Yifan Zhang, Zixin Li, Houzuo Guo, Qibo Wang, Bowen Guo, Xi Jiang, Yishu Liu, Shengjie Cui, Zhengda Wu, Min Yu, Lisha Zhu, Liyuan Chen, Ning Du, Dan Luo, Ye Lin, Ping Di, Yan Liu
The regenerative treatment of infectious vertical bone defects remains difficult and challenging today. Current clinical treatments are limited in their ability to control bacteria and infection, which is unfavorable for new bone formation and calls for a new type of material with excellent osteogenic and antibacterial properties. Here a multifunctional scaffold is synthesized that mimics natural bone nanostructures by incorporating silver nanowires into a hierarchical, intrafibrillar mineralized collagen matrix (IMC/AgNWs), to achieve the therapeutic goals of inhibiting bacterial activity and promoting infectious alveolar bone augmentation in rats and beagle dogs...
May 5, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)