Jesse Santos, Ping Wang, Avishai Shemesh, Fengchun Liu, Tasha Tsao, Oscar A Aguilar, Simon J Cleary, Jonathan P Singer, Ying Gao, Steven R Hays, Jeffrey Golden, Lorriana E Leard, Mary Ellen Kleinhenz, Nicholas A Kolaitis, Rupal J Shah, Aida Venado, Jasleen Kukreja, S Sam Weigt, John A Belperio, Lewis L Lanier, Mark R Looney, John R Greenland, Daniel R Calabrese
Primary graft dysfunction (PGD) limits clinical benefit after lung transplantation, a life-prolonging therapy for patients with end-stage disease. PGD is the clinical syndrome resulting from pulmonary ischemia-reperfusion injury (IRI), driven by innate immune inflammation. We recently demonstrated a key role for NK cells in the airways of mouse models and human tissue samples of IRI. Here we used 2 mouse models paired with human lung transplant samples to investigate the mechanisms whereby NK cells migrate to the airways to mediate lung injury...
October 3, 2023: JCI Insight