Eva Cabrera-Romero, Juan Pablo Ochoa, Roberto Barriales-Villa, Francisco José Bermúdez-Jiménez, Vicente Climent-Payá, Esther Zorio, María Angeles Espinosa, María Gallego-Delgado, Marina Navarro-Peñalver, Xabier Arana-Achaga, Jesús Piqueras-Flores, Victoria Espejo-Bares, José F Rodríguez-Palomares, Gemma Lacuey-Lecumberri, Javier López, Coloma Tiron, María Luisa Peña-Peña, Jose M García-Pinilla, Rebeca Lorca, Tomas Ripoll-Vera, Carles Díez-López, María Victoria Mogollon, Ana García-Álvarez, Luis Martínez-Dolz, María Brion, Jose María Larrañaga-Moreira, Juan Jiménez-Jáimez, María Isabel García-Álvarez, Silvia Vilches, Eduardo Villacorta, María Sabater-Molina, Itziar Solla-Ruiz, Ana Royuela, Fernando Domínguez, Jesús G Mirelis, Pablo Garcia-Pavia
BACKGROUND: Disease penetrance in genotype-positive (G+) relatives of families with dilated cardiomyopathy (DCM) and the characteristics associated with DCM onset in these individuals are unknown. OBJECTIVES: This study sought to determine the penetrance of new DCM diagnosis in G+ relatives and to identify factors associated with DCM development. METHODS: The authors evaluated 779 G+ patients (age 35.8 ± 17.3 years; 459 [59%] females; 367 [47%] with variants in TTN) without DCM followed at 25 Spanish centers...
April 30, 2024: Journal of the American College of Cardiology