Hanaa Skhoun, Meriem El Fessikh, Mohamed El Alaoui Al Abdallaoui, Mohammed Khattab, Aziza Belkhayat, Zahra Takki Chebihi, Amale Hassani, Rachid Abilkassem, Aomar Agadr, Nadia Dakka, Jamila El Baghdadi
BACKGROUND: Recurrent genetic abnormalities affecting pivotal signaling pathways are the hallmark of childhood acute lymphoblastic leukemia (ALL). The identification of these aberrations remains clinically important. Therefore, we sought to determine the cytogenetic profile and the mutational status of TP53 and RAS genes among Moroccan childhood cases of ALL. METHODS: In total, 35 patients with childhood ALL were enrolled in the study. The diagnosis and treatment were established in the Pediatric Hematology and Oncology Center at the Children's Hospital of Rabat...
April 27, 2024: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie