Brian Korniski, Arthur J Wittwer, Thomas L Emmons, Troii Hall, Stacy Brown, Ann D Wrightstone, Jeffrey L Hirsch, Jennifer A Gormley, Robin A Weinberg, Joseph W Leone, Jacqueline E Day, Jill E Chrencik, Cynthia D Sommers, H David Fischer, Alfredo G Tomasselli
The Janus kinase family consists of four members: JAK-1, -2, -3 and TYK-2. While JAK-2 and JAK-3 have been well characterized biochemically, there is little data on TYK-2. Recent work suggests that TYK-2 may play a critical role in the development of a number of inflammatory processes. We have carried out a series of biochemical studies to better understand TYK-2 enzymology and its inhibition profile, in particular how the TYK-2 phosphorylated forms differ from each other and from the other JAK family members...
May 28, 2010: Biochemical and Biophysical Research Communications