Wiltine G Moerman-van den Brink, Loes van Aken, Els M L Verschuur, Serge J W Walvoort, Yvonne C M Rensen, Jos I M Egger, Roy P C Kessels
Objective : Patients with Korsakoff's syndrome (KS) show executive dysfunction and neuropsychiatric symptoms. This study investigates whether specific executive subcomponents (shifting, updating, and inhibition) predict variance in neuropsychiatric symptoms. We hypothesized that shifting deficits, in particular, are associated with neuropsychiatric symptoms. Method : Forty-seven patients participated (mean age 61.5; 11 women). Executive function (EF) was measured using six component-specific tasks. Neuropsychiatric symptoms were measured with the Neuropsychiatric Inventory - Questionnaire (NPI-Q)...
March 19, 2020: Clinical Neuropsychologist
Tony Rao, Anya Topiwala
A diagnosis of alcohol use disorder is associated with a higher risk of dementia but a dose-response relationship between alcohol intake consumption and cognitive impairment remains unclear. Alcohol is associated with a range of effects on the central nervous system at different doses and acts on a number of receptors. Acute disorders include Wernicke's Encephalopathy (WE), traumatic brain injury, blackouts, seizures, stroke and hepatic encephalopathy. The most common manifestations of chronic alcohol consumption are Korsakoff's syndrome (KS) and alcohol-related dementia (ARD)...
February 28, 2020: Addiction
Roy P C Kessels, Sjoerd Murk, Serge J W Walvoort, Benjamin M Hampstead
Alcoholic Korsakoff's syndrome is characterized by severe amnesia, also affecting spatial memory. To date, research on cognitive rehabilitation in these patients is scarce. Aim of the present study is to examine the efficacy of a mnemonic strategy training in patients with Korsakoff's syndrome. A randomized controlled exploratory study was performed. A convenience sample of 14 patients with amnesia due to alcoholic Korsakoff's syndrome was included and randomized into a mnemonic strategy training group (n = 7) and a control group (n = 7)...
February 17, 2020: Cognitive Processing
Erik Oudman, Martijn J Schut, Antonia F Ten Brink, Albert Postma, Stefan Van der Stigchel
Introduction : Despite the interest in memory functioning in Korsakoff's syndrome (KS), visual working memory capacity in KS is still poorly understood. Results from the last decades on working memory limitations in KS appear to be mixed, clearly calling for further investigations. Method : We investigated visual working memory storage capacity of patients diagnosed with KS using a change detection paradigm. Nine patients diagnosed with KS and thirty age- and education- matched healthy controls were presented twice with 2, 3, 4, or 6 bars with different orientations and had to detect whether the orientation of the target bar had changed...
February 6, 2020: Journal of Clinical and Experimental Neuropsychology
Frédérique Robin, Ahmed Moustafa, Mohamad El Haj
We evaluated the relationship between autobiographical memory and mental imagery in Korsakoff syndrome (KS). We invited patients with KS and control participants to retrieve personal events and to perform measures of visual imagery (Taller/Wilder task), and spatial imagery (Clock Angles task). On the Taller/Wilder task, participants had to generate a mental image of an object presented as a word and determine whether the object was taller than it was wide. On the Clock Angles task, participants had to imagine the angle created by the hands on a clock set to a certain time and determine whether that angle was <90°...
January 29, 2020: Applied Neuropsychology. Adult
Mohamad El Haj, Roy P C Kessels, Jean-Louis Nandrino
BACKGROUND AND OBJECTIVES: While sex differences in cognitive abilities have been extensively studied in healthy populations, little is known about these differences in patients with Korsakoff syndrome (KS). METHODS: We investigated sex differences in verbal episodic memory, inhibition, and flexibility in 25 patients with KS and 25 control participants. RESULTS: The analysis demonstrated no significant differences between women with KS and men with KS on episodic memory and flexibility, but higher inhibition was observed in women with KS compared with men with KS...
January 15, 2020: American Journal on Addictions
Yvonne C M Rensen, Erik Oudman, Joukje M Oosterman, Roy P C Kessels
Confabulations generally refer to the emergence of memories of experiences and events that, in reality, never took place, and which are unintentionally produced. They are frequently observed in alcoholic Korsakoff's syndrome. The aim of the current study was to validate the Nijmegen-Venray Confabulation List (NVCL), an observation scale for quantifying both spontaneous and provoked confabulations. The NVCL was completed for 252 patients with alcoholic Korsakoff's syndrome. Exploratory and confirmatory factor analyses were conducted to test three- and four-factor models of the NVCL structure...
January 12, 2020: Assessment
G Chen, L M Chen, X M Li
A 43-year-old male presented with elevated serum creatinine for 4 years and developed abdominal pain for 3 days. He started peritoneal dialysis 2 months ago. Dialysis-related peritonitis was ruled out and acute gastroenteritis was diagnosed. The patient was administrated with ertapenem 500 mg/d. An acute mental abnormality developed 3 days later. After excluded organic encephalopathy, ertapenem was discontinued for the suspicion of antibiotic-related encephalopathy. The frequency of peritoneal dialysis was increased to accelerate the clearance of antibiotics...
January 1, 2020: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Mirjam Johanna van Dam, Berno van Meijel, Albert Postma, Erik Oudman
WHAT IS KNOWN ON THE SUBJECT?: Patients with Korsakoff's syndrome suffer from a broad range of comorbid somatic and/or psychiatric conditions. The various health problems in patients with Korsakoff's syndrome limit their ability to perform daily activities and also negatively affect their social functioning. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE?: Patients with Korsakoff's syndrome have complex somatic and psychiatric comorbid conditions co-occurring with behavioural and functional problems. They are compounded by patients' poor self-awareness regarding their health status and functioning...
December 26, 2019: Journal of Psychiatric and Mental Health Nursing
Pamela Brown, Robert M Heirene, Gareth-Roderique-Davies, Bev John, Jonathan J Evans
Background and Aims: Recent investigations have highlighted the value of neuropsychological testing for the assessment and screening of Alcohol-Related Brain Damage (ARBD). The aim of the present study was to evaluate the suitability of the Addenbrooke's Cognitive Examination (ACE-III) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for this purpose. Methods: Comparing 28 participants with ARBD (11 with Korsakoff's Syndrome and 17 with the umbrella "ARBD" diagnosis) and 30 alcohol-dependent participants without ARBD (ALs) we calculated Area Under the Curve (AUC) statistics, sensitivity and specificity values, base-rate adjusted predictive values, and likelihood ratios for both tests...
2019: Frontiers in Psychology
Malya Sahu, Marissa Beal, Keira Chism, Madeleine A Becker
No abstract text is available yet for this article.
October 10, 2019: Psychosomatics
Shihong Lin, Idris E Leppla, Haijuan Yan, Julia M Probert, Privia A Randhawa, Jeannie-Marie S Leoutsakos, John C Probasco, Karin J Neufeld
BACKGROUND: Wernicke-Korsakoff Syndrome (WKS) resulting from thiamine deficiency is classically defined as including encephalopathy, ataxia, and ophthalmoplegia. Only 16% of autopsy-confirmed patients with WKS exhibit all three signs. Caine-positive WKS criteria include two or more of the following: nutritional deficiency, delirium or mild memory impairment, cerebellar dysfunction/ataxia, and oculomotor abnormalities. OBJECTIVE: We describe Caine-positive WKS prevalence among psychiatric inpatients and compare pretreatment-versus-posttreatment neurocognitive improvement to an unaffected group...
August 14, 2019: Psychosomatics
Allan Thomson, Irene Guerrini, Elizabeth Jane Marshall
AIM: To offer an estimate of the incidence of anaphylactic reactions to parenteral products containing thiamine used in the treatment of Wernicke's encephalopathy (WE) and make recommendations. METHOD: Review of previously released data on some older products and parenteral thiamine use in some other countries; analysis of sales and adverse incident data on anaphylaxis for a contemporary parenteral product used in the UK, Pabrinex. RESULTS: It was difficult to estimate the incidence of related anaphylactic reactions to Pabrinex in the UK because the number of doses given is unknown...
September 30, 2019: Alcohol and Alcoholism
Samir Kashyap, Bhagat Cheema, Vaninder Chhabra
Background: Epidermoid cysts are benign, congenital lesions that originate from ectodermal cells, they are most commonly found in the cerebellopontine angle, but rarely in the ventricular system. There is limited literature regarding the different microsurgical techniques utilized to approach these lesions. Methods: A 63-year-old female with a recurrent third ventricular epidermoid cyst underwent gross total resection utilizing an endoscopic technique. We also reviewed the various endoscopic/microsurgical approaches and outcomes reported in literature...
2019: Surgical Neurology International
David Pang, Pete Duffield, Ed Day
Regular heavy consumption of alcohol is associated with a wide range of physical, psychological and social problems. All health-care clinicians should be able to screen for and detect problematic levels of alcohol consumption in their patients, and deliver an effective brief intervention. When patients with alcohol dependence are admitted to hospital there must be an assessment of whether medication is required to prevent withdrawal symptoms and potential delirium tremens and withdrawal seizures. Medically assisted alcohol withdrawal using a long-acting benzodiazepine such as chlordiazepoxide should be carefully monitored and titrated to effect, and the clinician should be aware of the risk of Wernicke-Korsakoff syndrome and other complications...
September 2, 2019: British Journal of Hospital Medicine
(no author information available yet)
No abstract text is available yet for this article.
2019: Neuropsychiatric Disease and Treatment
Jan W Wijnia, Erik Oudman, André I Wierdsma, Misha J Oey, Jeroen Bongers, Albert Postma
OBJECTIVES: Vitamin deficiencies may reflect less-than-optimal health in select populations. The aim of this study was to determine whether vitamin D supplementation (VDs) after malnutrition may be adversely related to cancer diagnoses in a selected group of patients with alcoholic Wernicke-Korsakoff syndrome (WKS). METHOD: This was a retrospective cohort study of all patients admitted to Slingedael Korsakoff Center, from 1996 to 2018. The patients were subdivided into three predefined groups depending on differences in VDs: "early" supplementation, which started during or before the previous hospital admission, before the transfer to our center; "late" supplementation, which started later in our center; and "no" VDs received...
May 29, 2019: Nutrition
Eunice Kasse, Erik Oudman, Marloes Olivier, Jan W Wijnia, Albert Postma
(Wernicke-)Korsakoff's syndrome (KS) is a neuropsychiatric syndrome, caused by vitamin B1 (thiamine) deficiency often resulting from chronic alcohol consumption. KS is characterized by severe cognitive problems, such as impaired explicit memory and executive functions. Visuospatial perception (VSP) refers to the identification of objects (object perception), and the localization of objects (space perception). Object perception can be described as the cooperation between visual representation and semantic information on the objects' functional properties...
July 14, 2019: Journal of Clinical and Experimental Neuropsychology
Antonio Carota, Julien Bogousslavsky
Hallucinations, delusions, and confabulations are common symptoms between neurology and psychiatry. The neurological diseases manifesting with such symptoms (dementia, epilepsy, Korsakoff's disease, brain tumors, Parkinson's disease, migraine, right hemisphere stroke and others) would be the key to understand their biological mechanisms, while the cognitive sciences, neuropharmacology and functional neuroimaging would be the tools of such researches. It is possible to understand the perceptive rules of the mind and the mechanisms of the human consciousness based on these symptoms...
2019: Frontiers of Neurology and Neuroscience
Karen G Langer
Memory and forgetfulness have been viewed since antiquity from perspectives of physical, emotional, and spiritual states of well-being, and conceptualized philosophically. Numerous discussions of memory loss, or case reports, existed, but a fundamental advance in conceptualization of memory loss as a pathological clinical phenomenon originated when Sauvages classified "amnesia" as a medical disorder, in 1763. Originally, amnesia was recognized as a weakening or dissolution of memory, according to a taxonomy that ascribed known causes to the disorder...
2019: Frontiers of Neurology and Neuroscience
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