Qin Li, Hang Yuan, Gang Zhao, Deqiong Ou, Jie Zhang, Liang Li, Siqi Li, Tianyu Feng, Rui Gu, Qiming Kou, Qijing Wang, Shan Li, Guanru Wang, Minghui Zhao, Huayang Yu, Jie Qu, Ping Lin, Kai Li
Hepatocellular carcinoma (HCC) is the main histological subtype of primary liver cancer and remains one of the most common solid malignancies globally. Ferroptosis was recently defined as an iron-catalyzed form of regulated necrosis. Because cancer cells exhibit higher iron requirements than noncancer cells, treatment with ferroptosis-inducing compounds may be a feasible strategy for cancer therapy. However, cancer cells develop acquired resistance to evade ferroptosis, and the mechanisms responsible for ferroptosis resistance are not fully clarified...
May 1, 2024: Biochemical Pharmacology