keyword
https://read.qxmd.com/read/38455817/a-comprehensive-review-of-the-immunomodulatory-effects-of-vitamin-d-in-sepsis
#21
REVIEW
Abhinav Ahuja, Sachin Agrawal, Sourya Acharya, Sunil Kumar
Sepsis remains a critical global health challenge characterised by a dysregulated immune response to infection, leading to systemic inflammation and organ dysfunction. This review examines the immunomodulatory effects of Vitamin D in sepsis, focusing on its regulation of immune cell function, modulation of cytokine production, and enhancement of antimicrobial responses. While the potential of Vitamin D as an adjunctive therapy in sepsis management is evident, challenges such as variability in Vitamin D status, uncertainties regarding optimal dosages and patient heterogeneity, and potential adverse effects require careful consideration...
February 2024: Curēus
https://read.qxmd.com/read/38447639/use-of-intravenous-albumin-a-guideline-from-the-international-collaboration-for-transfusion-medicine-guidelines
#22
Jeannie Callum, Nikolaos J Skubas, Aarti Bathla, Homa Keshavarz, Edward G Clark, Bram Rochwerg, Dean Fergusson, Sesmu Arbous, Seth R Bauer, Louise China, Mark Fung, Rachel Jug, Michael Neill, Cary Paine, Katerina Pavenski, Prakesh S Shah, Susan Robinson, Hua Shan, Zbigniew M Szczepiorkowski, Thierry Thevenot, Bovey Wu, Simon Stanworth, Nadine Shehata
BACKGROUND: Albumin is commonly employed across a wide range of clinical settings to improve hemodynamics, facilitate fluid removal, and manage complications of cirrhosis. The International Collaboration for Transfusion Medicine Guidelines developed guidelines for the use of albumin in patients requiring critical care, undergoing cardiovascular surgery, kidney replacement therapy, or experiencing complications of cirrhosis. METHODS: Co-chairs oversaw the guideline development process and the panel included researchers, clinicians, methodologists, and a patient representative...
March 4, 2024: Chest
https://read.qxmd.com/read/38438129/nutrition-of-newborns-with-hypoxic-ischaemic-encephalopathy-during-therapeutic-hypothermia-a-survey-of-practice-in-polish-neonatal-care-units
#23
JOURNAL ARTICLE
Aleksandra Warchoł, Przemko Kwinta
BACKGROUND: The nutritional practice for newborns with hypoxic-ischaemic encephalopathy during therapeutic hypothermia differs among Polish neonatal care units, as no guidelines are provided. We assessed the prevailing procedures. MATERIAL AND METHODS: Data was collected through an anonymous, web-based questionnaire. We surveyed aspects of the current nutritional practices and the reasoning behind the choice of the feeding strategy. RESULTS: Thirty-one responses were obtained (31/33, 94%)...
February 1, 2024: Journal of mother and child
https://read.qxmd.com/read/38436306/-clinical-practice-guidelines-for-meropenem-therapy-in-neonatal-sepsis-2024
#24
JOURNAL ARTICLE
(no author information available yet)
Meropenem is one of the most widely used special-grade antimicrobial agents in the treatment of neonatal sepsis. However, its irrational use has led to an increasingly severe problem of bacterial multidrug resistance. The guideline was developed following standardized methods and procedures, and provides 12 recommendations specifically addressing 9 clinical issues. The recommendations cover various aspects of meropenem use in neonates, including timing of administration, recommended dosage, extended infusion, monitoring and assessment, antimicrobial adjustment strategies, treatment duration, and treatment strategies for carbapenem-resistant Enterobacteriaceae infections...
February 15, 2024: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://read.qxmd.com/read/38411009/the-prevalent-causes-of-death-in-patients-with-peripheral-artery-disease-undergoing-revascularisation-or-amputation
#25
REVIEW
Stacey Telianidis, Sarah Joy Aitken
OBJECTIVE: Preventing untimely death in patients with peripheral artery disease (PAD) requires a detailed understanding of the predominant causes of death (COD). This literature review aims to describe how short- and long-term COD are reported in patients who had surgery for PAD. METHODS: A literature review was conducted according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines for articles reporting specific causes of mortality in patients who had surgery for all stages of PAD...
February 27, 2024: Vascular
https://read.qxmd.com/read/38410595/shenfu-injection-as-treatment-for-critical-illness-a-narrative-review-of-clinical-trials
#26
REVIEW
Noa Berlin, Aditya C Shekhar, Katherine M Berg
BACKGROUND AND OBJECTIVE: Shenfu injection (SFI) is a traditional herbal medicine derived from components of ginseng and aconite and is commonly used in China to treat a variety of conditions. Shenfu has been suggested to have beneficial effects in various critical illnesses, including heart failure, cardiac arrest, and septic shock. In recent years, there have been a number of studies reporting that SFI improves patient outcomes when used concurrently with other treatments, but its use has not been adopted outside of China...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38410083/stapled-anastomosis-versus-hand-sewn-anastomosis-with-mucosectomy-for-ileal-pouch-anal-anastomosis-a-systematic-review-and-meta-analysis-of-postoperative-outcomes-functional-outcomes-and-oncological-safety
#27
REVIEW
Mohamed Ali Chaouch, Mohammad Iqbal Hussain, Amine Gouader, Bassam Krimi, Alessandro Mazzotta, Adriano Carneira Da Costa, Niccolo Petrucciani, Mehdi Bouassida, Jim Khan, Faouzi Noomen, Hani Oweira
PURPOSE: This systematic review and meta-analysis aimed to compare outcomes between stapled ileal pouch-anal anastomosis (IPAA) and hand-sewn IPAA with mucosectomy in cases of ulcerative colitis and familial adenomatous polyposis. METHODS: This systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis) guidelines 2020 and AMSTAR 2 (Assessing the methodological quality of systematic reviews) guidelines...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38409062/the-use-of-extracorporeal-blood-purification-therapies-and-sequential-extracorporeal-support-in-patients-with-septic-shock-eroicass-a-study-protocol-for-a-national-non-interventional-observational-multicenter-prospective-study
#28
JOURNAL ARTICLE
Silvia De Rosa, Fiorenza Ferrari, Massimiliano Greco, Vincenzo Pota, Michele Umbrello, Antonella Cotoia, Laura Pasin, Federico Nalesso, Gianluca Paternoster, Gianluca Villa, Sergio Lassola, Sara Miori, Andrea Sanna, Vicenzo Cantaluppi, Marita Marengo, Fabrizio Valente, Marco Fiorentino, Giuliano Brunori, Giacomo Bellani, Antonino Giarratano
BACKGROUND: Septic shock, a critical condition characterized by organ failure, presents a substantial mortality risk in intensive care units (ICUs), with the 28-day mortality rate possibly reaching 40%. Conventional management of septic shock typically involves the administration of antibiotics, supportive care for organ dysfunction, and, if necessary, surgical intervention to address the source of infection. In recent decades, extracorporeal blood purification therapies (EBPT) have emerged as potential interventions aimed at modulating the inflammatory response and restoring homeostasis in patients with sepsis...
February 26, 2024: J Anesth Analg Crit Care
https://read.qxmd.com/read/38407122/compliance-with-maternal-sepsis-guidelines-in-a-tertiary-hospital-in-the-netherlands
#29
JOURNAL ARTICLE
Baukje S de Vries, Kim J C Verschueren, Sophie Jansen, Vincent Bekker, Marieke B Veenhof, Thomas van den Akker
OBJECTIVES: Sepsis is a common cause of maternal mortality and morbidity. Early detection and rapid management are essential. In this study, we evaluate the compliance with the implemented maternity-specific Early Warning Score (EWS), Rapid Response Team (RRT) protocol and the Surviving Sepsis Campaign (SSC) Hour-1 Bundle in a tertiary hospital in the Netherlands. METHODS: We performed a retrospective patient chart review from July 2019 to June 2020 at the Leiden University Medical Centre...
February 26, 2024: Hospital Practice (Minneapolis)
https://read.qxmd.com/read/38403523/transperineal-versus-transrectal-magnetic-resonance-imaging-targeted-biopsies-for-prostate-cancer-diagnosis-final-results-of-the-randomized-perfect-trial-ccafu-pr1
#30
JOURNAL ARTICLE
Guillaume Ploussard, Eric Barret, Gaëlle Fiard, Louis Lenfant, Bernard Malavaud, Gianluca Giannarini, Christophe Almeras, Richard Aziza, Raphaële Renard-Penna, Jean-Luc Descotes, François Rozet, Jean-Baptiste Beauval, Ambroise Salin, Morgan Rouprêt
BACKGROUND: Recent guidelines favor transperineal (TP) prostate biopsies over the transrectal (TR) approach due to a reduced sepsis risk. Yet, evidence from controlled trial comparing both approaches within the MRI-targeted pathway for significant prostate cancer (PCa) detection is lacking. OBJECTIVE: To compare the significant PCa detection rate between magnetic resonance imaging (MRI)-targeted TR and TP approaches in biopsy-naïve patients. DESIGN, SETTING, AND PARTICIPANTS: In this noninferiority controlled trial, we randomized (ratio 1:1) 270 MRI-positive biopsy-naïve patients...
February 24, 2024: European Urology Oncology
https://read.qxmd.com/read/38403429/appraisal-of-australian-and-new-zealand-paediatric-sepsis-guidelines
#31
JOURNAL ARTICLE
Rosemary Sasse, Meredith L Borland, Shane George, Shefali Jani, Eunicia Tan, Jocelyn Neutze, Natalie Phillips, Amit Kochar, Simon Craig, Anna Lithgow, Arjun Rao, Stuart R Dalziel, Amanda Williams, Franz E Babl, Grace Went, Elliot Long
OBJECTIVE: Clinical practice guidelines (CPGs) are an important tool for the management of children with sepsis. The quality, consistency and concordance of Australian and New Zealand (ANZ) childhood sepsis CPGs with the Australian Commission on Safety and Quality in Healthcare (ACSQHC) sepsis clinical care standards and international sepsis guidelines is unclear. METHODS: We accessed childhood sepsis CPGs for all ANZ states and territories through Paediatric Research in Emergency Departments International Collaborative members...
February 25, 2024: Emergency Medicine Australasia: EMA
https://read.qxmd.com/read/38402175/aetiology-and-use-of-antibiotics-in-pregnancy-related-infections-results-of-the-who-global-maternal-sepsis-study-gloss-1-week-inception-cohort
#32
JOURNAL ARTICLE
Carolina C Ribeiro-do-Valle, Mercedes Bonet, Vanessa Brizuela, Edgardo Abalos, Adama Baguiya, Fernando Bellissimo-Rodrigues, Mihaela Budianu, Lucian Puscasiu, Marian Knight, David Lissauer, Catherine Dunlop, Shevin T Jacob, Sadia Shakoor, Luis Gadama, Bouchra Assarag, João Paulo Souza, Jose G Cecatti
BACKGROUND: Pregnancy-related infections are important contributors to maternal sepsis and mortality. We aimed to describe clinical, microbiological characteristics and use of antibiotics by source of infection and country income, among hospitalized women with suspected or confirmed pregnancy-related infections. METHODS: We used data from WHO Global Maternal Sepsis Study (GLOSS) on maternal infections in hospitalized women, in 52 low-middle- and high-income countries conducted between November 28th and December 4th, 2017, to describe the frequencies and medians of maternal demographic, obstetric, and clinical characteristics and outcomes, methods of infection diagnosis and causative pathogens, of single source pregnancy-related infection, other than breast, and initial use of therapeutic antibiotics...
February 24, 2024: Annals of Clinical Microbiology and Antimicrobials
https://read.qxmd.com/read/38398420/updated-clinical-practice-guidelines-in-resuscitation-and-the-management-of-respiratory-distress-syndrome-in-extremely-preterm-infants-during-two-epochs-in-romania-impact-on-outcomes
#33
JOURNAL ARTICLE
Manuela Cucerea, Marta Simon, Mădălina Anciuc-Crauciuc, Raluca Marian, Monika Rusneac, Maria Livia Ognean
BACKGROUND: Adequate perinatal management is essential in caring for extremely preterm (EP) infants. We aimed to evaluate and compare the impact of different protocols on short-term outcomes. METHODS: A retrospective study was conducted on EP infants in a Romanian perinatal tertiary center during 2008-2012 and 2018-2022. RESULTS: Data on 270 EP infants (121 in period I, 149 in period II) were analyzed collectively and stratified into two subgroups by gestational age...
February 15, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38392609/challenges-in-septic-shock-from-new-hemodynamics-to-blood-purification-therapies
#34
REVIEW
Fernando Ramasco, Jesús Nieves-Alonso, Esther García-Villabona, Carmen Vallejo, Eduardo Kattan, Rosa Méndez
Sepsis and septic shock are associated with high mortality, with diagnosis and treatment remaining a challenge for clinicians. Their management classically encompasses hemodynamic resuscitation, antibiotic treatment, life support, and focus control; however, there are aspects that have changed. This narrative review highlights current and avant-garde methods of handling patients experiencing septic shock based on the experience of its authors and the best available evidence in a context of uncertainty. Following the first recommendation of the Surviving Sepsis Campaign guidelines, it is recommended that specific sepsis care performance improvement programs are implemented in hospitals, i...
February 3, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38392582/decrease-in-mortality-after-the-implementation-of-a-hospital-model-to-improve-performance-in-sepsis-care-princess-sepsis-code
#35
JOURNAL ARTICLE
Rosa Méndez, Angels Figuerola, Fernando Ramasco, Marta Chicot, Natalia F Pascual, Íñigo García, Andrés von Wernitz, Nelly D Zurita, Auxiliadora Semiglia, Alberto Pizarro, Carmen Saez, Diego Rodríguez
Sepsis is a time-dependent disease whose prognosis is influenced by early diagnosis and therapeutic measures. Mortality from sepsis remains high, and for this reason, the guidelines of the Surviving Sepsis Campaign recommend establishing specific care programs aimed at patients with sepsis. We present the results of the application of a hospital model to improve performance in sepsis care, called Princess Sepsis Code , with the aim of reducing mortality. A retrospective study was conducted using clinical, epidemiological, and outcome variables in patients diagnosed with sepsis from 2015 to 2022...
January 29, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38391573/catastrophic-streptococcus-pyogenes-disease-a-personalized-approach-based-on-phenotypes-and-treatable-traits
#36
JOURNAL ARTICLE
Juan Carlos Ruiz-Rodríguez, Luis Chiscano-Camón, Carolina Maldonado, Adolf Ruiz-Sanmartin, Laura Martin, Ivan Bajaña, Juliana Bastidas, Rocio Lopez-Martinez, Clara Franco-Jarava, Juan José González-López, Vicent Ribas, Nieves Larrosa, Jordi Riera, Xavier Nuvials-Casals, Ricard Ferrer
Streptococcal toxic shock syndrome (STTS) is a critical medical emergency marked by high morbidity and mortality, necessitating swift awareness, targeted treatment, and early source control due to its rapid symptom manifestation. This report focuses on a cohort of 13 patients admitted to Vall d'Hebron University Hospital Intensive Care Unit, Barcelona, from November 2022 to March 2023, exhibiting invasive Streptococcus pyogenes infections and meeting institutional sepsis code activation criteria. The primary infections were community-acquired pneumonia (61...
February 15, 2024: Antibiotics
https://read.qxmd.com/read/38389624/caudal-neuraxial-blocks-for-pain-relief-from-pelvic-neuropathy-caused-by-extensive-diffuse-large-b-cell-lymphoma
#37
Amanda Myles, Ammar Toubasi, Elizabeth Soladoye, Narayana Gowda, Joan Morny
Central neuraxial blocks can be a vital therapeutic tool for neuropathic pain, but they are infrequently implemented for pain management in cancer patients. Upon a literature review, further data on the role or efficacy of central nerve blocks for neuropathic cancer pain would be beneficial. Additionally, evidence-based guidelines and practices are lacking regarding additional interventions for neuropathic pain relief, a common manifestation of cancer burden. Here, we report the case of a 29-year-old male patient who presented in the ED with intractable neuropathic pain from extensive diffuse large B-cell lymphoma...
January 2024: Curēus
https://read.qxmd.com/read/38385415/acute-kidney-injury-among-covid-19-positive-patients-is-associated-with-higher-mortality-a-single-center-experience
#38
JOURNAL ARTICLE
Torki Al Otaibi, Ayman Nagib, Prasad Nair, Medhat A Halim, Mahmoud Khaled, Mohamed A Hammad, Tarek S Mahmoud, Islam Sobhy, Zakaria Zakaria, Ahmed Atta, Ahmed Deraz, Ahmed Mostafa, Mohamed Abuelmagd, Mohamed Shaker, Nabil Alserwy, Zoheer Fyyad, Suzann Rida, Hasaneen Aboatya, Mohamed Adel, Mohamed Balaha, Khaled Atea, Osama Gheith
OBJECTIVES: Renal complications of COVID-19 are not yet well studied. We aimed to evaluate acute kidney injury prevalence among hospitalized patients with COVID-19 infection and explore its effect on patient outcomes. MATERIALS AND METHODS: We retrospectively evaluated 586 hospitalized patients with COVID-19. Of these patients, 267 (45.5%) developed acute kidney injury, as classified according to the Kidney Disease Improving Global Outcomes guidelines. We compared this group with 319 patients (54...
January 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38383127/chronic-diarrhoea-due-to-trichohepatoenteric-syndrome-thes-in-an-infant
#39
JOURNAL ARTICLE
Shruthi Kumar Bharadwaj, Sheila Samanta Mathai, Smriti Bhargava, Leslie Edward S Lewis
An infant was admitted with suspected postinfectious malabsorption with watery diarrhoea, fever and failure to thrive. She had dehydration, acute kidney injury and metabolic acidosis, which were corrected with intravenous fluids and managed with empiric antibiotics and prophylactic antifungals. She also developed Escherichia coli sepsis, meningitis and Candida skin infections during hospitalisation, which were treated according to the culture reports. Intrauterine growth restriction, woolly hair and a broad nasal bridge with chronic refractory diarrhoea prompted genetic testing to rule out syndromic diarrhoea...
February 21, 2024: BMJ Case Reports
https://read.qxmd.com/read/38380927/use-of-the-sepsis-risk-calculator-in-belgian-newborns-a-retrospective-cohort-study
#40
JOURNAL ARTICLE
Bianca I Langer, Anne-Britt Johansson, Karin Mathé, Sarah Jourdain, Pierre R Smeesters
BACKGROUND: Prevention of early-onset neonatal sepsis (EONS) is a frequent reason why many newborns receive unnecessary antibiotics. The Sepsis Risk Calculator (SRC) was developed by the Kaiser Permanente Institute as a multivariate risk assessment of EONS, aiming to reduce laboratory testing and empiric neonatal antibiotic therapy. Our objective was to assess the potential of the SRC in reducing antibiotic use in our setting. METHODS: Late preterm and term newborns who received antibiotics from 2019 to 2020 in a tertiary Belgian hospital were included...
February 21, 2024: Pediatric Infectious Disease Journal
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