Shuai-Jun Chen, Fan Yu, Xiao Feng, Qian Li, Ye-Han Jiang, Li-Qin Zhao, Pei-Pei Cheng, Meng Wang, Lin-Jie Song, Li-Mei Liang, Xin-Liang He, Liang Xiong, Fei Xiang, Xiaorong Wang, Hong Ye, Wan-Li Ma
BACKGROUND: The alveolar epithelial type II cell (AT2) and its senescence play a pivotal role in alveolar damage and pulmonary fibrosis. Cell circadian rhythm is strongly associated with cell senescence. Differentiated embryonic chondrocyte expressed gene 1 (DEC1) is a very important circadian clock gene. However, the role of DEC1 in AT2 senescence and pulmonary fibrosis was still unclear. RESULTS: In this study, a circadian disruption model of light intervention was used...
April 26, 2024: Cell Communication and Signaling: CCS