cyclic diadenosine monophosphate (c-di-AMP) is a nucleotide secondary messenger that regulates osmolyte transport, central metabolism, biofilm development, and pathogenicity in many bacteria but is uncharacterized in T...
March 4, 2024: Molecular Oral Microbiology
https://read.qxmd.com/read/38435373/a-preservative-free-approach-effects-on-dry-eye-signs-and-symptoms-after-cataract-surgery
#29
JOURNAL ARTICLE
Per Jensen, Christian Nilsen, Morten Gundersen, Kjell Gunnar Gundersen, Rick Potvin, Parisa Gazerani, Xiangjun Chen, Tor P Utheim, Øygunn A Utheim
PURPOSE: To compare the effect of treatment with preservative-free dexamethasone, NSAIDs and trehalose/hyaluronic acid eye drops with the preservative benzalkonium chloride containing dexamethasone and NSAIDs after cataract surgery in dry versus non-dry eyes. PATIENTS AND METHODS: In this prospective randomized intervention study, dry eye tests were performed before and 6 weeks after cataract surgery. Patients were considered as having dry eye, SDE (sign of dry eye), if at least one of the following dry eye tests were abnormal; corneal fluorescein staining (CFS), non-invasive keratograph breakup time (NIKBUT) or tear osmolarity...
2024: Clinical Ophthalmology
https://read.qxmd.com/read/38429985/low-pulse-pressure-and-high-serum-complement-c1q-are-risk-factors-for-hemodialysis-headache-a-case-control-study
#30
JOURNAL ARTICLE
Quan Gan, Lily Zhang, Yuting Fang, Liu Yang, Ming Shi, Zheman Xiao
BACKGROUND AND OBJECTIVE: Hemodialysis headache (HDH) is a common complication of dialysis that negatively affects the patient's quality of life. The etiology and triggering factors of HDH are not fully understood. This study aims to assess the prevalence and characteristics of HDH among patients undergoing hemodialysis across multiple centers in China. Furthermore, we conducted a case-control study at one hospital to identify risk factors associated with HDH. METHODS: The study consisted of two phases including a cross-sectional observational study and a case-control study...
March 1, 2024: Headache
https://read.qxmd.com/read/38414267/secondary-polycythemia-in-acutely-ill-covid-19-patients-is-associated-with-higher-mortality-but-not-markedly-higher-thrombotic-risk
#31
JOURNAL ARTICLE
Marko Lucijanic, Ivan Krecak, Ena Soric, Anica Sabljic, Tamara Vasilj, David Cicic, Anamarija Vrkljan Vuk, Zvonimir Kremer, Ivo Dilber, Anton Glasnovic, Ozren Jaksic, Rajko Kusec
Secondary polycythemia is commonly observed among patients with chronic pulmonary diseases. However, its significance in the context of Coronavirus disease 2019 (COVID-19) is unknown. We retrospectively evaluated a total of 5872 hospitalized COVID-19 patients with mostly severe and critical symptoms, and without prior or subsequently diagnosed myeloproliferative neoplasm. Patients were stratified based on admission hemoglobin into four subgroups: anemia (hemoglobin <120 g/L for females and 130 g/L for males), normal hemoglobin, mild (hemoglobin 160-165 g/L for females and 165-185 g/L for males) and severe polycythemia (hemoglobin >165 g/L for females and >185 g/L for males)...
February 27, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
https://read.qxmd.com/read/38411885/evaluation-and-management-of-hyponatremia-in-heart-failure
#32
REVIEW
Giulio M Mondellini, Frederik H Verbrugge
PURPOSE OF REVIEW: To provide a contemporary overview of the pathophysiology, evaluation, and treatment of hyponatremia in heart failure (HF). RECENT FINDINGS: Potassium and magnesium losses due to poor nutritional intake and treatment with diuretics cause an intracellular sodium shift in HF that may contribute to hyponatremia. Impaired renal blood flow leading to a lower glomerular filtration rate and increased proximal tubular reabsorption lead to an impaired tubular flux through diluting distal segments of the nephron, compromising electrolyte-free water excretion...
February 27, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38411168/efficacy-of-nicorandil-and-ranolazine-in-prevention-of-contrast-induced-nephropathy-in-patients-with-mild-to-moderate-renal-dysfunction-a-randomized-controlled-trial
#33
JOURNAL ARTICLE
Jamal Yusuf, Gyan Prakash, Safal Safal, Vimal Mehta, Saibal Mukhopadhyay
INTRODUCTION: Contrast-induced nephropathy (CIN) is a common complication after percutaneous coronary intervention (PCI). There is conflicting evidence regarding efficacy of nicorandil in CIN prevention. With respect to ranolazine, there is physiological possibility as well as data in animal study regarding its protective effect against CIN; there is, however, no human data till date. AIM AND OBJECTIVES: To assess the efficacy of nicorandil and ranolazine in preventing CIN...
February 20, 2024: Coronary Artery Disease
https://read.qxmd.com/read/38391161/biological-characteristics-of-mechanosensitive-channels-mscs-and-mscl-in-actinobacillus-pleuropneumoniae
#34
JOURNAL ARTICLE
Jiajia Wan, Lu Dai, Huasong Xiao, Wendie Zhang, Rui Zhang, Tingting Xie, Yizhen Jia, Xuejun Gao, Jing Huang, Feng Liu
Actinobacillus pleuropneumoniae is an important respiratory pathogen that can cause porcine contagious pleuropneumonia (PCP), resulting in significant economic losses in swine industry. Microorganisms are subjected to drastic changes in environmental osmolarity. In order to alleviate the drastic rise or fall of osmolarity, cells activate mechanosensitive channels MscL and MscS through tension changes. MscL not only regulates osmotic pressure but also has been reported to secrete protein and uptake aminoglycoside antibiotic...
February 23, 2024: Journal of Bacteriology
https://read.qxmd.com/read/38387766/amino-acid-metabolism-and-map-kinase-signaling-pathway-play-opposite-roles-in-the-regulation-of-ethanol-production-during-fermentation-of-sugarcane-molasses-in-budding-yeast
#35
JOURNAL ARTICLE
Linghuo Jiang, Yuzhi Shen, Yongqiang Jiang, Weiping Mei, Liudan Wei, Jinrong Feng, Chunyu Wei, Xiufan Liao, Yiping Mo, Lingxin Pan, Min Wei, Yiying Gu, Jiashi Zheng
Sugarcane molasses is one of the main raw materials for bioethanol production, and Saccharomyces cerevisiae is the major biofuel-producing organism. In this study, a batch fermentation model has been used to examine ethanol titers of deletion mutants for all yeast nonessential genes in this yeast genome. A total of 42 genes are identified to be involved in ethanol production during fermentation of sugarcane molasses. Deletion mutants of seventeen genes show increased ethanol titers, while deletion mutants for twenty-five genes exhibit reduced ethanol titers...
February 20, 2024: Genomics
https://read.qxmd.com/read/38376892/uveitis-and-dry-eye-disease-in-children-a-cross-sectional-comparative-study
#36
JOURNAL ARTICLE
William Rojas-Carabali, Germán Mejía-Salgado, Valeria Villabona-Martínez, Doménico Barraquer-López, Carlos Cifuentes-González, Guillermo Marroquín, Pilar Del Rosario Guarnizo Zuccardi, Alejandra de-la-Torre
PURPOSE: This study aims to evaluate the ocular surface characteristics in children diagnosed with uveitis and explore the association between uveitis and dry eye disease (DED). METHODS: We included 84 children, 42 with uveitis and 42 healthy children. We performed the OSDI questionnaire and several ocular surface tests, including osmolarity, NITBUT, Schirmer test, and vital staining. We used Fisher's exact test and Mann-Whitney to compare variables and a binomial logistic regression to determine the factors associated with DED...
February 20, 2024: Ocular Immunology and Inflammation
https://read.qxmd.com/read/38374637/characterization-of-sshog1-and-shk1-using-efficient-gene-knockout-systems-through-repeated-protoplasting-and-crispr-cas9-ribonucleoprotein-approaches-in-sclerotinia-sclerotiorum
#37
JOURNAL ARTICLE
Jihyeon Ma, Sung-Won Park, Geonwoo Kim, Cheol Soo Kim, Hao-Xun Chang, Martin I Chilvers, Hyunkyu Sang
Sclerotinia sclerotiorum is the causal agent of sclerotinia stem rot in over 400 plant species. In a previous study, the group III histidine kinase gene of S. sclerotiorum ( Shk1 ) revealed its involvement in iprodione and fludioxonil sensitivity and osmotic stress. To further investigate the fungicide sensitivity associated with the high-osmolarity glycerol (HOG) pathway, we functionally characterized SsHog1 , which is the downstream kinase of Shk1 . To generate knockout mutants, split marker transformation combined with a newly developed repeated protoplasting method and CRISPR/Cas9 ribonucleoprotein (RNP) delivery approach were used...
February 19, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38372137/modulation-of-prostaglandin-transport-activity-of-slco2a1-by-annexin-a2-and-s100a10
#38
JOURNAL ARTICLE
Yoshinobu Nakamura, Masa-Aki Ito, Yukino Hoshino, Isao Matsuoka, Toshiaki Okada, Yasunobu Okada, Takeo Nakanishi
Solute carrier organic anion transporter family member 2A1 (SLCO2A1) is a prostaglandin (PG) transporter and serves as the osmosensitive ATP-permeable maxi-anion channel (Maxi-Cl). Since a heterotetrameric complex of annexin A2 (ANXA2) and S100A10 is obligatory for the channel activity; the present study aimed to determine if they regulate SLCO2A1-mediated PG transport. This study examined PGE2 uptake and ATP release in Anxa2 and/or S100a10 knockout (KO) murine breast C127 cells. Deletion of Slco2a1 decreased PGE2 -d4 uptake by wild-type (WT) cells in isotonic medium (290 mOsm/kg H2 O)...
February 19, 2024: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/38371041/isopropyl-alcohol-intoxication-treated-with-hemodialysis-a-case-report-and-short-review
#39
Sagar Kumar, Sarah Dabbas, Fnu Manisha, Huma Akta, Emad Al Jaber
Isopropyl alcohol (IPA) is a common constituent of rubbing alcohol, household cleaning agents, and antiseptic agents. Ingestion of IPA usually leads to self-resolving mild symptoms in most cases but can result in severe symptoms, including central nervous system depression or hemodynamic instability. Treatment is mainly supportive, and hemodialysis is generally reserved for severe intoxication. Limited data are available on the use of hemodialysis to treat IPA intoxication. We are presenting a case of accidental ingestion of IPA in an elderly female with dementia leading to severe intoxication requiring hemodialysis at relatively non-toxic serum levels of IPA...
January 2024: Curēus
https://read.qxmd.com/read/38370744/tmem16-and-tmem63-osca-proteins-share-a-conserved-potential-to-permeate-ions-and-phospholipids
#40
Augustus J Lowry, Pengfei Liang, Y C Serena Wan, Zhen-Ming Pei, Huanghe Yang, Yang Zhang
The calcium-activated TMEM16 proteins and the mechanosensitive/osmolarity-activated OSCA/TMEM63 proteins belong to the Transmembrane Channel/Scramblase (TCS) superfamily. Within the superfamily, OSCA/TMEM63 proteins, as well as TMEM16A and TMEM16B, likely function solely as ion channels. However, the remaining TMEM16 members, including TMEM16F, maintain an additional function as scramblases, rapidly exchanging phospholipids between leaflets of the membrane. Although recent studies have advanced our understanding of TCS structure-function relationships, the molecular determinants of TCS ion and lipid permeation remain unclear...
February 5, 2024: bioRxiv
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