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JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
#22
JOURNAL ARTICLE
Justin E Campbell, O Kennedy Rhoades, Calvin J Munson, Andrew H Altieri, James G Douglass, Kenneth L Heck, Valerie J Paul, Anna R Armitage, Savanna C Barry, Enrique Bethel, Lindsey Christ, Marjolijn J A Christianen, Grace Dodillet, Katrina Dutton, James W Fourqurean, Thomas K Frazer, Bethany M Gaffey, Rachael Glazner, Janelle A Goeke, Rancel Grana-Valdes, Victoria J Jenkins, Olivier A A Kramer, Samantha T Linhardt, Charles W Martin, Isis G Martinez Lopez, Ashley M McDonald, Vivienne A Main, Sarah A Manuel, Candela Marco-Méndez, Duncan A O'Brien, Owen R O'Shea, Christopher J Patrick, Clare Peabody, Laura K Reynolds, Alex Rodriguez, Lucia M Rodriguez Bravo, Amanda Sang, Yvonne Sawall, Khalil Smith, Fee O H Smulders, Uriah Sun, Jamie E Thompson, Brigitta van Tussenbroek, William L Wied
Climate change is altering the functioning of foundational ecosystems. While the direct effects of warming are expected to influence individual species, the indirect effects of warming on species interactions remain poorly understood. In marine systems, as tropical herbivores undergo poleward range expansion, they may change food web structure and alter the functioning of key habitats. While this process ('tropicalization') has been documented within declining kelp forests, we have a limited understanding of how this process might unfold across other systems...
February 16, 2024: Nature Ecology & Evolution
#23
JOURNAL ARTICLE
Calum Fraser, Christopher Sg Thompson, Justin C L Yeo
An elderly gentleman self-presented to A+E with a 7-day history of significant and progressive left-sided neck pain, swelling and fevers, despite oral antibiotics from his general practitioner. Examination revealed a large left-sided neck mass involving levels 2-5 of the neck that was firm to palpate, with erythematous overlying skin.An urgent CT scan demonstrated a large collection throughout the length of the left sternocleidomastoid muscle (SCM), measuring 13×5.5×4 cm, with extensive adjacent inflammatory change...
February 14, 2024: BMJ Case Reports
#24
JOURNAL ARTICLE
Megan C Graham, Katherine L Thompson, Gregory S Hawk, Christopher S Fry, Brian Noehren
Graham, MC, Thompson, KL, Hawk, GS, Fry, CS, and Noehren, B. Muscle fiber cross-sectional area is associated with quadriceps strength and rate of torque development after ACL injury. J Strength Cond Res XX(X): 000-000, 2023-The purpose of this study was to investigate the relationship between muscle fiber type-specific properties of the vastus lateralis and quadriceps muscle performance in individuals after an anterior cruciate ligament (ACL) tear. 26 subjects (22.0 ± 5.4 years) were included in this cross-sectional study, and all data were collected before ACL reconstruction...
February 13, 2024: Journal of Strength and Conditioning Research
#25
JOURNAL ARTICLE
Émilie Degagné, Paul D Donohoue, Suparna Roy, Jessica Scherer, Tristan W Fowler, Ryan T Davis, Gustavo A Reyes, George Kwong, Morena Stanaway, Vanina Larroca Vicena, Devin Mutha, Raymond Guo, Leslie Edwards, Benjamin Schilling, McKay Shaw, Stephen C Smith, Bryan Kohrs, Heinrich J Kufeldt, Glen Churchward, Finey Ruan, David B Nyer, Kyle McSweeney, Matthew J Irby, Christopher K Fuller, Lynda Banh, Mckenzi S Toh, Matthew Thompson, Arthur L G Owen, Zili An, Scott Gradia, Justin Skoble, Mara Bryan, Elizabeth Garner, Steven B Kanner
Allogeneic chimeric antigen receptor (CAR) T-cell therapies hold the potential to overcome many of the challenges associated with patient-derived (autologous) CAR T cells. Key considerations in the development of allogeneic CAR T-cell therapies include prevention of GvHD and suppression of allograft rejection. Here we describe preclinical data supporting the ongoing first-in-human clinical study, the CaMMouflage trial (NCT05722418), evaluating CB-011 in patients with relapsed/refractory multiple myeloma. CB-011 is a hypoimmunogenic, allogeneic anti-B cell maturation antigen (BCMA) CAR T-cell therapy candidate...
February 9, 2024: Cancer Immunology Research
#26
JOURNAL ARTICLE
Bo-Gyeom Kim, Gakyung Kim, Yoshinari Abe, Pino Alonso, Stephanie Ameis, Alan Anticevic, Paul D Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargalló, Marcelo C Batistuzzo, Francesco Benedetti, Sara Bertolín, Jan Carl Beucke, Irene Bollettini, Silvia Brem, Brian P Brennan, Jan K Buitelaar, Rosa Calvo, Miguel Castelo-Branco, Yuqi Cheng, Ritu Bhusal Chhatkuli, Valentina Ciullo, Ana Coelho, Beatriz Couto, Sara Dallaspezia, Benjamin A Ely, Sónia Ferreira, Martine Fontaine, Jean-Paul Fouche, Rachael Grazioplene, Patricia Gruner, Kristen Hagen, Bjarne Hansen, Gregory L Hanna, Yoshiyuki Hirano, Marcelo Q Höxter, Morgan Hough, Hao Hu, Chaim Huyser, Toshikazu Ikuta, Neda Jahanshad, Anthony James, Fern Jaspers-Fayer, Selina Kasprzak, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Gerd Kvale, Jun Soo Kwon, Luisa Lazaro, Junhee Lee, Christine Lochner, Jin Lu, Daniela Rodriguez Manrique, Ignacio Martínez-Zalacaín, Yoshitada Masuda, Koji Matsumoto, Maria Paula Maziero, Jose M Menchón, Luciano Minuzzi, Pedro Silva Moreira, Pedro Morgado, Janardhanan C Narayanaswamy, Jin Narumoto, Ana E Ortiz, Junko Ota, Jose C Pariente, Chris Perriello, Maria Picó-Pérez, Christopher Pittenger, Sara Poletti, Eva Real, Y C Janardhan Reddy, Daan van Rooij, Yuki Sakai, João Ricardo Sato, Cinto Segalas, Roseli G Shavitt, Zonglin Shen, Eiji Shimizu, Venkataram Shivakumar, Carles Soriano-Mas, Nuno Sousa, Mafalda Machado Sousa, Gianfranco Spalletta, Emily R Stern, S Evelyn Stewart, Philip R Szeszko, Rajat Thomas, Sophia I Thomopoulos, Daniela Vecchio, Ganesan Venkatasubramanian, Chris Vriend, Susanne Walitza, Zhen Wang, Anri Watanabe, Lidewij Wolters, Jian Xu, Kei Yamada, Je-Yeon Yun, Mojtaba Zarei, Qing Zhao, Xi Zhu, Paul M Thompson, Willem B Bruin, Guido A van Wingen, Federica Piras, Fabrizio Piras, Dan J Stein, Odile A van den Heuvel, Helen Blair Simpson, Rachel Marsh, Jiook Cha
White matter pathways, typically studied with diffusion tensor imaging (DTI), have been implicated in the neurobiology of obsessive-compulsive disorder (OCD). However, due to limited sample sizes and the predominance of single-site studies, the generalizability of OCD classification based on diffusion white matter estimates remains unclear. Here, we tested classification accuracy using the largest OCD DTI dataset to date, involving 1336 adult participants (690 OCD patients and 646 healthy controls) and 317 pediatric participants (175 OCD patients and 142 healthy controls) from 18 international sites within the ENIGMA OCD Working Group...
February 7, 2024: Molecular Psychiatry
#27
MULTICENTER STUDY
Krit Dwivedi, Michael Sharkey, Liam Delaney, Samer Alabed, Smitha Rajaram, Catherine Hill, Christopher Johns, Alexander Rothman, Michail Mamalakis, A A Roger Thompson, Jim Wild, Robin Condliffe, David G Kiely, Andrew J Swift
Background There is clinical need to better quantify lung disease severity in pulmonary hypertension (PH), particularly in idiopathic pulmonary arterial hypertension (IPAH) and PH associated with lung disease (PH-LD). Purpose To quantify fibrosis on CT pulmonary angiograms using an artificial intelligence (AI) model and to assess whether this approach can be used in combination with radiologic scoring to predict survival. Materials and Methods This retrospective multicenter study included adult patients with IPAH or PH-LD who underwent incidental CT imaging between February 2007 and January 2019...
February 2024: Radiology
#28
JOURNAL ARTICLE
Benjamin C Trumble, Matthew Schwartz, Andrew T Ozga, Gary T Schwartz, Christopher M Stojanowski, Carrie L Jenkins, Thomas S Kraft, Angela R Garcia, Daniel K Cummings, Paul L Hooper, Daniel Eid Rodriguez, Kenneth Buetow, Bret Beheim, Andrei Irimia, Gregory S Thomas, Randall C Thompson, Margaret Gatz, Jonathan Stieglitz, Caleb E Finch, Michael Gurven, Hillard Kaplan
Poor oral health is associated with cardiovascular disease and dementia. Potential pathways include sepsis from oral bacteria, systemic inflammation, and nutritional deficiencies. However, in post-industrialized populations, links between oral health and chronic disease may be confounded because the lower socioeconomic exposome (poor diet, pollution, low physical activity) often entails insufficient dental care. We assessed tooth loss, caries, and damaged teeth, in relation to cardiovascular and brain aging among the Tsimane, a subsistence population living a relatively traditional forager-horticulturalist lifestyle with poor dental health, but minimal cardiovascular disease and dementia...
January 31, 2024: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
#29
JOURNAL ARTICLE
Lynn C Sadler, John M D Thompson, Jane M Alsweiler, Christopher J D McKinlay, Robin Cronin, Erena Browne, Thea Baillie-Bellew, Amanda D Harvey, Meghan G Hill
OBJECTIVE: To investigate associations of the Fetal Pillow® with maternal and neonatal morbidity. DESIGN: Retrospective cohort. SETTING: Two tertiary maternity units, New Zealand. POPULATION OR SAMPLE: Full dilatation singleton, term, cephalic caesarean section, with three comparisons: at Unit A (1) before versus after introduction of the Fetal Pillow® (1 Jaunary 2016-31 October 2021); (2) with versus without the Fetal Pillow® after introduction (27 July 2017-31 October 2021); and (3) between Unit A and Unit B during the same time period (1 January 2019-31 October 2021)...
January 29, 2024: BJOG: An International Journal of Obstetrics and Gynaecology
#30
JOURNAL ARTICLE
Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C Macbeth, Elyza A Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M Chiu, Jeffrey R Moffitt, Ansel Hsiao, John J Mekalanos, Christophe Benoist, Dennis L Kasper
Canonically, the complement system is known for its rapid response to remove microbes in the bloodstream. However, relatively little is known about a functioning complement system on intestinal mucosal surfaces. Herein, we report the local synthesis of complement component 3 (C3) in the gut, primarily by stromal cells. C3 is expressed upon commensal colonization and is regulated by the composition of the microbiota in healthy humans and mice, leading to an individual host's specific luminal C3 levels. The absence of membrane attack complex (MAC) components in the gut ensures that C3 deposition does not result in the lysis of commensals...
February 15, 2024: Cell
#31
JOURNAL ARTICLE
Ahmed S Negm, Jeremy D Collins, Emily C Bendel, Edwin Takahashi, Erica M Knavel Koepsel, Kathleen J Gehling, Courtney E Burke, Devin R Barker, Wayne S Stenzel, Angela M Bathke, Stephanie F Polites, Arnoley S Abcejo, Jonathan M Morris, Christopher Favazza, Aiming Lu, Christopher J François, Phillip Young, Scott M Thompson
Lymphatic flow and anatomy can be challenging to study, owing to variable lymphatic anatomy in patients with diverse primary or secondary lymphatic pathologic conditions and the fact that lymphatic imaging is rarely performed in healthy individuals. The primary components of the lymphatic system outside the head and neck are the peripheral, retroperitoneal, mesenteric, hepatic, and pulmonary lymphatic systems and the thoracic duct. Multiple techniques have been developed for imaging components of the lymphatic system over the past century, with trade-offs in spatial, temporal, and contrast resolution; invasiveness; exposure to ionizing radiation; and the ability to obtain information on dynamic lymphatic flow...
February 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
#32
JOURNAL ARTICLE
Carlo Cervia-Hasler, Sarah C Brüningk, Tobias Hoch, Bowen Fan, Giulia Muzio, Ryan C Thompson, Laura Ceglarek, Roman Meledin, Patrick Westermann, Marc Emmenegger, Patrick Taeschler, Yves Zurbuchen, Michele Pons, Dominik Menges, Tala Ballouz, Sara Cervia-Hasler, Sarah Adamo, Miriam Merad, Alexander W Charney, Milo Puhan, Petter Brodin, Jakob Nilsson, Adriano Aguzzi, Miro E Raeber, Christoph B Messner, Noam D Beckmann, Karsten Borgwardt, Onur Boyman
Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12 months after confirmed severe acute respiratory syndrome coronavirus 2 infection. Analysis of >6500 proteins in 268 longitudinal samples revealed dysregulated activation of the complement system, an innate immune protection and homeostasis mechanism, in individuals experiencing Long Covid. Thus, active Long Covid was characterized by terminal complement system dysregulation and ongoing activation of the alternative and classical complement pathways, the latter associated with increased antibody titers against several herpesviruses possibly stimulating this pathway...
January 19, 2024: Science
#33
JOURNAL ARTICLE
Lukas Bajer, Marvin Ryou, Christopher C Thompson, Pavel Drastich
BACKGROUND/AIMS: Upper gastrointestinal bleeding (UGIB) is the most common GI condition requiring hospitalization, and can be diagnosed by direct visualization. The present study aimed to evaluate the safety and feasibility of using the PillSense system (EnteraSense Ltd.), a novel diagnostic tool designed for the rapid in vivo detection of UGIB, in human volunteers. METHODS: In the present study, 10 volunteers swallowed a PillSense capsule, followed by 2 servings of an autologous blood preparation...
January 17, 2024: Clinical Endoscopy
#34
JOURNAL ARTICLE
Ruiyang Ge, Christopher R K Ching, Anne S Bassett, Leila Kushan, Kevin M Antshel, Therese van Amelsvoort, Geor Bakker, Nancy J Butcher, Linda E Campbell, Eva W C Chow, Michael Craig, Nicolas A Crossley, Adam Cunningham, Eileen Daly, Joanne L Doherty, Courtney A Durdle, Beverly S Emanuel, Ania Fiksinski, Jennifer K Forsyth, Wanda Fremont, Naomi J Goodrich-Hunsaker, Maria Gudbrandsen, Raquel E Gur, Maria Jalbrzikowski, Wendy R Kates, Amy Lin, David E J Linden, Kathryn L McCabe, Donna McDonald-McGinn, Hayley Moss, Declan G Murphy, Kieran C Murphy, Michael J Owen, Julio E Villalon-Reina, Gabriela M Repetto, David R Roalf, Kosha Ruparel, J Eric Schmitt, Sanne Schuite-Koops, Kathleen Angkustsiri, Daqiang Sun, Ariana Vajdi, Marianne van den Bree, Jacob Vorstman, Paul M Thompson, Fidel Vila-Rodriguez, Carrie E Bearden
22q11.2 deletion syndrome (22q11DS) is the most frequently occurring microdeletion in humans. It is associated with a significant impact on brain structure, including prominent reductions in gray matter volume (GMV), and neuropsychiatric manifestations, including cognitive impairment and psychosis. It is unclear whether GMV alterations in 22q11DS occur according to distinct structural patterns. Then, 783 participants (470 with 22q11DS: 51% females, mean age [SD] 18.2 [9.2]; and 313 typically developing [TD] controls: 46% females, mean age 18...
January 2024: Human Brain Mapping
#35
JOURNAL ARTICLE
James R Cerhan, Matthew J Maurer, Brian K Link, Andrew L Feldman, Thomas M Habermann, David L Jaye, W Richard Burack, Timothy J McDonnell, Francisco Vega, Jennifer R Chapman, Sergei Syrbu, Kiran R Vij, Giorgio Inghirami, John P Leonard, Leon Bernal-Mizrachi, Umar Farooq, Thomas E Witzig, George J Weiner, Yucai Wang, Juan P Alderuccio, Susan L Slager, Melissa C Larson, Shaun M Riska, Brianna J Gysbers, Julianne J Lunde, Tanner W Reicks, Amy A Ayers, Colin B O'Leary, Kathleen J Yost, Hongfang Liu, Grzegorz S Nowakowski, Jia Ruan, Dai Chihara, Jean L Koff, Carla Casulo, Carrie A Thompson, Jonathon B Cohen, Brad S Kahl, Loretta J Nastoupil, Izidore S Lossos, Jonathan W Friedberg, Peter Martin, Christopher R Flowers
To address the current and long-term unmet health needs of the growing population of non-Hodgkin lymphoma (NHL) patients, we established the Lymphoma Epidemiology of Outcomes (LEO) cohort study (NCT02736357; https://leocohort.org/). A total of 7735 newly diagnosed patients aged 18 years and older with NHL were prospectively enrolled from 7/1/2015 to 5/31/2020 at 8 academic centers in the United States. The median age at diagnosis was 62 years (range, 18-99). Participants came from 49 US states and included 538 Black/African-Americans (AA), 822 Hispanics (regardless of race), 3386 women, 716 age <40 years, and 1513 rural residents...
January 13, 2024: American Journal of Hematology
#36
JOURNAL ARTICLE
Vladimir Belov, Tracy Erwin-Grabner, Moji Aghajani, Andre Aleman, Alyssa R Amod, Zeynep Basgoze, Francesco Benedetti, Bianca Besteher, Robin Bülow, Christopher R K Ching, Colm G Connolly, Kathryn Cullen, Christopher G Davey, Danai Dima, Annemiek Dols, Jennifer W Evans, Cynthia H Y Fu, Ali Saffet Gonul, Ian H Gotlib, Hans J Grabe, Nynke Groenewold, J Paul Hamilton, Ben J Harrison, Tiffany C Ho, Benson Mwangi, Natalia Jaworska, Neda Jahanshad, Bonnie Klimes-Dougan, Sheri-Michelle Koopowitz, Thomas Lancaster, Meng Li, David E J Linden, Frank P MacMaster, David M A Mehler, Elisa Melloni, Bryon A Mueller, Amar Ojha, Mardien L Oudega, Brenda W J H Penninx, Sara Poletti, Edith Pomarol-Clotet, Maria J Portella, Elena Pozzi, Liesbeth Reneman, Matthew D Sacchet, Philipp G Sämann, Anouk Schrantee, Kang Sim, Jair C Soares, Dan J Stein, Sophia I Thomopoulos, Aslihan Uyar-Demir, Nic J A van der Wee, Steven J A van der Werff, Henry Völzke, Sarah Whittle, Katharina Wittfeld, Margaret J Wright, Mon-Ju Wu, Tony T Yang, Carlos Zarate, Dick J Veltman, Lianne Schmaal, Paul M Thompson, Roberto Goya-Maldonado
Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by small sample sizes, lack of representativeness, data leakage, and/or overfitting. Here, we overcome these limitations with the largest multi-site sample size to date (N = 5365) to provide a generalizable ML classification benchmark of major depressive disorder (MDD) using shallow linear and non-linear models...
January 11, 2024: Scientific Reports
#37
JOURNAL ARTICLE
Nayna A Lodhia, Brent Hiramoto, Laura Horton, Alison H Goldin, Christopher C Thompson, Walter W Chan
BACKGROUND: Defecation dysfunction may contribute to chronic constipation (CC), but the impact of obesity on anorectal physiology in CC remains unclear. We aimed to evaluate the relationship between obesity and anorectal function on physiologic testing in patients presenting with CC. METHODS: This was a retrospective cohort study of consecutive adults who underwent high resolution anorectal manometry (HRAM) at a tertiary center for CC. Patient demographics, clinical history, surgical/obstetric history, medications, and HRAM results were reviewed...
January 6, 2024: Digestive Diseases and Sciences
#38
JOURNAL ARTICLE
Christopher K Tuggle, Jennifer L Clarke, Brenda M Murdoch, Eric Lyons, Nicole M Scott, Bedrich Beneš, Jacqueline D Campbell, Henri Chung, Courtney L Daigle, Sruti Das Choudhury, Jack C M Dekkers, Joao R R Dórea, David S Ertl, Max Feldman, Breno O Fragomeni, Janet E Fulton, Carmela R Guadagno, Darren E Hagen, Andrew S Hess, Luke M Kramer, Carolyn J Lawrence-Dill, Alexander E Lipka, Thomas Lübberstedt, Fiona M McCarthy, Stephanie D McKay, Seth C Murray, Penny K Riggs, Troy N Rowan, Moira J Sheehan, Juan P Steibel, Addie M Thompson, Kara J Thornton, Curtis P Van Tassell, Patrick S Schnable
Dramatic improvements in measuring genetic variation across agriculturally relevant populations (genomics) must be matched by improvements in identifying and measuring relevant trait variation in such populations across many environments (phenomics). Identifying the most critical opportunities and challenges in genome to phenome (G2P) research is the focus of this paper. Previously (Genome Biol, 23(1):1-11, 2022), we laid out how Agricultural Genome to Phenome Initiative (AG2PI) will coordinate activities with USA federal government agencies expand public-private partnerships, and engage with external stakeholders to achieve a shared vision of future the AG2PI...
January 3, 2024: Genome Biology
#39
JOURNAL ARTICLE
Joseph R Patterson, Joseph Kochmanski, Anna C Stoll, Michael Kubik, Christopher J Kemp, Megan F Duffy, Kajene Thompson, Jacob W Howe, Allyson Cole-Strauss, Nathan C Kuhn, Kathryn M Miller, Seth Nelson, Christopher U Onyekpe, John S Beck, Scott E Counts, Alison I Bernstein, Kathy Steece-Collier, Kelvin C Luk, Caryl E Sortwell
Examination of early phases of synucleinopathy when inclusions are present, but long before neurodegeneration occurs, is critical to both understanding disease progression and the development of disease modifying therapies. The rat alpha-synuclein (α-syn) preformed fibril (PFF) model induces synchronized synucleinopathy that recapitulates the pathological features of Parkinson's disease (PD) and can be used to study synucleinopathy progression. In this model, phosphorylated α-syn (pSyn) inclusion-containing neurons and reactive microglia (major histocompatibility complex-II immunoreactive) peak in the substantia nigra pars compacta (SNpc) months before appreciable neurodegeneration...
January 3, 2024: NPJ Parkinson's Disease
#40
JOURNAL ARTICLE
Isabel Song, Elizabeth W Thompson, Anurag Verma, Matthew T MacLean, Jeffrey Duda, Ameena Elahi, Richard Tran, Pavan Raghupathy, Sophia Swago, Mohamad Hazim, Abhijit Bhattaru, Carolin Schneider, Marijana Vujkovic, Drew A Torigian, Charles E Kahn, James C Gee, Arijitt Borthakur, Colleen M Kripke, Christopher C Carson, Rotonya Carr, Qasim Jehangir, Yi-An Ko, Harold Litt, Mark Rosen, David A Mankoff, Mitchell D Schnall, Haochang Shou, Julio Chirinos, Scott M Damrauer, Marina Serper, Jinbo Chen, Daniel J Rader, Walter R T Witschey, Hersh Sagreiya
The objective of this study is to define CT imaging derived phenotypes for patients with hepatic steatosis, a common metabolic liver condition, and determine its association with patient data from a medical biobank. There is a need to further characterize hepatic steatosis in lean patients, as its epidemiology may differ from that in overweight patients. A deep learning method determined the spleen-hepatic attenuation difference (SHAD) in Hounsfield Units (HU) on abdominal CT scans as a quantitative measure of hepatic steatosis...
January 2, 2024: Scientific Reports
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