Agnes Purwidyantri, Sarah Azinheiro, Aitor García Roldán, Tereza Jaegerova, Adriana Vilaça, Rofer Machado, M Fátima Cerqueira, Jérôme Borme, Telma Domingues, Marco Martins, Pedro Alpuim, Marta Prado
Identifying grape varieties in wine, related products, and raw materials is of great interest for enology and to ensure its authenticity. However, these matrices' complexity and low DNA content make this analysis particularly challenging. Integrating DNA analysis with 2D materials, such as graphene, offers an advantageous pathway toward ultrasensitive DNA detection. Here, we show that monolayer graphene provides an optimal test bed for nucleic acid detection with single-base resolution. Graphene's ultrathinness creates a large surface area with quantum confinement in the perpendicular direction that, upon functionalization, provides multiple sites for DNA immobilization and efficient detection...
January 19, 2023: ACS Sensors