Zhi Ma, Renjie Chang, Linjiang Zhu, Dianhao Zhu, Yanfeng Deng, Xinying Guo, Ziyi Cheng, Xiaolong Chen
Ectoine is a compatible solute that functions as a cell protector from various stresses, protecting cells and stabilizing biomolecules, and is widely used in medicine, cosmetics, and biotechnology. Microbial fermentation has been widely used for the large-scale production of ectoine, and a number of fermentation strategies have been developed to increase the ectoine yield, reduce production costs, and simplify the production process. Here, Corynebacterium glutamicum was engineered for ectoine production by heterologous expression of the ectoine biosynthesis operon ectBAC gene from Halomonas elongata , and a series of genetic modifications were implemented...
April 12, 2024: ACS Synthetic Biology