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JOURNAL ARTICLE
Loïc Deblais, Mary Drozd, Anand Kumar, Janet Antwi, James Fuchs, Rahul Khupse, Yosra A Helmy, Gireesh Rajashekara
INTRODUCTION: Control of Campylobacter from farm to fork is challenging due to the frequent emergence of antimicrobial-resistant isolates. Furthermore, poultry production systems are known reservoirs of Campylobacter . The twin-arginine translocation (Tat) pathway is a crucial bacterial secretion system that allows Campylobacter to colonize the host intestinal tract by using formate as the main source of energy. However, Tat pathway is also a major contributing factor for resistance to copper sulfate (CuSO4 )...
2024: Frontiers in Microbiology
#2
JOURNAL ARTICLE
Wei-Ting Wang, Yan-Yu Zhang, Zi-Rui Li, Juan-Min Li, Hai-Shan Deng, Yuan-Yuan Li, Hua-Yi Yang, Chi Chou Lau, Yi-Jing Yao, Hu-Dan Pan, Liang Liu, Ying Xie, Hua Zhou
BACKGROUND: Acute lung injury (ALI) is a continuum of lung changes caused by multiple lung injuries, characterized by a syndrome of uncontrolled systemic inflammation that often leads to significant morbidity and death. Anti-inflammatory is one of its treatment methods, but there is no safe and available drug therapy. Syringic acid (SA) is a natural organic compound commonly found in a variety of plants, especially in certain woody plants and fruits. In modern pharmacological studies, SA has anti-inflammatory effects and therefore may be a potentially safe and available compound for the treatment of acute lung injury...
April 15, 2024: Phytomedicine
#3
JOURNAL ARTICLE
Rebecca Castel, Virginie Tassistro, Stépahnie Lebarillier, Nathalie Dupuy, Yves Noack, Thierry Orsière, Laure Malleret
In the last two decades, awareness grew on the matter of the impact of environment on human health. Contaminants sorbed onto soil and settled dust can be ingested and thus represent a hazard, particularly to young children, who play on the ground and bring their hands and objects to their mouth. Metal(loid)s and polycyclic aromatic hydrocarbons (PAHs) are of concern as they are both carcinogenic to humans and ubiquitous in outdoor environments. The present study aims to assess the total and bioaccessible fractions of PAHs and metal(loid)s present in settled dust of four preschools located in industrial, urban, and suburban areas...
May 1, 2024: Environmental Science and Pollution Research International
#4
JOURNAL ARTICLE
Cristina Agostinis, Elide Lupi
A 45-year-old female patient with diffuse osteoarticular pain, particularly low back pain, was referred by a rheumatologist for an updated radiologic evaluation. The patient had experienced these symptoms for many years and was diagnosed with human leukocyte antigen B27-negative spondyloarthritis approximately 11 years prior, based on findings of bilateral erosive sacroiliitis at pelvic radiography (Fig 1A) and bone scintigraphy with technetium 99m methylene diphosphonate (Fig 1B). After 3 years of treatment with a tumor necrosis factor-α inhibitor (adalimumab), which was effective for pain, the patient was lost to follow-up...
April 2024: Radiology
#5
JOURNAL ARTICLE
Olivia Wagemann, Haiyan Liu, Guoqiao Wang, Xinyu Shi, Tobias Bittner, Marzia A Scelsi, Martin R Farlow, David B Clifford, Charlene Supnet-Bell, Anna M Santacruz, Andrew J Aschenbrenner, Jason J Hassenstab, Tammie L S Benzinger, Brian A Gordon, Kelley A Coalier, Carlos Cruchaga, Laura Ibanez, Richard J Perrin, Chengjie Xiong, Yan Li, John C Morris, James J Lah, Sarah B Berman, Erik D Roberson, Christopher H van Dyck, Douglas Galasko, Serge Gauthier, Ging-Yuek R Hsiung, William S Brooks, Jérémie Pariente, Catherine J Mummery, Gregory S Day, John M Ringman, Patricio Chrem Mendez, Peter St George-Hyslop, Nick C Fox, Kazushi Suzuki, Hamid R Okhravi, Jasmeer Chhatwal, Johannes Levin, Mathias Jucker, John R Sims, Karen C Holdridge, Nicholas K Proctor, Roy Yaari, Scott W Andersen, Michele Mancini, Jorge Llibre-Guerra, Randall J Bateman, Eric McDade
IMPORTANCE: Effects of antiamyloid agents, targeting either fibrillar or soluble monomeric amyloid peptides, on downstream biomarkers in cerebrospinal fluid (CSF) and plasma are largely unknown in dominantly inherited Alzheimer disease (DIAD). OBJECTIVE: To investigate longitudinal biomarker changes of synaptic dysfunction, neuroinflammation, and neurodegeneration in individuals with DIAD who are receiving antiamyloid treatment. DESIGN, SETTING, AND PARTICIPANTS: From 2012 to 2019, the Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU-001) study, a double-blind, placebo-controlled, randomized clinical trial, investigated gantenerumab and solanezumab in DIAD...
April 29, 2024: JAMA Neurology
#6
JOURNAL ARTICLE
Ana Lozano, Carolina Sánchez-Marrugo, Kevin Llinás-Caballero, Carlos Barrios, Nathalie Acevedo, Josefina Zakzuk, Luis Caraballo
OBJECTIVE: To quantify the production of Th1/Th2/Th17 cytokines induced by Ascaris lumbricoides antigens in peripheral blood mononuclear cells (PBMCs) using a multiplex technique. METHODS: PBMCs were cultured from individuals with mild A. lumbricoides infection (n = 20) and uninfected individuals (n = 21) and stimulated with A. lumbricoides extract (ExtAscaris), a mix of anti-CD2/CD3/CD28 (CDmix) as a positive control, and only medium (negative control). Cytokines in the supernatants were measured using the BD™ Cytometric Bead Array Human Th1/Th2/Th17 kit, to identify IFN-γ, TNF, IL-10, IL-6, IL-4, IL-2, and IL-17A...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#7
JOURNAL ARTICLE
Luis Fang, Dalgys Martínez, Catherine Meza-Torres, Ana Moreno-Woo, Nicole Pereira-Sanandres, Alex Domínguez-Vargas, Gloria Garavito, Eduardo Egea
OBJECTIVE: To evaluate the IgE reactivity of sera in patients suffering from type 1 diabetes (T1D), lupus nephritis (LN) and juvenile idiopathic arthritis (JIA) against a molecule constructed from T epitopes of A. lumbricoides allergens. METHODS: We designed and expressed a synthetic multi-epítope protein named MP1 from A. lumbricoides and house dust mites allergens. By indirect ELISA, we evaluated IgE-reactivity to MP1 and to the whole-body extract of Ascaris lumbricoides in 45 sera from Colombian Caribbean patients with lupus nephritis (LN; n=25), type 1 diabetes (T1D; n=10) and Juvenil idiopathic arthritis (JIA; n=10)...
February 1, 2024: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
#8
JOURNAL ARTICLE
Sen Li, Qian-Jun Ren, Can-Hao Xie, Yang Cui, Li-Tao Xu, Yi-Dan Wang, Su Li, Xing-Qiu Liang, Bin Wen, Ming-Kun Liang, Xiao-Fang Zhao
BACKGROUND: Liver fibrosis is a compensatory response during the tissue repair process in chronic liver injury, and finally leads to liver cirrhosis or even hepatocellular carcinoma. The pathogenesis of hepatic fibrosis is associated with the progressive accumulation of activated hepatic stellate cells (HSCs), which can transdifferentiate into myofibroblasts to produce an excess of the extracellular matrix (ECM). Myofibroblasts are the main source of the excessive ECM responsible for hepatic fibrosis...
April 21, 2024: World Journal of Gastroenterology: WJG
#9
JOURNAL ARTICLE
Francesco Andreozzi, Elettra Mancuso, Mariangela Rubino, Benedetta Salvatori, Micaela Morettini, Giuseppe Monea, Christian Göbl, Gaia Chiara Mannino, Andrea Tura
BACKGROUND/OBJECTIVES: Glucagon is important in the maintenance of glucose homeostasis, with also effects on lipids. In this study, we aimed to apply a recently developed model of glucagon kinetics to determine the sensitivity of glucagon variations (especially, glucagon inhibition) to insulin levels ("alpha-cell insulin sensitivity"), during oral glucose administration. SUBJECTS/METHODS: We studied 50 participants (spanning from normal glucose tolerance to type 2 diabetes) undergoing frequently sampled 5-hr oral glucose tolerance test (OGTT)...
2024: Frontiers in Endocrinology
#10
JOURNAL ARTICLE
Fatemeh Mahboubi, Javad Mohammadnejad, Sepideh Khaleghi
Without a doubt, cancer and its negative impact on human health have created many hurdles for people across the world since conventional approaches have not offered a reliable ability in the eradication of cancer. As a result, finding novel approaches, like using bimodal nanoparticles as a potential nanocarrier in molecular imaging and cancer therapy, is remarkably required these days. In the present study, ex-situ (Ge) and in-situ (Gi) green synthesized silver (Ag) nanoparticles entrapped in metal-organic framework nanocomposites (NMOF) coated with folic acid (FA) targeted chitosan (CS) was successfully developed as a novel bifunctional nanocarrier for detection and treatment of colon cancer cells...
April 30, 2024: Heliyon
#11
JOURNAL ARTICLE
Malarmugila Manimaran, Yin Yin Teo, James Chen Yong Kah, Adilet Beishenaliev, Yean Leng Loke, Yiing Yee Foo, Shiow-Fern Ng, Chin Fei Chee, Sek Peng Chin, Farid Nazer Faruqu, Chia-Yu Chang, Misni Misran, Lip Yong Chung, Bey Fen Leo, Shih-Hwa Chiou, Chia-Ching Chang, Sun Tee Tay, Lik Voon Kiew
INTRODUCTION: Over 75% of clinical microbiological infections are caused by bacterial biofilms that grow on wounds or implantable medical devices. This work describes the development of a new poly(diallyldimethylammonium chloride) (PDADMAC)/alginate-coated gold nanorod (GNR/Alg/PDADMAC) that effectively disintegrates the biofilms of Staphylococcus aureus ( S. aureus ), a prominent pathogen responsible for hospital-acquired infections. METHODS: GNR was synthesised via seed-mediated growth method, and the resulting nanoparticles were coated first with Alg and then PDADMAC...
2024: International Journal of Nanomedicine
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JOURNAL ARTICLE
Dongliang Wang, Naohiro Shimamura, Nobuhiko Miwa, Li Xiao
Gingival wound healing plays a critical role in maintaining oral health. However, this process can be delayed by oxidative stress and excessive inflammatory responses. In this study, we established a human inflammatory gingival tissue equivalent (iGTE) to investigate the inhibitory effects of hydrogen-rich water (HW), enzyme-digested edible bird's nest (EBND) and sialic acid (SA) on PMA (an inducer of oxidative free radicals)- and LPS (an inflammatory stimulus)-impaired wound healing. The iGTE was constructed by human gingival fibroblasts (hGFs), keratinocytes and macrophages under three-dimensional conditions...
April 29, 2024: Human Cell
#13
REVIEW
Ravinder Anand-Ivell, Kee Heng, Leen Antonio, Gyorgy Bartfai, Felipe F Casanueva, Mario Maggi, Terence W O'Neill, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick Cw Wu, Ilpo T Huhtaniemi, Richard Ivell
Insulin-like peptide 3 (INSL3) is a circulating biomarker for Leydig cell functional capacity in men, also indicating Leydig Cell Insufficiency (LCI) and potential primary hypogonadism. Using results from large cohort studies we explore sources of biological and technical variance, and establish a reference range for adult men. It is constitutively secreted with little within-individual variation and reflects testicular capacity to produce testosterone. The main INSL3 assays available indicate good concordance with low technical variance; there is no effect of ethnicity...
December 2024: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
#14
JOURNAL ARTICLE
Ayça Altay Benetti, Eugene Yang Zhi Tan, Zi Wei Chang, Ki Hyun Bae, Ma Thinzar Thwin, Ram Pravin Kumar Muthuramalingam, Kuo-Chieh Liao, Yue Wan, Lisa F P Ng, Laurent Renia, Jianping Liu, Xiaoyuan Chen, Yi Yan Yang, Kevin P White, Giorgia Pastorin
Chitosan, a natural polysaccharide derived from chitin, possesses biocompatibility, biodegradability, and mucoadhesive characteristics, making it an attractive material for the delivery of mRNA payloads to the nasal mucosa and promoting their uptake by target cells such as epithelial and immune cells (e.g., dendritic cells and macrophages). In this project, we aimed at developing novel lipid-based nanoformulations for mRNA delivery to counteract the pandemic caused by SARS-CoV-2 virus. The formulations achieved a mRNA encapsulation efficiency of ~80...
April 12, 2024: Vaccines
#15
JOURNAL ARTICLE
Uiechan Jeong, Sunhee Yoon, Sungjin Park, Tae-Joon Jeon, Sun Min Kim
In this study, we created a 3D Artificial Skin Platform that can be used for the treatment of pigmentation by artificially realizing the skin of pregnant women. For the stable realization of 3D artificial skin, a bilayer hydrogel composed of collagen type I and fibrin was designed and applied to the study to reduce the tension-induced contraction of collagen type I, the extracellular matrix (ECM) of artificial skin, by dynamic culture. Oxygen concentration and 17β-Estradiol (E2) concentration, which are highly related to melanin production, were selected as parameters of the pregnancy environment and applied to cell culture...
April 10, 2024: Micromachines
#16
JOURNAL ARTICLE
Paola Zuluaga, Julia Casado-Carbajo, Anna Hernández-Rubio, Marvin Bueno-Vélez, Carmen García-Martin, Robert Muga, Daniel Fuster
BACKGROUND: Vitamin D deficiency is a risk factor for liver disease, insulin resistance, and beta cell dysfunction. Individuals with alcohol use disorder (AUD) have many comorbidities, with a heavy burden of liver disease and metabolic complications, including type 2 diabetes mellitus (T2DM). OBJECTIVE: We aimed to analyze the prevalence and associations of vitamin D deficiency in patients admitted for in-hospital treatment of AUD. METHODS: A cross-sectional study was conducted in patients consecutively admitted for the treatment of AUD between January 2017 and October 2023...
April 9, 2024: Nutrients
#17
JOURNAL ARTICLE
Dina Maaliki, Maha Itani, Hala Jarrah, Carla El-Mallah, Diana Ismail, Yara E El Atie, Omar Obeid, Miran A Jaffa, Hana A Itani
Sodium chloride (NaCl) activates Th17 and dendritic cells in hypertension by stimulating serum/glucocorticoid kinase 1 (SGK1), a sodium sensor. Memory T cells also play a role in hypertension by infiltrating target organs and releasing proinflammatory cytokines. We tested the hypothesis that the role of T cell SGK1 extends to memory T cells. We employed mice with a T cell deletion of SGK1, SGK1fl/fl × tgCD4cre mice, and used SGK1fl/fl mice as controls. We treated the mice with L-NAME (0.5 mg/mL) for 2 weeks and allowed a 2-week washout interval, followed by a 3-week high-salt (HS) diet (4% NaCl)...
April 16, 2024: International Journal of Molecular Sciences
#18
JOURNAL ARTICLE
Florencio J D M Machado, Juan Marta-Enguita, Susan U Gómez, Jose A Rodriguez, José Antonio Páramo-Fernández, María Herrera, Beatriz Zandio, Nuria Aymerich, Roberto Muñoz, Rebeca Bermejo, Javier Marta-Moreno, Begoña López, Arantxa González, Carmen Roncal, Josune Orbe
Accurate etiologic diagnosis provides an appropriate secondary prevention and better prognosis in ischemic stroke (IS) patients; still, 45% of IS are cryptogenic, urging us to enhance diagnostic precision. We have studied the transcriptomic content of plasma extracellular vesicles (EVs) ( n = 21) to identify potential biomarkers of IS etiologies. The proteins encoded by the selected genes were measured in the sera of IS patients ( n = 114) and in hypertensive patients with ( n = 78) and without atrial fibrillation (AF) ( n = 20)...
April 16, 2024: International Journal of Molecular Sciences
#19
MULTICENTER STUDY
Anja Gäckler, Onurcan Ertasoglu, Hana Rohn, Justa Friebus-Kardash, Philipp-Christopher Ickerott, Oliver Witzke, Andreas Kribben, Bruno Vogt, Suzan Dahdal, Spyridon Arampatzis, Ute Eisenberger
TIMP-2 and IGFBP7 have been identified and validated for the early detection of renal injury in critically ill patients, but data on recovery of allograft function after kidney transplantation (KTx) are scarce. In a prospective observational multicenter cohort study of renal transplant recipients, urinary [TIMP-2] × [IGFBP7] was evaluated daily from day 1 to 7 after KTx. Different stages of early graft function were defined: immediate graft function (IGF) (decrease ≥ 10% in serum creatinine (s-crea) within 24 h post KTx); slow graft function (SGF) (decrease in s-crea < 10% within 24 h post KTx); and delayed graft function (DGF) (any dialysis needed within the first week after KTx)...
April 10, 2024: International Journal of Molecular Sciences
#20
JOURNAL ARTICLE
Nimra Aziz, Chiara Ruzza, Chiara Falcicchia, Annunziata Guarino, Marie Soukupova, Laila Asth, Valentina Aleotti, Barbara Bettegazzi, Michele Simonato, Silvia Zucchini
Neuroinflammation is associated with several neurological disorders including temporal lobe epilepsy. Seizures themselves can induce neuroinflammation. In an in vivo model of epilepsy, the supplementation of brain-derived neurotropic factor (BDNF) and fibroblast growth factor-2 (FGF-2) using a Herpes-based vector reduced epileptogenesis-associated neuroinflammation. The aim of this study was to test whether the attenuation of the neuroinflammation obtained in vivo with BDNF and FGF-2 was direct or secondary to other effects, for example, the reduction in the severity and frequency of spontaneous recurrent seizures...
April 9, 2024: International Journal of Molecular Sciences
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