Christophe Jayle, Frederic Favreau, Kequiang Zhang, Carole Doucet, Jean Michel Goujon, William Hebrard, Michel Carretier, Michel Eugene, Gerard Mauco, Jean Paul Tillement, Thierry Hauet
Acute renal failure (ARF) is often the consequence of an ischemia-reperfusion injury (IRI) and associated with high mortality. Warm ischemia (WI) is a crucial factor of tissue damage, and tissue destruction led by ischemia-reperfusion (I/R) can impact the early and long-term functional outcome. Trimetazidine (TMZ) is an anti-ischemic drug. Previously, we already verified its protective effect on a cold-ischemic pig kidney model by directly adding TMZ into the preservation solution (Faure JP, Baumert H, Han Z, Goujon JM, Favreau F, Dutheil D, Petit I, Barriere M, Tallineau C, Tillement JP, Carretier M, Mauco G, Papadopoulos V, Hauet T...
March 2007: American Journal of Physiology. Renal Physiology