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JOURNAL ARTICLE
Teresa T Nguyen, Dong Ho Shin, Sagar Sohoni, Sanjay K Singh, Yisel Rivera-Molina, Hong Jiang, Xuejun Fan, Joy Gumin, Frederick F Lang, Christopher Alvarez-Breckenridge, Filipa Godoy-Vitorino, Lisha Zhu, W Jim Zheng, Lijie Zhai, Erik Ladomersky, Kristen L Lauing, Marta M Alonso, Derek A Wainwright, Candelaria Gomez-Manzano, Juan Fueyo
BACKGROUND: Oncolytic viruses are considered part of immunotherapy and have shown promise in preclinical experiments and clinical trials. Results from these studies have suggested that tumor microenvironment remodeling is required to achieve an effective response in solid tumors. Here, we assess the extent to which targeting specific mechanisms underlying the immunosuppressive tumor microenvironment optimizes viroimmunotherapy. METHODS: We used RNA-seq analyses to analyze the transcriptome, and validated the results using Q-PCR, flow cytometry, and immunofluorescence...
July 2022: Journal for Immunotherapy of Cancer
#42
JOURNAL ARTICLE
L Claverias, X Daniel, I Martín-Loeches, P Vidal-Cortez, F Gómez-Bertomeu, S Trefler, R Zaragoza, M Borges-Sa, L F Reyes, G Quindós, J Peman, M Bodí, E Díaz, C Sarvisé, E Pico, E Papiol, J Solé-Violan, J Marín-Corral, J J Guardiola, A Rodríguez
OBJECTIVE: To determine the incidence and impact of Aspergillus spp. isolation (AI) on ICU mortality in critically ill patients with severe influenza pneumonia during the first 24h of admission. DESIGN: Secondary analysis of an observational and prospective cohort study. SETTING: ICUs voluntary participating in the Spanish severe Influenza pneumonia registry, between June 2009 and June 2019. PATIENTS: Consecutive patients admitted to the ICU with diagnosis of severe influenza pneumonia, confirmed by real-time polymerase chain reaction...
August 2022: Medicina intensiva
#43
REVIEW
Bojana Popovic, Aleksandra Radovanovic Spurnic, Jelena Velickovic, Aleksandra Plavsic, Milica Jecmenica-Lukic, Tijana Glisic, Dusan Ilic, Danka Jeremic, Jelena Vratonjic, Vladimir Samardzic, Zoran Gluvic, Tatjana Adzic-Vukicevic
Introduction: Patients with Cushing's syndrome (CS) represent a highly sensitive group during corona virus disease 2019 (COVID-19) pandemic. The effect of multiple comorbidities and immune system supression make the clinical picture complicated and treatment challenging. Case report: A 70-year-old female was admitted to a covid hospital with a severe form of COVID-19 pneumonia that required oxygen supplementation. Prior to her admission to the hospital she was diagnosed with adrenocorticotropic hormone (ACTH)-dependent CS, and the treatment of hypercortisolism had not been started yet...
2022: Frontiers in Endocrinology
#44
JOURNAL ARTICLE
Tevhide Sahin, Cem Simsek, Hatice Yasemin Balaban
Pandemics obligate providers to transform their clinical practice. An extensive effort has been put to find out feasible approaches for gastrointestinal diseases and also to manage coronavirus disease 2019 (COVID-19) related gastrointestinal conditions. Diarrhea, hepatitis, and pancreatitis can be seen in the COVID-19 course. Endoscopic procedures increase the risk of contamination for medical staff and patients despite precautions, therefore indications should be tailored to balance risks vs benefits. Furthermore, whether the immunosupression in inflammatory bowel diseases, liver transplantation, and autoimmune liver diseases increases COVID-19 related risks and how to modify immunosupression are topics of ongoing debate...
June 6, 2022: World Journal of Clinical Cases
#45
JOURNAL ARTICLE
Danna L Arellano, Patricia Juárez, Andrea Verdugo-Meza, Paloma S Almeida-Luna, Juan A Corral-Avila, Florian Drescher, Felipe Olvera, Samanta Jiménez, Bennett D Elzey, Theresa A Guise, Pierrick G J Fournier
Immunotherapies use components of the immune system, such as T cells, to fight cancer cells, and are changing cancer treatment, causing durable responses in some patients. Bone metastases are a debilitating complication in advanced breast and prostate cancer patients. Approved treatments fail to cure bone metastases or increase patient survival and it remains unclear whether immunotherapy could benefit patients. The bone microenvironment combines various immunosuppressive factors, and combined with T cell products could increase bone resorption fueling the vicious cycle of bone metastases...
August 2022: Journal of Bone and Mineral Research
#46
JOURNAL ARTICLE
Ibrahima Dokal Diallo, Najlae Lrhorfi, Wend-Yam Mohamed Traoré, Behyamet Onka, Latifa Chat, Nazik Allali
Cerebral aspergillosis is a fungal infection with a bad prognosis. It usually occurs in immunocompromised patients and manifests itself .Cross-sectional imaging reveals suggestive lesions.
2022: Global Pediatric Health
#47
Clara Silva, Mariana Pacheco, João E Silva, Edite Pereira, Jorge S Almeida
Acquired haemophilia is a rare haemorrhagic dyscrasia caused by autoantibodies against coagulation factors, most commonly factor VIII (FVIII). Even though about half of the cases are classified as idiopathic, acquired haemophilia is more common in the elderly and/or in individuals diagnosed with other immunogenic conditions such as malignancies, autoimmune diseases, or during puerperium. It can be life-threatening, presenting more frequently with major bleeding. We report two cases of acquired haemophilia classified as idiopathic in middle-aged patients with no predisposing factors identified during the diagnostic approach: their disease's progression and complications, choice of treatment, and why and when to change it...
December 2021: Curēus
#48
REVIEW
Seval Akpinar, Omur Kayikci, Emre Tekgunduz
Endothelial dysfunction and damage play important roles in the pathophysiology of graft versus host disease (GvHD) and hepatic venoocclusive disease/sinusoidal obstruction syndrome (VOD/SOS). Preliminary evidence suggests that defibrotide (DF) may decrease the risk of GvHD. We speculated that DF prophylaxis may have a synergistic effect with other immunosupressive agents by decreasing the incidence of GvHD and retrospectively evaluated the impact of a DF prophylaxis on the development of GvHD. Thirty-eight adult patients with various hematological neoplasms who underwent peripheral blood allogeneic hematopoietic stem cell transplantation from all donor types were included...
February 2022: Transfusion and Apheresis Science
#49
JOURNAL ARTICLE
Servin-Garrido Roberto Raúl, Ilhuicatzi-Alvarado Damaris, Jiménez-Chávez Ángel de Jesús, Moreno-Fierros Leticia
The Cry1Ac protoxin from Bacillus thuringiensis is a systemic and mucosal adjuvant, able to confer protective immunity in different infection murine models and induce both Th1 and TCD8+ cytotoxic lymphocyte responses, which are required to induce antitumor immunity. The Cry1Ac toxin, despite having not being characterized as an adjuvant, has also proved to be immunogenic and able to activate macrophages. Here, we investigated the potential antitumor adjuvant effect conferred by the Cry1Ac protoxin and Cry1Ac toxin in a triple negative breast cancer (TNBC) murine model...
2022: Breast Cancer: Basic and Clinical Research
#50
REVIEW
Nina Barišić, Daniel Turudić, Lorna Stemberger Marić, Goran Tešović
AIM: To analyse literature data on vaccine related induction, worsening of the disease and disease reccurrences as well as vaccine safety and efficacy among pediatric patients with acquired inflammatory immune-mediated neuromuscular disorders (NMD). METHODS: Medline, Pub Med and Scopus database search from 1975 to 2020 focused on pediatric age was conducted including peer reviews, meta analyses and epidemiological studies on vaccination and Guillain-Barré syndrome (GBS), Bell's palsy, optic neuritis (ON), myasthenia gravis (MG), chronic inflammatory demyelinating polyneuropathy (CIDP) and immune-mediated inflammatory myopathy (IM)...
January 2022: European Journal of Paediatric Neurology: EJPN
#51
JOURNAL ARTICLE
Abdul Raouf Wani, Lokender Kumar, Ritu Singhal, Amartya Chakraborti, Sagar Mohanrao Khot
Tuberculosis is a state of immunosupression which exposes the patients to further opportunistic pathogens like fungus. Methods: 102 newly diagnosed sputum positive pulmonary tuberculosis cases were enrolled. Significant fungal isolates were seen in 31/102 (30.4%) patients. Aspergillus spp. were isolated in 13/31(41.9%) of the positive fungal cultures while Candida spp. were isolated in 15/31 (48.4%). Low body mass index, duration of symptoms, haemoptysis, severity of radiological features and IgG Aspergillus antibodies were independent risk factors for positive fungal culture...
January 2022: Tropical Doctor
#52
JOURNAL ARTICLE
Jamael Hoosain, Eman Hamad
The use of Immunosuppression has led to the tremendous improvement in graft survival. However, immunosuppressants have been found to cause a variety of metabolic derangements including but not limited to: insulin resistance and diabetes, hyperlipidemia, hypertension, and weight gain after transplantation. This combination of metabolic risk factors may be associated with increased cardiovascular disease (Grundy et al., Circulation 112(17):2735, 2005). In addition many transplant recipients may have many of these risk factors pre-transplant that are exacerbated by immunosuppression...
2022: Handbook of Experimental Pharmacology
#53
REVIEW
Carmen de la Horra, Vicente Friaza, Rubén Morilla, Juan Delgado, Francisco J Medrano, Robert F Miller, Yaxsier de Armas, Enrique J Calderón
A Pneumocystis jirovecii is one of the most important microorganisms that cause pneumonia in immunosupressed individuals. The guideline for treatment and prophylaxis of Pneumocystis pneumonia (PcP) is the use of a combination of sulfa drug-containing trimethroprim and sulfamethoxazole. In the absence of a reliable method to culture Pneumocystis, molecular techniques have been developed to detect mutations in the dihydropteroate synthase gene, the target of sulfa drugs, where mutations are related to sulfa resistance in other microorganisms...
October 13, 2021: Journal of Fungi (Basel, Switzerland)
#54
JOURNAL ARTICLE
Satriyo Dwi Suryantoro, Mochammad Thaha, Pranawa, Djoko Santoso, Nunuk Mardiana, Widodo, Aditiawardana, Artaria Tjempakasari, Ardityo Rahmat Ardhany, Dana Pramudya, Decsa Medika Hertanto, Evy Febriane, Meryana, Maria Angela, Ari Christy Muliono, Handoko Tanuwidjaja, Philia Setiawan, David Sugiarto
Severe COVID-19 infection management for a recipient of kidney transplant has debatable prognosis and treatment. We described the case of a COVID-19 infected 70 year old female, previously had renal transplantation in 2017. The patient took immunosuppressive agents as routine drugs for transplant recipient status and received lopinavir/ritonavir, hydroxychloroquine, and dexamethasone daily at the hospitalization. Specific question arises about renal transplant recipients being infected by COVID-19 - whether the infection will get worse compared to those without immunosuppresive agent...
September 30, 2021: Journal of Infection in Developing Countries
#55
JOURNAL ARTICLE
Y Ren, Y Li, C Y Liu, D Lu, R Fu
Objective: To investigate the immunomodulatory effect of tacrolimus in severe aplastic anemia (SAA). Methods: Patients diagnosed with SAA at the Department of Hematology, General Hospital of Tianjin Medical University from June 2015 to January 2018 were enrolled. CD8+ T cells were sorted by immunomagnetic separation from peripheral blood of SAA patients. MTT method was used to detect the proliferation of CD8+ T cells. The SAA mouse model was established by total body irradiation (TBI) and donor lymphocyte infusion (DLI)...
June 29, 2021: Zhonghua Yi Xue za Zhi [Chinese medical journal]
#56
REVIEW
Olga V Morozova
Nanosilver with sizes 1-100 nm at least in one dimension is widely used due to physicochemical, anti-inflammatory, anti-angiogenesis, antiplatelet, antifungal, anticancer, antibacterial, and antiviral properties. Three modes of the nanosilver action were suggested: "Trojan horse", inductive, and quantum mechanical. The Ag+ cations have an affinity to thiol, amino, phosphate, and carboxyl groups. Multiple mechanisms of action towards proteins, DNA, and membranes reduce a risk of pathogen resistance but inevitably cause toxicity for cells and organisms...
September 14, 2021: International Journal of Molecular Sciences
#57
JOURNAL ARTICLE
Emir Cerme, Mert Oztas, Ilker Inanc Balkan, Esin Aktas Cetin, Serdal Ugurlu
Haemophagocytic lymphohistiocytosis (HLH) is a lethal complication of several infections, especially viral origin. Mycobacterium tuberculosis infection can also lead to HLH, yet it is an uncommon trigger. Considering the role of increased cytokines in HLH, autoinflammatory conditions, such as familial Mediterranean fever (FMF), might contribute to its development. Nevertheless, the possible relationship between FMF and HLH has been suggested only in some case reports. We present a case of FMF who admitted to the hospital with consitutional symptoms and chest pain regarding to recurrent pericarditis...
January 7, 2022: Modern rheumatology case reports
#58
MULTICENTER STUDY
Sinem Civriz Bozdağ, Güldane Cengiz Seval, İpek Yönal Hindilerden, Fehmi Hindilerden, Neslihan Andıç, Mustafa Baydar, Lale Aydın Kaynar, Selami Koçak Toprak, Hasan Sami Göksoy, Berrin Balık Aydın, Ufuk Demirci, Ferda Can, Vildan Özkocaman, Eren Gündüz, Zeynep Tuğba Güven, Zübeyde Nur Özkurt, Sinan Demircioğlu, Meral Beksaç, İdris İnce, Umut Yılmaz, Hilal Eroğlu Küçükdiler, Elgün Abishov, Boran Yavuz, Ünal Ataş, Yaşa Gül Mutlu, Volkan Baş, Fahir Özkalemkaş, Hava Üsküdar Teke, Vildan Gürsoy, Serhat Çelik, Rafiye Çiftçiler, Münci Yağcı, Pervin Topçuoğlu, Özcan Çeneli, Hamza Abbasov, Cem Selim, Muhlis Cem Ar, Orhan Kemal Yücel, Sevil Sadri, Canan Albayrak, Ahmet Muzaffer Demir, Nil Güler, Muzaffer Keklik, Hatice Terzi, Ali Doğan, Zeynep Arzu Yegin, Meltem Kurt Yüksel, Soğol Sadri, İrfan Yavaşoğlu, Hüseyin Saffet Beköz, Tekin Aksu, Senem Maral, Veysel Erol, Leylagül Kaynar, Osman İlhan, Ali Zahit Bolaman, Ömür Gökmen Sevindik, Arzu Akyay, Muhit Özcan, Günhan Gürman, Şule Ünal, Yasemin Yavuz, Reyhan Diz Küçükkaya, Güner Hayri Özsan
OBJECTIVE: Patients with solid malignancies are more vulnerable to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection than the healthy population. The outcome of SARS-CoV-2 infection in highly immunosuppressed populations, such as in patients with hematological malignancies, is a point of interest. We aimed to analyze the symptoms, complications, intensive care unit admissions, and mortality rates of patients with hematological malignancies infected with SARS-CoV-2 in Turkey...
February 23, 2022: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
#59
JOURNAL ARTICLE
Ming Yao, Anna Domogatskaya, Nils Ågren, Masaaki Watanabe, Kazuaki Tokodai, Michael Brines, Anthony Cerami, Bo-Göran Ericzon, Makiko Kumagai-Braesch, Torbjörn Lundgren
During intra-portal pancreatic islet transplantation (PITx), innate immune reactions such as the instant blood mediated inflammatory reaction (IBMIR) cause an immediate loss of islets. The non-hematopoietic erythropoietin analogue cibinetide has previously shown islet-protective effects in mouse PITx. Herein, we aimed to confirm cibinetide's efficacy on human islets, and to characterize its effect on IBMIR. We cultured human islets with pro-inflammatory cytokines for 18 hours with or without cibinetide. ATP content and caspase 3/7 activity were measured...
January 2021: Cell Transplantation
#60
Kaouther Maatallah, Hiba Boussaa, Hanene Lassoued Ferjani, Dhia Kaffel, Wafa Hamdi
Progressive pseudorheumatoid dysplasia can be confused with juvenile idiopathic arthritis. Treatment is mainly symptomatic and the prescription of immunosupressive agents is unnecessary. Surgery may be indicated at advanced stages of the disease.
August 2021: Clinical Case Reports
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