Ege A Yalcinbas, Bukola Ajanaku, Erik D Nelson, Renee Garcia-Flores, Kelsey D Montgomery, Joshua M Stolz, Joshua Wu, Heena R Divecha, Atharv Chandra, Rahul A Bharadwaj, Svitlana Bach, Anandita Rajpurohit, Ran Tao, Joo-Heon Shin, Joel E Kleinman, Thomas M Hyde, Daniel R Weinberger, Louise A Huuki-Myers, Leonardo Collado-Torres, Kristen R Maynard
IMPORTANCE: Habenula (Hb) pathophysiology is involved in many neuropsychiatric disorders, including schizophrenia. Deep brain stimulation and pharmacological targeting of the Hb are emerging as promising therapeutic treatments. However, little is known about the cell type-specific transcriptomic organization of the human Hb or how it is altered in schizophrenia. OBJECTIVE: To define the molecular neuroanatomy of the human habenula and identify transcriptomic changes in individuals with schizophrenia compared to neurotypical controls...
February 27, 2024: bioRxiv