Yining Li, Chao Liu, Xiaowan Han, Ren Sheng, Li Bao, Lijuan Lei, Yexiang Wu, Quanjie Li, Yuyan Zhang, Jing Zhang, Weizhi Wang, Yuhao Zhang, Shunwang Li, Chenyin Wang, Xinwei Wei, Jingrui Wang, Zonggen Peng, Yanni Xu, Shuyi Si
Osteoporosis is particularly prevalent among postmenopausal women and the elderly. In the present study, we investigated the effect of the novel small molecule E0924G (N-(4-methoxy-pyridine-2-yl)-5-methylfuran-2-formamide) on osteoporosis. E0924G significantly increased the protein expression levels of osteoprotegerin (OPG) and runt-related transcription factor 2 (RUNX2), and thus significantly promoted osteogenesis in MC3T3-E1 cells. E0924G also significantly decreased osteoclast differentiation and inhibited bone resorption and F-actin ring formation in receptor activator of NF-κB ligand (RANKL)-induced osteoclasts from RAW264...
April 11, 2024: Bioorganic Chemistry