keyword
https://read.qxmd.com/read/38473363/pixelwise-gradient-model-with-gan-for-virtual-contrast-enhancement-in-mri-imaging
#1
JOURNAL ARTICLE
Ka-Hei Cheng, Wen Li, Francis Kar-Ho Lee, Tian Li, Jing Cai
Background : The development of advanced computational models for medical imaging is crucial for improving diagnostic accuracy in healthcare. This paper introduces a novel approach for virtual contrast enhancement (VCE) in magnetic resonance imaging (MRI), particularly focusing on nasopharyngeal cancer (NPC). Methods : The proposed model, Pixelwise Gradient Model with GAN for Virtual Contrast Enhancement (PGMGVCE), makes use of pixelwise gradient methods with Generative Adversarial Networks (GANs) to enhance T1-weighted (T1-w) and T2-weighted (T2-w) MRI images...
February 29, 2024: Cancers
https://read.qxmd.com/read/38463945/validation-of-a-model-estimating-the-budget-impact-of-video-capsule-endoscopy-for-surveillance-of-crohn-s-disease-in-an-italian-center
#2
JOURNAL ARTICLE
Rhodri Saunders, Carlo Calabrese, Dania Gelli, Jason Davis, Rafael Torrejon Torres
Background: Crohn's disease is a chronic ailment affecting the gastrointestinal tract. Mucosal healing, a marker of reduced disease activity, is currently assessed in the colonic sections using ileocolonoscopy and magnetic resonance enteroscopy. Video capsule endoscopy (VCE) offers visualization of the entire GI mucosae. Objective: To validate a Crohn's disease model estimating the budget impact of VCE compared with the standard of care (SOC) in Italy. Methods: A patient-level, discrete-event simulation was developed to estimate the budget impact of VCE compared with SOC for Crohn's disease surveillance over 5 years in the Italian setting...
2024: Journal of health economics and outcomes research
https://read.qxmd.com/read/38379541/characterization-antioxidant-and-antitumor-activities-of-phenolic-compounds-from-amomum-villosum-lour
#3
JOURNAL ARTICLE
Ming Zhang, Xi-Xiang Shuai, Zhi Wei, Tao-Tao Dai, Chang-Bin Wei, Ya Li, Jun-Jun He, Li-Qing Du
Amomum villosum Lour. ( A. villosum ), known as Sharen in China, is widely used for culinary and medicinal purposes due to containing a diverse set of bioactive compounds. In this study, the optimum ethanol extraction process was optimized and the composition and biological activities (antioxidant and antitumor) of five different fractions (dichloromethane, petroleum ether, ethyl acetate, n -butanol and H2 O) extracted from the ethanol extract of A. villosum were investigated. The results showed that the optimal extraction conditions were extraction temperature 80°C, extraction time 120 min, ethanol concentration 40% and solid-liquid ratio 1:25 g/mL...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38279072/psychiatry-vice-chairs-of-education-expected-and-actual-responsibilities-satisfaction-and-work-barriers
#4
JOURNAL ARTICLE
Kim-Lan T Czelusta, Nital P Appelbaum
OBJECTIVES: The current study investigated the gap between actual and expected work responsibilities of psychiatry vice chairs of education (VCEs), their work satisfaction, and perceived work barriers. METHODS: Psychiatry VCEs were identified through professional memberships and school websites within the USA. In 2021, identified VCEs were emailed an anonymous survey that was based on past research on roles and responsibilities of VCEs. Through qualitative and quantitative questions, the survey assessed demographic characteristics, actual and expected work responsibilities, work satisfaction, and work barriers during time spent in the VCE role...
January 26, 2024: Academic Psychiatry
https://read.qxmd.com/read/38227849/diagnostic-yield-of-small-bowel-videocapsule-endoscopy-in-patients-with-iron-deficiency-anemia-a-systematic-review-and-meta-analysis
#5
JOURNAL ARTICLE
Roberta Elisa Rossi, Angelo Zullo, Silvia Ferretti, Giulia Migliorisi, Luigi Gatta, Vincenzo De Francesco, Alessandro Del Forno, Giacomo Marcozzi, Benedetta Masoni, Gianluca Franchellucci, Cesare Hassan, Alessandro Repici
BACKGROUND AND AIM: Gastrointestinal (GI) bleeding or malabsorption represents the most frequent aetiologies of iron deficiency anemia (IDA). The cause of IDA remains undetermined in ~10% to 20% of patients undergoing upper and lower GI endoscopies. In this scenario, a small bowel examination with videocapsule endoscopy (VCE) is recommended. We performed a systematic review with meta-analysis to evaluate the diagnostic yield of VCE in patients with IDA without overt bleeding, assessing the prevalence of either any lesion or lesions at high potential of bleeding...
January 17, 2024: Journal of Clinical Gastroenterology
https://read.qxmd.com/read/38047221/a-potential-pitfall-and-clinical-solutions-in-surface-guided-deep-inspiration-breath-hold-radiation-therapy-for-left-sided-breast-cancer
#6
JOURNAL ARTICLE
Chuan Zeng, Qiyong Fan, Xiang Li, Yulin Song, Licheng Kuo, Michalis Aristophanous, Laura I Cervino, Linda Hong, Simon Powell, Guang Li
PURPOSE: Deep inspiration breath hold (DIBH) is an effective technique to spare the heart in treating left-sided breast cancer. Surface-guided radiation therapy (SGRT) is increasingly applied in DIBH setup and motion monitoring. Patient-specific breathing behavior, either thoracically driven or abdominally driven (A-DIBH), should be unaltered, online identified, and monitored accordingly to ensure reproducible heart-sparing treatment. METHODS AND MATERIALS: Sixty patients with left-sided breast cancer treated with SGRT were analyzed: 20 A-DIBH patients with vertical chest elevation (VCE ≤ 5 mm) were prospectively identified, and 40 control patients were retrospectively and randomly selected for comparison...
2023: Advances in Radiation Oncology
https://read.qxmd.com/read/38001991/enteroscopy-versus-video-capsule-endoscopy-for-automatic-diagnosis-of-small-bowel-disorders-a-comparative-analysis-of-artificial-intelligence-applications
#7
REVIEW
Stefan Lucian Popa, Bogdan Stancu, Abdulrahman Ismaiel, Daria Claudia Turtoi, Vlad Dumitru Brata, Traian Adrian Duse, Roxana Bolchis, Alexandru Marius Padureanu, Miruna Oana Dita, Atamyrat Bashimov, Victor Incze, Edoardo Pinna, Simona Grad, Andrei-Vasile Pop, Dinu Iuliu Dumitrascu, Mihai Alexandru Munteanu, Teodora Surdea-Blaga, Florin Vasile Mihaileanu
BACKGROUND: Small bowel disorders present a diagnostic challenge due to the limited accessibility of the small intestine. Accurate diagnosis is made with the aid of specific procedures, like capsule endoscopy or double-ballon enteroscopy, but they are not usually solicited and not widely accessible. This study aims to assess and compare the diagnostic effectiveness of enteroscopy and video capsule endoscopy (VCE) when combined with artificial intelligence (AI) algorithms for the automatic detection of small bowel diseases...
November 7, 2023: Biomedicines
https://read.qxmd.com/read/37969128/recent-developments-in-the-assessment-and-management-of-inflammatory-bowel-disease-in-childhood-a-narrative-review
#8
REVIEW
Zachary Green, Robert Mark Beattie, James J Ashton
BACKGROUND AND OBJECTIVE: The landscape of paediatric inflammatory bowel disease (pIBD) continues to evolve in an era of increasing incidence. There have been rapid developments in understanding, as we begin to perceive IBD as a spectrum of conditions, alongside advancements in monitoring and treatment. The objective of this article was to provide an overview of recent advances and challenges in the management of pIBD, with a focus on sustainable healthcare, personalised therapy, genomics, new drugs and avenues for future optimisation...
October 30, 2023: Translational Pediatrics
https://read.qxmd.com/read/37954537/endoscopic-characterization-of-neoplastic-and-non-neoplastic-lesions-in-inflammatory-bowel-disease-systematic-review-in-the-era-of-advanced-endoscopic-imaging
#9
REVIEW
Andrea Cassinotti, Marco Parravicini, Thomas P Chapman, Marco Balzarini, Lorenzo Canova, Simone Segato, Valentina Zadro, Simon Travis, Sergio Segato
BACKGROUND: Current guidelines strongly recommend the use of validated classifications to support optical diagnosis of lesions with advanced endoscopic imaging in the lower gastrointestinal tract. However, the optimal strategy in inflammatory bowel disease (IBD) is still a matter of debate. OBJECTIVES: To analyze the accuracy of endoscopic classifications or single predictors for in vivo lesion characterization during endoscopic surveillance of IBD with advanced endoscopic imaging...
2023: Therapeutic Advances in Gastroenterology
https://read.qxmd.com/read/37940717/small-bowel-lesions-in-patients-with-iron-deficiency-anaemia-without-overt-bleeding-a-multicentre-study
#10
JOURNAL ARTICLE
Angelo Zullo, Vincenzo De Francesco, Luigi Gatta, Giuseppe Scaccianoce, Matteo Colombo, Roberto Bringiotti, Alessandro Azzarone, Angela Rago, Federico Corti, Alessandro Repici, Cesare Hassan, Roberta Elisa Rossi
The diagnostic work-up in iron deficiency anaemia (IDA) patients can be challenging when bleedings or malabsorption are not clinically manifest. Lesions on the small bowel mucosa may cause IDA. We evaluated the prevalence of lesions on the small bowel mucosa detected at Videocapsule Endoscopy (VCE) in IDA patients following negative upper and lower endoscopies. Clinical and endoscopic data collected in 5 centres were retrieved. Lesions with a high bleeding potential (P2) were computed, and predictive factors investigated at multivariate analysis...
November 9, 2023: Annals of Hematology
https://read.qxmd.com/read/37892343/small-intestinal-polyp-burden-in-pediatric-peutz-jeghers-syndrome-assessed-through-capsule-endoscopy-a-longitudinal-study
#11
JOURNAL ARTICLE
Jeremy Stewart, Nathan R Fleishman, Vincent S Staggs, Mike Thomson, Nicole Stoecklein, Caitlin E Lawson, Michael P Washburn, Shahid Umar, Thomas M Attard
The management of pediatric Peutz-Jeghers Syndrome (PJS) focuses on the prevention of intussusception complicating small intestinal (SI) polyposis. This hinges on the accurate appraisal of the polyp burden to tailor therapeutic interventions. Video Capsule Endoscopy (VCE) is an established tool to study SI polyps in children, but an in-depth characterization of polyp burden in this population is lacking. Methods: We performed a retrospective longitudinal cross-sectional analysis of VCE studies in pediatric PJS patients at our institution (CMKC) from 2010 to 2020...
October 12, 2023: Children
https://read.qxmd.com/read/37835409/assessment-of-narrow-band-imaging-algorithm-for-video-capsule-endoscopy-based-on-decorrelated-color-space-for-esophageal-cancer
#12
JOURNAL ARTICLE
Kai-Yao Yang, Yu-Jen Fang, Riya Karmakar, Arvind Mukundan, Yu-Ming Tsao, Chien-Wei Huang, Hsiang-Chen Wang
Video capsule endoscopy (VCE) is increasingly used to decrease discomfort among patients owing to its small size. However, VCE has a major drawback of not having narrow band imaging (NBI) functionality. The current VCE has the traditional white light imaging (WLI) only, which has poor performance in the computer-aided detection (CAD) of different types of cancer compared to NBI. Specific cancers, such as esophageal cancer (EC), do not exhibit any early biomarkers, making their early detection difficult. In most cases, the symptoms are unnoticeable, and EC is diagnosed only in later stages, making its 5-year survival rate below 20% on average...
September 25, 2023: Cancers
https://read.qxmd.com/read/37827027/characterizing-the-role-of-surgical-vice-chair-of-education-stakeholder-needs-and-current-practices
#13
JOURNAL ARTICLE
Zachary Whaley, Deanna Palenzuela, Kristina Dzara, Lori R Berkowitz, Joy Moses, Emil Petrusa, Roy Phitayakorn
INTRODUCTION: The role of a Department of Surgery (DoS) Vice Chair of Education (VCE) is a relatively new position intended to address the many changes and initiatives in medical education. The primary responsibilities and functions of a surgical VCE are not well described in the literature. This study examines the perceptions of stakeholders and current VCEs to develop a newly established position of VCE within an academic DoS. METHODS: We conducted semistructured interviews of 13 faculties in our DoS...
October 10, 2023: Journal of Surgical Research
https://read.qxmd.com/read/37793436/current-status-of-image-enhanced-endoscopy-in-inflammatory-bowel-disease
#14
REVIEW
Young Joo Yang
In inflammatory bowel disease (IBD), chronic inflammation leads to unfavorable clinical outcomes and increases the risk of developing colorectal neoplasm (CRN); thereby highlighting the importance of endoscopically evaluating disease activity as well as detecting and characterizing CRN in patients with IBD. With recent advances in image-enhanced endoscopic (IEE) technologies, especially virtual chromoendoscopy (VCE) platforms, this review discusses state-of-the-art IEE techniques and their applicability in assessing disease activity and surveillance colonoscopy in patients with IBD...
September 2023: Clinical Endoscopy
https://read.qxmd.com/read/37784188/small-intestinal-mucosal-abnormalities-using-video-capsule-endoscopy-in-intestinal-lymphangiectasia
#15
JOURNAL ARTICLE
Lin Lin, Kuiliang Liu, Hong Liu, Jianfeng Xin, Yuguang Sun, Song Xia, Wenbin Shen, Jing Wu
BACKGROUND: Intestinal lymphangiectasia (IL) is a rare protein-losing enteropathy caused by disorders of the intestinal lymphatics. There are only a few case reports and case series concerning the VCE (video capsule endoscopy) findings of IL. This work aimed to evaluate the VCE characteristics of small intestinal mucosal abnormalities in patients with IL, and to investigate the relationship between clinical and VCE characteristics. METHODS: Consecutive patients with IL who underwent VCE were enrolled in this retrospective study...
October 2, 2023: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/37773777/video-capsule-endoscopy-versus-computed-tomography-enterography-in-assessing-suspected-small-bowel-bleeding-a-systematic-review-and-diagnostic-test-accuracy-meta-analysis
#16
JOURNAL ARTICLE
Mohammad Yaghoobi, Julie Tan, Yousef Th A Th A Alshammari, Katie Scandrett, Khashayar Mofrad, Yemisi Takwoingi
Both computed tomography enterography (CTE) and video capsule endoscopy (VCE) are used in identifying small intestinal pathology in patients with suspected small bowel bleeding (SSBB) following normal upper gastrointestinal endoscopy and colonoscopy. Evidence of the comparative accuracy of these two modalities is crucial for clinical and healthcare decision-making. Comprehensive electronic searches were performed for studies on CTE and/or VCE with reference standard(s). Study selection, data extraction and quality assessment were completed by two authors independently...
November 1, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37759872/the-cannabigerol-derivative-vce-003-2-exerts-therapeutic-effects-in-6-hydroxydopamine-lesioned-mice-comparison-with-the-classic-dopaminergic-replacement-therapy
#17
JOURNAL ARTICLE
Santiago Rodríguez-Carreiro, Elisa Navarro, Eduardo Muñoz, Javier Fernández-Ruiz
(1) Background: A cannabigerol aminoquinone derivative, so-called VCE-003.2, has been found to behave as a neuroprotective agent (administered both i.p. and orally) in different experimental models of Parkinson's disease (PD) in mice. These effects were exerted through mechanisms that involved the activation of a regulatory site within the peroxisome proliferator-activated receptor-γ (PPAR-γ). (2) Methods: We are now interested in comparing such neuroprotective potential of VCE-003.2, orally administered, with the effect of the classic dopaminergic replacement therapy with L-DOPA/benserazide in similar conditions, using 6-hydroxydopamine-lesioned mice...
August 31, 2023: Brain Sciences
https://read.qxmd.com/read/37747706/on-column-capping-of-poly-dt-media-tethered-mrna-accomplishes-high-capping-efficiency-enhanced-mrna-recovery-and-improved-stability-against-rnase
#18
JOURNAL ARTICLE
Shiyi Che, Xue Feng, Zhengjun Li, Zhiguo Su, Guanghui Ma, Zhikao Li, Aibing Yu, Minsu Liu, Songping Zhang
The messenger RNA (mRNA) 5'-cap structure is indispensable for mRNA translation initiation and stability. Despite its importance, large-scale production of capped mRNA through in vitro transcription (IVT) synthesis using vaccinia capping enzyme (VCE) is challenging, due to the requirement of tedious and multiple pre-and-post separation steps causing mRNA loss and degradation. Here in the present study, we found that the VCE together with 2'-O-methyltransferase can efficiently catalyze the capping of poly dT media-tethered mRNA to produce mRNA with cap-1 structure under an optimized condition...
September 25, 2023: Biotechnology and Bioengineering
https://read.qxmd.com/read/37743535/small-bowel-disease-prevalence-on-video-capsule-endoscopy-in-chronic-granulomatous-disease-associated-inflammatory-bowel-disease
#19
JOURNAL ARTICLE
Sumona Bhattacharya, Uni Wong, Mian Khalid, Hanna Blaney, Matthew G Menkart, Jenna L Oringher, Sonia L Taneja, Christa S Zerbe, Suk See De Ravin, Harry L Malech, Steven M Holland, Christopher Koh, Theo Heller
BACKGROUND AND AIM: Patients with chronic granulomatous disease (CGD) may develop inflammatory bowel disease (IBD). Characterization of small bowel disease in this cohort is scarce. Here, we sought to determine the prevalence and characteristics of small bowel disease and evaluate the clinical utility of video capsule endoscopy (VCE) for its diagnosis. METHODS: A retrospective study was performed on patients with CGD who were evaluated for gastrointestinal disease with VCE as a part of ongoing natural history studies at a single academic center...
September 24, 2023: Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/37727201/differences-in-kinematic-changes-from-self-selected-to-fast-speed-gait-in-asymptomatic-adults-with-radiological-signs-of-femoro-acetabular-impingement
#20
JOURNAL ARTICLE
Fares Yared, Abir Massaad, Ziad Bakouny, Joeffroy Otayek, Aren-Joe Bizdikian, Joe Ghanimeh, Chris Labaki, Diane Ghanem, Ismat Ghanem, Wafa Skalli, Ayman Assi
Femoro-acetabular impingement (FAI) may present as alterations in the skeletal morphology of the hip. Repercussions of FAI can be witnessed in self-selected speed walking as well as physical exercise such as running or fast speed walking. The aim of this study was to investigate changes in kinematics at different gait speeds in subjects presenting with radiological findings invoking FAI. One hundred thirty asymptomatic adults underwent biplanar X-rays with a calculation of 3D hip parameters: acetabular anteversion, abduction and tilt, vertical center edge angle (VCE), femoral anteversion, neck-shaft angle, acetabular coverage of the femoral head, femoral head diameter and neck length...
August 2023: Curēus
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