Paul-Henry Koop, Constanze Schwenzer, Jan Clusmann, Mara S Vell, Julius Jaeger, Wenfang Gui, Christian Trautwein, Alexander Koch, Tony Bruns, Carolin V Schneider, Kai Markus Schneider
BACKGROUND AND AIMS: Primary biliary cholangitis (PBC) is a chronic, immune-mediated liver disease that can lead to fibrosis and cirrhosis. In this cohort study, we aimed to investigate morbidity and mortality in conjunction with metabolomic changes of PBC in a UK population-based cohort. METHODS: 454 participants with PBC and 908 propensity score (age, sex, BMI, ethnicity) matched controls without liver disease were included in the study. A subset of participants with PBC and controls were analysed for their metabolomic profile...
April 25, 2024: Liver International: Official Journal of the International Association for the Study of the Liver