Lana Luiza da Cruz Silva, Walmar Roncalli Pereira de Oliveira, Naiura Vieira Pereira, Ilana Halpern, Claudia Kwei-Fong Dai Tanabe, Mayra Servilha Grion Mattos, Mirian N Sotto
Epidermodysplasia verruciformis (EV) is a genodermatosis related to human beta-papillomavirus (beta-HPV), with a high risk of cutaneous squamous cell carcinoma (cSCC). Claudins are transmembrane proteins expressed in epithelia and may be altered during carcinogenesis. For a better understanding of the role of beta-HPV in cutaneous carcinogenesis, this claudin expression study was conducted on lesions of patients with and without EV. In this study, claudins-1, -2, -3, -4, -5, -7 and -11 expressions were analyzed by applying the immunohistochemistry technique, in samples of 108 normal skin, 39 flat warts and 174 cSCC...
June 9, 2020: Scientific Reports