Jiesi Xu, Siyu Chen, Wei Wang, Sin Man Lam, Yang Xu, Shaohua Zhang, Huimin Pan, Jingjing Liang, Xiahe Huang, Yu Wang, Ting Li, Yuqiang Jiang, Yingchun Wang, Mei Ding, Guanghou Shui, Hongyuan Yang, Xun Huang
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies, ranging from steatosis to nonalcoholic steatohepatitis (NASH). The factors promoting the progression of steatosis to NASH are still unclear. Recent studies suggest that mitochondrial lipid composition is critical in NASH development. Here, we showed that CDP-DAG synthase 2 (Cds2) was downregulated in genetic or diet-induced NAFLD mouse models. Liver-specific deficiency of Cds2 provoked hepatic steatosis, inflammation and fibrosis in five-week-old mice...
February 15, 2022: Science Bulletin