Rosaria Nardello, Fulvio Guccione, Claudia Gliubizzi, Antonio Marino, Mariarita Capizzi, Salvatore Mangano
BACKGROUND: Aripiprazole is a third-generation atypical antipsychotic drug that acts as a stabilizer of the dopaminergic and serotonergic system. As partial agonist of the dopamine (D2) and serotonin (5-HT1A) receptors, it appears to be effective in reducing mania in patients with bipolar disorder, tics in Tourette Syndrome, aggression in schizophrenia and autism spectrum disorder. Enuresis has been reported among its side effects. Only a few studies, with conflicting results, have investigated the relationship between aripiprazole and enuresis...
April 21, 2021: Journal of Medical Case Reports
Hui Jie Hu, Zhen Wei Zhang, Yu Liang, Yan Yan Luo, Qi Feng Dou, Cui Ping Song, Hui Min Zhang, Ying Zhao, Guang Run Tian, Ke Zhang, Qiu Fang Mao, Jing Gui Song, Soren Rittig, Jian Guo Wen
PURPOSE: This study aimed to investigate the prevalence, risk factors, and effects of primary nocturnal enuresis (PNE) on physical and mental health in young adults in mainland China. METHODS: An anonymous questionnaire was used to collect information including the sociodemographic characteristics, history of PNE, family history, daytime voiding symptoms, Pittsburgh Sleep Quality Index (PSQI) scores, Self-Esteem Scale (SES), and Self-Rating Depression Scale (SDS)...
March 2021: International Neurourology Journal
Cecilie S Jørgensen, Henriette T Horsdal, Veera M Rajagopal, Jakob Grove, Thomas D Als, Konstantinos Kamperis, Mette Nyegaard, G Bragi Walters, Viðar Örn Eðvarðsson, Hreinn Stefánsson, Merete Nordentoft, David Michael Hougaard, Thomas Werge, Ole Mors, Preben Bo Mortensen, Esben Agerbo, Søren Rittig, Kári Stefánsson, Anders D Børglum, Ditte Demontis, Jane H Christensen
BACKGROUND: Nocturnal enuresis (bedwetting) is a common disorder affecting 10-16% of 7-year-old children globally. Nocturnal enuresis is highly heritable, but its genetic determinants remain unknown. We aimed to identify genetic variants associated with nocturnal enuresis and explore its genetic architecture and underlying biology. METHODS: We did a genome-wide association study (GWAS) of nocturnal enuresis. Nocturnal enuresis cases were identified in iPSYCH2012, a large Danish population-based case cohort established to investigate mental disorders, on the basis of 10th revision of the International Statistical Classification of Diseases (ICD-10) diagnoses and redeemed desmopressin prescriptions in Danish registers...
March 2021: Lancet Child & Adolescent Health
Yasar Issi, Unal Biçakci
Desmopressin plays a major role in the treatment of monosymptomatic enuresis but has the drawback of a high relapse rate after medical treatment. This study investigated the effect of the type of treatment termination on relapse in a large population of patients. A total of 1013 patients who were admitted with bedwetting to our paediatric urology clinic between October 2016 and April 2018 were evaluated retrospectively. Four hundred forty-seven monosymptomatic enuresis patients were treated with 120 μg/day oral desmopressin lyophilisate for 3 months, after which the treatment was terminated in one of two ways: immediate cessation of desmopressin (group 1; N = 209) and structured withdrawal (group 2; N = 238)...
January 3, 2021: European Journal of Pediatrics
Angel Garcia-Fernandez, Peter Emanuel Petros
Introduction: In 2004, Patricia Skilling developed a new squatting-based pelvic floor rehabilitation method based on strengthening the three reflex pelvic muscles and ligaments hypothesized to control the closure and micturition reflexes. We adapted these methods to test our hypothesis that day/night enuresis was due to the inability of these muscles/ligaments to control an inappropriately activated micturition reflex. Material and methods: The trial commenced as a randomized control trial to be conducted over 4 months, but was converted to a prospective trial at 4 weeks by order of the Ethics Committee...
2020: Central European Journal of Urology
Pietro Ferrara, Giulia Franceschini, Federico Bianchi Di Castelbianco, Rachele Bombace, Alberto Villani, Giovanni Corsello
AIM: To describe the epidemiological aspects of nocturnal enuresis (NE). In this study we identify the prevalence and the familial conditions in a large, representative sample of children with monosymptomatic NE (MNE) and nonmonosyptomatic NE (NMNE). MATERIAL AND METHODS: In this descriptive-analytic study the Italian Society of Pediatrics (SIP) promoted a prevalence study of NE using a questionnaire involved 320 primary care Pediatricians from Northern, Central and Southern Italy, from January 2019 to July 2019, with a total of 130,000 children analyzed by questionnaire related to epidemiology and type of NE, familiarity, quality of sleep, eating and drinking habits, pharmacological and psychological/behavioural interventions and family involvement...
September 11, 2020: Italian Journal of Pediatrics
Minki Baek, Young Jae Im, Jung Keun Lee, Hyun Kyu Kim, Kwanjin Park
PURPOSE: Poor awakening in patients with enuresis has been assumed to be an adaptation to the chronic influence of arousal stimuli like lower urinary tract dysfunction (LUTD). This study aimed to examine the effect of controlling LUTD on improvement of awakening and cure of enuresis. MATERIALS AND METHODS: Data for 119 enuretic patients with overactive bladder were retrospectively analyzed. The patients received urotherapy, laxatives, and anticholinergic agents...
September 2020: Investigative and Clinical Urology
Anusha Gandhi, Dihong Zhou, Joseph Alaimo, Edwin Chon, Michael D Fountain, Sarah H Elsea
Caregivers of preschool and elementary school age children with Smith-Magenis syndrome (SMS), MBD5-associated neurodevelopmental disorder (MAND), and Pitt-Hopkins syndrome (PTHS) were surveyed to assess sleep disturbance and to identify disorder-specific sleep problems. Because of overlapping features of these rare genetic neurodevelopmental syndromes, data were compared to reports of sleep disturbance in children with autism spectrum disorder (ASD). While similarities were observed with ASD, specific concerns between disorders differed, including mean nighttime sleep duration, daytime sleepiness, night wakings, parasomnias, restless sleep, and bedwetting...
August 26, 2020: Journal of Autism and Developmental Disorders
Jorge A Whitley, Kathleen Kieran
INTRODUCTION: Monosymptomatic nocturnal enuresis (MNE) is one of the most common reasons for referral to pediatric urologists. Prior to subspecialist visits, many parents seek electronically available information online to gather information about this condition and potential treatment options. Previous publications suggest that electronically available information on medical conditions do not always align with evidence-based or expert recommendations. We wondered if the same was true for MNE...
July 18, 2020: Journal of Pediatric Urology
Valentin Gaubert, Hayriye Gidik, Vladan Koncar
Around 15% of children still wet their bed after five years old. Although bedwetting alarms have proven to be effective to achieve nighttime dryness, they are cumbersome so children could be reluctant to use them. Therefore, the moisture sensor and wire were made unobtrusive by seamlessly integrated them into fully textile underwear by using conductive yarns. Consequently, the alarm acceptability should be enhanced by improving children's comfort. Three conductive textile metallic yarns, made of silver or stainless steel, were considered to fabricate the urine leakage sensor...
June 23, 2020: Sensors
Qi-Xiang Song, Lei Wang, Xin Cheng, Yiru Hao, Zhiyong Liu, Paul Abrams
OBJECTIVES: To characterise the clinical features and to discover predictive factors of adult males with nocturnal enuresis (NE). PATIENTS AND METHODS: A total of 43 eligible adult male patients (mean age was 57.8 years) were recruited prospectively over a 2-year period. After documentation of medical history, lower urinary tract symptoms (LUTS) were assessed using the International Consultation on Incontinence Modular Questionnaire-male LUTS (ICIQ-MLUTS), and a 3-day ICIQ-bladder diary (ICIQ-BD)...
October 2020: BJU International
Patrina Hy Caldwell, Miriam Codarini, Fiona Stewart, Deirdre Hahn, Premala Sureshkumar
BACKGROUND: Enuresis (bedwetting) affects up to 20% of five-year-olds and can have considerable social, emotional and psychological effects. Treatments include alarms (activated by urination), behavioural interventions and drugs. OBJECTIVES: To assess the effects of enuresis alarms for treating enuresis in children. SEARCH METHODS: We searched the Cochrane Incontinence Specialised Register, which contains trials identified from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, MEDLINE In-Process, MEDLINE Epub Ahead of Print, ClinicalTrials...
May 4, 2020: Cochrane Database of Systematic Reviews
Sunish Patel, Antonella Bavuso Volpe, Sahar Awwad, Andreas G Schätzlein, Shozeb Haider, Boqian Liu, Ijeoma F Uchegbu
Lipidised analgesic peptide prodrugs self-assemble into peptide nanofibers; with the nanofiber morphology protecting the peptide from plasma degradation and improving therapeutic efficacy. Extending this learning, we hypothesised that a self-assembling lipidized peptide arginine vasopressin (AVP) receptor agonist, that had not been designed as a prodrug, could prove pharmacologically active and control urine production. The only approved AVP receptor agonist, desmopressin is indicated for the treatment of central diabetes insipidus (DI), bedwetting, haemophilia A and von Willebrand disease...
April 29, 2020: Scientific Reports
Remya Radhakrishnan Pillai, B Sara
Bedwetting, also called nocturnal enuresis, is a common developmental problem in school-aged children. In a study by Van Tijen, Messer, & Namdar (1998), children ranked it as the third most stressful life event, after parental fighting and divorce. About 15% of affected children outgrow bedwetting on their own each year without medical intervention (Kiddoo, 2015), but inadequate knowledge and lack of support and guidance from family may lead to low self-esteem and mental distress in children dealing with this situation...
February 1, 2020: Creative Nursing
Noreen Caswell, Kaya Kuru, Darren Ansell, Martin J Jones, Benjamin Jon Watkinson, Peter Leather, Andrew Lancaster, Paula Sugden, Eleanor Briggs, Carl Davies, Chooi Oh, Kina Bennett, Christian DeGoede
BACKGROUND: To date, no pre-void wearable alarm exists to treat nocturnal enuresis (NE)-night-time bedwetting, and children with NE and their families are disappointed in relation to the post-void moisture alarms and medicine currently available. Development of a safe, comfortable and non-invasive wearable pre-void alarm and associated technology, using advanced mechatronics, is underway (the MyPAD device). Each stage of development includes patient and public involvement (PPI), particularly with respect to human factors, in collaboration with physicians, radiologists, psychologists, nurses, engineers and designers...
January 23, 2020: Pharmaceutical Medicine
Ng Syiao Wei, Samir Kumar Praharaj
Background: The relationship between chronotypes and sleeping problems is not clear. The objective of the study was to identify the relative occurrence of chronotypes among college students and to explore adult psychological morbidity and childhood sleeping problems across chronotypes. Materials and Methods: One hundred and fifty undergraduate medical students were assigned into different chronotypes by Morningness-Eveningness Questionnaire and they were further assessed using Self-Reporting Questionnaire, Parasomnia Questionnaire (adapted from the Adult Sleep Disorders Questionnaire), and Pittsburgh Sleep Quality Index...
November 2019: Indian Journal of Psychiatry
Serra Sürmeli Döven
BACKGROUND: Monosymptomatic nocturnal enuresis (MNE) is a common urological problem. The association between the use of entertainment and communication devices (EECDs) at night and enuresis in MNE patients has yet to be reported in literature. This study aims to determine if an association exists between the use of EECDs before sleep and nocturnal enuresis. METHODS: Patients with MNE who presented to the Pediatric Nephrology Department of the center between January 30, 2019 and June 30, 2019 were included in the study...
December 20, 2019: Pediatrics International: Official Journal of the Japan Pediatric Society
Guy Bogaert, Raimund Stein, Shabnam Undre, Rien J M Nijman, Josine Quadackers, Lisette 't Hoen, Radim Kocvara, Selcuk Silay, Serdar Tekgul, Christian Radmayr, Hasan Serkan Dogan
BACKGROUND AND AIMS: The objective of this update of the EAU-ESPU guidelines recommendations for nocturnal enuresis was to review the recent published literature of studies, reviews, guidelines regarding the etiology, diagnosis and treatment options of nocturnal enuresis and transform the information into a practical recommendation strategy for the general practitioner, pediatrician, pediatric urologist and urologist. MATERIAL AND METHODS: Since 2012 a monthly literature search using Scopus® was performed and the relevant literature was reviewed and prospectively registered on the European Urology bedwetting enuresis resource center (http://bedwetting...
February 2020: Neurourology and Urodynamics
Ellen Collier, Carolina Varon, Sabine Van Huffel, Guy Bogaert
PURPOSE: That children with nocturnal enuresis ("bedwetting") are deep sleepers is a fact that their parents often state when asking for advice. However, until today no clear difference in sleep has been observed between children who do and do not wet the bed. This study investigates the difference in sleep parameters and heart rate variability (HRV) between enuretic and control children in their home setting by using a wearable sleep tracker during a long observation period...
November 14, 2019: Neurourology and Urodynamics
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