keyword
https://read.qxmd.com/read/37970465/lipidomic-insights-into-the-response-of-arabidopsis-sepals-to-mild-heat-stress
#1
JOURNAL ARTICLE
Zican Chen, Weronika Jasinska, Muhammad Ashraf, Leah Rosental, Jung Hong, Dabing Zhang, Yariv Brotman, Jianxin Shi
UNLABELLED: Arabidopsis sepals coordinate flower opening in the morning as ambient temperature rises; however, the underlying molecular mechanisms are poorly understood. Mutation of one heat shock protein encoding gene, HSP70-16 , impaired sepal heat stress responses (HSR), disrupting lipid metabolism, especially sepal cuticular lipids, leading to abnormal flower opening. To further explore, to what extent, lipids play roles in this process, in this study, we compared lipidomic changes in sepals of hsp70-16 and vdac3 (mutant of a voltage-dependent anion channel, VDAC3, an HSP70-16 interactor) grown under both normal (22 °C) and mild heat stress (27 °C, mild HS) temperatures...
September 2023: aBIOTECH
https://read.qxmd.com/read/36939788/plasma-lipidomic-subclasses-and-risk-of-hypertension-in-middle-aged-and-elderly-chinese
#2
JOURNAL ARTICLE
Zhenhua Niu, Qingqing Wu, Yaogan Luo, Di Wang, He Zheng, Yanpu Wu, Xiaowei Yang, Rong Zeng, Liang Sun, Xu Lin
UNLABELLED: While disrupted lipid metabolism is a well-established risk factor for hypertension in animal models, the links between various lipidomic signatures and hypertension in human studies remain unclear. We aimed to examine associations between plasma lipidomic profiles and prevalence of hypertension among 2248 community-living Chinese aged 50-70 years. Hypertension was defined according to 2020 International Society of Hypertension global hypertension practice guidelines and 2018 Chinese guidelines...
October 2022: Phenomics
https://read.qxmd.com/read/35992898/lipid-biomarker-profiling-of-adult-brugia-malayi-using-mass-spectrometry-detection
#3
JOURNAL ARTICLE
Ploypat Niyomploy, Suthee Mangmee, Phornpimon Tipthara, Atiporn Saeung, Onrapak Reamtong, Polkit Sangvanich
In this article, we first reported the lipid profile of adult Brugia malayi using ultra-performance liquid chromatography electrospray ionization mass spectrometry (UPLC-ESI-MS) to provide a promising drug target for lymphatic filariasis (LF). The MS and MS/MS data analysis indicated that there were target lipids, phosphatidylcholines (PC), at m / z 769.5612 and 831.5767 , which were found only in adult males, while at m / z 811.6072, they were found only in females, which is interesting for use as a biomarker in LF disease...
September 2022: 3 Biotech
https://read.qxmd.com/read/34900013/shear-mediated-platelet-activation-is-accompanied-by-unique-alterations-in-platelet-release-of-lipids
#4
JOURNAL ARTICLE
Alice Sweedo, Lisa M Wise, Yana Roka-Moiia, Fernando Teran Arce, S Scott Saavedra, Jawaad Sheriff, Danny Bluestein, Marvin J Slepian, John G Purdy
Introduction: Platelet activation by mechanical means such as shear stress exposure, is a vital driver of thrombotic risk in implantable blood-contacting devices used in the treatment of heart failure. Lipids are essential in platelets activation and have been studied following biochemical activation. However, little is known regarding lipid alterations occurring with mechanical shear-mediated platelet activation. Methods: Here, we determined if shear-activation of platelets induced lipidome changes that differ from those associated with biochemically-mediated platelet activation...
December 2021: Cellular and Molecular Bioengineering
https://read.qxmd.com/read/33967801/huanglong-antitussive-granule-relieves-acute-asthma-through-regulating-pulmonary-lipid-homeostasis
#5
JOURNAL ARTICLE
Hua Yan, Guiying Qian, Rui Yang, Zichen Luo, Xianzheng Wang, Tong Xie, Xia Zhao, Jinjun Shan
Background: Asthma is a respiratory disease with chronic airway inflammatory, and individuals with asthma exacerbations is one of the most frequent causes of hospitalization. Huanglong antitussive granule (HL Granule), a Chinese proprietary herbal medicine, has been proved to be effective in the clinical treatment of pulmonary disease. This study is devoted to the pharmacodynamics of HL Granule in acute asthma and the possible mechanism from the perspective of lipidomics. Methods: Mice were divided into four groups, control group, acute asthma model group, HL Granule treatment and montelukast sodium treatment group...
2021: Frontiers in Pharmacology
https://read.qxmd.com/read/32095097/oleanolic-acid-3-acetate-a-minor-element-of-ginsenosides-induces-apoptotic-cell-death-in-ovarian-carcinoma-and-endometrial-carcinoma-cells-via-the-involvement-of-a-reactive-oxygen-species-independent-mitochondrial-pathway
#6
JOURNAL ARTICLE
Hantae Jo, Jeong-Hyun Oh, Dong-Wook Park, Changho Lee, Churl K Min
Objectives: Oleanolic acid, a minor element of ginsenosides, and its derivatives have been shown to have cytotoxicity against some tumor cells. The impact of cytotoxic effect of oleanolic acid 3-acetate on ovarian cancer SKOV3 cells and endometrial cancer HEC-1A cells were examined both in vivo and in vitro to explore the underlying mechanisms. Methods: Cytotoxic effects of oleanolic acid 3-acetate were assessed by cell viability, phosphatidylserine exposure on the cell surface, mitochondrial release of cytochrome C, nuclear translocation of apoptosis-inducing factor, depolarization of mitochondrial transmembrane potential (ΔΨm ), and generation of reactive oxygen species (ROS)...
January 2020: Journal of Ginseng Research
https://read.qxmd.com/read/31978406/elevated-phosphatidylserine-specific-phospholipase-a1-level-in-hyperthyroidism
#7
JOURNAL ARTICLE
Kazuki Nakawatari, Makoto Kurano, Osamu Araki, Masako Nishikawa, Satoshi Shimamoto, Koji Igarashi, Junken Aoki, Masami Murakami, Yutaka Yatomi
OBJECTIVES: Although a single nucleotide polymorphism in a specific receptor for lysophosphatidylserine, a lysophospholipid mediator involved in the immune system, is reportedly associated with Graves' disease, the association between lysophosphatidylserine and thyroid disorders remains to be elucidated. Therefore, we aimed to investigate the association between the level of phosphatidylserine-specific phospholipase A1 (PS-PLA1), which produces lysophosphatidylserine, and thyroid disorders...
January 21, 2020: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://read.qxmd.com/read/21028921/simple-model-of-the-transduction-of-cell-penetrating-peptides
#8
JOURNAL ARTICLE
K Cahill
Cell-penetrating peptides (CPPs) such as HIV's trans-activating transcriptional activator (TAT) and polyarginine rapidly pass through the plasma membranes of mammalian cells by an unknown mechanism called transduction. They may be medically useful when fused to well-chosen chains of fewer than about 35 amino acids. The author offers a simple model of transduction in which phosphatidylserines and CPPs effectively form two plates of a capacitor with a voltage sufficient to cause the formation of transient pores (electroporation)...
September 2009: IET Systems Biology
https://read.qxmd.com/read/15256910/enrichment-of-non-apoptotic-human-spermatozoa-after-cryopreservation-by-immunomagnetic-cell-sorting
#9
JOURNAL ARTICLE
S Grunewald, U Paasch, H J Glander
Cryopreservation increases the rate of apoptotic spermatozoa with decreased capability to fertilise oocytes. In order to optimise the fertilisation rates, especially in assisted reproduction the use of apoptotic sperms should be avoided. Early events of apoptosis in cryopreserved spermatozoa are not detectable by conventional methods. However, the surface of apoptotic spermatozoa is characterised by externalisation of phosphatidylserine (PS), which has a high affinity to Annexin V. Therefore, colloid paramagnetic Annexin-V-conjugated microbeads (AN-MB) were tested for their ability to eliminate apoptotic spermatozoa from a total of 40 fresh and in TEST yolk buffer cryopreserved semen samples which were provided by 15 healthy volunteers...
2001: Cell and Tissue Banking
https://read.qxmd.com/read/8054258/effect-of-dietary-magnesium-deficiency-with-without-cholesterol-supplementation-on-phospholipid-content-in-liver-plasma-and-erythrocytes-of-rabbits
#10
JOURNAL ARTICLE
Q Zhou, M M Mahfouz, F A Kummerow
The effect of magnesium deficiency with/without supplementary cholesterol on phospholipid content in liver, plasma and erythrocytes was investigated in New Zealand White male rabbits. After the rabbits had been fed a low magnesium and/or high cholesterol diet for seven weeks, the phospholipid content in liver, plasma and erythrocytes was measured. Dietary magnesium deficiency produced a marked elevation of total phospholipid and certain individual phospholipids in the rabbit liver. The elevation was accentuated by cholesterol supplementation...
March 1994: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://read.qxmd.com/read/4060575/reversible-inactivation-and-reactivation-of-vaccinia-virus-by-manipulation-of-viral-lipid-composition
#11
JOURNAL ARTICLE
M Oie
The role of phospholipids in vaccinia virus was investigated by substituting viral lipids with specific phospholipids. Treatment of virus with sodium dodecyl sulfate, sodium deoxycholate, or Nonidet-P40 (NP-40) resulted in almost complete removal of viral lipid and led to inactivation of the virus. The inactivation induced by the former two was irreversible, but NP-40-treated virus was reactivated upon reassociation with phospholipids. Individual phospholipids, including phosphatidylserine (PS), phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, lysolecithin, sphingomyelin, and acyl bis(monoacylglycero)phosphate (ABMP), were tested for ability to reactivate NP-40-treated virus...
April 30, 1985: Virology
https://read.qxmd.com/read/2954026/effect-of-fish-oil-supplementation-on-the-n-3-fatty-acid-content-of-red-blood-cell-membranes-in-preterm-infants
#12
JOURNAL ARTICLE
S E Carlson, P G Rhodes, V S Rao, D E Goldgar
Very low birth weight infants demonstrate significant reductions in red blood cell membrane docosahexaenoic acid (DHA, 22:6n-3) following delivery unless fed human milk. The purpose of the present study was to determine if a dietary source of DHA (MaxEPA, R. P. Scherer Corporation, Troy, MI) could prevent the decline in red blood cell phospholipid DHA in very low birth weight infants whose enteral feeding consisted of a preterm formula without DHA. Longitudinal data were obtained on membrane phospholipid DHA in both unsupplemented and MaxEPA-supplemented infants by a combination of thin-layer and gas chromatography...
May 1987: Pediatric Research
https://read.qxmd.com/read/2838083/fluoride-dependent-calcium-induced-platelet-procoagulant-activity-shows-that-calpain-is-involved-in-increased-phospholipid-transbilayer-movement
#13
JOURNAL ARTICLE
P F Verhallen, E M Bevers, P Comfurius, R F Zwaal
Treatment of platelets with fluoride (10 mM) was found to result in a transient increase in Ca2+-permeability of the platelet plasma membrane. This phenomenon was used to provide supplementary evidence for the suggestions made earlier (Comfurius et al. (1985) Biochim. Biophys. Acta 815, 143; Verhallen et al. (1987) Biochim. Biophys. Acta 903, 206), that cytoskeletal disrupture by calpain is involved in the process leading to transbilayer movement of phosphatidylserine during expression of platelet procoagulant activity...
July 7, 1988: Biochimica et Biophysica Acta
https://read.qxmd.com/read/2773445/-the-significance-of-studying-phospholipids-in-the-diagnosis-of-hypothyroidism
#14
JOURNAL ARTICLE
N B Zelinskaia
Phospholipids and their fractions were examined in 85 patients with hypothyroidism of various severity grades in the state of decompensation. It was established that hypothyroidism is characterized by essential disorders of the phospholipid metabolism which occurs already at the initial stages of the disease advances with progression of its severity and is manifested in an increase of phosphatidylserine, lysophosphatidylcholine, sphingomyelin, phosphatidylethanolamine and reduction of phosphatidylcholine. Examination of phospholipids and their fractions is one of the important supplementary objective methods of diagnosis of hypothyroidism, especially, in young persons, a criterion of metabolic decompensation of the disease...
May 1989: Vrachebnoe Delo
https://read.qxmd.com/read/219891/divalent-cation-binding-to-phospholipid-veiscles-dependence-on-temperature-and-lipid-fluidity
#15
JOURNAL ARTICLE
J S Puskin, T Martin
Mn2+ binding to vesicles prepared from several different species of anionic phospholipids was determined as a function of temperature by electron paramagnetic resonance (EPR). The Mn2+ affinities of phosphatidylserine, cardiolipin and egg yolk phosphatidylglycerol all increased monitonically with temperature. Vesicles prepared from hydrogenated and natural (bovine) phosphatidylserine were monitored with respect to hydrocarbon chain fluidity as well as Mn2+ binding. Contrary to expectations based on surface potential considerations, the affinity of phosphatidylserine for divalent cations was apparently not lowered in going from the gel state to the lipid crystalline state of the bilayer...
March 23, 1979: Biochimica et Biophysica Acta
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