keyword
https://read.qxmd.com/read/32729306/pan-p63-but-not-%C3%AE-np63-p40-expression-in-undifferentiated-carcinoma-of-the-pancreas
#1
Łukasz Liszka
Undifferentiated carcinoma of the pancreas (UC) is a carcinoma without a definitive direction of differentiation. Tumour protein p63 is a regulator of squamous phenotype, which may also be engaged in tumour development. N-terminal isoforms of p63 are TAp63 and ΔNp63. Pan-p63 antibodies are able to detect both isoforms, whereas p40 antibodies recognise the ΔNp63 isoform only. The aim of the study was to describe pan-p63/p40 immunohistochemical expression patterns in pancreatic neoplasms: UC, ductal adenocarcinomas, neuroendocrine tumours, neuroendocrine carcinomas, serous cystic neoplasms, and solid pseudopapillary neoplasms...
2020: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://read.qxmd.com/read/32727769/egfr-mutated-lung-adenocarcinoma-metastasis-to-the-pancreas-mimicking-primary-pancreatic-ductal-carcinoma
#2
Can Cao, Max X Kong, Malathy Kapali, Koorosh Moezardalan, Qiuying Shi, Ali Azarm, Jinping Lai
BACKGROUND: The occurrence of lung adenocarcinoma metastasizing to the pancreas is overall rare and can histologically imitate primary pancreatic ductal carcinoma (PDAC). CASE REPORT: This is a case report of a 70-year-old female with a history of surgically resected right lung adenocarcinoma presenting for routine follow up without symptoms. CT scans revealed a pancreatic cystic mass with ductal dilatation that was sampled via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and thought to be a primary pancreatic mucinous neoplasm with high grade dysplasia suspicious for carcinoma based on smear cytology...
August 2020: Anticancer Research
https://read.qxmd.com/read/32712551/pancreatic-acinar-cystadenoma-in-a-background-of-diffuse-multifocal-pancreatic-cystic-lesions-a-case-report
#3
Mohammed Abdulrahman Alkhateeb, Deena Boqari, Nabeel Khalid Mansi
INTRODUCTION: Acinar cell cystadenoma (ACA) is very rare and benign neoplasm of the pancreas; it arises from the normal acinar parenchyma of the pancreas and may exist as solitary or diffuse lesions. PRESENTATION OF CASE: We here present a case of thirty-seven years old gentleman who incidentally was found to have multifocal cystic lesions distributed throughout the tail, body and uncinate process of the pancreas. DISCUSSION: Pre-operative diagnosis of pancreatic ACA remains very difficult and challenging despite advances in imaging techniques...
July 15, 2020: International Journal of Surgery Case Reports
https://read.qxmd.com/read/32705313/discrimination-of-serous-cystadenoma-from-mucinous-cystic-neoplasm-and-branch-duct-intraductal-papillary-mucinous-neoplasm-in-the-pancreas-with-ct
#4
Guang-Xian Wang, Zhi-Ping Wang, Hai-Ling Chen, Dong Zhang, Li Wen
PURPOSE: The imaging features of serous cystadenomas (SCAs) overlap with those of mucinous cystic neoplasms (MCNs) and branch duct intraductal papillary mucinous neoplasms (BD-IPMNs), and an accurate preoperative diagnosis is important for clinical treatment due to their different biological behaviors. The aim of this study was to provide a computed tomographic (CT) feature for the diagnosis of SCAs and estimate whether the "circumvascular sign" can contribute to the discrimination of SCAs from MCNs and BD-IPMNs...
July 23, 2020: Abdominal Radiology
https://read.qxmd.com/read/32699579/clinical-diagnosis-and-management-of-pancreatic-mucinous-cystadenoma-and-cystadenocarcinoma-single-center-experience-with-82-patients
#5
Zhi-Ming Zhao, Nan Jiang, Yuan-Xing Gao, Zhu-Zeng Yin, Guo-Dong Zhao, Xiang-Long Tan, Yong Xu, Rong Liu
BACKGROUND: Mucinous cystic neoplasm (MCN) of the pancreas is characterized by mucin-producing columnar epithelium and dense ovarian-type stroma and at risk for malignant transformation. Early diagnosis and treatment of MCN are particularly important. AIM: To investigate the clinical characteristics of and management strategies for pancreatic mucinous cystadenoma (MCA) and mucinous cystadenocarcinoma (MCC). METHODS: The clinical and pathological data of 82 patients with pancreatic MCA and MCC who underwent surgical resection at our department between April 2015 and March 2019 were retrospectively analyzed...
June 15, 2020: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/32665837/large-mucinous-cystic-neoplasm-of-the-pancreas-during-pregnancy-a-case-report
#6
Lúcia Carvalho, Tiago Ferreira, Luísa Frutuoso, Leonor Matos, Tiago Castro, Domingos Rodrigues, Vera Oliveira, Gil Gonçalves, Mário Nora, Horácio Scigliano
Mucinous cystic neoplasms (MCNs) of the pancreas occurring during pregnancy constitute a rare condition requiring special management due to its large size, malignant potential and the risk of fetal growth restriction. The key points to manage MCNs are to perform a correct diagnosis, accurately evaluate the grade of malignant potential in order to establish the right time for pancreatic surgery and to choose the most appropriate fetal mode of delivery. We describe a case of an incidental abdominal mass detected in a third-trimester pregnant woman...
July 2020: Journal of Surgical Case Reports
https://read.qxmd.com/read/32642818/-quality-of-indications-in-cystic-lesions-of-the-pancreas
#7
REVIEW
B W Renz, M Ilmer, J G D'Haese, J Werner
Cystic tumors of the pancreas (PCN) have increasingly gained importance in the clinical routine as they are frequently diagnosed as an incidental finding due to the continuous improvement in cross-sectional imaging. A differentiation is made between non-neoplastic and neoplastic cysts, whereby the latter has a tendency to malignant transformation to a varying extent. Therefore, they can be considered as precursor lesions of pancreatic cancer (PDAC). In addition to a detailed patient history and examination, imaging modalities, such as computed tomography (CT), magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS) with fine needle aspiration (FNA) are used for the differential diagnosis...
July 8, 2020: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://read.qxmd.com/read/32610423/-clinical-diagnosis-and-treatment-characteristics-of-pancreatic-cystic-neoplasms-in-pediatric-patients-a-report-of-13-cases
#8
H F Kuang, X Q Yan, X F Duan, H Q Bian, J Yang, Z C Zhu
Objective: To investigate the clinical characteristics of pancreatic cystic neoplasms in pediatric patients. Methods: The clinical data of 13 patients with pancreatic cystic neoplasm at Wuhan Children's Hospital from July 2007 to November 2019 were collected.There were 5 males and 8 females, with a mean age of 133 months(range: 9 to 170 months). Eleven patients presented with abdominal pain, vomiting, and a palpable mass. Tumors were located in the pancreatic head( n= 7), body( n= 2) and tail( n= 4), respectively...
July 1, 2020: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://read.qxmd.com/read/32601808/nondegenerated-cystic-neuroendocrine-tumor-of-the-pancreas-a-case-report
#9
Keisuke Noda, Tamotsu Kuroki, Mampei Yamashita, Takanori Hirayama, Koji Natsuda, Shinichiro Kobayashi, Takayuki Tokunaga, Kosho Yamanouchi, Hiroaki Takeshita, Shiro Miura, Shigeto Maeda
BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are typically solid neoplasms but, in very rare cases, present as cystic lesions. We describe a case of a cystic neuroendocrine tumor that developed as a small cystic lesion. CASE PRESENTATION: In 2011, a 66-year-old Japanese woman underwent computed tomography (CT) that revealed a cystic lesion in the tail of the pancreas measuring 9 mm. She did not have any symptoms. She underwent a CT scan every year thereafter...
June 29, 2020: Surgical Case Reports
https://read.qxmd.com/read/32589187/endoscopic-ultrasound-guided-fine-needle-aspiration-cytologic-evaluation-of-intraductal-papillary-mucinous-neoplasm-and-mucinous-cystic-neoplasms-of-pancreas
#10
Syed M Gilani, Adebowale J Adeniran, Guoping Cai
OBJECTIVES: To evaluate the role of endoscopic ultrasound-guided fine needle aspiration cytology in identifying mucinous cystic lesions (MCLs) in histologically proven cases of intraductal papillary mucinous neoplasm (IPMN) or mucinous cystic neoplasm (MCN) and risk of malignancy associated with each cytologic category based on the Papanicolaou Society of Cytopathology (PSC) guidelines. METHODS: All resected cases with histologic diagnosis of IPMN or MCN at our institution from January 1, 2004, to August 31, 2019, with associated cytology were included...
June 26, 2020: American Journal of Clinical Pathology
https://read.qxmd.com/read/32565660/giant-pancreatic-mucinous-cystadenoma-masquerading-as-renal-hydatid-disease
#11
Shanmugasundaram Rajaian, Ashwin Shekar Paulraj, Lakshman Murugesan, Premanand Sengottaiyan
Mucinous cystic neoplasms of the pancreas are the most common pancreatic cystic neoplasms. A 54-year-old female presented with an abdominal mass and was diagnosed to have a multilocular hydatid cyst from the left kidney by imaging. During surgery, a large thick-walled cyst with multiple loculi was seen arising from the upper pole of the left kidney and adherent to the distal pancreas and splenic vessels. The cyst was completely excised without hilar clamping. Histopathological examination confirmed mucinous cystadenoma arising from the pancreas...
April 2020: Urology Annals
https://read.qxmd.com/read/32525623/nondiagnostic-fine-needle-aspirates-of-the-pancreas-a-root-cause-analysis
#12
Hamza N Gokozan, Claire W Michael
BACKGROUND: Fine needle aspiration (FNA) of the pancreas is considered the primary and least invasive diagnostic method in the evaluation of pancreatic lesions. A nondiagnostic sample may trigger repeat FNA or a more invasive diagnostic procedure. The goal of this study was to identify the root causes of nondiagnostic samples. METHODS: We performed a retrospective review of FNAs of the pancreas categorized as nondiagnostic at our institution between 2008 and 2019...
June 11, 2020: Cancer Cytopathology
https://read.qxmd.com/read/32494507/role-of-cross-sectional-imaging-ct-mri-in-characterization-and-distinguishing-benign-from-malignant-potentially-malignant-cystic-lesions-of-pancreas
#13
Amy Sara Abraham, Betty Simon, Anu Eapen, Kirthi Sathyakumar, Anuradha Chandramohan, Ravish Sanghi Raju, Philip Joseph, Thomas Alex Kodiatte, Mahasampath Gowri
Objectives: The aim of the study was to evaluate the accuracy of computed tomography/magnetic resonance imaging (CT/MRI) in characterizing cystic lesions of the pancreas and in differentiating between benign and malignant/potentially malignant lesions. Material and Methods: A retrospective study was performed on patients with pancreatic cystic lesions who underwent pre-operative imaging and surgery between October 2004 and April 2017 at a tertiary care teaching hospital...
2020: Journal of Clinical Imaging Science
https://read.qxmd.com/read/32431986/serous-microcystic-cystadenocarcinoma-of-the-pancreas-with-synchronous-liver-metastases-clinical-characteristics-and-management
#14
Dimitrios Massaras, Eirini V Pantiora, John Koutalas, Elias C Primetis, Georgios P Fragulidis
Serous cystadenocarcinoma of the pancreas is a rare but well-established entity. The origin and evolution of this disorder remain unclear, but even metastatic cases have an excellent prognosis. These tumors are very similar to benign serous cystic neoplasms (SCNs) of the pancreas, except that they tend to be larger, are locally invasive, and present distant metastasis. The most frequent local invasion is adjacent vessels, spleen, stomach, and duodenum. The most common site of distant metastasis is the liver...
April 17, 2020: Curēus
https://read.qxmd.com/read/32415464/branch-type-intraductal-papillary-neoplasm-of-the-bile-duct-treated-with-laparoscopic-anatomical-resection-a-case-report
#15
Rumi Matono, Mizuki Ninomiya, Kazutoyo Morita, Takahiro Tomino, Yumi Oshiro, Tomoyuki Yokota, Takashi Nishizaki
BACKGROUND: Intraductal papillary neoplasm of the bile duct (IPNB) is characterized by an intraluminal, growing papillary tumor covered by neoplastic biliary epithelial cells with a fine fibrovascular core. IPNB was introduced as a precancerous and early neoplastic lesion in the 2010 World Health Organization classification of tumors of the digestive system. IPNB eventually invades the bile duct wall and progresses to invasive cholangiocarcinoma. IPNB resembles intraductal papillary mucinous neoplasm of the pancreas (IPMN), particularly the main pancreatic duct type...
May 15, 2020: Surgical Case Reports
https://read.qxmd.com/read/32411629/clinicoradiological-features-of-resected-serous-cystic-neoplasms-according-to-morphological-subtype-and-preoperative-tentative-diagnosis-can-radiological-characteristics-distinguish-serous-cystic-neoplasms-from-other-lesions
#16
Jae Seung Kang, Hyo Jun Kim, Yoo Jin Choi, Yoonhyeong Byun, Jeong Min Lee, Youngmin Han, Hongbeom Kim, Wooil Kwon, Jin-Young Jang
Purpose: Serous cystic neoplasm (SCN) of the pancreas is considered benign in most cases. However, some SCN patients undergo surgical resection because lesions could not be differentiated preoperatively. This study evaluated causes of resection for SCN, investigated clinical and radiological features of surgically resected SCNs, and compared characteristics of SCNs diagnosed accurately and those misdiagnosed. Methods: One hundred patients, who underwent surgery for pancreatic cystic tumors with pathological confirmation of SCN between 2000 and 2014 were retrospectively analyzed...
May 2020: Annals of Surgical Treatment and Research
https://read.qxmd.com/read/32389980/-a-case-of-epithelial-cyst-occurring-in-intrapancreatic-accessory-spleen
#17
Takuya Sakamoto, Yutaka Takeda, Yoshiaki Ohmura, Yoshiteru Katsura, Ayako Imada, Koki Takase, Keisuke Toya, Yoshirou Yukawa, Kenji Kawai, Kohei Murakami, Yoshinori Kagawa, Toru Masuzawa, Atsushi Takeno, Taishi Hata, Kohei Murata
Although accessory spleens are often found in clinical practice, it is rare to identify cystic disease in an intrapancreatic accessory spleen. Here, we report a case of an epithelial cyst that occurred in the intrapancreatic accessory spleen. The patient was a 54-year-old male. Liver dysfunction was identified by the primary care doctor, and abdominal CT showed a tumorous lesion in the pancreatic tail. The patient was then referred to our hospital. Contrast-enhanced CT revealed a multilocular cystic lesion in the pancreatic tail...
April 2020: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/32389915/-spindle-cell-type-anaplastic-carcinoma-of-the-pancreas-review-of-27-japanese-case-reports
#18
Kyoko Sakaguchi, Yu Kuroda, Hiroyuki Sugo, Ikuo Watanobe, Michio Machida, Kuniaki Kojima, Shunsuke Nagase, Kanako Ogura
Spindle cell type anaplastic carcinoma of the pancreas is extremely rare and has a very poor prognosis. A previously healthy 68-year-old woman was referred to our hospital due to a large tumor in the body of the pancreas. Abdominal computed tomography revealed an irregular, well-enhanced 140-mm tumor containing a cystic component. The patient underwent distal pancreatectomy for a possible malignant tumor (e.g., mucinous cystic neoplasms). Histological examination showed that the tumor contained spindle-shaped cells and adenocarcinoma with nuclear atypia, and a definitive diagnosis of anaplastic carcinoma spindle cell type was made...
2020: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://read.qxmd.com/read/32373202/chronic-exposure-to-excess-iron-promotes-emt-and-cancer-via-p53-loss-in-pancreatic-cancer
#19
Yangzom D Bhutia, Jiro Ogura, Paul J Grippo, Carolina Torres, Toshihiro Sato, Mitchell Wachtel, Sabarish Ramachandran, Ellappan Babu, Sathish Sivaprakasam, Devaraja Rajasekaran, Bradley Schniers, Nhu On, Logan Smoot, Muthusamy Thangaraju, Jaya P Gnana-Prakasam, Vadivel Ganapathy
Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pancreatic cancer as our primary focus, we employed cell culture studies to interrogate the connection between excess iron and cancer, and combined in vitro and in vivo studies to explore the connection further. Ferric ammonium citrate was used as an exogenous iron source...
March 2020: Asian journal of pharmaceutical sciences
https://read.qxmd.com/read/32358636/how-to-divide-the-pancreatic-parenchyma-in-patients-with-a-portal-annular-pancreas-laparoscopic-spleen-preserving-distal-pancreatectomy-for-serous-cystic-neoplasms
#20
Naohisa Kuriyama, Tomohide Hatanaka, Kazuaki Gyoten, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada, Hiroyuki Sakurai, Shugo Mizuno
BACKGROUND: Portal annular pancreas (PAP) is a rare pancreatic anomaly in which the uncinate process wraps annularly around the portal vein and fuses to the body of the pancreas. PAP is highly relevant to the development of postoperative pancreatic fistula (POPF) in pancreatic surgery. Here, we describe our experience and surgical technique of laparoscopic spleen-preserving distal pancreatectomy using Warshaw's procedure for patients with the PAP. CASE PRESENTATION: A 49-year-old woman with PAP was referred to our hospital for a suspicious mucinous cystic neoplasms 1...
May 1, 2020: Surgical Case Reports
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