Shannon M Lefler, Wafaa A Kaf, John A Ferraro
BACKGROUND:  Various extratympanic recording electrodes have been used to make electrocochleography (ECochG) and auditory brainstem response (ABR) measurements in clinics, translational research, and basic science laboratories. However, differences may exist in ECochG and ABR measurements depending on the different types of extratympanic electrodes that are used. PURPOSE:  The purpose of this research is to compare simultaneously recorded ECochG and ABR responses using three different extratympanic electrodes...
June 3, 2021: Journal of the American Academy of Audiology
Carla V Valenzuela, Jeffery T Lichtenhan, Shannon M Lefler, Kanthaiah Koka, Craig A Buchman, Amanda J Ortmann
OBJECTIVES/HYPOTHESIS: Previous studies have demonstrated that electrocochleography (ECochG) measurements made at the round window prior to cochlear implant (CI) electrode insertion can account for 47% of the variability in 6-month speech perception scores. Recent advances have made it possible to use the apical CI electrode to record intracochlear responses to acoustic stimuli. Study objectives were to determine 1) the relationship between intracochlear ECochG response amplitudes and 6-month speech perception scores and 2) to determine the relationship between behavioral auditory thresholds and ECochG threshold estimates...
May 21, 2021: Laryngoscope
Jason H Barnes, Linda X Yin, Aniket A Saoji, Matthew L Carlson
No abstract text is available yet for this article.
April 2021: World Journal of Otorhinolaryngology—Head and Neck Surgery
Rosamaria Santarelli, Pietro Scimemi, Marco Costantini, María Domínguez-Ruiz, Montserrat Rodríguez-Ballesteros, Ignacio Del Castillo
OBJECTIVES: Congenital profound hearing loss with preserved cochlear outer hair cell activity (otoacoustic emissions and cochlear microphonic) is the most common phenotype associated with mutations in the OTOF gene. The aim of this study was to investigate the pathophysiological mechanisms behind the auditory dysfunction in five patients (2 adults and 3 children) carrying biallelic mutations in OTOF, who showed an uncommon phenotype of mild hearing impairment associated with severe difficulties in speech perception and delay of language development...
April 27, 2021: Ear and Hearing
Qian Liu, Weiwei Guo, Shiming Yang, Xiaojun Ji, Chang Lin, Wei Chen
Background: In operations of cochlea implantation (CI), many surgeons choose to drill a window on the bone wall of cochlea basic rotation, when more and more patients receive CI with residual hearing, what damage this step would result in is unclear. Objective: To study the effect to inner ear hair cells which is caused by drilling during CI. Methods: 6 miniature pigs are equally divided into two groups, Round window niche of each pig in the experimental group was milled, while the pigs in control group wasn't...
April 21, 2021: Acta Oto-laryngologica
Stefan Weder, Christofer Bester, Aaron Collins, Chanan Shaul, Robert J Briggs, Stephen O'Leary
OBJECTIVES: Real-time electrocochleography (rt-ECochG) is a method to detect intracochlear potential changes during cochlear implantation (CI). Steep amplitude drops of the cochlear microphonic (CM) signal (so called "ECochG events") have been correlated with worse residual hearing outcomes. However, the sensitivity and specificity of monitoring CM amplitude on its own are too low to use it as a biomarker. The aim of this article was to establish if additional signal components would help to better predict postoperative hearing outcomes...
April 14, 2021: Otology & Neurotology
Hamed Fanaei, Akram Pourbakht, Sadegh Jafarzadeh
Introduction: This study aimed to evaluate the effects of bilateral carotid artery occlusion on cochlear oxidative stress and hearing status in rats. Methods: The rats were divided into two sets. The first set was used for electrophysiological recording (click and 4 kHz tone burst auditory brainstem responses and electrocochleography) on the day before surgery and then on the first, fourth, and seventh days after surgery. Animals of the second set were used for biochemical analysis...
November 2020: Basic and Clinical Neuroscience
Nilüfer Bal, Ufuk Derinsu
OBJECTIVE: To evaluate the association of listening to music loudly through personal listening devices with cochlear synaptopathy in young adults. METHODS: Fifty healthy young adults selected among 109 volunteers were included in the study. Participants of high risk (n=25) and low risk (n=25) groups estimated according to ETDNL (estimated total daily noise level) were evaluated using pure tone audiometry, tympanometry, matrix test, electrocochleography (EcochG) and auditory brainstem response (ABR) to evaluate the occurrence of cochlear synaptopathy...
April 3, 2021: Auris, Nasus, Larynx
Andrew Soulby, Steve Connor, Dan Jiang, Terry Nunn, Patrick Boyle, Irumee Pai
OBJECTIVES: The primary objective of this study was to establish the reproducibility of cochlear microphonic (CM) recordings obtained from a cochlear implant (CI) electrode contact during and immediately after insertion. This was achieved by evaluating the insertion angle and calculating the position of the apical electrode contact during insertion, using postoperative cone beam computed tomography (CBCT). The secondary objective was to create individualized patient maps of electrode contacts located within acoustically sensitive regions by correlating the CM amplitude to the electrode position determined using CBCT...
April 2, 2021: Ear and Hearing
Laura M Coraci, Andy J Beynon
This study determined electrocochleography (ECochG) parameter settings to obtain cochlear microphonics (CM) with less invasive flexible extra-tympanic membrane electrodes. In 24 adult normal-hearing subjects, CMs were elicited by presenting click stimuli at 100 dBnHL, tone bursts (2 kHz) and broadband (BB) CE-chirps® LS (Interacoustics, Middelfart, Denmark), both at 80 dBnHL. Different high-pass filters (HPFs) (3.3 Hz and 100 Hz, respectively) were used to investigate response quality of the CM. CMs were successfully obtained in 92-100% with click-, 75-83% with 2 kHz tone burst- and 58-63% with CE-chirp® -LS stimuli...
March 1, 2021: Audiology Research
Haider Alsarhan
Introduction: Meniere's disease (MD) is characterized by episodic symptoms, including vertigo, hearing loss, and tinnitus. Objectives: in this study, cases of unilateral tinnitus were investigated for MD. Method: Twenty-two patients who presented with chronic unilateral tinnitus on puretone audiograms showing an average threshold better than 25 dB HL and thresholds in the lower frequencies worse than those in the higher frequencies by more than 10 dB were suspected to have early-stage MD and underwent electrocochleography (ECochG)...
April 2021: Journal of Otology
Nasrin Yazdani, Benyamin Rahmaty, Meead Mousavi, Kayvan Aghazadeh, Sasan Dabiri, Reza Erfanian, Neda Jafari, Nima Rezazadeh, Ardavan Tajdini, Hamed Givzadeh
INTRODUCTION: The categorization of delayed endolymphatic hydrops (DEH) based on the ear which produces vertigo may sometimes cause misdiagnosis. OBJECTIVES: The aim of this study was investigating the vestibular-evoked myogenic potentials (VEMPs), electrocochleography (ECoG), and videonystagmography (VNG) in cases with DEH to determine the ear that originates symptoms. METHODS: In this cross-sectional study, 34 patients - 20 males and 14 females - with profound unilateral sensorineural deafness and vertigo attacks were recruited and evaluated by the ECoG, VNG, and VEMPs tests...
March 17, 2021: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Leanne Sijgers, Flurin Pfiffner, Julian Grosse, Norbert Dillier, Kanthaiah Koka, Christof Röösli, Alexander Huber, Adrian Dalbert
The use of electrocochleography (ECochG) for providing real-time feedback of cochlear function during cochlear implantation is receiving increased attention for preventing cochlear trauma and preserving residual hearing. Although various studies investigated the relationship between intra-operative ECochG measurements and surgical outcomes in recent years, the limited interpretability of ECochG response changes leads to conflicting study results and prevents the adoption of this method for clinical use. Specifically, the movement of the recording electrode with respect to the different signal generators in intracochlear recordings makes the interpretation of signal changes with respect to cochlear trauma difficult...
January 2021: Trends in Hearing
Christopher M Welch, Gregory Mannarelli, Lindsey Koehler, Steven A Telian
OBJECTIVE: To identify intraoperative neurophysiologic measures predictive of delayed progressive sensorineural hearing loss in the operative ear after a middle fossa approach (MCF) for resection of vestibular schwannoma (VS). STUDY DESIGN: Retrospective review. SETTING: Academic, tertiary referral center. PATIENTS: Subjects with vestibular schwannoma who underwent a MCF microsurgical resection of VS were analyzed for individuals whose hearing was initially preserved but subsequently developed progressive sensorineural hearing loss in the operative ear...
February 18, 2021: Otology & Neurotology
Minfei Qian, Qixuan Wang, Lu Yang, Zhongying Wang, Difei Hu, Bei Li, Yun Li, Hao Wu, Zhiwu Huang
This study was designed to investigate the effects of the aging process on peripheral and central auditory functions in adults with normal hearing. In this study, 149 participants with normal hearing were divided into four groups: aged 20-29, 30-39, 40-49 and 50-59 years for statistical purposes. Electrocochleography (EcochG), transient evoked otoacoustic emissions (TEOAE), Mandarin Hearing in Noise Test (MHINT) and the Gap Detection Test (GDT) were used. Our study found: (1) MHINT is significantly associated with aging (left ear R2 =0...
2021: American Journal of Translational Research
Viral D Tejani, Jeong-Seo Kim, Jacob J Oleson, Paul J Abbas, Carolyn J Brown, Marlan R Hansen, Bruce J Gantz
Changes in cochlear implant (CI) design and surgical techniques have enabled the preservation of residual acoustic hearing in the implanted ear. While most Nucleus Hybrid L24 CI users retain significant acoustic hearing years after surgery, 6-17 % experience a complete loss of acoustic hearing (Roland et al. Laryngoscope. 126(1):175-81. (2016), Laryngoscope. 128(8):1939-1945 (2018); Scheperle et al. Hear Res. 350:45-57 (2017)). Electrocochleography (ECoG) enables non-invasive monitoring of peripheral auditory function and may provide insight into the pathophysiology of hearing loss...
February 4, 2021: Journal of the Association for Research in Otolaryngology: JARO
Kevin Y Zhan, Oliver F Adunka, Adrien Eshraghi, William J Riggs, Sandra M Prentiss, Denise Yan, Fred F Telischi, Xuezhong Liu, Shuman He
Background: Congenital hearing loss is remarkably heterogeneous, with over 130 deafness genes and thousands of variants, making for innumerable genotype/phenotype combinations. Understanding both the pathophysiology of hearing loss and molecular site of lesion along the auditory pathway permits for significantly individualized counseling. Electrophysiologic techniques such as electrocochleography (ECochG) and electrically-evoked compound action potentials (eCAP) are being studied to localize pathology and estimate residual cochlear vs...
January 2021: Journal of Otology
Casper Grønlund, Louise Devantier, Mikael Karlberg, Bjarki Ditlev Djurhuus
Superior semicircular canal dehiscence syndrome (SCDS) is caused by a bony defect of the superior semicircular canal. The bony defect allows low-frequency acoustic stimuli of high intensity to travel to the vestibular organ. This can be induced by sound stimuli or pressure stimuli leading to vertigo, torsional nystagmus, pulsatile tinnitus, hyperacusis, hearing loss and autophony. SCDS is diagnosed with provocative testing, audiometry, CT-scan, vestibular evoked myogenic potentials and electrocochleography...
January 25, 2021: Ugeskrift for Laeger
Ursina Rüegg, Adrian Dalbert, Dorothe Veraguth, Christof Röösli, Alexander Huber, Flurin Pfiffner
The reliable prediction of cochlear implant (CI) speech perception outcomes is highly relevant and can facilitate the monitoring of postoperative hearing performance. To date, multiple audiometric, demographic, and surgical variables have shown some degree of correlation with CI speech perception outcomes. In the present study, postsurgical acoustic and electric hearing thresholds that are routinely assessed in clinical practice were compared to CI speech perception outcomes in order to reveal possible markers of postoperative cochlear health...
January 17, 2021: Journal of Clinical Medicine
Robert M Conway, Eric M Sugihara, David M Lee, Jaclyn Renker, Pedrom C Sioshansi, Seilesh C Babu
INTRODUCTION: Menière's disease is a clinical entity with no definitive objective testing. It has been hypothesized that underlying endolymphatic hydrops stiffens the basilar membrane leading to increased speed of the acoustic stimulus, therefore traveling wave velocity has been proposed as an objective test to aid in the diagnosis. The objective of this study is to compare electrocochleography frequency-specific action potential latency, basilar membrane traveling wave time, and summation to action potential (SP/AP) ratio in Menière's and non-Menière's patients...
February 1, 2021: Otology & Neurotology
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