Kai-Yu Huang, Gaurav Upadhyay, Yujin Ahn, Masayoshoi Sakakura, Gelson J Pagan-Diaz, Younghak Cho, Amanda C Weiss, Chen Huang, Jennifer W Mitchell, Jiahui Li, Yanqi Tan, Yu-Heng Deng, Austin Ellis-Mohr, Zhi Dou, Xiaotain Zhang, Sehong Kang, Qian Chen, Jonathan V Sweedler, Sung Gap Im, Rashid Bashir, Hee Jung Chung, Gabriel Popescu, Martha U Gillette, Mattia Gazzola, Hyunjoon Kong
Myokines and exosomes, originating from skeletal muscle, are shown to play a significant role in maintaining brain homeostasis. While exercise has been reported to promote muscle secretion, little is known about the effects of neuronal innervation and activity on the yield and molecular composition of biologically active molecules from muscle. As neuromuscular diseases and disabilities associated with denervation impact muscle metabolism, we hypothesize that neuronal innervation and firing may play a pivotal role in regulating secretion activities of skeletal muscles...
May 7, 2024: Proceedings of the National Academy of Sciences of the United States of America