Avian virus

Dejian Liu, Huijun Zheng, Yaqian Li, Peng Zhou, Hui Jin, Rui Luo
Janus kinase 1 (JAK1) is a member of JAK family of non-receptor protein tyrosine kinases that plays critical roles in transducing cytokine signals via JAK-signal transducer and activator of transcription (STAT) signaling pathway. The importance of JAK1 in innate immunity has been well-studied in mammals and fish, yet in avian remains largely unknown. Here, we cloned the full-length of the duck JAK1 (duJAK1) gene for the first time. DuJAK1 encoded a protein of 1152 amino acids and possessed high amino acid identity with goose and budgerigar JAK1s...
November 13, 2019: Molecular Immunology
Maki Kiso, Seiya Yamayoshi, Yuri Furusawa, Masaki Imai, Yoshihiro Kawaoka
Viral neuraminidase inhibitors show limited efficacy in mice infected with H7N9 influenza A viruses isolated from humans. Although baloxavir marboxil protected mice from lethal challenge infection with a low pathogenic avian influenza H7N9 virus isolated from a human, its efficacy in mice infected with a recent highly pathogenic version of H7N9 human isolates is unknown. Here, we examined the efficacy of baloxavir marboxil in mice infected with a highly pathogenic human H7N9 virus, A/Guangdong/17SF003/2016...
November 15, 2019: Viruses
Marisa Peyre, Linda Hoinville, James Njoroge, Angus Cameron, Daniel Traon, Flavie Goutard, Clémentine Calba, Vladimir Grosbois, Alexis Delabouglise, Viktor Varant, Julian Drewe, Dirk Pfeiffer, Barbara Häsler
Information about infectious diseases at the global level relies on effective, efficient and sustainable national and international surveillance systems. Surveillance systems need to be regularly evaluated to ensure their performance, the quality of the data and information provided, as well as to allocate resources efficiently. Currently available frameworks for evaluation of surveillance systems in animal or human health often treat technical, process and socio-economic aspects separately instead of integrating them...
September 18, 2019: Preventive Veterinary Medicine
Matthew W Hopken, Antoinette J Piaggio, Kristy L Pabilonia, James Pierce, Theodore Anderson, Zaid Abdo
Long-term viral archives are valuable sources of research data. Each archive can store hundreds of thousands of diverse sample types. In the current era of whole genome sequencing, archived samples become a rich source of evolutionary and epidemiological data that can span years, and even decades. However, the ability to obtain high quality viral whole genome sequences from samples of various types, age, and quality is inconsistent. A minimum quality threshold that helps predict the best success of obtaining high quality genomic sequences for both recent and archived samples is highly valuable...
November 12, 2019: Journal of Virological Methods
Zhihao Wang, Jiakun Zuo, Jiansen Gong, Jiangang Hu, Wei Jiang, Rongsheng Mi, Yan Huang, Zhaoguo Chen, Vanhnaseng Phouthapane, Kezong Qi, Chen Wang, Xiangan Han
Escherichia coli, Pasteurella multocida, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella spp. and Staphylococcus aureus are six bacterial pathogens of avian. However, these pathogens may cause many similar pathological changes, resulting in clinical isolates that are difficult to quickly and simultaneously detect and identify. Here, a multiplex polymerase chain reaction (m-PCR) assay is reported to rapidly identify targets genes (phoA, KMT1, ureR, toxA, invA, and nuc) of these six pathogens in clinical samples...
November 14, 2019: AMB Express
Ruiyun Li, Tao Zhang, Jian Xu, Jianyu Chang, Bing Xu
Here, we report the detection of a reassortant avian influenza A(H3N8) virus isolated from a wild bird in Poyang Lake, Jiangxi, China, in 2014. Phylogenetic analyses indicated that this virus is most likely derived from the Eurasian-origin H3Ny and HxN8 viruses and two strains endemic to China, namely, H5N1 and H5N6.
November 14, 2019: Microbiology Resource Announcements
Myeongji Cho, Hayeon Kim, Hyeon S Son
BACKGROUND: Polyomaviruses (PyVs) have a wide range of hosts, from humans to fish, and their effects on hosts vary. The differences in the infection characteristics of PyV with respect to the host are assumed to be influenced by the biochemical function of the LT-Ag protein, which is related to the cytopathic effect and tumorigenesis mechanism via interaction with the host protein. METHODS: We carried out a comparative analysis of codon usage patterns of large T-antigens (LT-Ags) of PyVs isolated from various host species and their functional domains and sequence motifs...
November 14, 2019: Virology Journal
Ryota Tsunekuni, Taichiro Tanikawa, Takaaki Nakaya, Takehiko Saito
BACKGROUND: We have previously developed a recombinant avian avulavirus serotype 10 (rAAvV-10/HA) expressing the hemagglutinin (HA) gene of a highly pathogenic avian influenza virus (HPAIV) as an emergency vaccine for poultry. rAAvV-10/HA can overcome the activity of the anti-AAvV-1 (Newcastle disease virus) antibody acquired by commercial chickens upon routine vaccination. Most chickens do not have the anti-AAvV-10 antibody, which could interfere with the vaccine efficacy. However, the vaccine efficacy of rAAvV-10/HA is not satisfactory in chickens even though it affords protection against an HPAIV challenge...
November 9, 2019: Vaccine
Zhe Hu, Yiran Zhang, Zhen Wang, Jingjing Wang, Qi Tong, Mingyang Wang, Honglei Sun, Juan Pu, Changqing Liu, Jinhua Liu, Yipeng Sun
BACKGROUND: H9N2 influenza viruses continuously circulate in multiple avian species and are repeatedly transmitted to humans, posing a significant threat to public health. To investigate the adaptation ability of H9N2 avian influenza viruses (AIVs) to mammals and the mutations related to the host switch events, we serially passaged in mice two H9N2 viruses of different HA lineages - A/Quail/Hong Kong/G1/97 (G1) of the G1-like lineage and A/chicken/Shandong/ZB/2007 (ZB) of the BJ/94-like lineage -and generated two mouse-adapted H9N2 viruses (G1-MA and ZB-MA) that possessed significantly higher virulence than the wide-type viruses...
November 12, 2019: Virology Journal
Yassmin Moatasim, Ahmed Kandeil, Basma Emad Aboulhoda, Rabeh El-Shesheny, Maha Alkhazindar, Elsayed Tarek AbdElSalam, Omnia Kutkat, Mina Nabil Kamel, Ahmed Nageh El Taweel, Ahmed Mostafa, Joseph T Hicks, Sary Khaleel Abd Elghaffar, Ghazi Kayali, Mohamed Ahmed Ali
The surveillance and virological characterization of H5N8 avian influenza viruses are important in order to assess their zoonotic potential. The genetic analyses of the Egyptian H5N8 viruses isolated through active surveillance in wild birds and domestic poultry in the winter of 2016/2017 showed multiple introductions of reassortant viruses. In this study, we investigated and compared the growth kinetics, infectivity, and pathogenicity of the three reassortant forms of H5N8 viruses detected in wild birds and domestic poultry in Egypt during the first introduction wave in the winter of 2016/2017...
October 27, 2019: Viruses
Yafen Song, Weiqiang Li, Wenbo Wu, Zhiting Liu, Zhuoliang He, Zuxian Chen, Bingbing Zhao, Siyu Wu, Chenghuai Yang, Xiaoyun Qu, Ming Liao, Peirong Jiao
H5Nx viruses have continuously emerged in the world, causing poultry industry losses and posing a potential public health risk. Here, we studied the phylogeny, pathogenicity, transmission, and immune response of four H5N6 avian influenza viruses in chickens and mice, which were isolated from waterfowl between 2013 and 2014. Their HA genes belong to Clade, circulated in China since 2008. Their NA genes fall into N6-like/Eurasian sublineage. Their internal genes originated from different H5N1 viruses...
November 10, 2019: Viruses
Seon-Ju Yeo, Duc-Duong Than, Hong-Seog Park, Haan Woo Sung, Hyun Park
A novel avian influenza virus (A/wild duck/Korea/K102/2018) (H2N9) was isolated from wild birds in South Korea in 2018, and phylogenetic and molecular analyses were conducted on complete gene sequences obtained by next-generation sequencing. Phylogenetic analysis indicated that the hemagglutinin (HA) and neuraminidase (NA) genes of the A/wild duck/Korea/K102/2018 (H2N9) virus belonged to the Eurasian countries, whereas other internal genes (polymerase basic protein 1 (PB1), PB2, nucleoprotein (NP), polymerase acidic protein (PA), matrix protein (M), and non-structural protein (NS)) belonged to the East Asian countries...
November 10, 2019: Viruses
Hao Yu, Kunpeng Zhang, Xumeng Ye, Wenqing Wang, Wenbo Wu, Xia Wang, Yun Guan, Zhuoliang He, Yong Wang, Peirong Jiao
There were five outbreaks of H7N9 influenza virus in humans in China since it emerged in 2013, infecting >1000 people. The H7N9 low pathogenic influenza virus was inserted into four amino acids in the HA protein cleavage site to mutate into the H7N9 highly pathogenic virus. This emerging virus caused 15 outbreaks in chickens from the end of 2016 to date. Two H7N9 avian influenza virus (AIV) strains, A/chicken/Guangdong/A46/2013 (LPAIV) and A/chicken/Guangdong/Q29/2017 (HPAIV), were selected to compare the pathogenicity and transmissibility between H7N9 LPAIVs and HPAIVs in chickens...
November 10, 2019: Viruses
Hailiang Sun, Jiate Lin, Zhiting Liu, Yanan Yu, Meihua Wu, Shuo Li, Yang Liu, Yaling Feng, Yuqian Wu, Mingliang Li, Peirong Jiao, Kaijian Luo, Ming Liao
The prevalence and variation of the H9N2 avian influenza virus (AIV) pose a threat to public health. A total of eight viruses isolated from farmed poultry in South China during 2017-2018 were selected as representative strains for further systematic study. Phylogenetic analyses indicated that these prevalent viruses belong to the Y280-like lineage and that the internal genes are highly similar to those of recently circulating human H7N9 viruses. The receptor-binding assay showed that most of the H9N2 isolates preferentially bound to the human-like receptor, increasing the risk of them crossing the species barrier and causing human infection...
November 8, 2019: Viruses
Suchun Wang, Baoxu Huang, Xuejun Ma, Ping Liu, Yang Wang, Xiaoguang Zhang, Lin Zhu, Qingying Fan, Yawei Sun, Kaicheng Wang
H7 subtype avian influenza virus infection is an emerging zoonosis in some Asian countries and an important avian disease worldwide. A rapid and simple test is needed to confirm infection in suspected cases during disease outbreaks. In this study, we developed a reverse transcription recombinase-aided amplification assay for the detection of H7 subtype avian influenza virus. Assays were performed at a single temperature (39°C) and the results were obtained within 20 min. The assay showed no cross-detection with Newcastle disease virus or infectious bronchitis virus, which are the other main respiratory viruses affecting birds...
November 12, 2019: Transboundary and Emerging Diseases
Denys Muzyka, Oleksandr Rula, Semen Tkachenko, Nataliia Muzyka, Susanne Köthe, Oleksandr Pishchanskyi, Borys Stegniy, Mary Pantin-Jackwood, Martin Beer
There have been three waves of highly pathogenic avian influenza (HPAI) outbreaks in commercial, backyard poultry, and wild birds in Ukraine. The first (2005-2006) and second (2008) waves were caused by H5N1 HPAI virus, with 45 outbreaks among commercial poultry (chickens) and backyard fowl (chickens, ducks, and geese) in four regions of Ukraine (AR Crimea, Kherson, Odesa, and Sumy Oblast). H5N1 HPAI viruses were isolated from dead wild birds: cormorants ( Phalacrocorax carbo ) and great crested grebes ( Podiceps cristatus ) in 2006 and 2008...
March 1, 2019: Avian Diseases
Hesham A Sultan, Abd-Elsatar Arafa, Shaimaa Talaat, Alaa A Gaballa, Walid H Kilany, Wael K Elfeil, Awad A Shehata, N Amarin
In late 2016, a highly pathogenic avian influenza (HPAI) virus subtype H5N8 clade was reported in Egypt in migratory birds; subsequently, the virus spread to backyard and commercial poultry in several Egyptian governorates, causing severe economic losses to the poultry industry. Here, a recombinant subunit commercial H5 vaccine prepared from the clade 2.3.2 H5 segment on baculovirus was evaluated in Pekin ducks ( Anasplatyrhynchos domesticus ) and Muscovy ducks ( Cairina moschata ) in Biosafety Level 3 isolators by using two vaccination regimes: either a single dose on day 10 and a challenge on day 31 or a double dose on days 10 and 28 and a challenge on day 49...
March 1, 2019: Avian Diseases
Walaa F Awadin, Abdelfattah H Eladl, Reham A El-Shafei, Mohamed A El-Adl, Abeer E Aziza, Hanaa S Ali, Mohamed A Saif
This study was performed to evaluate the effects of omega-3 supplementation on growth performance, clinical signs, post-mortem lesions, haemagglutination inhibition (HI) antibody titres, gene expression and histopathology in quails (Coturnix coturnix japonica) infected with Newcastle disease virus (NDV) and avian influenza virus (AIV) H9N2. One hundred, 40-day-old male quails were divided into 5 groups: G1, fed a control basal diet; G2A, infected with NDV; G2B, infected with H9N2; G3A, infected with NDV and given omega-3, and G3B, infected with H9N2 and given omega-3...
November 8, 2019: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
Alejandro Marín-López, Natalia Barreiro-Piñeiro, Sergio Utrilla-Trigo, Diego Barriales, Javier Benavente, Aitor Nogales, José Martínez-Costas, Javier Ortego, Eva Calvo-Pinilla
African horse sickness virus (AHSV) is an insect-borne pathogen that causes acute disease in horses and other equids. In an effort to improve the safety of currently available vaccines and to acquire new knowledge about the determinants of AHSV immunogenicity, new generation vaccines are being developed. In this work we have generated and tested a novel immunization approach comprised of nonstructural protein 1 (NS1) of AHSV serotype 4 (AHSV-4) incorporated into avian reovirus muNS protein microspheres (MS-NS1) and/or expressed using recombinant modified vaccinia virus Ankara vector (MVA-NS1)...
November 7, 2019: Vaccine
Alita Kongchanagul, Karnyart Samnuan, Ponthip Wirachwong, Somchaiya Surichan, Pilaipan Puthavathana, Punnee Pitisuttithum, Kobporn Boonnak
BACKGROUND: The emergence and spread of highly pathogenic avian influenza (H5N1) viruses have raised global concerns of a possible human pandemic, spurring efforts towards H5N1 influenza vaccine development and improvements in vaccine administration methods. We previously showed that a prime-boost vaccination strategy induces robust and broadly cross-reactive antibody responses against the hemagglutinin globular head domain. Here, we specifically measure antibodies against the conserved hemagglutinin stem region in serum samples obtained from the prior study to determine whether stalk-reactive antibodies can also be induced by the prime-boost regimen...
November 7, 2019: Vaccine
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"