James A Diao, Yixuan He, Rohan Khazanchi, Max Jordan Nguemeni Tiako, Jonathan I Witonsky, Emma Pierson, Pranav Rajpurkar, Jennifer R Elhawary, Luke Melas-Kyriazi, Albert Yen, Alicia R Martin, Sean Levy, Chirag J Patel, Maha Farhat, Luisa N Borrell, Michael H Cho, Edwin K Silverman, Esteban G Burchard, Arjun K Manrai
BACKGROUND: Adjustment for race is discouraged in lung-function testing, but the implications of adopting race-neutral equations have not been comprehensively quantified. METHODS: We obtained longitudinal data from 369,077 participants in the National Health and Nutrition Examination Survey, U.K. Biobank, the Multi-Ethnic Study of Atherosclerosis, and the Organ Procurement and Transplantation Network. Using these data, we compared the race-based 2012 Global Lung Function Initiative (GLI-2012) equations with race-neutral equations introduced in 2022 (GLI-Global)...
May 19, 2024: New England Journal of Medicine