Ineke J Gerridzen, Cees Mpm Hertogh, Karlijn J Joling, Ruth B Veenhuizen, Els Ml Verschuur, Tjeu Janssen, Marja F Depla
BACKGROUND: In the Netherlands, people with severe cognitive deficits due to Korsakoff syndrome are generally admitted to a specialized nursing home. Professional caregivers experience that these residents are often not aware of their deficits, and consequently, their willingness to accept care is relatively low. However, these residents need permanent support when performing daily tasks due to severe cognitive deficits. The combination of objective care needs and low subjective responsiveness makes caring for people with Korsakoff syndrome a complex undertaking...
May 21, 2020: Nursing Ethics
Beth Lloyd, Erik Oudman, Mareike Altgassen, Serge J W Walvoort, Roy P C Kessels, Albert Postma
OBJECTIVE: Patients with Korsakoff's syndrome (KS) have difficulty carrying out tasks which rely on prospective memory (PM). Since remembering to carry out an action in the future is crucial for living independently, it is of primary interest to develop strategies that improve PM performance in KS patients. DESIGN: The study employed a computer categorization task as an ongoing activity into which a PM task was embedded. We included episodic future thinking (EFT) and observational learning (Experiment 2) to boost PM...
May 18, 2020: British Journal of Clinical Psychology
Pedro C Barata, Raquel Serrano, Hugo Afonso, Alice Luís, Teresa Maia
Wernicke-Korsakoff syndrome (WKS) is a life-threatening and underdiagnosed neuropsychiatric condition caused by thiamine deficiency that comprises Wernicke encephalopathy and Korsakoff syndrome. Although mainly associated with chronic alcoholism, WKS can arise from other circumstances. This report describes a series of cases of WKS that were clinically evaluated by liaison psychiatrists on a nonpsychiatric inpatient unit. The cases illustrate a deficit in the recognition and adequate treatment of WKS, demonstrating its clinical complexity and the need to improve physicians' knowledge...
May 7, 2020: Primary Care Companion to CNS Disorders
Yoshiaki Ota, Aristides A Capizzano, Toshio Moritani, Shotaro Naganawa, Ryo Kurokawa, Ashok Srinivasan
Wernicke's encephalopathy (WE) is a severe and life-threatening illness resulting from vitamin B1 (thiamine) deficiency. The prevalence of WE has been estimated from 0.4 to 2.8%. If not treated properly, severe neurologic disorders such as Korsakoff psychosis and even death may occur. The classical triad of clinical symptoms (abnormal mental state, ataxia, and ophthalmoplegia) is found in only 16-33% of patients on initial examination. The originally described underlying condition of WE is alcoholism, but it accounts for about 50% of causes of WE...
May 10, 2020: Japanese Journal of Radiology
Maria Della Volpe Waizel, Zisis Gatzioufas, Stella Veliki, Despoina Sagri, Konstantin Gugleta, Hendrik P N Scholl, Nikolaos Kozeis
No abstract text is available yet for this article.
April 2020: Klinische Monatsblätter Für Augenheilkunde
Gabriele Janzen, Claudette J M van Roij, Joukje M Oosterman, Roy P C Kessels
The goal of the present study was to investigate spatial memory in a group of patients with amnesia due to Korsakoff's syndrome (KS). We used a virtual spatial memory task that allowed us to separate the use of egocentric and allocentric spatial reference frames to determine object locations. Research investigating the ability of patients with Korsakoff's amnesia to use different reference frames is scarce and it remains unclear whether these patients are impaired in using ego- and allocentric reference frames to the same extent...
2020: Frontiers in Human Neuroscience
Mohamad El Haj, Frédérique Robin
OBJECTIVE: The imagination inflation effect, which is a form of memory distortion, occurs when imagining an event that never happened may increase the tendency to falsely remember that it really occurred. We investigated this effect in Korsakoff's syndrome. METHOD: Our procedures consisted of 2 sessions and a recognition test. In Session 1, patients with Korsakoff's syndrome and controls listened to statements of actions (e.g., "hold the pen"), enacted the actions, or imagined performing the actions...
April 13, 2020: Neuropsychology
Wiltine G Moerman-van den Brink, Loes van Aken, Els M L Verschuur, Serge J W Walvoort, Yvonne C M Rensen, Jos I M Egger, Roy P C Kessels
Objective : Patients with Korsakoff's syndrome (KS) show executive dysfunction and neuropsychiatric symptoms. This study investigates whether specific executive subcomponents (shifting, updating, and inhibition) predict variance in neuropsychiatric symptoms. We hypothesized that shifting deficits, in particular, are associated with neuropsychiatric symptoms. Method : Forty-seven patients participated (mean age 61.5; 11 women). Executive function (EF) was measured using six component-specific tasks. Neuropsychiatric symptoms were measured with the Neuropsychiatric Inventory - Questionnaire (NPI-Q)...
March 19, 2020: Clinical Neuropsychologist
Rahul Rao, Anya Topiwala
A diagnosis of alcohol use disorder is associated with a higher risk of dementia, but a dose-response relationship between alcohol intake consumption and cognitive impairment remains unclear. Alcohol is associated with a range of effects on the central nervous system at different doses and acts on a number of receptors. Acute disorders include Wernicke's encephalopathy (WE), traumatic brain injury, blackouts, seizures, stroke and hepatic encephalopathy. The most common manifestations of chronic alcohol consumption are Korsakoff's syndrome (KS) and alcohol-related dementia (ARD)...
February 28, 2020: Addiction
Roy P C Kessels, Sjoerd Murk, Serge J W Walvoort, Benjamin M Hampstead
Alcoholic Korsakoff's syndrome is characterized by severe amnesia, also affecting spatial memory. To date, research on cognitive rehabilitation in these patients is scarce. Aim of the present study is to examine the efficacy of a mnemonic strategy training in patients with Korsakoff's syndrome. A randomized controlled exploratory study was performed. A convenience sample of 14 patients with amnesia due to alcoholic Korsakoff's syndrome was included and randomized into a mnemonic strategy training group (n = 7) and a control group (n = 7)...
February 17, 2020: Cognitive Processing
Erik Oudman, Martijn J Schut, Antonia F Ten Brink, Albert Postma, Stefan Van der Stigchel
Introduction : Despite the interest in memory functioning in Korsakoff's syndrome (KS), visual working memory capacity in KS is still poorly understood. Results from the last decades on working memory limitations in KS appear to be mixed, clearly calling for further investigations. Method : We investigated visual working memory storage capacity of patients diagnosed with KS using a change detection paradigm. Nine patients diagnosed with KS and thirty age- and education- matched healthy controls were presented twice with 2, 3, 4, or 6 bars with different orientations and had to detect whether the orientation of the target bar had changed...
February 6, 2020: Journal of Clinical and Experimental Neuropsychology
Frédérique Robin, Ahmed Moustafa, Mohamad El Haj
We evaluated the relationship between autobiographical memory and mental imagery in Korsakoff syndrome (KS). We invited patients with KS and control participants to retrieve personal events and to perform measures of visual imagery (Taller/Wilder task), and spatial imagery (Clock Angles task). On the Taller/Wilder task, participants had to generate a mental image of an object presented as a word and determine whether the object was taller than it was wide. On the Clock Angles task, participants had to imagine the angle created by the hands on a clock set to a certain time and determine whether that angle was <90°...
January 29, 2020: Applied Neuropsychology. Adult
Mohamad El Haj, Roy P C Kessels, Jean-Louis Nandrino
BACKGROUND AND OBJECTIVES: While sex differences in cognitive abilities have been extensively studied in healthy populations, little is known about these differences in patients with Korsakoff syndrome (KS). METHODS: We investigated sex differences in verbal episodic memory, inhibition, and flexibility in 25 patients with KS and 25 control participants. RESULTS: The analysis demonstrated no significant differences between women with KS and men with KS on episodic memory and flexibility, but higher inhibition was observed in women with KS compared with men with KS...
January 15, 2020: American Journal on Addictions
Yvonne C M Rensen, Erik Oudman, Joukje M Oosterman, Roy P C Kessels
Confabulations generally refer to the emergence of memories of experiences and events that, in reality, never took place, and which are unintentionally produced. They are frequently observed in alcoholic Korsakoff's syndrome. The aim of the current study was to validate the Nijmegen-Venray Confabulation List (NVCL), an observation scale for quantifying both spontaneous and provoked confabulations. The NVCL was completed for 252 patients with alcoholic Korsakoff's syndrome. Exploratory and confirmatory factor analyses were conducted to test three- and four-factor models of the NVCL structure...
January 12, 2020: Assessment
G Chen, L M Chen, X M Li
A 43-year-old male presented with elevated serum creatinine for 4 years and developed abdominal pain for 3 days. He started peritoneal dialysis 2 months ago. Dialysis-related peritonitis was ruled out and acute gastroenteritis was diagnosed. The patient was administrated with ertapenem 500 mg/d. An acute mental abnormality developed 3 days later. After excluded organic encephalopathy, ertapenem was discontinued for the suspicion of antibiotic-related encephalopathy. The frequency of peritoneal dialysis was increased to accelerate the clearance of antibiotics...
January 1, 2020: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Mirjam Johanna van Dam, Berno van Meijel, Albert Postma, Erik Oudman
WHAT IS KNOWN ON THE SUBJECT?: Patients with Korsakoff's syndrome suffer from a broad range of comorbid somatic and/or psychiatric conditions. The various health problems in patients with Korsakoff's syndrome limit their ability to perform daily activities and also negatively affect their social functioning. WHAT THE PAPER ADDS TO EXISTING KNOWLEDGE?: Patients with Korsakoff's syndrome have complex somatic and psychiatric comorbid conditions co-occurring with behavioural and functional problems. They are compounded by patients' poor self-awareness regarding their health status and functioning...
December 26, 2019: Journal of Psychiatric and Mental Health Nursing
Pamela Brown, Robert M Heirene, Gareth-Roderique-Davies, Bev John, Jonathan J Evans
Background and Aims: Recent investigations have highlighted the value of neuropsychological testing for the assessment and screening of Alcohol-Related Brain Damage (ARBD). The aim of the present study was to evaluate the suitability of the Addenbrooke's Cognitive Examination (ACE-III) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) for this purpose. Methods: Comparing 28 participants with ARBD (11 with Korsakoff's Syndrome and 17 with the umbrella "ARBD" diagnosis) and 30 alcohol-dependent participants without ARBD (ALs) we calculated Area Under the Curve (AUC) statistics, sensitivity and specificity values, base-rate adjusted predictive values, and likelihood ratios for both tests...
2019: Frontiers in Psychology
Malya Sahu, Marissa Beal, Keira Chism, Madeleine A Becker
No abstract text is available yet for this article.
October 10, 2019: Psychosomatics
Shihong Lin, Idris E Leppla, Haijuan Yan, Julia M Probert, Privia A Randhawa, Jeannie-Marie S Leoutsakos, John C Probasco, Karin J Neufeld
BACKGROUND: Wernicke-Korsakoff Syndrome (WKS) resulting from thiamine deficiency is classically defined as including encephalopathy, ataxia, and ophthalmoplegia. Only 16% of autopsy-confirmed patients with WKS exhibit all three signs. Caine-positive WKS criteria include two or more of the following: nutritional deficiency, delirium or mild memory impairment, cerebellar dysfunction/ataxia, and oculomotor abnormalities. OBJECTIVE: We describe Caine-positive WKS prevalence among psychiatric inpatients and compare pretreatment-versus-posttreatment neurocognitive improvement to an unaffected group...
August 14, 2019: Psychosomatics
Allan Thomson, Irene Guerrini, Elizabeth Jane Marshall
AIM: To offer an estimate of the incidence of anaphylactic reactions to parenteral products containing thiamine used in the treatment of Wernicke's encephalopathy (WE) and make recommendations. METHOD: Review of previously released data on some older products and parenteral thiamine use in some other countries; analysis of sales and adverse incident data on anaphylaxis for a contemporary parenteral product used in the UK, Pabrinex. RESULTS: It was difficult to estimate the incidence of related anaphylactic reactions to Pabrinex in the UK because the number of doses given is unknown...
December 1, 2019: Alcohol and Alcoholism
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