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https://read.qxmd.com/read/31619547/treatment-of-pediatric-glioblastoma-with-combination-olaparib-and-temozolomide-demonstrates-2-year-durable-response
#1
REVIEW
Andge Valiakhmetova, Sergey Gorelyshev, Alexander Konovalov, Yuri Trunin, Alexander Savateev, David E Kram, Eric Severson, Amanda Hemmerich, Claire Edgerly, Daniel Duncan, Nicholas Britt, Richard S P Huang, Julia Elvin, Vincent Miller, Jeffrey S Ross, Laurie Gay, Joshua McCorkle, Andrew Rankin, Rachel L Erlich, Yakov Chudnovsky, Shakti H Ramkissoon
For pediatric patients with high-grade gliomas, standard-of-care treatment includes surgery, chemotherapy, and radiation therapy; however, most patients ultimately succumb to their disease. With advances in genomic characterization of pediatric high-grade gliomas, the use of targeted therapies in combination with current treatment modalities offer the potential to improve survival in this patient population. In this report, we present the case of a 3-year-old girl with glioblastoma who continues to experience an exceptional and durable response (>2 years) to the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib...
October 16, 2019: Oncologist
https://read.qxmd.com/read/31422571/chordoid-glioma-an-entity-occurring-not-exclusively-in-the-third-ventricle
#2
Bao Yang, Chenlong Yang, Jiang Du, Jingyi Fang, Guang Li, Shuo Wang, Yulun Xu
Chordoid gliomas are extremely rare entities, which are generally considered occurring exclusively in the third ventricle. Despite the low-grade histological grade, aggressive behaviors have been reported in literatures. Due to the low morbidity, the origins, clinical, and radiological features, management and prognosis are still yet to be well elucidated. We retrospectively reviewed the clinical profiles from a series of 6 patients with chordoid gliomas. All patients underwent surgical treatment, and the diagnoses were based on histopathological examinations...
August 17, 2019: Neurosurgical Review
https://read.qxmd.com/read/31347764/bevacizumab-in-treating-the-cystic-components-of-pediatric-low-grade-gliomas-a-report-of-four-patients
#3
Erica Levenbaum, Shehanaz Ellika, David N Korones
Low-grade gliomas (LGG) are among the most common types of brain tumors in children and young adults. These tumors often consist of solid and cystic components. Bevacizumab is a documented treatment for progressive LGG, yet the impact of therapy on the cystic component of these tumors is unknown. We present four patients with prominently cystic LGG treated with bevacizumab at the time of progression. In each case, the cystic component responded to treatment. This is the first known study to investigate bevacizumab's impact on the cystic component of low-grade gliomas...
July 26, 2019: Pediatric Blood & Cancer
https://read.qxmd.com/read/31303610/-magnetic-resonance-imaging-features-of-glioma-with-brg-brm-associated-factor-53a-expression
#4
Li Meng, Xiaoyi Wang, Qiongqiong He, Tingting Guan, Zaide Han, Wu Xing
To explore the magnetic resonance imaging (MRI) characteristics of glioma with Brg/Brm-associated factor 53a (BAF53a) expression.
 Methods: A total of 121 patients with glioma was divided into a BAF53a high expression group (n=79) and a low expression group (n=42) according to the results of immunohistochemistry. Then the MRI characteristics, including lesion location, number, boundary, maximum diameter, peripheral edema, midline structure shift, homogeneity, cystic necrosis, hemorrhage, strengthening degree, ependymal strengthening, pia mater enhancement, deep white matter invasion and lesion across the midline (total 14 items), were analyzed...
May 28, 2019: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/31289531/clinical-value-of-magnetic-resonance-imaging-in-identifying-multiple-cerebral-gliomas-from-primary-central-nervous-system-lymphoma
#5
Yushan Chen, Alai Zhan
Clinical value of magnetic resonance imaging (MRI) in identifying and diagnosing multiple cerebral glioma (MCG) from primary central nervous system lymphoma (PCNSL) was evaluated. A total of 21 patients with MCG diagnosed clinically and pathologically in Zhangzhou Municipal Hospital from March 2016 to April 2017 were selected as group A, and 30 patients with PCNSL diagnosed in Zhangzhou Affiliated Hospital of Fujian Medical University during the same period as group B. Plain MRI, enhanced MRI and diffusion weighted imaging (DWI) were performed in all patients, the apparent diffusion coefficient (ADC) value of lesions was measured, and the diagnostic efficacy of ADC for MCG and PCNSL was evaluated by receiver operating characteristic (ROC) curve...
July 2019: Oncology Letters
https://read.qxmd.com/read/31266714/diffuse-midline-glioma-metastasis-to-the-peritoneal-cavity-via-ventriculo-peritoneal-shunt-case-report-and-review-of-literature
#6
REVIEW
Sean Stephens, Gert Tollesson, Thomas Robertson, Robert Campbell
Extraneural dissemination of primary intracranial tumours to the peritoneal cavity via ventriculoperitoneal shunts is rare, with medulloblastoma and germ-cell tumours most common and gliomas seldom implicated. This report is the first described case of a diffuse midline glioma H3 K27M-mutant disseminating to the peritoneal cavity via a shunt. A four-year-old female presented with a large solid-cystic lesion centred on the suprasellar cistern, histologically revealed to be diffuse midline glioma H3 K27M-mutant...
June 29, 2019: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/31254282/intraclass-correlations-of-measured-magnetic-resonance-imaging-volumes-of-laser-interstitial-thermal-therapy-treated-high-grade-gliomas
#7
Thomas Noh, Brent Griffith, James Snyder, Yuren Zhou, Laila Poisson, Ian Lee
BACKGROUND AND OBJECTIVES: Laser interstitial thermal therapy (LITT) is a minimally invasive therapeutic option for the treatment of brain tumors. Previous studies have quantitatively followed the ablated volumes of high-grade gliomas. Reported treatment volumes range from 28% to 100%, with no reported interobserver analysis. Because these volumes are subjectively measured, it is necessary to establish concordance between clinicians. STUDY DESIGN/MATERIALS AND METHODS: Utilizing Brainlab tumor analysis software (Brainlab, Munich, Germany), five physician users traced out tumor volumes slice-by-slice on 10 treated tumors in eight patients...
June 28, 2019: Lasers in Surgery and Medicine
https://read.qxmd.com/read/31100526/successful-surgery-of-an-exophytic-brainstem-glioma-mimicking-a-cerebellar-pontine-angle-tumor
#8
K Roessler, E Heynold, R Coras, Lücking, M Buchfelder
BACKGROUND: Non tectal plate exophytic brainstem gliomas with pilocytic histology are very rare and occur mainly in children. Because of their eloquent location, therapy consists in most cases of bioptic histological verification and radiotherapy in case of progression. CASE DESCRIPTION: We report on a 43- year's old adult patient who presented with intermittent tinnitus and reduced hearing on his left ear as well as a slight left sided ataxia. MR imaging revealed a left sided solid cystic cerebellar- pontine angle (CPA) tumor completely obliterating the CPA...
May 14, 2019: World Neurosurgery
https://read.qxmd.com/read/31092699/prognostic-value-of-magnetic-resonance-imaging-features-in-low-grade-gliomas
#9
Liang Deng, Liangfang Shen, Lin Shen, Zhao Zhao, Yingpeng Peng, Hongjiao Liu, Haipeng Liu, Guangying Zhang, Zhanzhan Li, Kai Li, Erdong Shen, Yuanyuan Liu, Chao Liu, Xinqiong Huang
INTRODUCTION: The treatment strategy for low-grade gliomas (LGGs) is still controversial, and there are no standardized criteria to predict the prognosis of patients with LGGs. Magnetic resonance imaging(MRI) is a routine test for pre-operative diagnosis for LGG and can reflects the destructive features for the tumor. In this study, we aimed to explore the relationship between the MRI features and prognosis in patients with LGG. METHODS: Clinical data of 80 patients with pathologically proved LGGs from January 2010 and December 2016 were analyzed retrospectively...
May 15, 2019: Bioscience Reports
https://read.qxmd.com/read/31048046/a-rare-high-grade-glioma-with-a-histone-h3-k27m-mutation-in-the-hypothalamus-of-an-adult-patient-a-case-report
#10
Pin He, Wei Chen, Xi Xiong Qiu, Yi Bin Xi, Hong Guan, Jun Xia
BACKGROUND: "Diffuse midline glioma, H3 K27M-mutant" is a new tumor entity described in the revised 2016 World Health Organization classification. It is most frequently observed in children, and develops in midline structures including the brainstem, thalamus, and spine. We describe a rare diffuse midline glioma with an H3 K27M mutation arising in the hypothalamus of an adult. CASE DESCRIPTION: A 27-year-old woman was admitted to our department complaining of amenorrhea, polydipsia, and diuresis for the previous 3 months, as well as headache and lethargy for approximately 10 days...
April 29, 2019: World Neurosurgery
https://read.qxmd.com/read/30976372/angiocentric-glioma-mimicking-encephalomalacia
#11
Hannah Harmsen, Bret C Mobley, Larry T Davis
Angiocentric glioma is a rare low-grade neoplasm of the central nervous system which typically presents with medication-refractory seizures in children and young adults. On magnetic resonance imaging, angiocentric glioma is classically T1 hypointense and T2/FLAIR hyperintense. We present the case of a 40-year-old male who had been followed by our institution for 17 years for management of epilepsy. Initial and repeat brain imaging showed an apparent region of cystic encephalomalacia in the right frontal lobe...
June 2019: Radiology case reports
https://read.qxmd.com/read/30956201/hemorrhagic-brain-metastasis-as-the-initial-manifestation-of-esophageal-adenocarcinoma
#12
Hussein Algahtani, Bader Shirah, Yehya Seddeq, Hatim Al-Maghraby
Esophageal carcinoma metastasis to the brain is very rare with less than 300 cases published worldwide. The reported incidence rates of esophageal carcinoma metastases to the brain range from 0.3% to 13%. It is associated with a worse prognosis than brain metastases from other solid tumors. The most common form of metastasis is cystic lesions while hemorrhagic metastasis represents a rare subset of an infrequent entity. It is extremely rare for esophageal carcinoma to present as an isolated brain metastasis with only three cases reported worldwide...
January 2019: Gulf Journal of Oncology
https://read.qxmd.com/read/30774368/lncrna-small-nucleolar-rna-host-gene-20-predicts-poor-prognosis-in-glioma-and-promotes-cell-proliferation-by-silencing-p21
#13
Xiang-Sheng Li, Fa-Zheng Shen, Li-Yong Huang, Lei Hui, Rui-Hua Liu, Yan-Juan Ma, Bao-Zhe Jin
Background: In multiple cancers, long non-coding RNA small nucleolar RNA host gene 20 ( lncRNA SNHG20 ) is generally dysregulated. In the present study, both the biological role and clinicopathological value of lncRNA SNHG20 in glioma are explored. Methods: Real-time PCR was employed to determine lncRNA SNHG20 expression in glioma patients. The prognostic role of expression of lncRNA SNHG20 was evaluated in a retrospective cohort study. In addition, the association between lncRNA SNHG20 expression and the clinicopathological features of glioma patients, such as tumor recurrence, survival status, follow-up time, WHO grade, resection extent, tumor location, Karnofsky performance scale score, cystic change, tumor size, gender and age, was discussed...
2019: OncoTargets and Therapy
https://read.qxmd.com/read/30701155/a-case-of-pleomorphic-xanthoastrocytoma-with-intracranial-hemorrhage-in-a-child
#14
Yusuke Takamine, Shun Yamamuro, Koichiro Sumi, Takashi Ohta, Katsunori Shijo, Yoko Nakanishi, Taku Homma, Atsuo Yoshino
Intracranial hemorrhage associated with lower grade glioma is unusual. Furthermore, pleomorphic xanthoastrocytoma (PXA) with intracranial hemorrhage, especially in a children, is extremely rare. We report here a rare case of child PXA with intracranial hemorrhage. An 11-year-old girl was admitted with headache and convulsions. A computed tomography scan demonstrated intracranial hemorrhage in the right temporal lobe. An angiogram revealed no vascular disease including arteriovenous malformation, angioma or aneurysm...
January 2019: NMC Case Report Journal
https://read.qxmd.com/read/30633222/papillary-glioblastoma-exhibiting-a-neuroradiological-cyst-with-a-mural-nodule-a-case-report
#15
Taku Homma, Yuya Hanashima, Toshiya Maebayashi, Yoko Nakanishi, Toshiyuki Ishige, Takashi Ohta, Atsuo Yoshino, Hiroyuki Hao
RATIONALE: Glioblastomas are malignant, infiltrating gliomas classified as grade IV by the World Health Organization. Genetically, most glioblastomas do not exhibit the isocitrate dehydrogenase (IDH) 1/2 gene mutation and rarely harbor the 1p/19q co-deletion. Neuroradiologically, glioblastomas rarely form a cyst with a mural nodule lesion. PATIENT CONCERNS: In this study, a 78-year-old woman, with speech difficulty and forgetfulness, had a cystic tumor with a mural nodule in the right frontoparietal lobe...
January 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30569607/use-of-bevacizumab-as-a-single-agent-or-in-adjunct-with-traditional-chemotherapy-regimens-in-children-with-unresectable-or-progressive-low-grade-glioma
#16
Nataliya Zhukova, Revathi Rajagopal, Adrienne Lam, Lee Coleman, Peter Shipman, Thomas Walwyn, Molly Williams, Michael Sullivan, Martin Campbell, Kanika Bhatia, Nicholas G Gottardo, Jordan R Hansford
In pediatric low-grade gliomas not amenable to complete resection, various chemotherapy regimens are the mainstream of treatment. An excellent overall survival of these patients makes justification of the intensification of chemotherapy difficult and calls for the development of new strategies. Bevacizumab, a humanized monoclonal antibody directed against Vascular endothelial growth factor (VEGF), has been successfully used in combination with irinotecan in a number of adult and pediatric studies and reports...
December 19, 2018: Cancer Medicine
https://read.qxmd.com/read/30497142/chordoma-of-the-corpus-callosum-case-report
#17
Lorenzo Rinaldo, David S Priemer, Alexander O Vortmeyer, Aaron A Cohen-Gadol, Daniel J Brat, Anita Mahajan, Caterina Giannini, Terry C Burns
Chordomas are neoplasms that typically arise from midline skeletal structures and rarely originate within the intradural compartment of the CNS. A chordoma arising from the corpus callosum has not been previously described. The authors report the surgical management of a chordoma originating within the splenium of the corpus callosum. To determine the incidence and distribution of intracranial intradural chordoma, a literature search for additional cases was performed. MEDLINE was searched using the MeSH keyword "chordoma," yielding 2010 articles...
November 1, 2018: Journal of Neurosurgery
https://read.qxmd.com/read/30459887/adverse-event-with-the-use-of-carmustine-wafers-and-postoperative-radiochemotherapy-for-the-treatment-of-high-grade-glioma
#18
Federico Salle, Wissem Lahiani, Edgardo Spagnuolo, Stéphane Palfi
Randomized, controlled trials have shown significant improvement of survival after implantation of 1,3-bis(2-Chloroethyl)-1-nitrosourea (BCNU) wafers for patients suffering from high-grade glioma. A combination of local chemotherapy with BCNU and concomitant radiochemotherapy with temozolomide (TMZ) appears to be attractive to enhance the overall survival, even though these treatments may potentially cumulate their toxicity. We report a clinical case of a patient submitted to this combined treatment protocol...
October 2018: Asian Journal of Neurosurgery
https://read.qxmd.com/read/30450984/unusual-presentation-of-epilepsy-of-germinoma-located-in-the-frontal-lobe-case-report-and-literature-review
#19
Fang Wang, Guoqing Wang, Mengzhao Feng, Dingkang Xu, Fuyou Guo
Germinoma is rare in peripheral lobar locations in the brain, with only 10 cases of primary frontal lobe germinoma having been reported in the previous literature. Epilepsy is a rare manifestation of germinomas. We describe an unusual case of a primary frontal germinoma in a 21-year-old man who presented with epilepsy. A presumptive diagnosis of abscess or cystic glioma was made, and then, we performed microsurgery under magnetic resonance imaging (MRI) neuronavigation guidance. Postoperative histopathologic examination identified the tumour as a rare germinoma...
November 19, 2018: British Journal of Neurosurgery
https://read.qxmd.com/read/30389317/cell-division-cycle-associated-7-like-predicts-unfavorable-prognosis-and-promotes-invasion-in-glioma
#20
Fa-Zheng Shen, Xiang-Sheng Li, Ji-Wei Ma, Xiang-Yang Wang, Shu-Peng Zhao, Lei Meng, Shu-Feng Liang, Xin-Li Zhao
BACKGROUND: Cell division cycle associated 7 like (CDCA7L) belongs to the JPO protein family, which is recently identified as a target gene of c-Myc and is frequently dysregulated in multiple cancers. This study aimed to explore the clinicpathological value and biological role of CDCA7L in glioma. METHODS: CDCA7L expression in glioma patients was determined using the Oncomine database, and the prognostic role of CDCA7L expression was assessed in a retrospective cohort study...
October 24, 2018: Pathology, Research and Practice
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