Junzhi Yi, Hui Zhang, Fangyuan Bao, Zhichu Chen, Yuliang Zhong, Tianning Ye, Xuri Chen, Jingyi Qian, Mengya Tian, Min Zhu, Zhi Peng, Zongyou Pan, Jianyou Li, Zihao Hu, Weiliang Shen, Jiaqi Xu, Xianzhu Zhang, Youzhi Cai, Mengjie Wu, Hua Liu, Jing Zhou, Hongwei Ouyang
The knee joint has long been considered a closed system. The pathological effects of joint diseases on distant organs have not been investigated. Herein, our clinical data showed that post-traumatic joint damage, combined with joint bleeding (hemarthrosis), exhibits a worse liver function compared with healthy control. With mouse model, hemarthrosis induces both cartilage degeneration and remote liver damage. Next, we found that hemarthrosis induces the upregulation in ratio and differentiation towards Th17 cells of CD4+ T cells in peripheral blood and spleen...
May 8, 2024: Signal Transduction and Targeted Therapy