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JOURNAL ARTICLE
Sheena E Martenies, Alice Oloo, Sheryl Magzamen, Nan Ji, Roxana Khalili, Simrandeep Kaur, Yan Xu, Tingyu Yang, Theresa M Bastain, Carrie V Breton, Shohreh F Farzan, Rima Habre, Dana Dabelea
Past studies support the hypothesis that the prenatal period influences childhood growth. However, few studies explore the joint effects of exposures that occur simultaneously during pregnancy. To explore the feasibility of using mixtures methods with neighborhood-level environmental exposures, we assessed the effects of multiple prenatal exposures on body mass index (BMI) from birth to age 24 months. We used data from two cohorts: Healthy Start (n = 977) and Maternal and Developmental Risks from Environmental and Social Stressors (MADRES; n = 303)...
May 13, 2024: Environmental Research
#42
JOURNAL ARTICLE
Diana N Carvajal, Ivonne McLean, Lin-Fan Wang, Dalia Brahmi, Judy C Washington
Since European settlement, the United States has controlled the reproduction of communities of color through tactics ranging from forced pregnancies, sterilizations, and abortions to immigration policies and policies that separate children from their families. Lesbian, gay, bisexual, transgender, queer (or questioning), asexual, intersex, and gender diverse people (LGBTQIA+) have been persecuted for sexual behavior and gender expression, and also restricted from having children. In response, women of color and LGBTQIA+ communities have organized for Reproductive Justice (RJ) and liberation...
April 2024: Family Medicine
#43
Ali Z Ansari, Assem Al Sayed, Srihita Patibandla, Sarthak Kumar, Laasya Patibandla, Rashad Ali
Placental abruption is a serious medical condition that can occur during pregnancy, involving the premature separation of the placenta from the inner uterine wall before childbirth. This detachment often leads to severe bleeding, and if conventional methods prove ineffective in managing the bleeding, a hysterectomy may be deemed necessary to ensure the mother's safety. This case report details the management of a 22-year-old female, gravida IV, para III, who experienced placental abruption during her fourth pregnancy...
April 2024: Curēus
#44
JOURNAL ARTICLE
Elizabeth Glanet Durom, V A Aneesha, Nerella Venkata Pavan Kumar, Ajmi Bin Azeez, M Karikalan, Madhu C Lingaraju, Subhashree Parida, Avinash G Telang, Thakur Uttam Singh
Ethion is a class II moderately toxic organothiophosphate pesticide. The main objective of this study was to evaluate the maternal and foetal toxicity of ethion in rats. Pregnant rats were divided into 5 groups. Group I served as control. Group II, III, IV, and V were orally administered with 0.86, 1.71, 3.43, and 6.9mg/kg of ethion respectively, from gestational day (GD) 6 to 19. Dams were sacrificed on GD 20. Maternal toxicity was assessed by body weight gain, foetal resorptions, oxidative stress, liver and kidney function tests, and histopathology...
May 9, 2024: Reproductive Toxicology
#45
JOURNAL ARTICLE
Yannis Hadjiyannis, Jennifer M Jones, Irina Chibisov, Joseph Kiss, Kim Gabert, Joan Sevcik, Suzanne Bakdash, Anna Binstock, Carolyn Kilonsky, Kristiina Parviainen, Alesia Kaplan
Anti-PP1PK alloimmunization is rare given ubiquitous P1PK expression. Prevention of recurrent miscarriages and hemolytic disease of the fetus and newborn (HDFN) in pregnant individuals with anti-PP1PK antibodies has relied upon individual reports. Here, we demonstrate the successful management of maternal anti-PP1PK alloimmunization in a 23-year-old, G2P0010, with therapeutic plasma exchange (TPE), intravenous immunoglobulin (IVIG), and monitoring of anti-PP1Pk titers. Twice-weekly TPE (1.5 plasma volume [PV], 5% albumin replacement) with weekly titers and IVIG (1 g/kg) was initiated at 9 weeks of gestation (WG)...
June 2024: Journal of Clinical Apheresis
#46
JOURNAL ARTICLE
Maziar Mahmoudian, Zahra Lorigooini, Mohammad Rahimi-Madiseh, Sahreh Shabani, Hossein Amini-Khoei
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with worldwide increasing incidence. Maternal separation (MS) stress at the beginning of life with its own neuroendocrine changes can provide the basis for development of ASD. Rosmarinic acid (RA) is a phenolic compound with a protective effect in neurodegenerative diseases. The aim of this study was to determine the effect of RA on autistic-like behaviors in maternally separated mice focusing on its possible effects on neuroimmune response and nitrite levels in the hippocampus...
May 10, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
#47
JOURNAL ARTICLE
Meng-Meng Zhang, Ming Dang, Xu Wu, Li Ou, Min Li, Chong-Bo Zhao, Pei-Feng Wei, Tai-Wei Dong, Yao Li, Chun-Jie Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Da-Jian-Zhong decoction (DJZD) is a herbal formula clinically used for abdominal pain and diarrhea induced by spleen-Yang deficiency syndrome. Recently, treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) with DJZD has received increasing attention, but the underlying mechanism of action remains elusive. AIM OF THE STUDY: We aimed to evaluate the therapeutic effect of DJZD on IBS-D rats and to elucidate the underlying mechanisms...
May 8, 2024: Journal of Ethnopharmacology
#48
JOURNAL ARTICLE
Hsien-Ming Wu, Liang-Hsuan Chen, Wei-Jung Chiu, Chia-Lung Tsai
In this study, we investigate the effects of microRNA-138-5p and GPR124-regulated inflammasome and downstream LIF-STAT and adhesion molecules signaling in human decidual stromal cells. After informed consent was obtained from women aged 25-38 years undergoing surgical termination of the normal pregnancy and spontaneous miscarriage after 6-9 weeks of gestation, human decidual stromal cells were separated from the decidual tissue. Extracellular vesicles with microRNA (miRNA) between cells have been regarded as critical factors for embryo-maternal interactions on embryo implantation and programming of human pregnancy...
May 1, 2024: Journal of Molecular Endocrinology
#49
JOURNAL ARTICLE
Emma V Preston, Marlee R Quinn, Paige L Williams, Thomas F McElrath, David E Cantonwine, Ellen W Seely, Blair J Wylie, Michele R Hacker, Karen O'Brien, Florence M Brown, Camille E Powe, Andrea Bellavia, Zifan Wang, Kathryn S Tomsho, Russ Hauser, Tamarra James-Todd
PURPOSE: Pregnancy and the postpartum period are increasingly recognised as sensitive windows for cardiometabolic disease risk. Growing evidence suggests environmental exposures, including endocrine-disrupting chemicals (EDCs), are associated with an increased risk of pregnancy complications that are associated with long-term cardiometabolic risk. However, the impact of perinatal EDC exposure on subsequent cardiometabolic risk post-pregnancy is less understood. The Environmental Reproductive and Glucose Outcomes (ERGO) Study was established to investigate the associations of environmental exposures during the perinatal period with post-pregnancy parental cardiometabolic health...
May 8, 2024: BMJ Open
#50
JOURNAL ARTICLE
Janet T Y Leung, Daniel T L Shek
Although overparenting is a growing phenomenon across the globe, there is a severe lack of longitudinal studies examining the trajectory of overparenting and its effects on early adolescent development, particularly in non-Western contexts. The study collected three waves of longitudinal data from 1328 early Chinese adolescents in Hong Kong with an interval of 1 year to examine the stability and change of perceived paternal and maternal overparenting and their effects on adolescent psychological wellbeing...
May 8, 2024: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
#51
JOURNAL ARTICLE
Raiyan R Khan, Rafael F Guerrero, Ronald J Wapner, Matthew W Hahn, Anita Raja, Ansaf Salleb-Aouissi, William A Grobman, Hyagriv Simhan, Robert M Silver, Judith H Chung, Uma M Reddy, Predrag Radivojac, Itsik Pe'er, David M Haas
Adverse pregnancy outcomes (APOs) affect a large proportion of pregnancies and represent an important cause of morbidity and mortality worldwide. Yet the pathophysiology of APOs is poorly understood, limiting our ability to prevent and treat these conditions. To search for genetic markers of maternal risk for four APOs, we performed multi-ancestry genome-wide association studies (GWAS) for pregnancy loss, gestational length, gestational diabetes, and preeclampsia. We clustered participants by their genetic ancestry and focused our analyses on three sub-cohorts with the largest sample sizes: European, African, and Admixed American...
May 7, 2024: Scientific Reports
#52
JOURNAL ARTICLE
Elaine Symanski, Kristina W Whitworth, Hector Mendez-Figueroa, Kjersti M Aagaard, Iman Moussa, Juan Alvarez, Adrien Chardon Fabian, Kurunthachalam Kannan, Cheryl L Walker, Cristian Coarfa, Melissa A Suter, Hamisu M Salihu
INTRODUCTION: The Maternal and Infant Environmental Health Riskscape (MIEHR) Center was established to address the interplay among chemical and non-chemical stressors in the biological, physical, social, and built environments that disproportionately impact perinatal health among Black pregnant people in a large and diverse urban area with documented disparities in the U.S. METHODS: The MIEHR cohort is recruiting non-Hispanic Black and non-Hispanic white pregnant people who deliver their infants at major obstetric hospitals in Houston, Texas...
2024: Front Reprod Health
#53
JOURNAL ARTICLE
Lori R Bernstein, Amelia C L Mackenzie, Charles L Chaffin, Se-Jin Lee, Duane C Kraemer, Istvan Merchenthaler
BACKGROUND: Elevated FSH often occurs in women of advanced maternal age (AMA, age ≥ 35) and in infertility patients undergoing controlled ovarian stimulation (COS). There is controversy on whether high endogenous FSH contributes to infertility and whether high exogenous FSH adversely impacts patient pregnancy rates. METHODS: The senescence-accelerated mouse-prone-8 (SAMP8) model of female reproductive aging was employed to assess the separate impacts of age and high FSH activity on the percentages (%) of viable and mature ovulated oocytes recovered after gonadotropin treatment...
May 6, 2024: Reproductive Biology and Endocrinology: RB&E
#54
JOURNAL ARTICLE
P Bureš, E Del Guacchio, J Šmerda, M Özcan, P Blizňáková, M Vavrinec, E Michálková, P Veselý, K Veselá, F Zedek
The invasive tetraploid Cirsium vulgare hybridizes with both Cirsium and Lophiolepis. Its conflicted position in molecular phylogenies, and its peculiar combination of morphological, anatomical, and genomic features that are alternatively shared with representatives of Cirsium or Lophiolepis, strongly suggest its intergeneric hybrid origin. Genetic relationships of C. vulgare (8 samples) with genus Lophiolepis (11 species) and other representatives of genus Cirsium (12 species) were evaluated using restriction site-associated DNA sequencing (RADseq) and examined using analytical and imaging approaches, such as NeighborNet, Heatmap, and STRUCTURE, to identify nuclear genomes admixture...
May 5, 2024: Plant Biology
#55
JOURNAL ARTICLE
Amanda Gollo Bertollo, Maiqueli Eduarda Dama Mingoti, Jesiel de Medeiros, Gilnei Bruno da Silva, Giovana Tamara Capoani, Heloisa Lindemann, Joana Cassol, Daiane Manica, Tacio de Oliveira, Michelle Lima Garcez, Margarete Dulce Bagatini, Lilian Caroline Bohnen, Walter Antônio Roman Junior, Zuleide Maria Ignácio
Major depressive disorder (MDD) is a severe disorder that causes enormous loss of quality of life, and among the factors underlying MDD is stress in maternal deprivation (MD). In addition, classic pharmacotherapy has presented severe adverse effects. Centella asiatica (C. asiatica) demonstrates a potential neuroprotective effect but has not yet been evaluated in MD models. This study aimed to evaluate the effect of C. asiatica extract and the active compound madecassic acid on possible depressive-like behavior, inflammation, and oxidative stress in the hippocampus and serum of young rats submitted to MD in the first days of life...
May 4, 2024: Molecular Neurobiology
#56
JOURNAL ARTICLE
Isabelle Monier, Anne Ego, Alice Hocquette, Alexandra Benachi, François Goffinet, Nathalie Lelong, Camille LE Ray, Jennifer Zeitlin
BACKGROUND: Small-for-gestational age (SGA) is defined as a birthweight below a birthweight-percentile threshold, usually the 10th percentile, with the 3rd or 5th percentile used to identify severe SGA. SGA is used as a proxy for growth restriction in the newborn, but SGA newborns can be physiologically small and healthy. This definition also excludes growth restricted newborns who have weights above the 10th percentile. To address these limits, a Delphi study developed a new consensus definition of growth restriction in the newborn based on neonatal anthropometric and clinical parameters, but it has not been evaluated...
April 30, 2024: American Journal of Obstetrics and Gynecology
#57
JOURNAL ARTICLE
Keng Ioi Vong, Sangmoon Lee, Kit Sing Au, T Blaine Crowley, Valeria Capra, Jeremiah Martino, Meade Haller, Camila Araújo, Hélio R Machado, Renee George, Bryn Gerding, Kiely N James, Valentina Stanley, Nan Jiang, Kameron Alu, Naomi Meave, Anna S Nidhiry, Fiza Jiwani, Isaac Tang, Ashna Nisal, Ishani Jhamb, Arzoo Patel, Aakash Patel, Jennifer McEvoy-Venneri, Chelsea Barrows, Celina Shen, Yoo-Jin Ha, Robyn Howarth, Madison Strain, Allison Elizabeth Ashley-Koch, Matloob Azam, Sara Mumtaz, Gyang Markus Bot, Richard H Finnell, Zoha Kibar, Ahmed I Marwan, Gia Melikishvili, Hal S Meltzer, Osvaldo M Mutchinick, David A Stevenson, Henry J Mroczkowski, Betsy Ostrander, Erica Schindewolf, Julie Moldenhauer, Elaine H Zackai, Beverly S Emanuel, Sixto Garcia-Minaur, Beata A Nowakowska, Roger E Stevenson, Maha S Zaki, Hope Northrup, Hanna K McNamara, Kimberly A Aldinger, Ian G Phelps, Mei Deng, Ian A Glass, Bernice Morrow, Donna M McDonald-McGinn, Simone Sanna-Cherchi, Dolores J Lamb, Joseph G Gleeson, Allison Elizabeth Ashley Koch, Hal S Meltzer, Joan Le, Kit Sing Au, Hope Northrup, Gyang Markus Bot, Valeria Capra, Richard H Finnell, Zoha Kibar, Philip J Lupo, Helio R Machado, Camila Araújo, Tony Magana, Ahmed I Marwan, Gia Melikishvili, Osvaldo M Mutchinick, Roger E Stevenson, Anna Yurrita, Maha S Zaki, Sara Mumtaz, José Ramón Medina-Bereciartu, Caroline M Kolvenbach, Shirlee Shril, Friedhelm Hildebrandt, Mahmoud M Noureldeen, Aida Ms Salem, Yukitoshi Takahashi, Hormos Salimi-Dafsari, H Westley Phillips, Brian Hanak, Bülent Kara, Ayfer Sakarya Güneş, David D Gonda, Salman Kirmani, Tinatin Tkemaladze, Joseph G Gleeson
Meningomyelocele is one of the most severe forms of neural tube defects (NTDs) and the most frequent structural birth defect of the central nervous system. We assembled the Spina Bifida Sequencing Consortium to identify causes. Exome and genome sequencing of 715 parent-offspring trios identified six patients with chromosomal 22q11.2 deletions, suggesting a 23-fold increased risk compared with the general population. Furthermore, analysis of a separate 22q11.2 deletion cohort suggested a 12- to 15-fold increased NTD risk of meningomyelocele...
May 3, 2024: Science
#58
JOURNAL ARTICLE
Alexander Paping, Anja Bluth, Ammar Al Naimi, Mina Mhallem, Magdalena Kolak, Andrzej Jaworowski, Hubert Huras, Maddalena Morlando, George Daskalakis, Pedro Viana Pinto, Loïc Sentilhes, Heleen J van Beekhuizen, Vedran Stefanovic, Karin A Fox, Olivier Morel, Charline Bertholdt, Thorsten Braun
INTRODUCTION: Placenta accreta spectrum (PAS) can lead to major peripartum morbidity. Appropriate management approaches depend on the clinical severity, each individual's preference, and the treating team's expertise. Peripartum hysterectomy is the most frequently used treatment option. However, it can impact psychological well-being and fertility. We investigated whether conservative treatment with focal resection or leaving the placenta in situ is associated with comparable or lower maternal morbidity than hysterectomy in centers of excellence within the International Society for placenta accreta spectrum (IS-PAS)...
May 2, 2024: Acta Obstetricia et Gynecologica Scandinavica
#59
JOURNAL ARTICLE
Gebretsadik Shibre, Wubegzier Mekonnen, Damen Haile Mariam
INTRODUCTION: Aggregate statistics of maternal health care services have improved in Ethiopia. Nevertheless, the country has one of the lowest Universal Health Coverage (UHC) service coverage indices, with slight improvement between 2000 and 2019. There are disparity studies that focus on a single dimension of inequality. However, studies that combine multiple dimensions of inequality simultaneously may have important policy implications for closing inequalities. In this study, we investigated education inequalities in the receipt of maternal health care services in rural and urban areas separately, and we examined whether these inequalities decreased, increased, or remained unchanged...
2024: Frontiers in Public Health
#60
JOURNAL ARTICLE
E Torres-Maravilla, F A Carvalho, S Holowacz, J Delannoy, L Lenoir, E Jacouton, F Barbut, P Langella, L G Bermúdez-Humarán, A-J Waligora-Dupriet
Oral administration of probiotics has been proposed as a promising biotherapy to prevent and treat different diseases related to gastrointestinal disorders, such as irritable bowel syndrome (IBS). Due to the increasing research area on the characterisation of new probiotic bacterial strains, it is necessary to perform suitable in vitro experiments, using pertinent cellular models, in order to establish appropriate readout profiles based on IBS symptoms and subtypes. In this work, a collection of 30 candidate strains, belonging mainly to the Lactobacillus and Bifidobacterium genera, were screened using three different sets of in vitro experiments with different readouts to identify promising probiotic strains with: (1) the ability to inhibit the synthesis of IL-8 production by TNF-α stimulated HT-29 cells, (2) immunomodulatory properties quantified as increased IL-10 levels in peripheral blood mononuclear cell (PBMCs), and (3) the ability to maintain epithelial barrier integrity by increasing the trans-epithelial/endothelial electrical resistance (TEER) values in Caco-2 cells...
April 30, 2024: Beneficial Microbes
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