Halim Awadie, Amir Klein, David Tate, Bilel Jideh, Iddo Bar-Yishai, Kathleen Goodrick, Golo Ahlenstiel, Michael J Bourke
BACKGROUND AND AIMS: Although sporadic duodenal and/or ampullary adenomas (DAs) are uncommon, they are increasingly diagnosed during upper endoscopy. These patients have a 3- to 7-fold increased risk of colonic neoplasia as compared with the normal population. It is unknown, however, whether they also have an increased risk of additional small-bowel (SB) polyps. Our aim was to establish the prevalence of small-bowel (SB) polyps in patients with DA. METHODS: In a single-center, prospective study, we used video capsule endoscopy (VCE) to investigate the prevalence of SB polyps in patients with a DA compared with patients undergoing VCE for obscure gastrointestinal bleeding (OGIB) or iron deficiency anemia (IDA)...
July 24, 2020: Gastrointestinal Endoscopy
Nicole L Stone, Alexandra J Murphy, Timothy J England, Saoirse E O'Sullivan
Embase and Pubmed were systematically searched for articles addressing the neuroprotective properties of phytocannabinoids, aside from cannabidiol and Δ9 -tetrahydrocannabinol, including Δ9 -tetrahydrocannabinolic acid (Δ9 -THCA), Δ9 -tetrahydrocannabivarin (Δ9 -THCV), cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabichromene (CBC), cannabichromenic acid (CBCA), cannabichromevarin (CBCV), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabigerivarin (CBGV), cannabigerovarinic acid (CBGVA), cannabichromevarinic acid (CBCVA) cannabidivarinic acid (CBDVA) and cannabinol (CBN)...
July 1, 2020: British Journal of Pharmacology
Carmen Navarrete, Adela García-Martin, Martín Garrido-Rodríguez, Leyre Mestre, Ana Feliú, Carmen Guaza, Marco A Calzado, Eduardo Muñoz
Multiple Sclerosis (MS) is characterized by a combination of inflammatory and neurodegenerative processes in the spinal cord and the brain. Natural and synthetic cannabinoids such as VCE-004.8 have been studied in preclinical models of MS and represent promising candidates for drug development. VCE-004.8 is a multitarget synthetic cannabidiol (CBD) derivative acting as a dual Peroxisome proliferator-activated receptor-gamma/Cannabinoid receptor type 2 (PPARγ/CB2 ) ligand agonist that also activates the Hypoxia-inducible factor (HIF) pathway...
June 26, 2020: Neurobiology of Disease
A O Akopova, O M Mikcheeva, P L Shcherbakov, A I Parfenov
The article describes clinical observations of helminthiasis detection in 18 of 208 patients during video capsule endoscopy (VCE). Indications for the appointment of VCE were complex clinical situations associated with the search for inflammatory diseases of the small intestine and sources of small intestine bleeding. Because of the high cost of VCE the diagnosis of parasitic diseases should be based on laboratory techniques in clinical practice. Only in case of anemia of unknown etiology VCE demonstrates high efficiency...
November 15, 2019: Terapevticheskiĭ Arkhiv
Hyoung-Geun Kim, Young Sung Jung, Seon Min Oh, Hyun-Ji Oh, Jung-Hwan Ko, Dae-Ok Kim, Se Chan Kang, Yeong-Geun Lee, Dae Young Lee, And Nam-In Baek
(1) Background: Many flavonoids derived from natural sources have been reported to exhibit antioxidant and anti-inflammatory effects. Our preliminary study suggested that Coreopsis lanceolata flowers (CLFs) include high flavonoid content; (2) Methods: CLFs were extracted in 80% (v/v) aqueous methanol and fractionated into ethyl acetate, n -butanol, and water fractions. Repeated column chromatographies for the organic fractions led to the isolation of seven flavanones. Quantitative analysis of the flavanones was carried out using reversed-phase high-performance liquid chromatography...
June 19, 2020: Antioxidants (Basel, Switzerland)
Yuemei Xu, Yingjie Wu, Zhenzhen Dai, Feizhen Xia, Feng Xu
BACKGROUND: Blue rubber bleb nevus syndrome (BRBNS) is a rare congenital disease characterized by multifocal venous malformations. It remains a considerable challenge in treating the gastrointestinal (GI) venous malformations due to multiple lesions throughout the GI tract, and the likelihood of recurrence. We report a case study of BRBNS in the GI tract, in which GI venous malformations and related GI bleeding were successfully treated with a combination of multiple endoscopic procedures...
June 10, 2020: BMC Gastroenterology
André Artan Kharazmi, Saeid Aslani, Malene Fey Kristiansen, Eva Efsen Dahl, Mark Berner-Hansen
BACKGROUND: Indications and diagnostic yield of small-bowel video capsule endoscopy (SB-VCE) are communicated in recent clinical academic guidelines. However, guidelines are based mainly on relatively few, small, selection-biased studies at experienced centers, and thus we lack information on indications and diagnostic yield of SB-VCE in the real-world community setting. The aim of the study was to evaluate indications and diagnostic yield of SB-VCE in the real-world community setting...
June 8, 2020: BMC Gastroenterology
Abdirahman Elmi, Rosella Spina, Arnaud Risler, Stéphanie Philippot, Ali Mérito, Raphaël E Duval, Fatouma Mohamed Abdoul-Latif, Dominique Laurain-Mattar
Water extract of Acacia seyal bark is used traditionally by the population in Djibouti for its anti-infectious activity. The evaluation of in vitro antibacterial, antioxidant activities and cytotoxicity as well as chemical characterization of Acacia seyal bark water and methanolic extracts were presented. The water extract has a toxicity against the MRC-5 cells at 256 μg/mL while the methanolic extract has a weak toxicity at the same concentration. The methanolic extract has a strong antioxidant activity with half maximal inhibitory concentration (IC50 ) of 150 ± 2...
May 21, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jie Wu, Zhiheng Huang, Ha Wu, Min Ji, Yuhuan Wang, Zifei Tang, Ying Huang
BACKGROUND: Meckel's diverticulum (MD) is the most common congenital anomaly of the gastrointestinal tract and is also an important cause of bloody stool and anemia in children. However, there are few data about video capsule endoscopy (VCE) for MD in children. This study aimed to evaluate the diagnostic value of VCE for MD in children. MATERIALS AND METHODS: children who underwent VCE for obscure gastrointestinal bleeding from October 1st 2015 to August 31st 2019 at the Children's Hospital of Fudan University were included in this retrospective study...
June 2020: Revista Española de Enfermedades Digestivas
Ricardo Hannum Resende, Igor Braga Ribeiro, Diogo Turiani Hourneaux de Moura, Facundo Galetti, Rodrigo Silva de Paula Rocha, Wanderley Marques Bernardo, Paulo Sakai, Eduardo Guimarães Hourneaux de Moura
Background and study aims  Ulcerative colitis (UC) and Crohn's disease (CD) have higher risk of colorectal cancer (CRC). Guidelines recommend dysplasia surveillance with dye-spraying chromoendoscopy (DCE). The aim of this systematic review and meta-analysis was to review all randomized clinical trials (RCTs) available and compare the efficacy of different endoscopic methods of surveillance for dysplasia in patients with UC and CD. Methods  Databases searched were Medline, EMBASE, Cochrane and SCIELO/LILACS...
May 2020: Endoscopy International Open
Nicholas Placone, Runalia Bahar, Surinder Mann
Background/Aims: Optimal small bowel (SB) preparation for video capsule endoscopy (VCE) is controversial. Our study aimed to support the use of a specified volume of 4 liters of clear liquids for bowel preparation for VCE. Methods: A retrospective review of 284 patients who underwent SB preparation with 2 liters of polyethylene glycol (PEG) and 284 patients who had 4 liters of clear liquid preparation. We analyzed image quality, endoscopic findings, completion rate, and transit times...
March 31, 2020: Clinical Endoscopy
Nidhi Shah, Chen Chen, Nataly Montano, David Cave, Rebecca Siegel, Nina T Gentile, Alexander T Limkakeng, Anita B Kumar, Yan Ma, Andrew C Meltzer
OBJECTIVE: The assessment of the severity of upper gastrointestinal hemorrhage in emergency department (ED) patients is difficult to assess with commonly available diagnostic tools. Small studies have shown that video capsule endoscopy (VCE) is a promising risk-stratification method and may be better than current clinical decision rules such as the Rockall score and the Glasgow Blatchford score. This review aims to assess the accuracy of VCE to detect active upper gastrointestinal hemorrhage compared to a reference standard...
June 2020: American Journal of Emergency Medicine
Mun Seob Ahn, Hyo Eun Lee, Kwang Soo Cheon, Huoung Gi Joo, Ochang Chemical Safety Community, Bu-Soon Son
To prevent chemical accidents, the United States (US), the European Union (EU), and the Republic of Korea operate legal systems, such as risk management plans (RMP) and process safety management (PSM), to prevent chemical accidents inside and outside the workplace. The duty to implement chemical accident prevention systems and the criteria for being a target workplace are dependent on the designated quantities of chemicals handled. A chemical accident prevention system is obligatory for storage and handling of legally declared chemicals in the workplace...
March 16, 2020: International Journal of Environmental Research and Public Health
Zihan Huang, Xiang Liu, Fei Yang, Guoxin Wang, Nan Ge, Sheng Wang, Jintao Guo, Siyu Sun
BACKGROUND: Owing to the development of double-balloon enteroscopy (DBE) and video capsule endoscopy (VCE) in recent years, direct visualization of the entire small intestinal mucosa has become possible. Because of the nonspecific symptoms and the anatomic location of the small bowel, diagnosis of isolated small bowel Crohn's disease (CD) remains a challenge. The aim of this research was to explore the value of DBE for isolated small bowel CD in situations where routine tests cannot confirm the diagnosis...
February 26, 2020: BMC Gastroenterology
Hyun Joo Song
For improved examination of video capsule endoscopy (VCE) and device-assisted enteroscopy (DAE), bowel preparation is an essential issue. Multiple factors like air bubbles, food material in the small bowel, and gastric and small bowel transit time affect the small bowel visualization quality (SBVQ), diagnostic yield (DY) and cecal completion rate (CR). Bowel preparation with polyethylene glycol (PEG) solution enhances SBVQ and DY, but it has no effect on CR. Bowel preparation with PEG solution 2 L is similar to PEG 4 L in SBVQ, DY, and CR...
February 25, 2020: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Dimitrios Papanagnou, Anne M Messman, Jeremy Branzetti, Gretchen Diemer, Cherri Hobgood, Laura R Hopson, Linda Regan, Xiao C Zhang, Michael A Gisondi
Objectives: Despite increasing prevalence in emergency medicine (EM), the vice chair of education (VCE) role remains ambiguous with regard to associated responsibilities and expectations. This study aimed to identify training experiences of current VCEs, clarify responsibilities, review career paths, and gather data to inform a unified job description. Methods: A 40-item, anonymous survey was electronically sent to EM VCEs. VCEs were identified through EM chairs, residency program directors, and residency coordinators through solicitation e-mails distributed through respective listservs...
February 2020: AEM Education and Training
Mohammed El-Dallal, Ye Chen, Qianyun Lin, Shana Rakowsky, Lindsey Sattler, Joshua Foromera, Laurie Grossberg, Adam S Cheifetz, Joseph D Feuerstein
BACKGROUND: Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer. We sought to assess the comparative efficacy of virtual chromoendoscopy (VCE) vs high definition white light endoscopy (HDWLE) or dye-spraying chromoendoscopy (DCE) through a meta-analysis and rating the quality of evidence. METHODS: A systematic review of the literature was performed through February 15, 2019. Primary outcomes were number of patients in whom dysplasia was identified and number of dysplastic lesions identified in these patients...
February 8, 2020: Inflammatory Bowel Diseases
Mari Hayashida, Jun Miyoshi, Tatsuya Mitsui, Miki Miura, Daisuke Saito, Akihito Sakuraba, Soko Kawashima, Noriko Ikegaya, Kazuhito Fukuoka, Miho Karube, Yoshinori Komagata, Shinya Kaname, Annabelle A Okada, Shunji Fujimori, Minoru Matsuura, Tadakazu Hisamatsu
BACKGROUND AND AIMS: Small intestinal lesions in patients with Behçet disease (BD) have a risk of perforation and hemorrhage requiring surgery. However, no screening strategy for such lesions has been established. We investigated small intestinal lesions in BD patients with video capsule endoscopy (VCE) and analyzed clinical characteristics to identify noninvasive biomarkers of such lesions. METHODS: This study included 33 BD patients who underwent VCE (PillCam® SB3) at our institution from June 2016 to January 2019...
January 30, 2020: Journal of Gastroenterology and Hepatology
Majid Alsahafi, Paula Cramer, Nazira Chatur, Fergal Donnellan
Background/Aim: There are limited data evaluating the impact of inpatient video capsule endoscopy (VCE) on the need for therapeutic interventions in hospitalized patients with obscure gastrointestinal bleeding (OGIB). The objective of this study was to determine the impact of inpatient VCE on the need for therapeutic interventions and rehospitalization for recurrent bleeding. Patients and Methods: Hospitalized patients who underwent VCE for OGIB indication were retrospectively included...
January 30, 2020: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Katherine Stewart, Ashwani Kumar Sharma
BACKGROUND: Gastrointestinal (GI) bleeding is a common patient presentation to the Emergency Department (ED) and the source can be difficult to diagnose. PROCEDURE: Computed tomography angiography (CTA) is a new but validated modality with high sensitivity and specificity for diagnosis and treatment of GI bleeds, especially in differentiating arterial from venous bleeding. With high reported validity of CTA, some studies have suggested its ability to better triage patients in the ED and impact ED workflow and resource utilization...
January 11, 2020: American Journal of Emergency Medicine
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