Uris Ros, Lohans Pedrera, Ana J Garcia-Saez
Pore-forming proteins (PFPs) are of special interest because of the association of their activity with the disruption of the membrane impermeability barrier and cell death. They generally convert from a monomeric, soluble form into transmembrane oligomers that induce the opening of membrane pores. The study of pore formation in membranes with molecular detail remains a challenging endeavor because of its highly dynamic and complex nature, usually involving diverse oligomeric structures with different functionalities...
May 1, 2021: Current Opinion in Structural Biology
Carol Durno, Ayse Bahar Ercan, Vanessa Bianchi, Melissa Edwards, Melyssa Aronson, Melissa Galati, Eshetu G Atenafu, Gadi Abebe-Campino, Abeer Al-Battashi, Musa Alharbi, Vahid Fallah Azad, Hagit N Baris, Donald Basel, Raymond Bedgood, Anne Bendel, Shay Ben-Shachar, Deborah T Blumenthal, Maude Blundell, Miriam Bornhorst, Annika Bronsema, Elizabeth Cairney, Sara Rhode, Shani Caspi, Aghiad Chamdin, Stefano Chiaravalli, Shlomi Constantini, Bruce Crooks, Anirban Das, Rina Dvir, Roula Farah, William D Foulkes, Zehavit Frenkel, Bailey Gallinger, Sharon Gardner, David Gass, Mithra Ghalibafian, Catherine Gilpin, Yael Goldberg, Catherine Goudie, Syed Ahmer Hamid, Heather Hampel, Jordan R Hansford, Craig Harlos, Nobuko Hijiya, Saunders Hsu, Junne Kamihara, Rejin Kebudi, Jeffrey Knipstein, Carl Koschmann, Christian Kratz, Valerie Larouche, Alvaro Lassaletta, Scott Lindhorst, Simon C Ling, Michael P Link, Rebecca Loret De Mola, Rebecca Luiten, Michal Lurye, Jamie L Maciaszek, Vanan MagimairajanIssai, Ossama M Maher, Maura Massimino, Rose B McGee, Naureen Mushtaq, Gary Mason, Monica Newmark, Garth Nicholas, Kim E Nichols, Theodore Nicolaides, Enrico Opocher, Michael Osborn, Benjamin Oshrine, Rachel Pearlman, Daniel Pettee, Jan Rapp, Mohsin Rashid, Alyssa Reddy, Lara Reichman, Marc Remke, Gabriel Robbins, Sumita Roy, Magnus Sabel, David Samuel, Isabelle Scheers, Kami Wolfe Schneider, Santanu Sen, Duncan Stearns, David Sumerauer, Carol Swallow, Leslie Taylor, Gregory Thomas, Helen Toledano, Patrick Tomboc, An Van Damme, Ira Winer, Michal Yalon, Lee Yi Yen, Michal Zapotocky, Shayna Zelcer, David S Ziegler, Stefanie Zimmermann, Cynthia Hawkins, David Malkin, Eric Bouffet, Anita Villani, Uri Tabori
PURPOSE: Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection in these individuals. PATIENTS AND METHODS: Data were collected from patients with confirmed CMMRD who were registered in the International Replication Repair Deficiency Consortium. Tumor spectrum, efficacy of the surveillance protocol, and malignant transformation of low-grade lesions were examined for the entire cohort...
May 4, 2021: Journal of Clinical Oncology
Raquel Ferrer-Oliveras, Manel Mendoza, Sira Capote, Laia Pratcorona, Enrique Esteve-Valverde, Lluis Cabero-Roura, Jaume Alijotas-Reig
Coronavirus disease-2019 (COVID-19) related to Coronavirus-2 (SARS-CoV-2) is a worldwide health concern. Despite the majority of patients will evolve asymptomatic or mild-moderate upper respiratory tract infections, 20% will develop severe disease. Based on current pathogenetic knowledge, a severe COVID-19 form is mainly a hyperinflammatory, immune-mediated disorder, triggered by a viral infection. Due to their particular immunological features, pregnant women are supposed to be particularly susceptible to complicate by intracellular infections as well as immunological disturbances...
May 4, 2021: Archives of Gynecology and Obstetrics
C Santa, C L Valente, M Mesquita, J Lopes, I Cardoso, P Barreira, I Lopes
Background. Acute urticaria is a common condition in the pediatric emergency department (ED) and no data is available in Portugal. Objective. We aimed to characterize the prevalence, etiology and management of acute urticaria in children presenting at an ED of a portuguese central hospital and report the follow-up investigation when drug or food allergy was suspected. Methods. Retrospective study of clinical records from children admitted to the ED with acute urticaria during one year period. Results. 250 children were included, mean age of 7...
May 4, 2021: European Annals of Allergy and Clinical Immunology
Tomer Boldes, Ohad Hilly, Uri Alkan, Yotam Shkedy, Sara Morgenstern, Thomas Shpitzer, Gideon Bachar, Aviram Mizrachi
OBJECTIVE: To evaluate the precision and utility of Fine-needle aspiration (FNA) in differentiating between benign and malignant parotid tumors, and the implications of FNA results on management and outcomes. DESIGN: Retrospective case series. SETTING: Tertiary medical center. PARTICIPANTS: All adults who underwent preoperative FNA, followed by postoperative histological examination, between 1986-2014. MAIN OUTCOME MEASURES: Differences in clinical management and outcomes of patients with parotid masses in light of FNA results...
May 4, 2021: Clinical Otolaryngology
Eugene Vernyuy Yeika, Brecht Ingelbeen, Ben-Lawrence Kemah, Frankline Sevidzem Wirsiy, Joseph Nkeangu Fomengia, Marianne A B van der Sande
OBJECTIVE: To evaluate and compare the prevalence, reasons, sources, and factors associated with self-medication with antibiotics (SMA) within Africa. METHODS: Systematic review and meta-analysis. An electronic search of PubMed and Google Scholar databases was performed for observational studies conducted between January 2005 and February 2020. Two reviewers independently screened abstracts and full texts using the PRISMA flowchart and performed quality assessment of eligible studies...
May 3, 2021: Tropical Medicine & International Health
Patrick D Shaw Stewart, Julia L Bach
This review seeks to explain three features of viral respiratory illnesses that have perplexed generations of virologists: (1) the seasonal timing of respiratory illness and the rapid response of outbreaks to weather, specifically temperature; (2) the common viruses causing respiratory illness worldwide, including year-round disease in the Tropics; (3) the rapid arrival and termination of epidemics caused by influenza and other viruses. The inadequacy of the popular explanations of seasonality is discussed, and a simple hypothesis is proposed, called temperature dependent viral tropism (TDVT), that is compatible with the above features of respiratory illness...
May 3, 2021: Reviews in Medical Virology
Daisuke Nishioka, Junko Saito, Keiko Ueno, Naoki Kondo
BACKGROUND: Children's healthy development is important. While governmental public assistance benefits financially troubled families, it cannot compensate for a lack of social support. Single-parenthood is a health risk factor for children owing to low-income-associated food insecurity and stress. No study has investigated the association between single-parenthood and health status in children from families receiving public assistance. This study aimed to examine the association between single-parent households and children's health among public assistance recipients in Japan by using linkage data of two municipal public assistance databases and administrative medical assistance data...
May 3, 2021: BMC Pediatrics
Jin Young Jang, Byung Chul Chun
BACKGROUND: An acute upper respiratory tract infection (URI) is the most common disease worldwide, irrespective of age or sex. This study aimed to evaluate the short-term effect of diurnal temperature range (DTR) on emergency room (ER) visits for URI in Seoul, Korea, between 2009 and 2013. METHODS: Daily ER visits for URI were selected from the National Emergency Department Information System, which is a nationwide daily reporting system for ER visits in Korea. URI cases were defined according to International Classification of Diseases, 10th Revision codes J00-J06...
May 3, 2021: Environmental Health and Preventive Medicine
Jonathan J Halford, Michael R Sperling, Dimitrios Arkilo, Mahnaz Asgharnejad, Celia Zinger, Rengyi Xu, Matthew During, Jacqueline A French
OBJECTIVE: To evaluate the safety, tolerability, and pharmacokinetics of soticlestat, a first-in-class cholesterol 24-hydroxylase inhibitor, in adults with developmental and/or epileptic encephalopathies (DEE). METHODS: The study comprised a 30-day, randomized, double-blind, placebo-controlled phase (Part A), followed by a 55-day open-label phase (Part B) ( ID: NCT03166215) . In Part A, patients with DEE and at least one bilateral motor seizure during the 4-week prospective baseline period were randomized 4:1 to receive soticlestat or placebo, in addition to their usual antiseizure medication...
April 22, 2021: Epilepsy Research
Hye-Youn Cho, Soojung Park, Laura Miller, Huei-Chen Lee, Robert Langenbach, Steven R Kleeberger
Mucin-5AC (MUC5AC) is a major secreted mucin in pathogenic airways. To determine its role in mucus-related airway disorders, Muc5ac -deficient ( Muc5ac-/- ) and wild-type ( Muc5ac+/+ ) mice were compared in bleomycin-induced pulmonary fibrosis, respiratory syncytial virus (RSV) disease, and ozone toxicity. Significantly greater inflammation and fibrosis by bleomycin were developed in Muc5ac-/- lungs compared to Muc5ac+/+ lungs. More severe mucous cell metaplasia in fibrotic Muc5ac-/- lungs coincided with bronchial Muc2 , Muc4 , and Muc5b overexpression...
May 3, 2021: Toxicologic Pathology
Sameer Acharya, Janette Lee, Tyler Kelly, Binay K Kshetree
COVID-19 has not spared a single system in the human body. Although acute respiratory failure culminating sometimes in death remains the most common manifestation of severe infection, hypercoagulability leading to deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke have also been identified widely. Here, we describe a young patient with a COVID-19 infection who developed right basilic vein thrombosis. This case demonstrates how thrombosis can occur in uncommon sites and how clinicians should be vigilant for thrombotic complications in both the inpatient and outpatient settings...
March 29, 2021: Curēus
Chi Hoon Bae, Sun-Jae Lee
Follicular bronchiolitis is a rare pulmonary disorder characterized by the presence of multiple hyperplastic lymphoid follicles with a peribronchiolar distribution. An 11-year-old girl with total atelectasis of the right middle lobe (RML) and diffuse multiple small nodules at both lung bases presented to our hospital with frequent upper respiratory infections and pneumonia. The disease progressed during a 3-month period of macrolide therapy, and thoracoscopic biopsy with lobectomy of the atelectatic RML was performed...
2021: International Journal of Clinical and Experimental Pathology
Bakri Elsheikh, Steven Severyn, Songzhu Zhao, David Kline, Matthew Linsenmayer, Kristina Kelly, Marco Tellez, Amy Bartlett, Sarah Heintzman, Jerry Reynolds, Gary Sterling, Tristan Weaver, Kiran Rajneesh, Stephen J Kolb, W David Arnold
Objective: Investigation of the safety, tolerability, and treatment effect of nusinersen treatment in non-ambulatory adults with spinal muscular atrophy (SMA). Methods: Non-ambulatory individuals, aged 18 years or older with genetically confirmed 5q SMA were enrolled. In participants with spinal fusion, fluoroscopy guided cervical C1-C2 lateral approach was used. Outcomes at 2, 6, 10, and 14 months post-treatment were compared with baseline assessment. Forced vital capacity (FVC) was the primary outcome, and RULM, HFMSE, the modified SMA-FRS, and ulnar nerve electrophysiology [compound muscle action potential (CMAP), single motor unit size, and motor unit number] were secondary...
2021: Frontiers in Neurology
Albert Busquets, Blai Ferrer-Uris, Rosa Angulo-Barroso, Peter Federolf
Performance and control of upright bipedal posture requires a constant and dynamic integration of relative contributions of different sensory inputs (i. e., sensory reweighting) to enable effective adaptations as individuals face environmental changes and perturbations. Children with gymnastic experience showed balance performance closer to that of adults during and after proprioceptive alteration than children without gymnastic experience when their center of pressure (COP) was analyzed. However, a particular COP sway can be achieved through performing and coordinating different postural movements...
2021: Frontiers in Psychology
Zahra Shabani
The coronavirus disease of 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 (SARS CoV-2), that already appeared as a global pandemic. Presentation of the disease often includes upper respiratory symptoms like dry cough, dyspnea, chest pain, and rhinorrhea that can develop to respiratory failure, needing intubation. Furthermore, the occurrence of acute and subacute neurological manifestations such as stroke, encephalitis, headache, and seizures are frequently stated in patients with COVID-19...
May 2, 2021: Acta Neurologica Belgica
Stephen Among James, Wai Keat Yam
Rhinoviruses (RV), especially Human rhinovirus (HRVs) have been accepted as the most common cause for upper respiratory tract infections (URTIs). Pleconaril, a broad spectrum anti-rhinoviral compound, has been used as a drug of choice for URTIs for over a decade. Unfortunately, for various complications associated with this drug, it was rejected, and a replacement is highly desirable. In silico screening and prediction methods such as sub-structure search and molecular docking have been widely used to identify alternative compounds...
April 24, 2021: Computational Biology and Chemistry
Stephanie Salim, Lokot Donna Lubis, Cut Adeya Adella, Milahayati Daulay, Eka Roina Megawati
INTRODUCTION: Nowadays, acute respiratory infection (ARI) is the most common cause of high morbidity and mortality rate in children. ARI is defined as an infection either in the upper or lower respiratory tract that lasts for 14 days and caused by either viruses or bacteria. The incidence of ARI in 2017 is 20.54%, with the most prominent characteristic in children aged 1 to 4 years. Factors that affect ARI frequency are gender, birth weight, nutritional status, immunization status, vitamin A status, exclusive breastfeeding, smoke exposure, family income, and mother's formal education...
April 30, 2021: Folia Medica
Dongmei Huang, Aerxin Habuding, Miao Yuan, Gang Yang, Kaisheng Cheng, Dengke Luo, Chang Xu
INTRODUCTION: The treatment of extralobar pulmonary sequestration (ELS) remains divergent. This study aims to demonstrate the characters of ELS in children for optimal clinical management in the future. MATERIAL AND METHODS: A retrospective analysis was conducted for ELS patients' treatment in our center from January 2013 to April 2020. RESULTS: In total, 85 patients were included, containing 70 upper-diaphragmatic, 7 intra-diaphragmatic, and 8 infra-diaphragmatic ELS...
April 30, 2021: Pediatric Pulmonology
Laurent Faroux, Thibault Lhermusier, Flavien Vincent, Luis Nombela-Franco, Didier Tchétché, Marco Barbanti, Mohamed Abdel-Wahab, Stephan Windecker, Vincent Auffret, Diego Carter Campanha-Borges, Quentin Fischer, Erika Muñoz-Garcia, Ramiro Trillo-Nouche, Troels Jorgensen, Vicens Serra, Stefan Toggweiler, Giuseppe Tarantini, Francesco Saia, Eric Durand, Pierre Donaint, Enrique Gutierrez-Ibanes, Harindra C Wijeysundera, Gabriela Veiga, Giuseppe Patti, Fabrizio D'Ascenzo, Raul Moreno, Christian Hengstenberg, Chekrallah Chamandi, Lluis Asmarats, Rosana Hernandez-Antolin, Joan Antoni Gomez-Hospital, Juan Gabriel Cordoba-Soriano, Uri Landes, Victor Alfonso Jimenez-Diaz, Ignacio Cruz-Gonzalez, Mohammed Nejjari, François Roubille, Éric Van Belle, German Armijo, Saifullah Siddiqui, Giuliano Costa, Sameh Elsaify, Thomas Pilgrim, Hervé le Breton, Marina Urena, Antonio Jesus Muñoz-Garcia, Lars Sondergaard, Montserrat Bach-Oller, Chiara Fraccaro, Hélène Eltchaninoff, Damien Metz, Maria Tamargo, Victor Fradejas-Sastre, Andrea Rognoni, Francesco Bruno, Georg Goliasch, Marcelo Santaló-Corcoy, Jesus Jimenez-Mazuecos, John G Webb, Guillem Muntané-Carol, Jean-Michal Paradis, Antonio Mangieri, Henrique Barbosa Ribeiro, Francisco Campelo-Parada, Josep Rodés-Cabau
BACKGROUND: Among patients with acute coronary syndrome following transcatheter aortic valve replacement (TAVR), those presenting with ST-segment elevation myocardial infarction (STEMI) are at highest risk. OBJECTIVES: The goal of this study was to determine the clinical characteristics, management, and outcomes of STEMI after TAVR. METHODS: This was a multicenter study including 118 patients presenting with STEMI at a median of 255 days (interquartile range: 9 to 680 days) after TAVR...
May 4, 2021: Journal of the American College of Cardiology
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