Nicha Tokavanich, Aditi Gupta, Mizuki Nagata, Akira Takahashi, Yuki Matsushita, Marilia Yatabe, Antonio Ruellas, Lucia Cevidanes, Koutaro Maki, Tetsutaro Yamaguchi, Noriaki Ono, Wanida Ono
OBJECTIVES: Primary failure of eruption (PFE) is a genetic disorder exhibiting the cessation of tooth eruption. Loss-of-function mutations in parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH/PTHrP receptor, PPR) were reported as the underlying cause of this disorder in humans. We showed in a PFE mouse model that PTHrP-PPR signaling is responsible for normal dental follicle cell differentiation and tooth eruption. However, the mechanism underlying the eruption defect in PFE remains undefined...
December 4, 2019: Oral Diseases