Sandra Moceri, Natascha Bäuerle, Johanna Habermeyer, Veronika Ratz-Wirsching, Julia Harrer, Jörg Distler, Anja Schulze-Krebs, Ivanna K Timotius, Alexandra Bluhm, Maike Hartlage-Rübsamen, Steffen Roßner, Jürgen Winkler, Wei Xiang, Stephan von Hörsten
Parkinson's disease (PD) is a common neurodegenerative movement disorder, characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of aggregated alpha synuclein (aSyn). The disease often presents with early prodromal non-motor symptoms and later motor symptoms. Diagnosing PD based purely on motor symptoms is often too late for successful intervention, as a significant neuronal loss has already occurred. Furthermore, the lower prevalence of PD in females is not well understood, highlighting the need for a better understanding of the interaction between sex and aSyn, the crucial protein for PD pathogenesis...
December 1, 2023: Behavioural Brain Research