Taralynn M Mack, Michael A Raddatz, Yash Pershad, Daniel C Nachun, Kent D Taylor, Xiuqing Guo, Alan R Shuldiner, Jeffrey R O'Connell, Eimear E Kenny, Ruth J F Loos, Susan Redline, Brian E Cade, Bruce M Psaty, Joshua C Bis, Jennifer A Brody, Edwin K Silverman, Jeong H Yun, Michael H Cho, Dawn L DeMeo, Daniel Levy, Andrew D Johnson, Rasika A Mathias, Lisa R Yanek, Susan R Heckbert, Nicholas L Smith, Kerri L Wiggins, Laura M Raffield, April P Carson, Jerome I Rotter, Stephen S Rich, Ani W Manichaikul, C Charles Gu, Yii-Der Ida Chen, Wen-Jane Lee, M Benjamin Shoemaker, Dan M Roden, Charles Kooperberg, Paul L Auer, Pinkal Desai, Thomas W Blackwell, Albert V Smith, Alexander P Reiner, Siddhartha Jaiswal, Joshua S Weinstock, Alexander G Bick
Clonal hematopoiesis of indeterminate potential (CHIP), whereby somatic mutations in hematopoietic stem cells confer a selective advantage and drive clonal expansion, not only correlates with age but also confers increased risk of morbidity and mortality. Here, we leverage genetically predicted traits to identify factors that determine CHIP clonal expansion rate. We used the passenger-approximated clonal expansion rate method to quantify the clonal expansion rate for 4,370 individuals in the National Heart, Lung, and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) cohort and calculated polygenic risk scores for DNA methylation aging, inflammation-related measures and circulating protein levels...
June 4, 2024: Nature aging